E2748
|
EGCG Octaacetate
|
EGCG Octaacetate(AcEGCG) is a pro-drug of epigallocatechin-3-gallate (EGCG). EGCG have potent anti-oxidative, anti-mitotic and anti-angiogenic properties.
|
E2438
|
Ginsenoside Rg3
|
Ginsenoside Rg3 is a ginsenoside found in Panax japonicus var. and Panax ginseng, mainly used for the study of tumor diseases.
|
E3570
|
Artemisia annua Extract
|
Artemisia annua Extract is extracts from artemisia annua, which have antiviral activity.
|
E0657
|
Rubiadin 1-methyl ether
|
Rubiadin-1-methyl ether, a natural anthraquinone compound isolated from the root of Morinda officinalis How, can inhibit osteoclastic bone resorption through blocking NF-κB pathway and may be a promising agent for the prevention and treatment of bone diseases characterized by excessive bone resorption.
|
E2693
|
Phycocyanobilin
|
Phycocyanobilin (PCB) is an open-chain tetrapyrrole chromophore covalently bonded to both polypeptide chains of C-Phycocyanin (C-PC), the most represented biliprotein of Spirulina platensis, the mechanisms by which it protected cells included the reduction of oxidative stress damage, which could contribute to its clinical efficacy for the treatment of neurodegenerative diseases.
|
S8989
|
Xanthatin
|
Xanthatin is a sesquiterpene lactone isolated from Xanthium strumarium leaves, which can inhibit the nuclear factor kappa-B (NF-κB), mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STATs) signaling pathways.
|
E0599
|
Arecaidine hydrochloride
|
Arecaidine hydrochloride, a constituent of the nut of Areca catechu, inhibits the uptake of GABA and beta-alanine, but not that of glycine.
|
S0563
|
10-Deacetyl-7-xylosyl paclitaxel
|
10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis, causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Bad protein, as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL , which leads to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9.
|
E3387
|
Sophora flavescens Extract
|
Sophora flavescens Extract (Sophora angustifolia root Extract) is extracted from Chinese traditional herb Kushen (Sophora flavescens Aiton).
|
E1138
|
CQ31
|
CQ31, a small molecule, selectively activates caspase activation and recruitment domain-containing 8 (CARD8).
|
E3682
|
Pseudostellaria heterophylla Extract
|
Pseudostellaria heterophylla Extract(Radix Pseudostellaria Extract) is an active ingredient extracted from Pseudostellaria heterophylla, which can be used in the treatment of diabetes.
|
E0769
|
Ginsenoside Rh4
|
Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.
|
E2683
|
Ursodeoxycholic acid sodium
|
Ursodeoxycholic acid sodium is a sodium salt of a naturally occurring bile acid that is used to treat a variety of hepatic and gastrointestinal diseases.
|
E0671
|
Deacetylasperulosidic acid
|
Deacetylasperulosidic acid, a major phytochemical constituent of Morinda citrifolia fruit, has antioxidant activity by increasing superoxide dismutase (SOD) activity, as well as anticlastogenic activity by suppressing the induction of chromosome aberrations in Chinese hamster ovary cells and mice.
|
S8233
|
Prodigiosin
|
Prodigiosin is a natural red pigment produced by numerous bacterial species which can inhibit Wnt/β-catenin pathway.
|
S6975
|
N-Vanillyldecanamide
|
N-Vanillyldecanamide is a capsaicinoid isolated from the fruits of Capsicum annuum, which can significantly reduce the radical length of Lactuca sativa seedling in a dose-dependent manner.
|
E3199
|
Petasites Japonicus Extract
|
Petasites Japonicus Extract regulates osteoblast differentiation at least in part through Runt-related transcriptional factor 2 (RUNX2) and Osterix, suggesting an aqueous extract of P. japonicus leaves is likely to be useful as an alternative therapeutic for preventing and treating osteoporosis.
|
E0758
|
Silydianin
|
Silydianin is an active constituent of <i>Silybium marianum</i>, with exhibit anti-collagenase, antitumor and anti-elastase activities.
|
E2548
|
N-(p-Coumaroyl) Serotonin
|
N-(p-Coumaroyl) Serotonin (p-coumaroylserotonin) is a polyphenol isolated from the seeds of safflower and has antioxidative, anti-atherogenic and anti-inflammatory properties, can inhibits PDGF-induced on phosphorylation of PDGF receptor and Ca2+ release from sarcoplasmic reticulum.
|
E2274
|
Hexahydrocurcumin
|
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor.
|
E0477
|
N-Caffeoyl O-methyltyramine
|
N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
|
E2833
|
1,5-Anhydro-D-glucitol
|
1,5-Anhydro-D-glucitol (1,5-Anhydroglucitol, 1,5-AG) is a naturally occurring monosaccharide found in nearly all foods, supporting reliable evidences for early forecast and screening of diabetes mellitus.
|
E2354
|
Valepotriate
|
Valepotriate, an unstable iridoid isolated from Valeriana jatamansi Jones, has anti-epileptic by significantly increasing the expression of GABAA, glutamic acid decarboxylase 65, and Bcl-2 and reduce the expression of caspase-3.
|
E2641
|
trans-Chalcone
|
Trans-Chalcone, the backbone of flavonoids, also is a potent fatty acid synthase (FAS) with IC50 of 17.1 μg/mL, and α-amylase inhibitor, causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7, exerting antifungal and anticancer activities.
|
E0738
|
Gipsoside
|
Gypenoside is a triterpene saponin from gypsophila paniculata L.
|
E0831
|
Pseudocoptisine chloride
|
Pseudocoptisine chloride (Isocoptisine chloride) is a quaternary alkaloid with benzylisoquinoline skeleton isolated from Corydalis Tuber, inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM, showing anti-inflammatory and anti-amnestic effects.
|
E3505
|
Shrubalthea Flower Extract
|
|
E3503
|
Papaya Leaf Extract
|
|
E3684
|
Semen Persicae Extract
|
|
E3685
|
Ampelopsis grossedentata Extract
|
|
E3686
|
60% Garcinia cambogia Extract
|
|
E3687
|
Radix Actinidiae Extract
|
|
E3698
|
Stevia rebaudiana Extract
|
|
E3725
|
Sapindus saponaria Linnaeus nutshell Extract (40%)
|
|
E3726
|
Sapindus saponaria Linnaeus nutshell Extract (70%)
|
|
E3727
|
Daphne genkwa Sieb.et Zucc. Extract
|
|
E3728
|
Brassica rapa Extract
|
|
E3729
|
Ulmus macrocarpa Hance seeds Extract
|
|
E3730
|
Tetradium ruticarpum fruits Extract
|
|
E3731
|
Chinese Gallnut Extract
|
|
E3732
|
Cortex Acanthopanacis Senticosus Extract
|
|
E3733
|
Faeces Trogopterori Extract
|
|
E3734
|
Schisandrae Chinensis fructus Extract
|
Schisandrae Chinensis fructus Extract is extracted from Schisandra chinensis Fructus, the dry ripe fruit of <i>Schisandra chinensis</i> (Turcz.) Baill.. Schisandrae Chinensis fructus is mainly used for the treatment of dysphoria and palpitation, insomnia. Schisandrae Chinensis fructus and its active ingredients show a protective role in Neurological diseases, including cerebrovascular diseases, neurodegenerative diseases, or depression.
|
E3735
|
Ficus hirta Vahl Extract
|
|
E3736
|
Gymnema sylvestre Extract
|
|
E3752
|
Abrus precatorius Bean Extract
|
|
E3773
|
Marasmius Extract
|
|
E3778
|
Magnoliae Flos Extract
|
|
E3822
|
Coix Lacryma-Jobi Seed Extract
|
Coix lacryma-jobi seed Extract is extracted from Coix lacryma-jobi L.. Coix lacryma-jobi seed has anti-inflammatory activity, hypoglycemic activity, the ability to decrease the amount of lipid components in the serum and hypocholesterolemic activity.
|
E3837
|
Citrus Maxima Peel Extract
|
|
E3647
|
Pyrrosiae Folium Extract
|
|
E3041
|
Alpiniae Katsumadai Extract
|
|
E3061
|
Castor Bean Extract
|
|
E3063
|
Pygeum Topengii Bark Extract
|
|
E3123
|
Rhubarb Extract
|
|
E3127
|
Rice Flour Extract
|
|
E3129
|
Garlic Extract (1%)
|
|
E3166
|
Fermented Blank Bean Extract
|
|
E3167
|
Amomum Kravanh Fruit Extract
|
|
E3174
|
Eucommia Extract (Bark, Branch and Leaf)
|
|
E3201
|
Honey Extract
|
|
E3221
|
Downy Rosemyrtle Root Extract
|
|
E3289
|
Knoxia Valerianoides Extract
|
|
E3365
|
Weigela Grandiflora Fortune Extract
|
|
E3392
|
Balsam Pear Extract
|
|
E3458
|
Ilex Paraguariensis Extract
|
|
E3485
|
Matcha Powder
|
|
E3507
|
Rose-of-Sharon Seed Extract
|
|
E3521
|
Auricledleaf Swallowwort Root Extract
|
|
E3544
|
Cattail Pollen Extract
|
|
E3759
|
Periploca Sepium Extract
|
|
E3764
|
Rose Pelargonium Leaf Extract
|
|
E3847
|
Fructus Akebiae Extract
|
|
E3876
|
Processed Aconite Extract
|
|
E3522
|
Achyranthes bidentata root Extract
|
|
E3523
|
Antrodia cinnamomea Extract
|
|
E3524
|
Oregano Extract
|
|
E3525
|
Origanum vulgare leaf Extract
|
|
E3526
|
Clematis apiifolia Extract
|
|
E3527
|
Glossy privet fruit Extract
|
|
E3528
|
Parsley Extract
|
|
E3529
|
Achillea millefolium Extract
|
|
E3530
|
Boat-fruited sterculia seed Extract
|
|
E3532
|
Wedelia Extract
|
|
E3533
|
Loquat leaf Extract
|
|
E3534
|
Hops Extract
|
|
E3535
|
Japanese ardisia Extract
|
|
E3536
|
Oyster mushroom Extract
|
|
E3537
|
Apple cider vinegar Extract
|
|
E3538
|
Apple Extract
|
|
E3539
|
Grape skin Extract
|
|
E3540
|
Grapefruit Extract
|
|
E3541
|
Grapefruit Seed Extract
|
|
E3543
|
Dandelion Extract
|
|
E3545
|
Pu-erh tea Extract
|
|
E3547
|
Extract of Scandent Schefflera Stem and Leaf
|
|
E3548
|
Chia seed Extract
|
|
E3549
|
Qamgur Extract
|
|
E3550
|
Philippine flemingia root Extract
|
|
E3551
|
Stephania Extract
|
|
E3552
|
Euphorbia lathyris Extract
|
|
E3553
|
Climbing groundsel Extract
|
|
E3554
|
Rhizoma homalomenae Extract
|
|
E3555
|
Acmella oleracea Extract
|
|
E3556
|
Pharbitis Extract
|
|
E3557
|
Radix Peucedani Extract
|
|
E3558
|
Euryale ferox Extract
|
|
E3559
|
Radix rubiae Extract
|
|
E3560
|
Incised notopterygium rhizome Extract
|
|
E3561
|
Polygonum fagopyrum seed Extract
|
|
E3563
|
Eggplant Extract
|
|
E3564
|
Celery Extract
|
|
E3565
|
Celery seed Extract
|
|
E3566
|
Largeleaf Gentian Root Extract
|
|
E3567
|
Ash bark Extract
|
|
E3568
|
Natural indigo Extract
|
|
E3569
|
Caulis sinomenii Extract
|
|
E3571
|
Green Walnut Husk Extract
|
|
E3572
|
Green Tangerine peel Extract
|
|
E3580
|
Ginseng Extract
|
Ginseng is one of the most widely used herbal remedies, because it is believed to improve energy, physical and emotional health, and well-being.
|
E3645
|
Pomegranate seed Extract
|
|
E3646
|
Selaginella Doederleinii Extract
|
|
E3648
|
Pyrrosia lingua Extract
|
|
E3649
|
Centaurea cyanus Extract
|
|
E3650
|
Diospyroskaki leaf Extract
|
|
E3651
|
Lycopodiastrum casuarinoides Extract
|
|
E3652
|
Rehmanniae radix praeparata Extract
|
|
E3654
|
Althaea rosea Extract(root)
|
|
E3655
|
Althaea rosea Extract(leaves)
|
|
E3656
|
Dichroa febrifuga Extract
|
|
E3657
|
Salvia japonica Extract
|
|
E3659
|
Silybum mariamum Extract
|
|
E3660
|
Polypodiodes niponica Extract
|
|
E3661
|
Prunus persica Extract
|
|
E3662
|
Buffalo Horn Extract
|
|
E3663
|
Retinerus luffae Fructus Extract
|
|
E3664
|
Luffa Cylindrica Stem Extract
|
|
E3665
|
60% Yucca schidigera Extract
|
|
E3666
|
Chloranthus helostegius Extract
|
|
E3667
|
Pine pollen Extract (flower)
|
|
E3668
|
Pine pollen Extract (flower bud )
|
|
E3669
|
Pine Nodular Branch Extract
|
|
E3670
|
Pine Bark Extract
|
Pine Bark Extract is extracted from Pine bark. Pine bark extract is rich in bioflavonoids, predominantly proanthocyanidins, which are antioxidants. Pine Bark extract is used for preventing or treating various chronic conditions associated with oxidative stress. This is an update of a previously published review.
|
E3671
|
Mesembryanthemum spectabile Extract
|
|
E3672
|
Pine needles Extract
|
|
E3673
|
Pine nuts Extract
|
|
E3674
|
Caesalpinia sappan Extract
|
|
E3676
|
Prunus cerasus Extract
|
|
E3677
|
Semen Ziziphi Spinosae Extract
|
|
E3678
|
Vitex agnus-castus Extract
|
|
E3679
|
Semen aesculi Extract
|
|
E3680
|
Aesculus chinensis Bunge fruits Extract
|
|
E3681
|
Cynomorium Songaricum Extract
|
|
E3683
|
Santalum album Extract
|
|
E3444
|
Spirulina Extract
|
|
E3445
|
Roselle Extract
|
|
E3446
|
Chinese Starjasmine stem Extract
|
|
E3447
|
Air-Plant herb Extract
|
|
E3449
|
Green tea Extract
|
|
E3450
|
Phaseolus radiatus seed Extract
|
|
E3451
|
Mung bean peel Extract
|
|
E3452
|
Green Coffee bean Extract
|
|
E3453
|
Gnetum parvifolium Extract
|
|
E3454
|
Verbena herbs Extract
|
|
E3455
|
Puff-ball Extract
|
|
E3456
|
Purslane Extract
|
|
E3459
|
Malan Extract
|
|
E3460
|
Bones of Cervus elaphus’ Extract
|
|
E3461
|
Strychnos Extract
|
|
E3462
|
Coriaria Root Extract
|
|
E3463
|
Masson pine needle Extract
|
|
E3464
|
Maca extract
|
|
E3465
|
Radix Ophiopogonis Extract
|
|
E3466
|
Barley grass Extract
|
|
E3467
|
Malt fruit Extract
|
|
E3468
|
Chasteberry Extract
|
|
E3470
|
Mango leaf Extract
|
|
E3471
|
Mang Grass Extract
|
|
E3472
|
Spicate clerodendranthus Extract
|
|
E3473
|
Ternate buttercup root Extract
|
|
E3474
|
Fructus Chebulae Extract
|
|
E3475
|
Coleus forskohlii Extract
|
|
E3477
|
Rose hip Extract
|
|
E3482
|
Myrtle Extract
|
|
E3483
|
Bee flower Extract
|
|
E3486
|
Jasmine flower Extract
|
|
E3488
|
Fucus vesiculosis Extract
|
|
E3489
|
Cuttlefish grass Extract
|
|
E3487
|
Ecliptae Herba Extract
|
|
E3490
|
Peony flower Extract
|
|
E3491
|
Paeonia suffruticosa root bark Extract
|
|
E3492
|
Vitex negundo seed Extract
|
|
E3493
|
Oyster Extract
|
|
E3494
|
Oyster Shell Extract
|
|
E3495
|
Oyster Peptide
|
Oyster peptide is derived from oyster meat by modern bio-enzymatic hydrolysis technology, and further separation, purification, deodorization and spray drying process.
|
E3497
|
Momordicae Semen Extract
|
|
E3498
|
Pigeon pea leaves Extract
|
|
E3484
|
Ashitaba Extract
|
|
E3480
|
Rosemary Extract
|
|
E3478
|
Rose Extract
|
|
E3476
|
Myrrh Extract
|
|
E3448
|
Chinese Astilbe rhizome Extract
|
|
E3469
|
Cranberry Extract
|
|
E3499
|
Basella rubra Extract
|
|
E3500
|
Agaric Extract
|
|
E3501
|
Hibiscus mutabilis flower Extract
|
|
E3502
|
Papaya Extract
|
|
E3504
|
Oroxylum indicum seed Extract
|
|
E3506
|
Hibiscus bark Extract
|
|
E3508
|
Magnolia Obovata Extract
|
|
E3509
|
Akebia quinata Extract
|
|
E3510
|
Costustoot Extract
|
|
E3512
|
Milk thistle Extract
|
|
E3513
|
Pumpkin seed Extract
|
|
E3514
|
Burdock root Extract
|
|
E3515
|
Great Burdock Achene Extract
|
|
E3516
|
Beautiful millettia root Extract
|
|
E3517
|
Ox-gall Extract
|
|
E3518
|
Daphniphyllum calycinum Extract
|
|
E3519
|
OX liver Extract
|
|
E3520
|
Beef tendon grass Extract
|
|
E3200
|
Bee Pollen Extract
|
|
E3203
|
Hibiscus Flower Extract
|
|
E3204
|
Citri Sarcodactylis Fructus Extract
|
|
E3206
|
Spirodelae Herba Extract
|
|
E3207
|
Blighted Wheat Extract
|
|
E3208
|
White Prepared Lateral Root of Aconite Extract
|
|
E3209
|
Aconiti Lateralis Radix Praeparata Extract
|
|
E3210
|
Rubi Fructus Extract
|
|
E3212
|
Prunus Humilis Bunge Extract
|
|
E3213
|
Glycyrrhizae Rhizoma Extract
|
|
E3214
|
Nardostachyos Rhizoma Extract
|
|
E3215
|
Kansui Radix Extract
|
|
E3216
|
Citrus Extract
|
|
E3217
|
Penthorum Chinense Pursh Extract
|
|
E3218
|
Zingiberis Rhizoma Extract
|
|
E3219
|
Flos Ascheri Extract
|
|
E3222
|
Sedum Aizoon Extract
|
|
E3223
|
Alpiniae Officinarum Rhizoma Extract
|
|
E3224
|
Puerariae Lobatae Radix Extract
|
|
E3225
|
Pueraria Flower Extract
|
|
E3226
|
Devil's Claw Extract
|
|
E3340
|
Jiao San Xian Extract
|
Jiao Sanxian is composed of Jiao Malt(Coke Malt), Jiao Hawthorn (Coke Hawthorn) and Jiao Shenqu.
|
E3354
|
Camellia nitidissima Extract
|
|
E3355
|
Cinchona Extract
|
|
E3356
|
Witch hazel Extract
|
|
E3357
|
Lysimachia christinae Hance extract
|
|
E3358
|
Rhizoma fagopyri dibotryis Extract
|
|
E3360
|
Lonicera japonica Extract
|
Lonicera japonica Extract (Japanese honeysuckle Extract), isolated from the leaves and flowers of Lonicera japonica (Japanese honeysuckle), possesses antipyretic, antibiotic, antioxidant, and anti-inflammatory activities.
|
E3361
|
Calendula officinalis flower Extract
|
|
E3362
|
Enoki mushroom Extract
|
|
E3363
|
Decumbent Bugle Herb Extract
|
|
E3364
|
Physalis alkekengi Extract
|
|
E3366
|
Fineleaf schizonepeta herb Extract
|
|
E3367
|
Garlic chives Extract
|
|
E3368
|
Chinese Chive seed Extract
|
|
E3369
|
Radix Platycodonis Extract
|
|
E3371
|
Chrysanthemi Extract
|
|
E3372
|
Chicory Extract
|
|
E3374
|
Exocarpium Citri Rubrum Extract
|
|
E3376
|
Saw palmetto Extract
|
|
E3377
|
Symphytum officinale Extract
|
|
E3378
|
Selaginella Extract
|
|
E3379
|
Cassia seed Extract
|
|
E3380
|
Coffee fruit Extract
|
|
E3381
|
Cabinda Extract
|
|
E3382
|
Camu Camu fruit Extract
|
|
E3383
|
Kacip fatimah Extract
|
|
E3384
|
Kava Extract
|
|
E3385
|
Cocoa Extract
|
|
E3386
|
Wormwood Extract
|
|
E3388
|
Latifolin Extract
|
|
E3389
|
Sophora alopecuroides seed Extract
|
|
E3391
|
Balsam Pear Powder
|
|
E3393
|
Fructus azedarach Extract
|
|
E3394
|
Quassia Extract
|
|
E3395
|
Tartary buckwheat Extract
|
|
E3396
|
Bitter almond Extract
|
|
E3397
|
Coltsfoot Extract
|
|
E3398
|
Sunflower dish Extract
|
|
E3399
|
Kelp Extract
|
|
E3400
|
Chili pepper Extract
|
|
E3401
|
Polygonum hydropiper Extract
|
|
E3402
|
Moringa oleifera leaf Extract
|
|
E3403
|
Moringa pterygosperma seed Extract
|
|
E3404
|
Radish seed Extract
|
|
E3405
|
Eupatorium fortunei Extract
|
|
E3407
|
Blueberry Extract
|
|
E3408
|
Radix Euphorbiae Ebracteolatae Extract
|
|
E3409
|
Geranium wilfordii Extract
|
|
E3406
|
Blue indigo Extract
|
|
E3410
|
Tripterygium wilfordii Extract
|
|
E3411
|
Veratrum nigrum L. Extract
|
|
E3412
|
Quinoa Extract
|
|
E3413
|
Plum Extract
|
|
E3414
|
Semen litchi Extract
|
|
E3415
|
Forsythia suspensa Extract
|
|
E3416
|
Lotus seed Extract
|
|
E3417
|
Nitidum Extract
|
|
E3418
|
Rhizoma Anemones Raddeanae Extract
|
|
E3419
|
Ganoderma lucidum Extract
|
|
E3420
|
Trumpet creeper Extract
|
|
E3421
|
Diverse wormwood herb Extract
|
|
E3422
|
Spearmint Extract
|
|
E3423
|
Gentian Extract
|
|
E3424
|
Solanum nigrum Extract
|
|
E3425
|
Dragon's blood Extract
|
|
E3426
|
Piper betle L. Extract
|
|
E3427
|
Uniflower swisscentaury root Extract
|
|
E3428
|
Reed rhizome Extract
|
|
E3429
|
Aloe vera Extract
|
|
E3431
|
Asparagus Extract
|
|
E3432
|
Calamine Extract
|
|
E3434
|
Deer antler velvet Extract
|
|
E3433
|
Rhaponticum carthamoides transformed root Extract
|
|
E3435
|
Pyrola herb Extract
|
|
E3436
|
Liquidambar formosana Extract
|
|
E3437
|
Apocynum venetum Extract
|
|
E3438
|
Momordica grosvenori Extract
|
|
E3439
|
Basil Extract
|
|
E3440
|
Tamarind Extract
|
|
E3441
|
Radish root Extract
|
|
E3442
|
Radish leaves Extract
|
|
E3359
|
Honeysuckle flower Extract
|
|
E3811
|
Cashew Extract
|
|
E3812
|
Rhamnus Cathartica Extract
|
|
E3813
|
Chrysanthemum Indicum Extract
|
|
E3814
|
Phyllanthus Urinaria Extract
|
|
E3815
|
Caulis Polygoni Multiflori Extract
|
|
E3816
|
Emilia Sonchifolia Extract
|
|
E3817
|
Eucalyptus Globulus Fruit Extract
|
|
E3818
|
Solidago Decurrens Extract
|
|
E3820
|
Leonurus Japonicus Extract
|
|
E3821
|
Alpinia Oxyphyllae Extract
|
|
E3824
|
Scepteridium Ternatum Extract
|
|
E3825
|
Herba Artemisiae Capillaris Extract
|
|
E3826
|
Tremella Extract
|
|
E3827
|
Ginkgo Biloba Extract
|
Ginkgo biloba Extract is extracted from the leaves of the Ginkgo biloba L.. Ginkgo biloba Extract is used in an extensive range of disorders and diseases, including depressed mood, multi-infarct dementia, cerebral insufficiency (characterized by symptoms such as memory impairment, poor concentration, anxiety, and confusion), myocardial ischemia, stroke, thrombosis, and peripheral occlusive arterial disease (POAD).
|
E3829
|
Epimedium Brevicornu Extract
|
|
E3830
|
Prunus Serrulata Extract
|
|
E3831
|
Cherry Powder Extract (Pink) Extract
|
|
E3832
|
Cherry Extract
|
|
E3833
|
Cherry Extract (Brown) Extract
|
|
E3834
|
Jasminum Nudiflorum Extract
|
|
E3835
|
Cordyceps Militaris Extract
|
|
E3836
|
Cole Flowers Extract
|
|
E3838
|
Phyllanthus Emblica Extract
|
|
E3839
|
Houttuynia Cordata Extract
|
|
E3840
|
Ulmus Pumila Bark Extract
|
|
E3841
|
Kale Extract
|
|
E3842
|
Corn Extract
|
|
E3843
|
Corn Stigma Extract
|
|
E3844
|
Polygonatum Odoratum Extract
|
|
E3845
|
Radix Curcumae Root Extract
|
|
E3846
|
Semen Pruni Extract
|
|
E3848
|
Hypericum Sampsonii Extract
|
|
E3849
|
Scrophularia Ningpoensis Extract
|
|
E3850
|
Rhizoma Corydalis Extract
|
|
E3851
|
Radix Polygalae Extract
|
|
E3852
|
Oenothera Biennis Extract
|
|
E3853
|
Blueberry Fruit Extract
|
|
E3854
|
Coriolus Versicolor Extract
|
|
E3855
|
Ruta Graveolens Extract
|
|
E3857
|
Gieditsia Sinensis Lam Fruit Extract
|
|
E3858
|
Quillaia Extract
|
|
E3859
|
Lycopus Extract
|
|
E3860
|
Euphorbia Helioscopia Extract
|
|
E3861
|
Rhizoma Alismatis Extract
|
|
E3862
|
Japanese Xylosma Twig Extract
|
|
E3863
|
Swertia Bimaculata Extract
|
|
E3864
|
Cockroach Extract
|
|
E3865
|
Catharanthus Roseus Extract
|
|
E3867
|
Fritillariae Thunbergii Bulbus Extract
|
|
E3868
|
Pearl Extract
|
|
E3869
|
Anemarrhena Extract
|
|
E3870
|
Gardenia Fruit Extract
|
Gardenia fruit Extract is extracted from the fruits of Gardenia jasminoides Ellis., a flowering plant belonging to Rubiaceae family. Gardenia fruit is used not only as a food coloring but also as a medicine to treat hepatic disorders, headache, jaundice, inflammation, and hypertension.
|
E3871
|
Valeriana Root Extract
|
|
E3872
|
Hovenia Dulcis Fruit Extract
|
|
E3873
|
Hovenia Dulcis Seed Extract
|
|
E3874
|
Hovenia Dulcis Extract
|
|
E3875
|
Unripe Bitter Orange Extract
|
|
E3877
|
Processed Cyperus Extract
|
|
E3878
|
Stalactitum Extract
|
|
E3879
|
Glabrous Sarcandra Herb Extract
|
|
E3880
|
Rhizoma Paridis Extract
|
|
E3881
|
Swine'S Gallbladder Extract
|
|
E3882
|
Swine'S Liver Extract
|
Pig's liver Extract is extract from the liver of swine, a valuable edible slaughter by-products suitable for human consumption.
|
E3883
|
Umbellate Pore Fungus Extract
|
|
E3884
|
Galium Aparine Extract
|
|
E3885
|
Swine‘S Pancreas Extract
|
|
E3886
|
Bamboo Sap Extract
|
|
E3887
|
Bamboo Shaving Extract
|
|
E3888
|
Cortex Illicii Extract
|
|
E3889
|
Cumin Extract
|
|
E3890
|
Lithospermum Erythrorhizon Extract
|
|
E3891
|
Red Cabbages Extract
|
|
E3892
|
Viola Philphica Munda Extract
|
|
E3893
|
Alfalfa Extract
|
|
E3894
|
Ardisia Japonica Extract
|
|
E3895
|
Perilla Frutescens Extract
|
|
E3896
|
Perilla Leaf Extract
|
|
E3897
|
Purple Perilla Seed Extract
|
|
E3898
|
Radix Asteris Extract
|
|
E3899
|
Echinacea Extract (flower)
|
Purple coneflower Extract is extracted from purple coneflower, the flower of Echinacea purpurea, Echinacea angustifolia or Echinacea pallida. Purple coneflower is used as a treatment for respiratory tract infections and inflammatory conditions, including common cold, coughs, bronchitis, and inflammation of mouth and pharynx.
|
E3900
|
Echinacea Extract
|
|
E3901
|
Ribes Henryi Root Extract
|
|
E3801
|
Morchella Extract
|
|
E3802
|
Inula Cappa Extract
|
|
E3803
|
Goat Liver Powder Extract
|
|
E3804
|
Aspen Flower Extract
|
|
E3805
|
Psyllium Husk Extract
|
|
E3806
|
Allium Cepa Extract
|
|
E3807
|
Chamomile Extract
|
|
E3808
|
Jerusalem Artichoke Extract
|
|
E3809
|
Datura Metel Extract
|
|
E3810
|
Bauhinia Variegata Extract
|
|
E3700
|
Descurainiae Semen Lepidii Semen Extract
|
|
E3701
|
Phryma Leptostachya L. var. asiatica Hara Extract
|
|
E3702
|
Eupolyphage sinensis Walker Extract
|
|
E3703
|
Talinum paniculatum Extract
|
|
E3704
|
Rumex madaio Makino Extract
|
|
E3705
|
Smilax glabra Extract
|
|
E3706
|
Cortex pseudolaricis Extract
|
|
E3707
|
Chenopodium ambrosioides Extract
|
|
E3708
|
Cephaelis ipecacuanha Extract
|
|
E3709
|
Lagotis glauca Extract
|
|
E3710
|
Chinese Dodder Seed Extract
|
|
E3712
|
Pisum sativum Extract
|
|
E3713
|
Vaccariae semen Extract
|
|
E3714
|
Clematis chinensis Extract
|
|
E3715
|
Crinum Asiaticum Extract
|
|
E3716
|
Equisetum arvense Extract
|
|
E3717
|
Lactuca sativa Extract
|
|
E3718
|
Marsdeniae Tenocissimae Extract
|
|
E3719
|
Seed of Chinese Tallowtree Extract
|
|
E3720
|
Oolong tea Extract
|
|
E3721
|
Fructus mume Extract
|
|
E3722
|
Zaocys dhumnades Extract
|
|
E3723
|
Lindera aggregata leaves Extract
|
|
E3724
|
Ficus carica Extract
|
|
E3737
|
Passiflora caerulea Linnaeus Extract
|
|
E3738
|
Lycopersicon esculentum Miller Extract
|
|
E3739
|
Panax quinquefolium Extract
|
|
E3740
|
Isodon serra Extract
|
|
E3741
|
Herba Siegesbeckiae Extract
|
|
E3742
|
SHILAJIT Asphaltum Extract
|
|
E3743
|
Asarum heterotropoides Extract
|
|
E3744
|
Prunella Vulgaris Extract
|
|
E3745
|
Corydalis decumbens Extract
|
|
E3746
|
hsian-tsao Extract
|
|
E3747
|
Agrimonia pilosa Extract
|
|
E3748
|
Epimedium Extract
|
|
E3749
|
Curculigo orchioides Extract
|
|
E3750
|
Opuntia dillenii Extract
|
|
E3753
|
Coriander Extract
|
|
E3754
|
Coriander Roots Extract
|
|
E3755
|
Cyperus Rotundus Extract
|
|
E3756
|
Vetiveria Zizanioides Extract
|
|
E3757
|
Shiitake Mushroom Extract
|
|
E3760
|
Cymbopogon Citratus Extract
|
|
E3761
|
Elsholtzia Ciliata Extract
|
|
E3762
|
Amomum Extract
|
|
E3763
|
Sweet Potatoes Extract
|
|
E3765
|
Citrus Medica Extract
|
|
E3766
|
Feverfew Extract
|
|
E3767
|
Justicia Gendarussa Extract
|
|
E3768
|
Foeniculum Vulgare Extract
|
|
E3769
|
Cirsium Setosum Extract
|
|
E3770
|
Wheat Germ Extract
|
|
E3771
|
Millet Extracts Extract
|
|
E3772
|
Eyebright Extract
|
|
E3774
|
Chlorella Pyrenoidosa Extract
|
|
E3775
|
Valeriana Officinalis Extract
|
|
E3776
|
Allium Macrostemnon Extract
|
|
E3777
|
Tinospora Cordifolia Extract
|
|
E3780
|
Oyster Mushroom Extract
|
|
E3781
|
Bombyx Moril Extract
|
|
E3782
|
Arctostaphylos Uva Ursi Leaf Extract
|
|
E3783
|
Spiraea Salicifolia Extract
|
|
E3784
|
Cynanchum Paniculatum Extract
|
|
E3785
|
Radix Dipsaci Extract
|
|
E3786
|
Radix Scrophulariae Extract
|
|
E3787
|
Flos Inulae Extract
|
|
E3788
|
Smallanthus Sonchifolius Extract
|
|
E3789
|
Saussurea Involucrata Extract
|
|
E3790
|
Sambucus Adnata Extract
|
|
E3791
|
Surgentodoxa Cuneata Extract
|
|
E3792
|
Lavandula Angustifolia Extract
|
|
E3793
|
Urtica Fissa Extract
|
|
E3794
|
Brucea Javanica Extract
|
|
E3796
|
Flaxseed Extract
|
|
E3795
|
Commelina Communis Extract
|
|
E3797
|
Butea Superba Extract
|
|
E3798
|
Avena Sativa L. Extract
|
|
E3799
|
Arrhenatherum Elatius Extract
|
Arrhenatherum elatius Extract is extracted from <I>Arrhenatherum elatius</i> (L.) Pressl.. Arrhenatherum elatius has ability to remove heavy metals from soil.
|
E3800
|
Nidus Collocaliae Extract
|
|
E3576
|
Semen celosiae Extract
|
|
E3577
|
Okra Extract
|
|
E3579
|
Undaria pinnatifida Extract
|
|
E3582
|
Ginseng leaf Extract
|
|
E3583
|
Honeysuckle flower Extract
|
|
E3584
|
Lonicera japonica vine Extract
|
|
E3585
|
Desertliving cistanche herb Extract
|
|
E3586
|
Myristica fragrans Extract
|
|
E3587
|
Cinnamon Extract
|
|
E3588
|
Boswellia Extract
|
|
E3589
|
Evodia Lepta Bark Extract
|
|
E3591
|
Common burreed tuber Extract
|
|
E3592
|
Panax notoginseng Root Extract
|
|
E3590
|
Radix berberidis Extract
|
|
E3593
|
Panax notoginseng Rhizoma Extract
|
|
E3594
|
Radix tetrastigme Extract
|
|
E3595
|
White mulberry root-bark Extract
|
|
E3596
|
Phellinus linteus Extract
|
|
E3597
|
Herba taxilli Extract
|
|
E3598
|
Morus alba bark Extract
|
|
E3599
|
Mantis egg-case Extract
|
|
E3600
|
Mulberry Extract
|
|
E3601
|
Mulberry Extract (leaves)
|
Mulberry Extract (leaves) is extracted from Mulberry (Morus alba L.) leaves , which are traditional Chinese herbs. Mulberry leaves exert several biological functions, such as antioxidant, anti-inflammation, antidiabetic, and antitumor.
|
E3658
|
Double coptis chinensis Extract
|
|
E3689
|
Radix Asparagi Extract
|
Radix Asparagi Extract is extracted from the dry root of Asparagus cochinchinensis (Lour.) Merr.(Liliaceae). Asparagi radix is efficacious against inflammation diseases due to its high antioxidant activity. The extract from Asparagi radix can inhibit browning reaction of mushroom, similar to ascorbic acid.
|
E3690
|
Semiaquilegiae Radix Extract
|
|
E3691
|
Gastrodia Rhizome Extract
|
|
E3692
|
lucid asparagus Extract
|
|
E3693
|
Arisaema erubescens Extract
|
|
E3694
|
Geranium Extract
|
|
E3695
|
Hypericum japonicum Extract
|
|
E3696
|
Panax notoginseng Extract
|
|
E3578
|
Fringed pink Extract
|
|
E3139
|
Angelica Sinensis Extract
|
|
E3169
|
Angelicae Pubescentis Radix Extract
|
|
E3170
|
Typhonium giganteum Engl Extract
|
|
E3171
|
Lamiophlomis Herba Extract
|
|
E3172
|
Juniper Berry Extract
|
|
E3173
|
Eucommiae Cortex Extract
|
|
E3175
|
Eucommia Ulmoides Male Flower Extract
|
|
E3176
|
Curcumae Rhizoma Extract
|
|
E3177
|
Centipeda Minima Extract
|
|
E3178
|
Catechu Extract
|
|
E3179
|
Pinelliae Preparatum Rhizoma Extract
|
|
E3181
|
Anona Squamosa Leaf Extract
|
|
E3182
|
Carica Papaya Fruit Extract
|
|
E3183
|
Carica Papaya Leaf Extract
|
|
E3184
|
Solanum Lycopersicum Extract
|
|
E3185
|
Psidium Guajava Extract
|
|
E3186
|
Sennae Folium Extract
|
|
E3187
|
Descolor Cinquefoil Herb Extract
|
|
E3188
|
Cissus Quadrangularis Extract
|
|
E3189
|
Saposhnikoviae Radix Extract
|
|
E3190
|
Stephaniae Tetrandrae Radix Extract
|
|
E3191
|
Euphorbia Hirta Extract
|
|
E3193
|
Saponaria Officinalis Extract
|
|
E3194
|
Torreyae Semen Extract
|
|
E3195
|
Combretumalfredii Hance Extract
|
|
E3196
|
Suzuki Extract
|
|
E3197
|
Canarii Fructus Extract
|
|
E3198
|
Kadsura longipedunculata Ratan Extract
|
|
E3227
|
Uncaria Extract
|
|
E3228
|
Cynodon Dactylon Extract
|
|
E3229
|
Lycii Fructus Extract
|
|
E3230
|
Eriocauli Flos Extract
|
|
E3231
|
Setariae Fructus Germinatus Extract
|
|
E3232
|
Rhizoma Drynariae Extract
|
|
E3233
|
Trichosanthis Fructus Extract
|
|
E3234
|
Trichosanthis Pericarpium Extract
|
|
E3235
|
Hypericum Perforatum Extract
|
|
E3236
|
Champion Wood Fern Extract
|
|
E3237
|
Euonymus alatus Sieb Extract
|
|
E3238
|
Bidens Bipinnata Extract
|
|
E3239
|
Osmanthus Extract
|
|
E3240
|
Longan Extract
|
|
E3241
|
Cinnamomi Ramulus Extract
|
|
E3242
|
Gecko Extract
|
|
E3243
|
Pinus Pinaster Bark Extract
|
|
E3244
|
Laminaria Japonica Extract
|
|
E3245
|
Piperis Kadsurae Caulis Extract
|
|
E3246
|
Lygodii Spora Extract
|
|
E3247
|
Hainan Nightshade Fruit Extract
|
|
E3248
|
Oriental Variegated Coralbean Bark Extract
|
|
E3299
|
Polygonum Cuspidatum Extract
|
|
E3300
|
Pericarpium Zanthoxyli peel Extract
|
|
E3301
|
Peanut hull Extract
|
|
E3302
|
Peanut seed coat Extract
|
|
E3303
|
Achyranthes bidentata Blume root Extract
|
Achyranthes bidentata Blume root Extract, isolated from the dried roots of Achyranthes bidentata Blume, has a beneficial effect on inhibition of adipogenesis and controlling body weight in rats fed with a high-fat diet.
|
E3304
|
Sophora japonica fruit Extract
|
Sophora japonica fruit Extract (Fructus Sophorae Extract, Rexflavone), isolated from the fruits of <i>Sophora japonica</i>, contains high contents of isoflavones, and is a health functional food ingredient that significantly improves the menopausal index.
|
E3305
|
Sophora flower Extract
|
Sophora flower Extract is extracted from dried flowers of <i>Sophora japonica</i> (Huaihua), which is used in China, Japan and Korea for treating haematemesis and bleeding haemorrhoids.
|
E3306
|
Phellodendron amurense bark Extract
|
Phellodendron amurense bark Extract (Nexrutine), isolated from the barks of <i>Phellodendron amurense</i>, has shown a favorable effect on prostate cancer in vivo and in vitro.
|
E3308
|
Daylily flower Extract
|
Daylily flower Extract, isolated from the flower and bud parts of Hemerocallis citrina, has the effects of neuroprotection.
|
E3309
|
Polygala fallax Hemsl. rhizome Extract
|
|
E3310
|
Brassica juncea seed Extract
|
Brassica juncea seed Extract, isolated from the seeds of brown (<i>Brassica juncea</i>) mustard, contains abundant phenolic compound.
|
E3311
|
Rhizoma polygonati root Extract
|
Rhizoma polygonati root Extract, isolated from the roots of <i>Rhizoma polygonati</i>, has been used for a long history with many chemical components in inducing anti-cancer, anti-aging, anti-diabetes, anti-fatigue, and more prevention of diseases or acts as nutrition sources in food
|
E3312
|
Rhizoma Coptidis Root Extract
|
Rhizoma coptidis root Extract, isolated from the dried roots of medicinal plants from <i>Rhizoma coptidis</i> (Ranunculaceae), has been used by Chinese medicinal physicians for more than 2000 years.
|
E3313
|
Rhizoma Coptidis Fibrous Root Extract
|
|
E3315
|
Astragalus rhizome Extract
|
Astragalus rhizome Extract, isolated from the rhizome of Radix Astragali, contains main constituents of polysaccharides, flavonoids, and saponins, amino acids and trace elements, with anti-inflammatory, immunomodulation, anti-oxidant, and anticancer effects.
|
E3316
|
Scutellariae rhizome Extract
|
Scutellariae rhizome Extract is isolated from the rhizome of <i>Scutellaria baicalensis</i>, which contains baicalin as a main constituent, has long been used in China, Japan, and Korea as a traditional medicine and functional food for inflammation, fever, hepatitis, allergic disease, hypertension, etc.
|
E3317
|
Okra fruit Extract
|
Okra fruit extract (Abelmoschus esculentus fruit extract), isolated from the fruits of <i>Abelmoschus esculentus</i>, is used as an alternative treatment because of its various medicinal properties, such as antidiabetic, antioxidant, antiplasmodial, antibacterial, anticancer, analgesic, antidiarrheal, and anti-inflammatory properties.
|
E3318
|
Cistus Incanus Extract
|
Cistus Incanus Extract, isolated from Mediterranean shrub species Cistus incanus L., is rich in polyphenolic compounds, possesses significant antioxidant activity, and may be effective active ingredients for the cosmetic industry.
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E3319
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Grifola frondosa Extract
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E3321
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Fructus cannabis Extract
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E3322
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Agastache rugosa Extract
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E3323
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Plumeria rubra Extract
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E3324
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Herba abri Extract
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E3325
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Croton crassifolius Geisel. Extract
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E3326
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Gizzard pepsin Extract
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E3327
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Chinese fevervine herb Extract
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E3328
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Suberect spatholobus stem Extract
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E3329
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Centella asiatica Extract
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E3330
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Agaricus blazei Extract
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E3331
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Impatiens balsamina L. Extract
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E3332
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Nerium oleander Extract
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E3333
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Viburnum dilatatum Extract
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E3334
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Bacopa monniera Extract
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E3335
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Curcuma longa Extract
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E3337
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Larva of a Silkworm with Batrytis Extract
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E3338
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Lignum Dalbergiae odoriferae Extract
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E3339
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Malt Extract
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E3341
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Hawthorn Extract
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E3342
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Carob bean Extract
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E3343
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Gynostemma pentaphyllum Extract
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Gynostemma pentaphyllum Extract, isolated from the herb of <i>Gynostemma pentaphyllum</i>, enhances exercise performance by promoting myotube differentiation and mitochondrial metabolism through the upregulation of PGC-1α in C2C12 skeletal muscle.
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E3344
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Yeast extract
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E3345
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ElderBerry Extract
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E3346
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Oriental Paperbush flower Extract
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E3347
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Mustard Extract
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E3348
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Capsella bursa-pastoris Extract
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E3349
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Broccoli Extract
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E3350
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Goodyera kwangtungensis Tso. extract
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E3351
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Abrus mollis Extract
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E3352
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Radix Tinosporae Extract
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E3353
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Acacia farnesiana Extract
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E3574
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Cyclocarya paliurus Extract
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E3121
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Chaulmoogratree Seed Extract
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E3307
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Soybean Extract
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Soybean Extract, isolated from the seeds of Soybean, modulates retinoic acid-related genes and shows photo-protective effects, suggesting that soybean Extract could be an anti-ageing ingredient that can be safely used under the sunlight.
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E2762
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Azadirachtin B
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Azadirachtin B, a limonoid isolated from seed kernels of <i>Azadirachta indica</i>, has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties.
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E3122
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Arecae Pericarpium Extract
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E3124
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Cirsii Japonici Herba Extract
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E3125
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Hordeum Vulgare Extract
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E3126
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Rice Extract
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E3128
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Isatidis Folium Extract
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E3130
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Garlic Extract
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E3131
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Jujubae Fructus Extract
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E3132
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Citrus Aurantium Flower Extract
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E3134
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Sphaeranthus Africanus Extract
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E3135
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Salvia Miltiorrhiza Extract
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E3137
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Fermented Soybean Extract
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E3138
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Lophatheri Herba Extract
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E3141
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Codonopsis Pilosula Extract
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E3142
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Semen Canavaliae Extract
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E3143
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Ground Ginseng Extract
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E3145
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Kochiae Fructus Extract
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E3146
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Sweet Potato Root Extract
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E3148
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Euphorbiae Humifusae Herba Extract
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E3149
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Pheretima Extract
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E3150
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Dinian Herb Extract
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E3151
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Sanguisorbae Radix Extract
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E3152
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Junci Medulla Extract
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E3153
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Corchorus Olitorius Extract
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E3154
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Hanging vine fruit extract
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E3156
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Clitoria Ternatea Flower Extract
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E3157
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Erycibes Caulis Extract
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E3158
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Caryophylli Flos Flower Extract
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E3159
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Caryophylli Flos Extract
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E3160
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Eurycoma Longifolia Extract
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E3162
|
Wax Gourd Peel Extract
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|
E3163
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Fructus Cucurbitae Extract
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E3164
|
Malvae Fructus Extract
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E3165
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Rabdosiae Rubescentis Herba Extract
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E3168
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Bean Sprout Extract
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E3034
|
Cynanchi Atrati Extract
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E3035
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Dittany Bark Extract
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E3037
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Solanum lyratum Extract
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E3038
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White Kidney Bean Extract
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E3039
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Angelica Root Extract
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E3040
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Stemonae Extract
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E3042
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Lily Bulbs Extract
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E3043
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Thymus Serpillum Extract
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E3044
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Passion Fruit Extract
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E3045
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Chinese Arborvilea Seed Extract
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E3047
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Isatis Extract
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E3048
|
Chestnut Extract
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E3049
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Lobeliae Chinensis Extract
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E3050
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Pinelliae Extract
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E3051
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Scutellaria Barbata Extract
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E3046
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Patriniae Extract
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E3052
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Cabbage Extract
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E3053
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Mentha Arvensis Leaf Extract
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E3054
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Primula Malacoides Extract
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E3055
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Rhizoma Menispermi Extract
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E3056
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Coasial GIehnia Root Extract
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E3059
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Piper longum Extract
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E3060
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Dioscorea Sativa Extract
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E3064
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Polygonum Aviculare Extract
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E3065
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Lentil Extract
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E3066
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Miraclefruit Extract
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E3067
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Trionycis Carapax Extract
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E3068
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Arccae Semen Extract
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E3069
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Spinach Extract
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E3070
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Macleaya Cordata Extract
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E3071
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Malaytea Scurfpea Extract
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E3072
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Paniculata Extract
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E3073
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Silkworm Chrysalis Extract
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E3074
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Xanthium Sibiricum Extract
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E3075
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Atractylodis Rhizoma Extract
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E3076
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Brown Rice Extract
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E3077
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Tsaoko Fructus Extract
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E3078
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Sarcandra Glabra Extract
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E3079
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Aconiti Kusnezoffii Radix Extract
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E3080
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Platycladi Cacumen Extract
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E3081
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Tea Seed Extract
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E3082
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Bupleurum Extract
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E3083
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Cicada Slough Extract
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E3084
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Hedera Helix Extract
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E3085
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Dichroae Radix Extract
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|
E3086
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5% Artichoke Leaf EXTRACT
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|
E3087
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Artichoke Extract
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E3088
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Plantaginis Herba Extract
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E3089
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Plantaginis Semen Extract
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E3090
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Aquilariae Lignum Resinatum Extract
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|
E3091
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Citri Reticulatae Pericarpium Extract
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|
E3092
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Paeoniae Radix Rubra Extract
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E3093
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Vignae Semen Extract
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E3094
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Flatstem Milkvetch Seed Extract
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E3095
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Pyrethrum Extract
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E3096
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Broussonetiae Fructus Extract
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E3098
|
Fritillariae Cirrhosae Bulbus Extract
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|
E3099
|
Fritillaria Cirrhosa Seed Extract
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E3100
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Sichuan Pepper Extract
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|
E3101
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Toosendan Fructus Extract
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E3102
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Cyathulae Root Extract
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|
E3103
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Aconiti Root Extract
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|
E3104
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Chuanxiong Rhizoma Extract
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|
E3105
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Cochinchina Cudrania Root Extract
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|
E3106
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Dioscoreae Nipponicae Rhizoma Extract
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|
E3107
|
Andrographis Herba Extract
|
|
E3109
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Cymbidium Extract
|
|
E3110
|
Graviola Extract
|
|
E3111
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Tribulus Terrestris Extract
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|
E3112
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Rosa Roxburghii Fruit Extract
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E3113
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Rosa Roxburghii Root Extract
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|
E3115
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Erythrina Variegata Extract
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|
E3116
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Acanthopanax Senticosus Extract
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|
E3117
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Amla Extract
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E3118
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Processed Cyperi Rhizoma Extract
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|
E3119
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Damiana Extract
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|
E3249
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Mimosa Pudica Root Extract
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|
E3250
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Mimosa Pudica Extract
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|
E3251
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Tropaeolum Majus Extract
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|
E3253
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Chrysanthemum Morifolium Ramat Extract
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|
E3254
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Terminalia Chebula Extract
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E3255
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Albiziae Flos Extract
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E3256
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Albiziae Cortex Extract
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E3257
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Polygoni Multiflori Root Extract
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|
E3258
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Nelumbinis Folium Extract
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E3259
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Walnut Extract
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|
E3260
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Seminis Juglandis Septum Extract
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E3261
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Juglandis Semen Extract
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|
E3262
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Walnut Leave Extract
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|
E3263
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Black Soya Bean Extract
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|
E3264
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Black Bone Rattan extract
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|
E3265
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Black Pepper Extract
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|
E3266
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Black Carrot Extract
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|
E3267
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Black Coffee Extract
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|
E3268
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Black Quinoa Extract
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|
E3269
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Black Ant Extract
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|
E3270
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Blackberry Extract
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|
E3271
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Black Cohosh Extract
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|
E3272
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Black Garlic Extract
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|
E3273
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Black Sesame Extract
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|
E3274
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Nigella Sativa Extract (Herb)
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|
E3275
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Nigella Sativa Extract (Seed)
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E3276
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Red Ginseng Extract
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|
E3277
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Black Tea Extract
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E3278
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Black Tea Root Extract
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|
E3279
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Kombucha Extract
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|
E3280
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Trifolium Pratense Extract
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|
E3281
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Eleutherine Plicata Extract
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E3282
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Taxus Cuspidata Extract
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|
E3283
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Red Bean Extract
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E3284
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Safflower Extract
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|
E3285
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Rhodiola Rosea Extract
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|
E3286
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Rambutan Extract
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|
E3287
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Red Yeast Rice extract
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|
E3288
|
Red Raspberry Extract
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|
E3290
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Citrus Grandis Fruit Extract
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|
E3291
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Hydrolyzed Rhodophycea Extract
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|
E3292
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Hericium Erinaceus Extract
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|
E3293
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Magnolia Bark Extract
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|
E3294
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Piper Nigrum Seed Extract
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|
E3296
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Juglans Regia Extract
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|
E3297
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Fenugreek Seed Extract
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|
E3298
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Viscum Coloratum Extract
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|
E3019
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Semen Ginkgo Extract
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|
E3020
|
Hedyotic Diffusa Extract
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|
E3021
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Chaga Mushroom Extract
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|
E3022
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Bletilla Striata Root Extract
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|
E3023
|
White Mustard Seed Extract
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|
E3024
|
Ampelopsis Japonica Root Extract
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|
E3025
|
Salix Alba Bark Extract
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|
E3026
|
White Radish Extract
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|
E3027
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Imperata Cylindrica Root Extract
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|
E3028
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Chelidonium Majus Extract
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|
E3029
|
White Paeony Root Extract
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|
E3031
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Bunge Auriculate Root Extract
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|
E3032
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Atractyloides Macrocephala Root Extract
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|
E3033
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Pulsatillae Extract
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|
E3001
|
Donkey-hide gelatin Extract
|
Donkey-hide gelatin Extract is extracted from Donkey-hide gelatin (Asini Corii Colla, ACC), a gelatinous Chinese medicine known as Ejiao in Chinese. Donkey-hide gelatin is applied as an important food therapy product to optimize immune response, improve metabolic balance and treat gynecological diseases.
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E3002
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Asafetida Extract
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|
E3003
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Artemisis Princeps Leaf Extract
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|
E3004
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Eucalyptus Leaf Extract
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|
E3005
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Boesenbergia Pandurata Extract
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|
E3006
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Fructus Anisi Stellati Extract
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|
E3007
|
Marlea platanifolia Extract
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|
E3008
|
Eight clawed Golden Dragon extract
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|
E3009
|
Morinda Root Extract
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|
E3010
|
Muira Puama Extract
|
|
E3011
|
Sarsaparilla Extract
|
|
E3012
|
Semen Lablab Album Extract
|
|
E3013
|
Chinese Cabbage Extract
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|
E3014
|
White Tea Extract
|
|
E3015
|
Amomum Kravanh Extract
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|
E3016
|
Cissus modecoides var Extract
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|
E3017
|
Poria Cocos Extract
|
|
E3018
|
Giant typhonium rhizome extract
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|
E3000
|
Ligusticum Sinense Extract
|
Ligusticum Sinense Extract is extracted from Ligusticum sinense, a Chinese medicinal plant.
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E3603
|
Ramulus Mori Extract
|
Ramulus Mori Extract is extracted from Ramulus mori (Mulberry twigs), the dry branch of <i>Morus alba</i> L.. Ramulus Mori is a traditional medicine widely used for diabetes treatment. The major active components of Ramulus Mori are mulberroside A, oxyresveratrol, resveratrol, 4-hydroxycinnamic acid, 7-hydroxycoumarin, and morin, and the components have been demonstrated to possess anti-cancer, anti-hypertensive, anti-diabetic, and anti-inflammatory properties.
|
E3604
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Adenophora Stricta Extract
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Adenophora stricta Extract is extracted from Adenophora stricta Miq.. Adenophora stricta is commonly used to reduce phlegm, clear lung and tonify stomach.
|
E3605
|
Sea buckthorn Extract (fruits)
|
Sea buckthorn Extract (fruits) is extracted from the fruits of sea buckthorn (<i>Hippophae rhamnoides</i> L.). Sea buckthorn has significant cardioprotective activity and exerts many positive healing effects on the cardiovascular system, including inhibiting blood platelet activation (especially platelet aggregation), lowering cholesterol concentration and blood pressure, and providing antioxidant activity. Sea buckthorn also has antibacterial and antiviral properties.
|
E3606
|
Sea buckthorn Extract (leaves)
|
Sea buckthorn Extract (leaves) is extracted from the leaves of sea buckthorn (Hippophae rhamnoides L.). Sea buckthorn has significant cardioprotective activity and exerts many positive healing effects on the cardiovascular system, including inhibiting blood platelet activation (especially platelet aggregation), lowering cholesterol concentration and blood pressure, and providing antioxidant activity. Sea buckthorn also has antibacterial and antiviral properties.
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E3607
|
Crateva nurvala Extract
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Crateva nurvala Extract is extracted from the stem bark of Crataeva nurvala Buch.. Crateva nurvala, an important medicinal plant, has been studied mainly with the stem bark part for obstructive and nonobstructive uropathies. Crateva nurvala is also used for the treatment of prostate enlargement and bladder sensitivity.
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E3608
|
Semen astragali complanati Extract
|
Semen astragali complanati Extract is extracted from Semen Astragali Complanati, the dried ripe seed of Flatstem Milkvetch (Astragalus complanatus Bunge) (Leguminosae). The major contents of Semen astragali complanati include fatty acids, amino acids, polysaccharides, flavonoids, triterpene glycosides and trace elements. Semen astragali complanati exhibits a number of therapeutic effects on chronic diseases such as cardiovascular diseases, diabetes mellitus and cancers.
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E3609
|
Elaeagnus angustifolia Extract
|
Elaeagnus angustifolia Extract is extracted from the fruits of Elaeagnus angustifolia L.. Elaeagnus angustifolia fruit extract has acute and chronic anti-inflammatory activities.
|
E3610
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Amomum villosum Extract
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Amomum villosum Extract is extracted from Amomum villosum Lour., a herbaceous plant in the ginger family. Amomum villosum has been proven to be effective in treating gastrointestinal diseases. Treatment with Amomum villosum water extract significantly attenuates intestinal inflammation in inflammatory bowel disease (IBD) rats.
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E3611
|
Camellia japonica Extract
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Camellia japonica Extract is extracted from the flowers of Camellia japonica L.. Camellia japonica possesses antimicrobial, antioxidant and antitumoral activity and as being a huge source of polyphenols such as the catechins.
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E3612
|
Cremastra appendiculata Extract
|
Cremastra appendiculata Extract is extracted from Cremastra appendiculata (Pseudobulbus Cremastrae seu Pleiones), the dried pseudostem of plants of the Orchidaceae family. Cremastra appendiculata has antibacterial, antihypertensive, gout, antitumor, and acetylcholine receptor M3-blocking effects. The extract of cremastra appendiculata can be used to treat Lewis lung cancer, liver cancer, and breast cancer.
|
E3613
|
Sophora tonkinensis Extract
|
Sophora tonkinensis Extract is extracted from the dried root ofSophora tonkinensis Gapnep.. Sophora tonkinensis is used in the treatment of pharyngeal and laryngeal diseases. Sophora tonkinensis has hepatoprotective, immunomodulatory, and anticancer effects and produces obvious toxicity to the liver and nervous and cardiovascular systems.
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E3614
|
Arnica montana Extract
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Arnica montana Extract is extracted from the flowers of Arnica montana L. (Asteraceae). Arnica montana possesses anti-inflammatory, immune-modulatory, anti-sclerotic, analgesic, antifungal, antioxidant, antibacterial, and anticancer bioactivities.
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E3615
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Anisodus tangutcus Extract
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Anisodus tangutcus Extract is extracted from the root of Scopolia tangutica Maxim. Anisodus tanguticus root has an important active tropane alkaloid, Anisodine. Anisodine has significant therapeutic effects on ocular diseases, motion sickness and migraine, acute circulatory shock, and organophosphorus pesticide poisoning.
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E3616
|
Kaempferia galanga Extract
|
Kaempferia galanga Extract is extracted from the rhizome of Kaempferia galanga L. (Zingiberaceae). Kaempferia galanga is used to get relief from indigestion, swelling, pain, high blood pressure, and dyslipidemia.
|
E3617
|
Galega officinalis Extract
|
Galega officinalis Extract is extracted from the seeds of Galega officinalis L.. Galega officinalis extract has hypoglycemic and antioxidant properties.
|
E3618
|
Yam Extract
|
Yam Extract is extracted from yam (Chinese yam), the rhizome of various species of genus Dioscorea opposita Thunb. (Dioscoreaceae). Yam contains mainly proteins, sugars, vitamins, fats, choline, amylase, iodine, iron, calcium, phosphorus, and other indispensable trace elements in the human body. The main pharmacological effects of yam are antioxidative, anti-aging, anti-tumor, and hypoglycemic. Yam also can enhance immunity.
|
E3619
|
Lonicerae Flos Extract
|
Lonicerae Flos Extract is extracted from Lonicerae flos, the flower bud of Lonicera macranthoides Hand.-Mazz., Lonicera hypoglauca Miq., Lonicera confusa DC., or Lonicera fulvotomentosa Hsu et S. C. Cheng. Lonicerae flos is a traditional Chinese medicine used in the treatment of inflammatory and infectious diseases. Lonicerae flos extract increases survival rates of cecal ligation and puncture (CLP)-induced septic rats.
|
E3620
|
Corni Fructus Extract
|
orni Fructus Extract is extracted from the fruits of Fructus Corni (Cornus officinalis Sieb. et Zucc.). Fructus Corni is a traditional Chinese herbal medicine that possesses pharmacological actions against inflammation, diabetic nephropathy, tumors, oxidation and aging.
|
E3621
|
Crataegi fructus Extract
|
Crataegi fructus Extract is extracted from the fruits of Crataegi fructus (hawthorn). Crataegi fructus is dry ripe fruit of Crataegus pinnatifida Bge.var. major N. E. Br. or Crataegus pinnatifida Bge.. The extracts and compounds from fructus crataegi show a variety of pharmacological activities, such as a protective effect on patients with heart failure, as well as an increased force of myocardial contraction, improved coronary circulation, antioxidant effects and antimicrobial activities.
|
E3623
|
Pelargonium hortorum Extract
|
Pelargonium hortorum Extract is extracted from Pelargonium hortorum L.H. Bailey. Pelargonium cultivars have been reported as metal hyperaccumulators, with the ability to acidify soil pH. Pelargonium hortroum has the ability to accumulate Pb in shoots.
|
E3624
|
Phytolaccae Radix Extract
|
Phytolaccae Radix Extract is extracted from Phytolaccae Radix (the dried root of Phytolacca acinosa Roxb. or Phytolacca americana L.). Radix Phytolaccae is widely used for the treatment of inflammation-related diseases.
|
E3625
|
Cnidii Fructus Extract
|
Cnidii Fructus Extract is extracted from Cnidii Fructus, the dry ripe fruit of Cnidium monnieri (L.)Cuss.. Chinese herbal medicine Cnidii Fructus has an outstanding effect on chronic lumbar pain and impotence, also has been used against osteoporosis with high frequency.
|
E3626
|
Snake Gallbladder Extract
|
Snake Gallbladder Extract is extracted from Snake gallbladder. Snake gallbladder has multiple pharmacological effects, such as relieving coughs and asthma, as well as improving human immunity and visual acuity. Snake gallbladder has been believed in various Asian countries to improve visual acuity and alleviate rheumatism
|
E3627
|
Belamcandae Rhizoma Extract
|
Belamcandae Rhizoma Extract is extracted from dry roots of Belamcanda chinensis (L.) DC.. Belamcanda chinensis is mainly used to treat sore throat, bronchitis, and chronic tracheitis. Isoflavonoids, including irigenin, isolated from the rhizome of Belamcanda chinensis have been suggested to possess not only antioxidative and anti-inflammatory, but also antitumor activities.
|
E3629
|
Lycopodii Herba Extract
|
Lycopodii Herba Extract is extracted from Lycopodii Herba, the dried whole plant of Lycopodium japonicum Thunb. (Lycopodiaceae). Lycopodii Herba possesses anti-inflammation activity, antioxidative activity, and antitumor activity; and has been traditionally used for the prevention and treatment of various diseases such as rheumatoid arthritis, contusion, quadriplegia, dysmenorrhea.
|
E3630
|
Massa Medicata Fermentata Extract
|
|
E3631
|
Cimicifugae Rhizoma Extract
|
|
E3632
|
Rehmanniae Radix Extract
|
|
E3633
|
Ginger Extract
|
|
E3634
|
Ginger Extract(1%)
|
|
E3635
|
Chasteberry Extract
|
|
E3636
|
Ocimum sanctum Extract
|
|
E3637
|
Acorus tatarinowii Extract
|
|
E3638
|
Lysinotus pauciflorus Extract
|
|
E3639
|
Gypsum fibrosum Extract
|
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E3640
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Dendrobii caulis Extract
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E3641
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Salvia Chinensis Benth Extract
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E3642
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Haliotidis concha Extract
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E3643
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Pomegranate Peel Extract
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E0840
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Yakuchinone A
|
Yakuchinone A, a natural product isolated from Alpinia oxyphylla Miquel (Zingiberaceae), has strong inhibitory effects on the synthesis of prostaglandins (PGs) and leukotrienes (LTs).
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E2012
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Ginkgolide K
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Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway, and possesses neuroprotective activity.
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S0970
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Curzerene
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Curzerene, a sesquiterpene isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity, inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression and induces cell apoptosis.
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E0583
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Isoscabertopin
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Isoscabertopin is a sesquiterpene lactone isolated from <i>Elephantopus scaber L</i> and shows anti-tumor activities.
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E0543
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OJV-VI
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OJV-VI is isolated from <i>ophiopogonis</i>.
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E2023
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Hypocrellin B
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Hypocrellin B is a natural product isolated from the fungi <i>Hypocrella bambusae</i> and <i>Shiraia bambusicola</i> with the induction of apoptosis.
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S6370
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Dendrophenol
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Dendrophenol (Moscatilin) is from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. Dendrophenol (Moscatilin) almost completely suppresses (97%) the AFB1-induced SOS response with an IC50 of 0.08 μM.
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S0938
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Sakuranetin
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Sakuranetin belongs to the group of methoxylated flavanones, with a widely bioactivity of antiproliferative against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320), antiviral activity towards human rhinovirus 3 and influenza B virus, antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties.
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E0505
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Olive oil
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Olive oil comes from the fruits of Olea europae trees with a beneficial effect on human health, including the antioxidant activity and anti-inflammatory activity when olive oil is in regular diet.
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E0506
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Soybean oil
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Soybean oil is a vegetable oil extracted from the seeds of the soybean (Glycine max).
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E0656
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7-Methylcoumarin
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7-Methylcoumarin can inhibit the growth of S. aureus and the growth of Gram-positive bacteria within a concentration of 0.8–3.6 μg/ml, and also has a strong hepatoprotective activity.
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E0748
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Opoponax oil
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Opoponax oil is isolated and extracted from Commiphora erythraea (opoponax), with a promising insecticidal property.
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E1124
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Narciclasine
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Narciclasine (Lycoricidinol), an isocarbostyril alkaloid narciclasine, targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells. Narciclasine suppresses phosphorylation, activation, dimerization, and nuclear translocation of STAT3 by directly binding with the STAT3 SH2 domain and leads STAT3 degradation. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
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E0650
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γ-Terpinene
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γ-Terpinene (γ-TPN), a monoterpene, is an orally active antioxidant compound which can scavenge radicals directly.
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E0651
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Garlic oil
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Garlic oil blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis by inducing phase II drug-metabolizing enzymes.
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S4448
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Imidacloprid-urea
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Imidacloprid-urea with a role as a marine xenobiotic metabolite, is the primary imidacloprid soil metabolite, whereas imidacloprid-olefin is the main plant-relevant metabolite and is more toxic to insects than imidacloprid.
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E0653
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Trans-ferulic acid
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Trans-ferulic acid is a potent activator of AMPKunder high glucose condition.
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E0478
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Procyanidin C1
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Procyanidin C1 is a polyphenolic component of grape seed extract, increases the healthspan and lifespan of mice through its action on senescent cells. PCC1 is a natural senotherapeutic agent with in vivo activity and a potential intervention to delay, alleviate or prevent age-related pathologies.
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S0936
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Aloin B
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Aloin B (Isobarbaloin), isolated from Aloe vera, is one isomer of Aloin and has anti-hepatitis B virus (HBV) acyivity.
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S0944
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Benzoylaconitine
|
Benzoylaconine (Isaconitine, Pikraconitin) is an alkaloid derived from the Chinese traditional medicine Radix Aconiti Lateralis Preparata (Fuzi). Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-κB signaling in IL-1β-induced human synovial cells.
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E0239
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(-)-Catechin gallate
|
(-)-Catechin gallate ((-)-CG) is a catechin polyphenol that has been found in green tea extracts with diverse biological activities.
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E0240
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Procyanidin B1
|
Procyanidin B1, a natural polyphenolic compound that has antioxidant properties, inhibits Kv10.1 channel and suppresses the evolution of hepatoma.
|
E0241
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Asiaticoside B
|
Asiaticoside B is a triterpene glycoside isolated from Centella asiatica (L.) Urban, with anti-cancer activity.
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E0242
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Picrocrocin
|
Picrocrocin, the chemical most responsible for the bitter taste of saffron, is isolated from saffron and inhibits proliferation of cancer cells.
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E0243
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Emodin-8-glucoside
|
Emodin-8-glucoside (Emodin glucoside B, Anthraglycoside B, Emodin glucoside B) is an anthraquinone derivative isolated from Aloe vera, binds to minor groove of DNA.
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E0244
|
Acevaltrate
|
Acevaltrate, an active component derived from the herbal plant Valeriana jatamansi Jones, is strikingly potent to induce GBM cell apoptosis. Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50 of 22.8 μM and 42.3 μM, respectively.
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E0246
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β-Anhydroicaritin
|
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has antiosteoporosis, estrogen regulation and antitumor properties.
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E0247
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Militarine
|
Militarine is a major chemical constituent of the tuber of Bletilla striata (Thunb.) Reichb.f., with a prominent neuroprotective effect.
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E0248
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Rehmannioside D (Rhmannioside D)
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Rehmannioside D (Rhmannioside D) is an iridoid glycoside that has been found in Rehmannia glutinosa.
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E0249
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Pseudolaric Acid A
|
Pseudolaric acid A, a Hsp90 inhibitor with an IC50 of 0.60 μM, 2.72 μM, 1.36 μM, 2.92 μM and 6.16 μM in HL-60, A549, SMMC-7721, HeLa and SW480 cells respectively, is the main bioactive ingredient in Pseudolarix cortex, and induces cell cycle arrest at G2/M phase and promotes cell death through caspase-8/caspase-3 pathway, demonstrating potent antiproliferation and anticancer activities.
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E0212
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Cornuside
|
Cornuside is a bisiridoid glucoside compound isolated from the fruit of Cornus officinalis SIEB. et ZUCC. Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting NF-κB activation in RAW 264.7 macrophages. Cornuside attenuates apoptosis in rat cortical neurons.
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E0213
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Bruceine D
|
Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.
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E0215
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Isorhapontigenin
|
Isorhapontigenin (ISOR), isolated from Belamcanda chinensis, is a derivative of stilbene. Isorhapontigenin possessed potent antioxidative activity. Isorhapontigenin suppresses interleukin-1β-induced inflammation and cartilage matrix damage in rat chondrocytes.
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E0216
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Hinokiflavone
|
Hinokiflavone, isolated from Selaginella P. Beauv, Juniperus phoenicea and Rhus succedanea, possesses excellent pharmacological activities, including anti-inflammatory, antioxidant and antitumor activity. Hinokiflavone induces apoptosis and inhibits migration of breast cancer cells via EMT signalling pathway.
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E0190
|
Invert sugar
|
Invert Sugar is a popular sweetener.
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E0211
|
Dihydroberberine
|
Dihydroberberine, a hydrogenated derivative of Berberine (BBR), exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways.
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S0941
|
3,29-O-dibenzoyloxykarounidiol
|
3,29-O-dibenzoyloxykarounidiol is a triterpenoid isolated from Trichosanthes kirilowii Maxim.
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S5813
|
Isoginkgetin
|
Isoginkgetin is a naturally derived biflavonoid with anti-tumor activity. Isoginkgetin directly inhibits the chymotrypsin-like, trypsin-like, and caspase-like activities of the 20S proteasome. Isoginkgetin also is a general inhibitor of Pre-mRNA splicing.
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S0958
|
Zingibroside R1
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Zingibroside R1, isolated from rhizomes of Panax zingiberensis Wu et Feng (Araliaceae), has some anti-HIV-1 activity. Zingibroside R1 shows the inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells with IC50 of 91.3 µM and the growth of MT-4 cells with CC50 of 46.2 µM.
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E0206
|
Ginkgetin
|
Ginkgetin is a biflavone from Ginkgo biloba leaves with anti-cancer, anti-inflammatory, anti-microbial, anti-adipogenic, and neuroprotective activities.
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E0207
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Chebulinic acid
|
Chebulinic acid, a phenolic compound isolated from Terminalia chebula fruit, is a novel Influenza viral neuraminidase inhibitor. Chebulinic acid is a antiangiogenic agent through inhibiting the actions of VEGF. Chebulinic acid shows antitumour activity.
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E0208
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Herbacetin
|
Herbacetin is a natural flavonoid compound found in flaxseed with strong antioxidant, antitumor and anti-inflammatory activity.
|
E0209
|
Cinobufotalin
|
Cinobufotalin, extracted from the skin secretion of the giant toad, is a novel SREBP1 inhibitor that suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
|
E0210
|
Quercetin 3-O-β-D-glucuronide
|
Quercetin 3-O-β-D-glucuronide (Miquelianin, Q3GA) is one of the quercetin metabolites with antioxidant activity.
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E0222
|
Glaucocalyxin A
|
Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells.
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E0225
|
Licochalcone B
|
Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.
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E0226
|
Chebulagic acid
|
Chebulagic acid, isolated form Terminalia chebula Retz, is a reversible and non-competitive inhibitor of maltase with a Ki value of 6.6 μM. Chebulagic acid shows potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. Chebulagic acid also shows potent COX–LOX dual inhibition activity with IC50 values of 15 μM, 0.92 μM and 2.1 μM for COX-1, COX-2 and 5-LOX respectively.
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E0233
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14-Deoxy-11,12-didehydroandrographolide
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14-Deoxy-11,12-didehydroandrographolide (deAND), a diterpenoid in Andrographis paniculata (Burm. f.) Nees with hypotensive, anti-inflammatory, anti-asthma, and anti-cancer activities.
|
E0177
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Hydrocortisone sodium succinate
|
Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators.
|
E0201
|
Hypaconitine
|
Hypaconitine (Deoxymesaconitine) is an active diterpene alkaloid derived from Aconitum species. Hypaconitine inhibits TGF-β1-induced epithelial–mesenchymal transition.
|
E0202
|
Benzoylmesaconine
|
Benzoylmesaconine (Mesaconine 14-benzoate) is a main Aconitum alkaloid isolated from several Aconitum species with potent pharmacological activities, such as analgesia and anti-inflammation.
|
E0204
|
Poricoic acid A
|
Poricoic acid A is isolated from the surface layer of Poria cocos. Poricoic acid A activates AMPK to attenuate fibroblast activation and abnormal extracellular matrix remodelling in renal fibrosis. Poricoic acid A also is a modulator of tryptophan hydroxylase-1 (TPH-1).
|
E0205
|
Strictosamide
|
Strictosamide is the main representative constituent of Nauclea officinalis Pierre ex Pitard (Rubiaceae) with anti-inflammatory and analgesic activities.
|
S7758
|
Trabectedin
|
Trabectedin (Ecteinascidin 743, ET-743) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata with antitumour activity. Trabectedin binds to the N2 of guanine in the minor groove, causing DNA damage and affecting transcription regulation in a promoter- and gene-specific manner.
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S0651
|
N-Butanoyl-L-homoserine lactone
|
N-Butyryl-L-homoserine lactone (N-Butanoyl-L-homoserine lactone, N-Butyrylhomoserine lactone, C4-HSL) is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). N-Butyryl-L-homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and cellular metabolism.
|
E0160
|
Hexaminolevulinate hydrochloride
|
Hexaminolevulinate hydrochloride (5-Aminolevulinic acid hexyl ester hydrochloride) is a tumour photosensitizer.
|
E0365
|
Fucoidan
|
Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.
|
S0920
|
Ginkgolide J
|
Ginkgolide J is a minor constituent of terpene trilactone mixture of Ginkgo biloba leaves extract that inhibits GlyR-operated channels with IC50 of 2.0 μM. Ginkgolide J also inhibits cell death of rodent hippocampal neurons caused by Aβ1–42. Ginkgolide J exhibits anti‑inflammatory activity.
|
E0198
|
Pristane
|
Pristane (2,6,10,14-Tetramethylpentadecane, TMPD) is a natural saturated terpenoid alkane obtained primarily from shark liver oil that is widely used to induce tumorgenesis in mice and arthritis and lupus nephritis in rats.
|
E1029
|
Miglustat
|
Miglustat (Zavesca, N‐butyldeoxynojirimycin, OGT 918) is an orally administered ceramide glucosyltransferase inhibitor which prevents the lysosomal accumulation of glucocerebroside.
|
E0196
|
Alloxan Monohydrate
|
Alloxan Monohydrate is the most popular diabetogenic agents used for assessing the antidiabetic or hypoglycemic capacity of test compounds.
|
S9793
|
4-Hydroxynonenal
|
4-Hydroxynonenal (4-HNE, HNE, 4-hydroxy Nonenal, 4-hydroxy-2-nonenal) is one of the major end products of lipid peroxidation and has been widely accepted as an inducer of oxidative stress.
|
E0150
|
Carrageenan
|
Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity.
|
E0149
|
Papain
|
Papain (papaya proteinase I) is a sulfhydryl protease from the latex of the papaya fruit. Papain breaks down intercellular matrix of cartilage.
|
E0156
|
Thioacetamide
|
Thioacetamide (TAA) is a hepatotoxin frequently used for experimental purposes which produces centrilobular necrosis after a single dose administration.
|
E0154
|
Taurocholic acid sodium salt
|
Taurocholic acid sodium salt (Sodium Taurocholate, TANa) is a sodium salt of taurocholic acid and occurs in the bile of mammals. Taurocholic acid is used as a cholagogue and choleretic.
|
E0143
|
ITE
|
ITE (2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester) is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) that directly binds to AHR with a Ki of 3 nM.
|
S6812
|
Z-Guggulsterone
|
Z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Z-Guggulsterone exhibits anti-inflammatory effects in microglia. Z-Guggulsterone induces apoptosis in gastric cancer cells through the intrinsic mitochondria-dependent pathway.
|
E0129
|
Oxysophocarpine
|
Oxysophocarpine (OSC) is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) by targeting the Nrf2/HO-1 axis. OSC protects cells against apoptosis and inflammatory responses and compromised miR-155 activity by attenuating MAPK and NF-κB pathways.
|
E0130
|
Apigenin-7-O-glucuronide
|
Apigenin-7-O-glucuronide (Apigenin-7-glucuronide) is the major flavonoid found in milk thistle. Apigenin 7-o-glucuronide inhibits tumor necrosis factor alpha (TNF-α) and total nitrite release in lipopolysaccharide-activated macrophages.
|
E0015
|
Iberiotoxin
|
Iberiotoxin (IbTX) is a toxin purified from the scorpion Buthus tamulus. Iberiotoxin is a potent blocker of the large conductance Ca(2+)-activated K+ channel with a Kd of ~1 nM.
|
S0947
|
Cafestol
|
Cafestol is a natural diterpenes extracted from coffee beans. Cafestol induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. Cafestol inhibits PI3K/Akt pathway. Cafestol also can reduce the production of ROS in the leukemia cell line HL60.
|
E0023
|
5,7-Dihydroxychromone
|
5,7-Dihydroxychromone (DHC), a natural antioxidant extracted from plants, is a potent activator of Nrf2/ARE signal. 5,7-dihydroxychromone also is a potent activator of PPARγ and LXRα. 5,7-Dihydroxychromone may contributes to regulate blood glucose levels and shows anti-diabetic property.
|
E0046
|
β-Cyclodextrin
|
β-Cyclodextrin (β-CD, Beta-Cyclodextrin) is a cyclic derivative of starch prepared from partially hydrolyzed starch (maltodextrin) by an enzymatic process. β-Cyclodextrin can be used as complexing agents to increase aqueous solubility of poorly soluble drugs and to increase their bioavailability and stability.
|
E0124
|
Chelerythrine
|
Chelerythrine (Toddaline, Broussonpapyrine) is a potent, selective antagonist of PKC with an IC50 of 0.66 μM. Chelerythrine also inhibits the BclXL-Bak BH3 peptide binding with an IC50 of 1.5 μM. Chelerythrine shows antitumor, antidiabetic and anti-inflammatory activity.
|
S8152
|
Cucurbitacin I
|
Cucurbitacin-I (Elatericin B, JSI 124, NSC 521777), a natural cell-permeable triterpenoid isolated from Cucurbitaceae, is a novel selective inhibitor of JAK2/STAT3.
|
S7580
|
Leptomycin B
|
Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM.
|
E0037
|
Bradykinin
|
Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF.
|
S0950
|
Hibifolin
|
Hibifolin (Gossypetin-8-O-β-D-glucuronide) is a flavonol glycoside and acts as a potential inhibitor of adenosine deaminase (ADA) with a Ki of 49.92 μM. Hibifolin prevents β-amyloid-induced neurotoxicity in cultured cortical neurons.
|
E0010
|
Hypocrellin A
|
Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC.
|
E0027
|
5-Hydroxymethylcytosine
|
5-Hydroxymethylcytosine (5hmC) is a naturally existing component in mammalian genomic DNA and is regarded as the sixth DNA base. 5-Hydroxymethylcytosine is an intermediate metabolite in active DNA demethylation. 5-Hydroxymethylcytosine is epigenetic marks known to affect global gene expression in mammals.
|
E0025
|
2-Hydroxybenzylamine
|
2-Hydroxybenzylamine (2-(Aminomethyl)phenol, 2-HOBA, NSC 127870) is a naturally occurring compound found in buckwheat and is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. 2-HOBA reduces inflammation and plaque apoptotic cells and promotes efferocytosis and features of stable plaques. 2-HOBA has potential for use as a nutrition supplement due to its ability to protect against the damaging effects of oxidative stress.
|
E0008
|
Atractylodin
|
Atractylodin (Atractydin) is one of the major constituents of the rhizome of Atractylodes lancea and inhibits N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity with an IC50 of 2.81 µM. Atractylodin also inhibits interleukin-6 (IL-6) by blocking NPM-ALK activation and MAPKs.
|
E0009
|
Harmane
|
Harmane (Harman, Aribine, Aribin, Locuturine, Locuturin, Loturine, Passiflorin, 1-Methylnorharman, NSC 54439) is a common compound in several foods, plants and beverages. Harmane is a selective monoamine oxidase inhibitors with IC50s of 0.5 μM and 5 μM for human MAO A and MAO B, respectively. Harmane also inhibits the apurinic/apyrimidinic (AP) endonuclease activity of the UV endonuclease induced by phage T4.
|
E0022
|
Ophiopogonin D
|
Ophiopogonin D (OJV-VI, Deacetylophiopogonin C) is a steroidal glycoside isolated from Chinese herb Radix ophiopogonis and shows anti-tumor property. Ophiopogonin D could suppress TGF-β1-mediated metastatic behavior of MDA-MB-231 cells by regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis. Ophiopogonin D attenuates PM2.5-induced inflammation via suppressing the AMPK/NF-κB pathway in mouse pulmonary epithelial cells.
|
S9197
|
Maltohexaose
|
Maltohexaose (Amylohexaose) is a polysaccharide with 6 units of glucose and can be classified as a maltodextrin.
|
S0943
|
Arenobufagin
|
Arenobufagin is a natural bufadienolide from toad venom and induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.
|
S6909
|
Levomefolic acid
|
Levomefolic acid (5-MTHF, LMSR, Metafolin, Nutrifolin) is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.
|
S6927
|
Dihydroresveratrol
|
Dihydroresveratrol is a natural product possessing significant biological activities. Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator.
|
S3166
|
Calcium 2-oxoglutarate
|
Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle. 2-oxoglutarate is a reversible inhibitor of tyrosinase with IC50 of 15 mM.
|
S6100
|
Picrotoxin
|
Picrotoxin (Picrotin, Cocculin, Cocculus, NSC 403139), a plant alkaloid, is a non-competitive antagonist of neuronal GABA and glycine receptors.
|
S5910
|
Alpha-Estradiol
|
Alpha-Estradiol (α-Estradiol, 17 alpha-Estradiol, Alfatradiol, Epiestradiol, Epiestrol, Alora, 17 α-E2), a natural, non-feminizing stereoisomer, a hormonally almost inactive isomer of physiological 17 beta-estradiol (17 β-E2), is a weak inhibitor of estrogen.
|
S3761
|
Eucalyptol
|
Eucalyptol (NSC 6171, 1,8-Cineol, 1,8-cineole, 1,8-Epoxy-p-menthane, 1,8-Oxido-p-menthane, Cineol, Cineole) is a monoterpenoid oil present in many plants, principally the Eucalyptus species, and has been reported to have anti-inflammatory and antioxidative effects. Eucalyptol controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.
|
S5417
|
Spectinomycin dihydrochloride pentahydrate
|
Spectinomycin dihydrochloride pentahydrate (Trobicin) is a widely used antibiotic that inhibits bacterial protein synthesis by blocking translocation of messenger RNA and transfer RNAs on the ribosome.
|
S5972
|
Hydrocortisone hemisuccinate
|
Hydrocortisone hemisuccinate (A-hydrocort, Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid with anti-inflammatory properties, is an inhibitor of proinflammatory cytokine with IC50 of 6.7 μM and 21.4 μM for Interleukin-6 (IL-6) and IL-3, respectively.
|
S9827
|
Iodoacetamide
|
Iodoacetamide (IA, IAM, 2-Iodoacetamide) is an alkylating agent that is commonly used for alkylation of cysteine during sample preparation for proteomics.
|
S5958
|
Metformin
|
Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.
|
S5937
|
DL-Carnitine
|
DL-Carnitine ((±)-Carnitin) is a racemic mixture of L-Carnitine and D-Carnitine that regulates fatty acid transport in the mitochondrion. DL-carnitine is found to be ineffective or toxic, for example, to muscle cells and to the myocardium. DL-Carnitine causes symptoms of myasthenia and cardiac arrhythmias.
|
S5955
|
Thiamine nitrate
|
Thiamine (Vitamin B1) nitrate is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives.
|
S5888
|
Beclamide
|
Beclamide (N-Benzyl-3-chloropropionamide, beta-chlorpropionamide) exhibits sedative and anticonvulsant properties.
|
S5199
|
Oxytetracycline hydrochloride
|
Oxytetracycline (OTC, Oxycycin, Stevacin, Terramycin) hydrochloride is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.
|
S4486
|
Thiamine monochloride
|
Thiamine (Vitamin B1) monochloride is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives.
|
S4495
|
Quinine
|
Quinine, an alkaloid derived from the bark of the cinchona tree, is an anti-malaria agent and a potassium channel inhibitor that inhibits mSlo3 (KCa 5.1) channel currents evoked by voltage pulses to +100 mV with IC50 of 169 μM.
|
S4490
|
Tetracycline
|
Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.
|
S3590
|
Triolein
|
Triolein is an inhibitor of metalloproteinase-1 (MMP-1) and reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes.
|
S4713
|
Atropine
|
Atropine (Atropen, Atnaa, Tropine tropate, DL-Hyoscyamine) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect.
|
S5193
|
L-Thyroxine sodium salt pentahydrate
|
L-Thyroxine (Levothyroxine, L-T4) sodium salt pentahydrate is a synthetic T4 hormone used to counterbalance hypothyroidism.
|
S5260
|
ATP
|
ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) is a multifunctional nucleoside triphosphate and an important endogenous signaling molecule in immunity and inflammation.
|
S5790
|
Folinic acid
|
Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).
|
S6466
|
Eicosapentaenoic acid ethyl ester
|
Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.
|
S4979
|
Procaine penicillin G
|
Penicillin G Procaine (PGP, Penicillin G Procaine, Bicillin C-R), a crystalline complex combining penicillin G with procaine, is a β-lactam antibiotic.
|
S5922
|
L-Carnitine hydrochloride
|
L-Carnitine ((R)-Carnitine, Levocarnitine) hydrochloride improves oxygen saturation, and inhibits leukotriene synthesis. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation.
|
S0911
|
Hypaphorine
|
Hypaphorine which is abundantly found in vaccaria semen, counteracts inflammation via inhibition of ERK or/and NFκB signaling pathways.
|
S4857
|
L-Ornithine
|
L-ornithine ((S)-2,5-Diaminopentanoic acid) has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia. It is one of the key reactants in the urea cycle.
|
S3578
|
Pyrroloquinoline quinone
|
Pyrroloquinoline quinone (PQQ, Methoxatin) is a natural anti-oxidant with anti-oxidative and anti-aging effects. Pyrroloquinoline quinone prevents estrogen deficiency-induced osteoporosis.
|
S4496
|
Maltose monohydrate
|
Maltose (Maltobiose, Malt Sugar, Beta-Maltose, D-Maltose) monohydrate, an non-essential nutrient that provides energy, is an intermediate in the intestinal digestion of glycogen and starch, and is found in germinating grains (and other plants and vegetables).
|
S9631
|
Puromycin aminonucleoside
|
Puromycin aminonucleoside (NSC 3056, PAN, Stylomycin aminonucleoside, ARDMA, SAN), the aminonucleoside portion of the antibiotic puromycin, is a reversible inhibitor of dipeptidyl-peptidase II and cytosol alanyl aminopeptidase that induces apoptosis in mesangial cells (MCs) accompanied by declined cell viability and enhanced inflammatory response.
|
S7428
|
Rocaglamide
|
Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity.
|
S3569
|
Spermidine
|
Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy.
|
S4438
|
Benzophenone
|
Benzophenone (Diphenyl ketone, Benzoylbenzene) filters out both UVA and UVB rays and is widely used in a great variety of sunscreens and personal care products.
|
S4440
|
2-Phenylacetamide
|
2-Phenylacetamide, the main compound isolated from the seeds of Lepidium apetalum Willd (LA) with estrogenic activities, increases the expression of Estrogen receptorα (ERα), ERβ and GPR30 in the uterus and MCF-7 cells.
|
S4425
|
Rifamycin S
|
Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation.
|
S4436
|
Pleuromutilin
|
Pleuromutilin (Drosophilin B, Mutilin 14-glycolate), the lead compound for novel antibiotics, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.
|
S4494
|
Methionine
|
Methionine (MRX-1024, D-Methionine) is an activitor of GABAA receptor that modulates neuronal activity.
|
S3588
|
Hexylene glycol
|
Hexylene glycol (HG, 2-Methyl-2,4-pentanediol, MPD) is an oxygenated solvent derived from acetone that has been used widely in industrial chemicals and cosmetics. Hexylene glycol exhibits antibacterial and antifungal properties.
|
S3595
|
D-Gluconic acid
|
D-Gluconic acid is an antifungal agent.
|
S6446
|
Sodium citrate dihydrate
|
Sodium citrate dehydrate (Trisodium citrate dihydrate, Citric acid trisodium salt dihydrate) is the preferred anticoagulant.
|
S3594
|
Adipic acid
|
Adipic acid (Hexanedioic acid) is an important dicarboxylic acid used for the manufacture of nylon and polyurethane plastics.
|
S3596
|
Polyvinylpyrrolidone
|
Polyvinylpyrrolidone (PVP, Polyvidone, Povidone) is an inert, water-soluble, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and cater both hydrophilic and lipophilic drugs. Polyvinylpyrrolidone has been widely tested and used as an effective wound healing accelerator.
|
S3598
|
Sucrose
|
Sucrose (D-(+)-Saccharose), a common sugar produced naturally in plants, is a disaccharide, a molecule composed of two monosaccharides:glucose and fructose.
|
S4424
|
Hyaluronidase
|
Hyaluronidase (Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase, Amphadase, Hydase, Vitrase) is a naturally occurring enzyme that degrades hyaluronic acid, which constitutes an essential part of the extracellular matrix.
|
S0235
|
Lavendustin B
|
Lavendustin B inhibits HIV-1 integrase (IN) interaction with its cognate cellular cofactor lens epithelium-derived growth factor (LEDGF/p75). Lavendustin B is an inhibitor of Tyrosine Kinase and also a competitive inhibitor of glucose transporter 1 (Glut1).
|
S9794
|
Melittin
|
Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme.
|
S3168
|
cis-Resveratrol
|
cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.
|
S3499
|
Monocaprylin
|
Monocaprylin (2,3-dihydroxypropyl octanoate, Monoctanoin, 1-Octanoyl-rac-glycerol, MC) exhibits an excellent antibacterial activity against Staphylococcus aureus and Escherichia coli.
|
S0921
|
Wilforine
|
Wilforine (WR), a sesquiterpene pyridine alkaloid found in T. wilfordii plants, significantly inhibits the efflux activity of P-glycoprotein (P-gp).
|
S3351
|
Sodium phenylpyruvate
|
Sodium phenylpyruvate (Phenylpyruvic acid sodium salt) inhibits amino acid formation and depresses oxygen consumption.
|
S2995
|
4-Hydroxyphenylpyruvic acid
|
4-Hydroxyphenylpyruvic acid (4-HPPA), an abundant colon metabolite of polyphenols, is a potent scavenger that suppresses levels of free radicals and cyclooxygenase-2 (COX-2) and contributes to reduced risk of colon cancer development.
|
S6918
|
Oleandrin (PBI-05204)
|
Oleandrin (PBI-05204, Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol) is an inhibitor of Na+/K+-ATPase with IC50 of 0.62 μM. Oleandrin induces apoptosis and reduces migration of human glioma cells in vitro.
|
S6990
|
Phytohemagglutinin
|
Phytohemagglutinin (PHA, Phaseolus vulgaris agglutinin) is expressed in Pichia pastoris using native signal peptides, or the Saccharomyces alpha-factor preprosequence, to direct proteins into the secretory pathway. Phytohemagglutinin induces apoptosis in human HEp-2 carcinoma cells via increasing proapoptotic protein Bax and activating caspases-3.
|
P1201
|
LL37 (Human cathelicidin)
|
LL37 (Human cathelicidin, Ropocamptide) is a cathelicidin-related antimicrobial peptide with potent chemotactic and immunomodulatory properties.
|
S3069
|
Deoxycholic acid sodium salt
|
Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brown adipose tissue (BAT) thermogenic activity.
|
S3248
|
2'-Deoxyadenosine 5'-monophosphate
|
2'-Deoxyadenosine 5'-monophosphate (5'-dAMP), an endogenous metabolite, is only photosensitized degraded under acidic conditions.
|
S3268
|
2'-Deoxycytidine 5'-monophosphate
|
2'-Deoxycytidine-5'-monophosphoric acid (dCMP) is an endogenous metabolite that can be used as a model to describe mechanisms of DNA-strand breaks induced by secondary electrons and decomposes primarily by dissociation of the C-O phosphoester bond.
|
S3318
|
N-Acetyl-L-arginine dihydrate
|
N-Acetyl-L-arginine (Ac-Arg-OH) dihydrate is an endogenous metabolite.
|
S3319
|
Levoglucosan
|
Levoglucosan (LG, LEV, Leucoglucosan, Glucosan, 1,6-anhydro-b-D-Glucose) is an endogenous metabolite.
|
S3324
|
Sodium 2-(1H-indol-3-yl)acetate
|
Sodium 2-(1H-indol-3-yl)acetate (3-Indoleacetic acid sodium, Indole-3-acetic acid sodium, 3-IAA sodium) is an endogenous metabolite.
|
S3326
|
Phytic acid dipotassium salt
|
Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM.
|
S3331
|
2-Aminoethylphosphonic acid
|
2-Aminoethylphosphonic acid (2-AEP, (2-Aminoethyl)phosphonic acid) is a type of abundant and ubiquitous naturally occurring phosphonate used as sources of phosphorus by many prokaryotic lineages.
|
S3335
|
Phospho(enol)pyruvic acid monopotassium salt
|
Phospho(enol)pyruvic acid monopotassium salt (Potassium 1-carboxyvinyl hydrogenphosphate) is an endogenous metabolite.
|
S3343
|
Methyl β-D-Galactopyranoside
|
Methyl β-D-Galactopyranoside (Methyl beta-D-galactoside, Methylgalactoside) is an endogenous metabolite.
|
S3370
|
3-Methoxytyramine hydrochloride
|
3-Methoxytyramine (3-O-methyl Dopamine, 3MT) hydrochloride, a major extracellular metabolite of dopamine, is a neuromodulator that in certain situations may be involved in movement control.
|
S3310
|
D-(+)-Galacturonic acid monohydrate
|
D-(+)-Galacturonic acid monohydrate (D-Galacturonic acid hydrate, d-GalA, D-galUA) is an endogenous metabolite that can be used in engineering Saccharomyces cerevisiae.
|
S3323
|
2-Hydroxycaproic acid
|
2-Hydroxyhexanoic acid (2-Hydroxyhexanoic acid) is an endogenous metabolite.
|
S2997
|
DL-Tartaric acid
|
DL-Tartaric Acid (2,3-Dihydroxysuccinic acid) is a white, crystalline organic acid isolated from many plants, particularly tamarinds and grapes and is used as an antioxidant and an additive agent to give a sour taste.
|
S3087
|
N-Acetyl-DL-methionine
|
N-Acetyl-DL-methionine is an active endogenous metabolite that decreases the hepatic glutathione level in male Bom:NMRI mice.
|
S3092
|
Glyoxylic acid monohydrate
|
Glyoxylic acid monohydrate (2,2-Dihydroxyacetic acid) is an atmospherically relevant ketoacid.
|
S3093
|
Pyrazole
|
Pyrazole (1H-pyrazole) is a five membered heteroaromatic ring with two nitrogen atoms is of immense significance. Pyrazole is an indispensable anchor for design and development of new pharmacological agents.
|
S3094
|
N-Acetyl-L-alanine
|
N-Acetyl-L-alanine (NAAL, Ac-Ala-OH) is an active endogenous metabolite.
|
S3157
|
3-Hydroxybenzaldehyde
|
3-Hydroxybenzaldehyde (3-HBA), one of the benzaldehydes commonly found in nature, is produced by 3-hydroxybenzyl-alcohol dehydrogenase, and is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans (ALDH2). 3-Hydroxybenzaldehyde exhibits vasculoprotective effects.
|
S3315
|
6-Hydroxyindole
|
6-Hydroxyindole (1H-indol-6-ol) is an endogenous potent and long-lasting OATP1B1 inhibitor with IC50 of ~10 μM.
|
S3334
|
Glycolaldehyde dimer
|
Glycolaldehyde dimer (2,5-Dihydroxy-1,4-dioxane, 1,4-Dioxane-2,5-diol, DD) is an active endogenous metabolite that appears moderate absorbent and fluorescent, when it reacts with glycine (Gly)/ammonium sulfate (AS).
|
S3336
|
Heptadecanoic acid
|
Heptadecanoic acid (C17:0), an odd chain saturated fatty acid, significantly inhibits cell proliferation, and migration, while promoting apoptosis in PC‑9 and PC‑9/GR cells. Heptadecanoic acid is associated with several diseases, including the incidence of coronary heart disease, prediabetes and type 2 diabetes as well as multiple sclerosis.
|
S3337
|
L-Histidinol dihydrochloride
|
L-Histidinol dihydrochloride, a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture.
|
S3338
|
D-(-)-Lyxose
|
D-(-)-Lyxose (D-Lyxose) is an active endogenous metabolite.
|
S3345
|
Nα-Acetyl-L-lysine
|
Nα-Acetyl-L-lysine (Ac-Lys-OH, N(alpha)-Acetyllysine) is an active endogenous metabolite.
|
S3347
|
3-Methylglutaric acid
|
3-Methylglutaric acid (MGA, 3MG acid) is a conspicuous C6 dicarboxylic organic acid that can be used as a single solid-state NMR standard compound to perform all calibration steps except for magnet shimming.
|
S3348
|
O-Acetyl-L-serine hydrochloride
|
O-Acetyl-L-serine (OAS, O-Acetylserine, O-Acetyl-L-serine) hydrochloride (HCl) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants that displays a signalling function leading to changes in transcript levels of a specific gene set irrespective of the sulfur status of the plant.
|
S3358
|
4-Acetamidobutyric acid
|
4-Acetamidobutanoic acid (N-acetyl GABA) is a derivative of Gamma-aminobutyric acid (GABA) resulting from the monoacetylation of the nitrogen of GABA.
|
S3360
|
Bis(2-ethylhexyl) phthalate
|
Bis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio.
|
S3095
|
Itaconic acid
|
Itaconic acid, a macrophage-specific (Mϕ-specific) metabolite, mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid is also a precursor of polymers, chemicals, and fuels that can be synthesized by many fungi.
|
S3096
|
L-Histidine monohydrochloride monohydrate
|
L-Histidine monohydrochloride monohydrate (L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O), a structural analogue of the essential amino acid L-histidine, is a reversible inhibitor of protein biosynthesis which evokes disparate responses from non-tumorigenic and tumorigenic cells in culture.
|
S3098
|
N-Acetylglycine
|
N-Acetylglycine (NAGly, Aceturic acid, Acetamidoacetic acid), a minor constituent of numerous foods, is not genotoxic or acutely toxic.
|
S3097
|
5,6-Dimethylbenzimidazole
|
5,6-Dimethylbenzimidazole (5,6-DMB, Dimezol, Dimedazol, 5,6-Dimethyl-1H-benzo[d]imidazole, 5,6-Dimethyl-1H-benzimidazole) is a vitamin B12 precursor.
|
S3107
|
D-Pyroglutamic acid
|
D-Pyroglutamic acid (D-5-Oxoproline, D-Pyr-OH, 5-oxo-D-proline, (R)-5-Oxopyrrolidine-2-carboxylic acid) is an active endogenous metabolite that antagonizes the disruption of passive avoidance behaviour induced by the N-methyl-D-aspartate receptor antagonist AP-5.
|
S3109
|
N-Acetyl-L-leucine
|
N-acetyl-L-leucine is an active endogenous metabolite that accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus.
|
S3111
|
Pyridoxal hydrochloride
|
Pyridoxal hydrochloride (HQ) is an active endogenous metabolite.
|
S3365
|
(S)-(-)-1-Phenylethanol
|
(S)-(-)-1-Phenylethanol ((S)-1-Phenylethanol, (S)-(-)-Phenylethanol) is an enantiomer of 1-Phenylethanol with flavor properties.
|
S3366
|
Monoethyl malonic acid
|
Monoethyl malonic acid (Ethyl hydrogen malonate, Monoethyl malonate, 3-Ethoxy-3-oxopropanoic acid) is the major urinary metabolites of ethyl 3-ethoxypropionate (EEP).
|
S3320
|
(R)-3-Hydroxybutanoic acid
|
(R)-3-Hydroxybutanoic acid (R-3HB, D-3-hydroxybutyric acid) is a monomer of PHB (poly[(R)-3-hydroxybutyrate]) with wide industrial and medical applications. (R)-3-hydroxybutyric acid can also serve as chiral precursor for synthesis of pure biodegradable PHB and its copolyesters.
|
S3049
|
Calcium 2-hydroxy-4-(methylthio)butanoate
|
Calcium 2-hydroxy-4-(methylthio)butanoate is an active endogenous metabolite.
|
S3135
|
2-Amino-1-phenylethanol
|
2-Amino-1-phenylethanol (2-APE) is a noradrenaline analogue.
|
S3221
|
Thymidine 5'-monophosphate disodium salt
|
Thymidine-5'-monophosphate (5'-Thymidylic acid) disodium salt is an active endogenous metabolite.
|
S3311
|
Myosmine
|
Myosmine is not only one of the minor tobacco alkaloids but is also present in various foods. Myosmine has low affinity against a4b2 nicotinic acetylcholinergic receptors (nAChR) with Ki of 3300 nM.
|
S3321
|
N-Methylnicotinamide
|
N-Methylnicotinamide (MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide) is an active endogenous metabolite that improves endothelial dysfunction and attenuates atherogenesis via the modulation of ADMA-DDAH axis.
|
S3325
|
L-Cysteic acid monohydrate
|
L-Cysteic acid monohydrate (CAM) is an active endogenous metabolite.
|
S3329
|
(L)-Dehydroascorbic acid
|
(L)-Dehydroascorbic acid (DHA) is an oxidized form of l-Ascorbic acid (AsA) that efficiently scavenges non-thermal plasma-induced hydroxyl radicals in the presence of thiols and fails to scavenge hydroxyl radicals by itself.
|
S3342
|
Petroselinic acid
|
Petroselinic acid (PSA) is a positional isomer of oleic acid isolated from the vegetable oil of Coriandrum sativum fruits. Petroselinic acid can be used for the fermentation of new sophorolipids.
|
S3344
|
Serotonin creatinine sulfate monohydrate
|
Serotonin (5-Hydroxytryptamine) creatinine sulfate monohydrate is an active endogenous metabolite.
|
S3346
|
1-Methylnicotinamide chloride
|
1-Methylnicotinamide (1-MNA, 3-Carbamoyl-1-methylpyridin-1-ium, Trigonellamide) chloride is an active endogenous metabolite of nicotinamide that exhibits anti-inflammatory and anti-thrombotic activities. 1-Methylnicotinamide enhances tumor vasculature formation and markedly increases prostacyclin (PGI2) generation.
|
S3349
|
Phosphocholine chloride calcium salt tetrahydrate
|
Phosphocholine (Phosphorylcholine) chloride calcium salt tetrahydrate is an active endogenous metabolite.
|
S3350
|
Cholesteryl linoleate
|
Cholesteryl linoleate is less polar lipid in human nasal fluid that contributes to the inherent antibacterial activity.
|
S3352
|
Tricosanoic acid
|
Tricosanoic acid is an aliphatic carboxylic acid that exhibits a strong hair-growing effect.
|
S3353
|
Lithium acetoacetate
|
Lithium acetoacetate (LiAcAc, Acetoacetic acid lithium salt, Lithium 3-oxobutanoate) is an active endogenous metabolite that affects the growth of cells. Lithium acetoacetate can be used as an acetoacetate standard for the measurement of acetoacetate in biological samples.
|
S3354
|
DL-2,3-Diaminopropionic acid monohydrochloride
|
DL-2,3-Diaminopropionic acid monohydrochloride (2,3-Diaminopropanoic acid hydrochloride) is an active endogenous metabolite.
|
S3355
|
3-Hydroxyanthranilic acid
|
3-Hydroxyanthranilic Acid (3-HAA, 3-HANA), a tryptophan metabolite, has an immunomodulatory effect that may result from inhibition of PI3K/Akt/mTOR and NF-κB activity, thereby decreasing the production of pro-inflammatory mediators.
|
S3356
|
Phosphonoacetic acid
|
Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.
|
S3357
|
Elaidic acid
|
Elaidic acid is a major trans fatty acid that inhibits cell viability, elevates cell apoptosis by enhancing oxidative stress. Elaidic acid can be used as a pharmaceutical solvent.
|
S3359
|
Isomaltulose hydrate
|
Isomaltulose (Palatinose) hydrate is a disaccharide carbohydrate widely used during exercise to maintain glycaemia and hydration.
|
S3361
|
(3-Carboxypropyl)trimethylammonium chloride
|
(3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine, γBB hydrochloride) is an intermediary metabolite by gut microbes from dietary L-carnitine in mice.
|
S3362
|
D-Gulonic acid γ-lactone
|
D-Gulonic acid γ-lactone (Gulonolactone, D-Gulono-1,4-lactone, 1,4-D-Gulonolactone) is an active endogenous metabolite.
|
S3363
|
DL-Mandelic acid
|
DL-Mandelic acid (MA, 2-Hydroxy-2-phenylacetic acid, Amygdalic acid, Almond acid) can be intercalated into Zn-Al layered double hydroxide (LDH) by an anion-exchange reaction to build a novel antimicrobial layered material.
|
S3367
|
cis-4-Hydroxy-D-proline
|
cis-4-Hydroxy-D-proline (H-D-cis-Hyp-OH) is an endogenous metabolite that can be used to study the specificity and kinetics of D-alanine dehydrogenase.
|
S3368
|
Uridine-5'-diphosphate disodium salt
|
Uridine-5'-diphosphate (UDP) disodium salt is a potent, selective and natural agonist of P2Y6 receptor with EC50 = 300 nM and pEC50 of 6.52, respectively. Uridine-5'-diphosphate (UDP) disodium salt is also an antagonist of P2Y14 receptor with pEC50 of 7.28.
|
S3371
|
N-Acetyl-D-mannosamine
|
N-Acetyl-D-mannosamine (ManNAc, N-acetyl-beta-mannosamine), a precursor of a sialic acid, improves the age-dependent attenuation of synaptic transmission and long-term potentiation (LTP). N-Acetyl-D-mannosamine treatment is a potential therapeutic application for cognitive dysfunction.
|
S3088
|
(±)-Methyl Jasmonate
|
(±)-Methyl Jasmonate (MeJA, Methyl jasmonate, Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate), a phytohormone that acts as a vital cell regulator in plants, is a new candidate for the treatment of Inflammatory bowel diseases (IBDs), modulating the expression of the major classes of caspase-type protease families.
|
S3169
|
2'-Deoxyuridine 5'-monophosphate disodium salt
|
2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.
|
S3322
|
Nicotinuric acid
|
Nicotinuric acid (NUA) is the major detoxification product of nicotinic acid and may serve as a simple quantitative index of hepatic biotransformation of nicotinic acid.
|
S3332
|
D-Mannosamine hydrochloride
|
D-Mannosamine hydrochloride ((2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride) is an active endogenous metabolite.
|
S3364
|
3-Hydroxyphenylacetic acid
|
3-Hydroxyphenylacetic acid (3-HPAA) is a phenolic acid mostly found in olive oil wastewater and an intestinal metabolite of the dietary flavonoid quercetin. 3-Hydroxyphenylacetic acid exhibits antimicrobial properties.
|
S3040
|
Isocitric acid trisodium salt
|
Isocitric acid (DL-Isocitric acid) trisodium salt is an active endogenous metabolite.
|
S3089
|
12-Hydroxydodecanoic acid
|
12-Hydroxydodecanoic acid (G12) is an active endogenous metabolite.
|
S3341
|
Palmitoleic acid
|
Palmitoleic acid (POA, Palmitoleate) stimulates the uptake of glucose in liver through activation of AMPK and FGF-21, dependent on PPARα.
|
S2989
|
Nα-Acetyl-L-asparagine
|
Nα-Acetyl-L-asparagine (N-Acetylasparagine, (S)-2-acetamido-4-amino-4-oxobutanoic acid) is an endogenous metabolite that exists in human brain.
|
S2991
|
Thiamine monophosphate chloride dihydrate
|
Thiamine monophosphate chloride dihydrate (Vitamin B1 Monophosphate Chloride, Sineurina, Phosphothiamine) is an endogenous metabolite.
|
S2992
|
Sodium mesoxalate monohydrate
|
Sodium mesoxalate monohydrate (sodium 2,2-dihydroxymalonate) is an endogenous metabolite.
|
S2993
|
D-Saccharic acid potassium salt
|
D-Saccharic acid potassium salt (D-Glucaric acid potassium, Potassium bisaccharate) is an endogenous metabolite.
|
S2999
|
Acetic acid octyl ester
|
Acetic acid octyl ester (Octyl acetate) is one of the major components of essential oils in the vittae, or oil tubes, of the wild parsnip (Pastinaca sativa). Acetic acid octyl ester exhibits antioxidant activity.
|
S3006
|
Methyl isoeugenol
|
Methyl isoeugenol (Methylisoeugenol) is an eugenol analogue isoeugenol isolated from Acori Tatarinowii Rhizoma. Methyl isoeugenol is a highly attractive lure for Z. diversus and would be a valuable inclusion as an attractant in monitoring and male annihilation programs.
|
S3009
|
Menthone
|
Menthone is one of the main volatile components of the essential oil of peppermint (Mentha piperita L.). Menthone is used as antioxidant agent and has a good compensatory effect with significant reduction in DNA damages in sperm cells.
|
S3091
|
Methyl acetoacetate
|
Methyl acetylacetate (MAA, Acetoacetate methyl ester, Methyl 3-oxobutanoate, Methyl 3-oxobutyrate, Methyl acetoacetate, Methyl acetylacetate), an endogenous metabolite, is used as a chemical reagent used in the synthesis of pharmaceuticals.
|
S2998
|
Isophorone
|
Isophorone (IPHO), an α,β-unsaturated cyclic ketone, is a clear liquid with a camphor-like odor. Isophorone is used as a precursor to polymers.
|
S3313
|
Nudifloric Acid
|
Nudifloric acid (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid), isolated from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities.
|
S3317
|
cis-3-Hexenyl hexanoate
|
Cis-3-Hexenyl hexanoate ((Z)-3-hexenyl hexanoate) is a kind of plant volatile that brings tropical and pulpy profile with citrus and green nuances to all kinds of fruit flavors.
|
S3327
|
Disodium 5'-inosinate monohydrate
|
Disodium 5'-inosinate monohydrate (Inosine 5'-monophosphate disodium salt hydrate) is an endogenous metabolite.
|
S3333
|
(2R,3R)-(-)-2,3-Butanediol
|
(2R,3R)-(-)-2,3-Butanediol ((2R,3R)-Butane-2,3-diol) is an endogenous metabolite.
|
S2990
|
Dihydroxyfumaric acid hydrate
|
Dihydroxyfumaric acid hydrate (DHF) is an endogenous metabolite. The diester derivative of dihydroxyfumaric acid hydrate (DHF) has been used exclusively as an electrophile in organic synthesis.
|
S2988
|
DL-5-Hydroxylysine hydrochloride
|
DL-5-Hydroxylysine hydrochloride, an endogenous metabolite, is a racemic mixture of D- and L- enantiomers of 5-hydroxylysine which may be used as potential target markers for radical-induced protein oxidation.
|
S2994
|
DL-Homocysteine
|
DL-Homocysteine is a weak neurotoxin that affects the production of kynurenic acid (KYNA) in the brain. DL-Homocysteine inhibits the activity of both KYNA biosynthetic enzymes, kynurenine aminotransferases (KATs) I and II.
|
S3099
|
δ-Valerolactone
|
δ-Valerolactone (Tetrahydro-2H-pyran-2-one, 5-Valerolactone, oxan-2-one) is an endogenous metabolite.
|
S3328
|
N-Formyl-L-methionine
|
N-Formyl-L-methionine (For-Met-OH) is an endogenous metabolite.
|
S6955
|
Insulin (human)
|
Insulin (human) (Insulin regular) is a polypeptide hormone that regulates the level of glucose. Insulin is commonly used to treat hyperglycemia in patients with diabetes. Potency: 29 units/mg.
|
S2986
|
9-Methoxycanthin-6-one
|
9-Methoxycanthin-6-one is present in intact plant parts and in callus tissues of different explants with anti-tumour activity.
|
S3108
|
2,5-Dimethylpyrazine
|
2,5-Dimethylpyrazine (NSC 49139) is an endogenous metabolite.
|
S2996
|
L-DAB HBR
|
L-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) is an inhibitor of GABA (Gamma-aminobutyric acid) transaminase with IC50 of >500 μM. L-DAB HBR exhibits antitumor activity.
|
S3029
|
Malonic acid
|
Malonic acid (MOA), one of the major dicarboxylic acids (DCAs) in aerosols, has been identified experimentally and computationally to be a strong acid. Malonic acid (MOA) acts as a mediate bridge for the formation of pure SA-A-based clusters.
|
S3086
|
Maleic acid
|
Maleic acid inhibits glutamate decarboxylase (GAD) activity, thus enhances acid sensitivity of Listeria monocytogenes. Maleic acid affects the extracellular GABA levels.
|
S3090
|
trans-Aconitic acid
|
trans-Aconitic acid (TAA) is an abundant constituent in the leaves of Echinodorus grandiflorus, a medicinal plant used to treat rheumatoid arthritis in Brazil.
|
S3101
|
2-Deoxy-D-ribose
|
2-Deoxy-D-ribose (Thyminose, Deoxyribose) is an endogenous metabolite.
|
S3118
|
L-Homoserine
|
L-Homoserine (L-Hse) is an important biosynthetic intermediate of threonine, methionine and lysine.
|
S3123
|
3-Methyl-2-buten-1-ol
|
3-Methyl-2-buten-1-ol (Prenol, Prenyl alcohol, Dimethylallyl alcohol) is an endogenous metabolite.
|
S3143
|
Pyruvic acid
|
Pyruvic acid (Acetylformic acid) is an important organic chemical intermediate that plays a role in cardiomyocyte pathophysiology and therapy. Pyruvic acid markedly increases the level of lactate dehydrogenase (LDH) and creatine kinase (CK) and reduces the level of Ca2+Mg2+-ATPase and Na+K+-ATPase.
|
S3084
|
Guanosine 5'-triphosphate trisodium salt
|
Guanosine 5'-triphosphate (5'-GTP, Guanosine triphosphate, H4GTP) trisodium salt is an enhancer of myogenic cell differentiation in a murine cells. Guanosine 5'-triphosphate trisodium salt up-regulates miRNA (specifically miR133a and miR133b) and myogenic regulator factor and induces human myogenic precursor cells to release exosomes stuffed with guanosine based molecules (mainly guanosine) in the extracellular milieu.
|
S3125
|
N-Formylglycine
|
N-Formylglycine (2-formamidoacetic acid, For-Gly-OH, FGly) is an endogenous metabolite.
|
S3126
|
Sodium 2-hydroxybutanoate
|
Sodium 2-hydroxybutanoate (Sodium 2-hydroxybutyrate, Sodium DL-2-hydroxybutyrate), converted from 2-Aminobutyric acid, is an intermediate metabolite.
|
S3127
|
2,4-Dihydroxypyrimidine-5-carboxylic acid
|
2,4-Dihydroxypyrimidine-5-carboxylic Acid (Uracil 5-carboxylic acid, Isoorotic acid, 5-Carboxyuracil) is an endogenous metabolite.
|
S3128
|
N-Acetyl-D-galactosamine
|
N-Acetyl-D-galactosamine (D-N-Acetylgalactosamine) is an endogenous metabolite.
|
S3131
|
L-(-)-Glucose
|
L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose promotes food intake while cannot be used by cells as an energy source because it cannot be phosphorylated by hexokinase.
|
S3134
|
D-(-)-Tartaric acid
|
D-(-)-Tartaric acid is the unnatural isomer of Tartaric acid which is an important chiral chemical building block with broad industrial and scientific applications.
|
S3141
|
Maleimide
|
Maleimide exhibits fluorescence quenching ability and can be used for the specific detection of thiol analytes as fluorogenic probes. Maleimide is also used for production of antibody-drug conjugate (ADC) which is used in cancer research.
|
S3142
|
Potassium sorbate
|
Potassium sorbate (Sorbic acid potassium) is a nonpoisonous food preservative isolated from Sorbus aucuparia. Potassium sorbate is an effective inhibitor of most molds and yeasts and some bacteria.
|
S3145
|
Pimelic acid
|
Pimelic acid (Heptanedioic acid, 1,5-Pentanedicarboxylic acid, 1,7-Heptanedioic acid) originating from fatty acid synthesis pathway is a bona fide precursor of biotin in B. subtilis.
|
S3152
|
Glutaric acid
|
Glutaric acid (GA) is an attractive C5 dicarboxylic acid with wide applications in the biochemical industry.
|
S3159
|
Citraconic acid
|
Citraconic acid (CA) is a kind of methyl-branched fatty acids that exists in wild soybean.
|
S3316
|
5-Hydroxy-1-tetralone
|
5-hydroxy-1-tetralone is a fluorescent labeling reagent for the determination of glycosphingolipid from small amounts of biological samples.
|
S3330
|
Maleamic acid
|
Maleamic acid ((Z)-4-Amino-4-oxobut-2-enoic acid) is an endogenous metabolite.
|
S3339
|
3-(2-Hydroxyphenyl)propionic acid
|
3-(2-Hydroxyphenyl)propanoic acid (Melilotic acid, Melilotate, 2-hydroxybenzenepropanoic acid) is an endogenous metabolite.
|
S2987
|
4-Methyl-2-oxovaleric acid
|
4-Methyl-2-oxovaleric acid (Ketoleucine, 4-MOV, KIC, 4-Methyl-2-oxopentanoic acid, alpha-Ketoisocaproic acid, alpha-ketoisocaproate, 2-Oxoisohexanoate) is released by Astrocytes to neurons and can be reaminated by aminotransferase to leucine. 4-Methyl-2-oxovaleric acid reduces the rate of protein degradation in skeletal muscle. 4-Methyl-2-oxovaleric acid acts as an uncoupler of oxidative phosphorylation (OXPHOS) and as a metabolic inhibitor possibly through its inhibitory effect on alpha-ketoglutarate dehydrogenase (oxoglutarate dehydrogenase complex, OGDC) activity.
|
S3266
|
L-Anserine nitrate salt
|
L-Anserine nitrate salt, a dipeptide found in most animal tissues, exhibits antioxidant properties, anti-crosslinking, and anti-glycation activities. L-Anserine protects against neurotoxicity induced by ER-stress inducers.
|
S1273
|
Amarogentin
|
Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. Amarogentin induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. Amarogentin (AG) interacts with the α2 subunit of AMP-activated protein kinase (AMPK) and activates the trimeric kinase with EC50 of 277 pM.
|
S0923
|
Isoliquiritin apioside
|
Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
|
S2869
|
Adamantane
|
Adamantane is a colorless, crystalline chemical compound first isolated from petroleum with a camphor-like odor. Adamantane is used to treat influenza A virus infections.
|
S9690
|
Caerulein (FI-6934)
|
Caerulein (Ceruletide, Cerulein, FI-6934), a cholecystokinin (CCK) receptor agonist, is a safe and effective cholecystokinetic agent and small bowel and exocrine pancreatic stimulant.
|
S6924
|
D-Luciferin sodium salt
|
D-Luciferin (D-(-)-Luciferin, Firefly luciferin) sodium salt is the natural substrate of luciferases that catalyze the production of light in bioluminescent insects.
|
S3290
|
Procyanidin B2
|
Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possess anti-inflammatory, anti-oxidant and anti-cancer activities. Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages. Procyanidin B2 significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.
|
S9700
|
Tapinarof
|
Tapinarof (GSK2894512, Benvitimod, WBI 1001, DHPS, DMVT 505) is a natural agonist of aryl hydrocarbon receptor (AhR) and induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) with EC50 of 0.16 nM. Tapinarof induces cellular apoptosis in CD4+ T cells in a dosedependent manner with IC50 of 5.2 μM.
|
S6919
|
Brevilin A
|
Brevilin A (6-O-Angeloylplenolina), a sesquiterpene lactone isolated from Centipeda minima, is a selective inhibitor of STAT3 and attenuates the JAKs activity by blocking the JAKs tyrosine kinase domain JH1. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation.
|
S0924
|
Pteryxin
|
Pteryxin ((+)-Pteryxin), a dihydropyranocoumarin derivative found in Apiaceae family, is a potent inhibitor of butyrylcholinesterase (BChE) with IC50 of 12.96 μg/ml. Pteryxin inhibits LPS-induced nitric oxide production in mouse peritoneal macrophages with IC50 of 20 µM. Pteryxin is potential for Alzheimer's disease (AD) treatment.
|
S0973
|
Wilforgine
|
Wilforgine, one of the major bioactive sesquiterpene alkaloids in Tripterygium wilfordii Hook. F., induces microstructural and ultrastructural changes in the muscles of M. separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system.
|
S3254
|
Plantagoside
|
Plantagoside, a flavanone glucoside isolated from the seeds of Plantago asiatica, is a specific and non-competitive alpha-mannosidase inhibitor with IC50 of 5 μM.
|
S3253
|
Xylobiose
|
Xylobiose (1,4-β-D-Xylobiose, 1,4-D-Xylobiose), a disaccharide of xylose monomers, is a natural substrate that can be hydrolysed by Beta-D-Xylosidase/alpha-L-arabinofuranosidase from Selenomonas ruminantium (SXA).
|
S3252
|
Xylotriose
|
Xylotriose (1,4-b-D-Xylotriose, 1,4-beta-D-xylotriose) is a natural xylooligosaccharide substrate that can be hydrolysed by catalytically efficient beta-D-xylosidase from Selenomonas ruminantium (SXA).
|
S3222
|
Raspberry ketone glucoside
|
Raspberry ketone glucoside (RKG), a natural product in raspberry fruit, is an antioxidant that has the inhibitory effect on the melanin synthesis.
|
S3223
|
L-Quebrachitol
|
L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.
|
S3226
|
Dehydroabietic acid
|
Dehydroabietic acid (DAA, DHAA), a naturally occurring diterpene resin acid derived from coniferous plants such as Pinus and Picea, displays anti-inflammatory activity via suppression of Src-, Syk-, and TAK1-mediated pathways.
|
S3278
|
Kaempferol-3-O-neohesperidoside
|
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid isolated from the leaf extract of Primula latifolia Lapeyr. and Primula vulgaris Hudson, stimulates glycogen synthesis in rat soleus muscle via PI3K - GSK-3 pathway and MAPK - PP1 pathway.
|
S3289
|
Daphnoretin
|
Daphnoretin (Dephnoretin, Thymelol), a biologically active compound isolated from Wikstroemia indica C.A. Mey., is a protein kinase C (PKC) activator. Daphnoretin inhibits the proliferation, invasion, and migration of tumor cells and promote its apoptosis by regulating the activity of Akt signal pathway.
|
S3295
|
Taxifolin 7-rhamnoside
|
Taxifolin 7-rhamnoside (TR, Taxifolin 7-O-rhamnoside, Taxifolin 7-O-α-L-rhamnoside), a flavonoid isolated from Hypericum japonicum, shows antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).
|
S3224
|
Cinobufagin
|
Cinobufagin (Cinobufagine), an active ingredient of Venenum Bufonis, inhibits tumor development. Cinobufagin increases ATM and Chk2 and decreases CDC25C, CDK1, and cyclin B. Cinobufagin inhibits PI3K, AKT and Bcl-2 while increases levels of cleaved caspase-9 and caspase-3. Thus, Cinobufagin induces cell cycle arrest at the G2/M phase and apoptosis.
|
S3230
|
L-Fucitol
|
L-Fucitol (1-Deoxy-D-galactitol), a galactitol analogue isolated from Myristica fragrans (Nutmeg), inhibits galactitol-positive strains of Escherichia coli K12.
|
S3233
|
Emetine hydrochloride
|
Emetine hydrochloride (NSC 33669), a principal alkaloid extracted from the root of ipecac clinically used as an emetic and antiprotozoal drug, reduces HIFs (hypoxia-inducible factors; HIF-1α and HIF-2α), PDK1, RhoA, Rho-kinases (ROCK1 and ROCK2) and BRD4. Emetine hydrochloride inhibits cellular autophagy and has anti-malarial, anti-viral, anti-bacterial and anti-amoebic effect.
|
S3236
|
Mesaconitine
|
Mesaconitine, one of the aconite alkaloids in Aconiti tuber, increases the [Ca2+]i level in endothelial cells by influx of Ca2+ from extracellular spaces.
|
S3238
|
Resibufogenin
|
Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.
|
S3245
|
Nodakenetin
|
Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.
|
S3251
|
Goitrin
|
Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. Goitrin exhibits antiviral and antiendotoxin activity.
|
S3262
|
Scopolin
|
Scopolin, a coumarin isolated from Arabidopsis thaliana (Arabidopsis), attenuates hepatic steatosis through activation of SIRT1-mediated signaling cascades, a potent regulator of lipid homeostasis.
|
S3267
|
Kaempferol-3-O-rutinoside
|
Kaempferol-3-O-rutinoside (Nicotiflorin, Nikotoflorin, Kaempferol 3-O-β-rutinoside), a flavonoid extracted from Carthamus tinctorius, alters the shape and structure of injured neurons, decreases the number of apoptotic cells, down-regulates expression of p-JAK2, p-STAT3, caspase-3, and Bax and decreases Bax immunoredactivity, and increases Bcl-2 protein expression and immunoreactivity.
|
S3271
|
Caudatin
|
Caudatin (Cauldatin), one species of C‑21 steroidal from Cynanchum auriculatum (C. auriculatum), effectively inhibits human glioma growth in vitro and in vivo through triggering cell cycle arrest and apoptosis.
|
S3273
|
Hypericin
|
Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).
|
S3291
|
Myristicin
|
Myristicin (Myristicine), a terpene-like active component in Nutmeg which is the seed of Myristica fragrans, is a weak inhibitor of monamine oxidase (MAO) and a mechanism-based inhibitor of CYP1A2.
|
S3296
|
Hispidulin
|
Hispidulin (Dinatin), an active natrual ingredient in a number of traditional Chinese medicinal herbs, exhibits inhibitory activity against the oncogenic protein kinase Pim-1 with IC50 of 2.71 μM. Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells. Hispidulin exerts anti-osteoporotic and bone resorption attenuating effects via activating the AMPK signaling pathway.
|
S3300
|
Desoxyrhaponticin
|
Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.
|
S3301
|
Cynarin
|
Cynarin (Cynarine) is an artichoke phytochemical that possesses a variety of pharmacological features including free-radical scavenging, antioxidant, antihistamic and antiviral activities. Cynarin blocks the interaction between the CD28 of T-cell receptor and CD80 of antigen presenting cells. Cynarin triggers Nrf2 nuclear translocation, restores the balance of glutathione (GSH) and reactive oxygen species (ROS), and inhibits mitochondrial depolarization.
|
S3305
|
Medicagenic acid
|
Medicagenic acid (Castanogenin), a bioactive triterpenoid pentacyclic glycoside isolated from Herniaria glabra L., has low xanthine oxidase, collagenase, elastase, and tyrosinase inhibitory activity.
|
S3240
|
Phaseoloidin
|
Phaseoloidin, a homogentisic acid glucoside from Nicotiana attenuata trichomes, contributes to the plant's resistance against lepidopteran herbivores. Phaseoloidin has anti-complement effects.
|
S3242
|
Loureirin B
|
Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.
|
S3246
|
Picfeltarraenin IB
|
Picfeltarraenin IB, a cucurbitacin glycoside isolated from Picriafel-terrae, is an inhibitor of acetylcholinesterase (AChE). Picfeltarraenin IB can be used for the treatment of herpes infections, cancer and inflammation.
|
S3260
|
3'-hydroxy Puerarin
|
3'-hydroxy Puerarin is an isoflavone isolated from Puerariae Lobatae Radix.
|
S3264
|
Atractyloside potassium salt
|
Atractyloside potassium salt (ATR potassium salt), a toxic diterpenoid glycoside isolated from the fruits of Xanthium sibiricum (Cang'erzi), is a powerful and specific inhibitor of mitochondrial ADP/ATP carriers. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart.
|
S3269
|
Acetylcorynoline
|
Acetylcorynoline, a major alkaloid component derived from Corydalis bungeana which is a traditional Chinese medical herb, shows anti-inflammatory properties. Acetylcorynoline may decrease egl-1 expression to suppress apoptosis pathways and increase rpn5 expression to enhance the activity of proteasomes.
|
S3270
|
Genipin 1-O-beta-D-gentiobioside
|
Genipin 1-O-beta-D-gentiobioside (GG, Genipin 1-β-D-gentiobioside, Genipin 1-gentiobioside, Genipin 1-β-gentiobioside, Genipin gentiobioside) is a bioactive iridoid glycoside isolated from Gardenia jasminoides Ellis (Zhizi in Chinese) that exhibits hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.
|
S3275
|
Senkyunolide I
|
Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. Senkyunolide I (SEI, SENI) up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. Senkyunolide I (SEI, SENI) promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9.
|
S3297
|
Hosenkoside A
|
Hosenkoside A is a bioactive baccharane glycoside isolated from the seeds of impatiens balsamina.
|
S3303
|
Cyperotundone
|
Cyperotundone (CYT) is an active constituent in Chuanxiong Rhizoma and Cyperi Rhizoma (CRCR) for treating migraine.
|
S3307
|
Galangin 3-methyl ether
|
Galangin 3-methyl ether (3-O-Methylgalangin, 3-Methylgalangin), isolated from Lychnophora markgravii aerial parts, shows strong antibacterial and antifungal effects.
|
S3308
|
Caftaric acid
|
Caftaric acid (CA, Caffeoyl tartaric acid) is a natural product that shows anti-oxidant and anti-inflammatory effects.
|
S3276
|
Hosenkoside K
|
Hosenkoside K is a bioactive baccharane glycoside isolated from the seeds of impatiens balsamina.
|
S6906
|
Capric acid
|
Capric acid (DA, Decanoic acid, Decylic acid), a component of medium-chain triclycerides occurring naturally in coconut oil and palm kernel oil, contributes to seizure control through direct AMPA receptor inhibition. Capric acid is also a modulating ligand for PPARs. Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.
|
S6899
|
Licochalcone D
|
Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. Licochalcone D inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone D inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage.
|
S3265
|
9''-Methyl salvianolate B
|
9''-Methyl salvianolate B (9'-methyllithospermate B, 9'-Methyl lithospermate B, 9'''-Methyl salvianolate B) is an active constituent in ethanol extract of Radix Salviae Miltiorrhizae.
|
S6885
|
Ailanthone
|
Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.
|
S0917
|
Allosecurinin
|
Allosecurinine (Phyllochrysine) is a Securinega alkaloid isolated from M.indica and M.discoidea with antifungal activity.
|
S0906
|
6-Methoxydihydroavicine
|
6-Methoxydihydroavicine (6-Methoxy Dihydrosanguinarine) is an lkaloid isolated from the fruits of M.cordata.
|
S3288
|
Absinthin
|
Absinthin (Absynthine) is a naturally produced triterpene lactone from Artemisia absinthium with anti-inflammatory properties. Absinthin significantly enhances the expression of matrix metalloproteinase-8 (MMP-8) and is a possible treatment candidate for Acute lung injury (ALI).
|
S3287
|
Rosamultin
|
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.
|
S6340
|
Guanidinoacetic acid
|
Guanidinoacetic acid (Guanidino acetic acid, GAA, Glycocyamine, Guanidinoacetate), the natural precursor of creatine, is under investigation as a dietary agent. Guanidinoacetic acid exhibits potential ergogenic benefits for physically active men and women.
|
S3220
|
Trigonelline
|
Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.
|
S3235
|
Sinapine
|
Sinapine is an alkaloid isolated from seeds of the cruciferous species with antioxidant, antitumor and radio-protective activities. Sinapine inhibits the proliferation of Caco-2 cells via downregulation of P-glycoprotein.
|
S3261
|
Myrislignan
|
Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) dose-dependently in LPS-stimulated macrophage cells. Myrislignan inhibits the NF-κB signalling pathway activation.
|
S3279
|
Polyphyllin B (Formosanin C)
|
Polyphyllin B (Formosanin C, FC), a diosgenin saponin isolated from Paris formosana, is an immunomodulator with antitumor activity. Polyphyllin B (Formosanin C, FC) induces apoptosis.
|
S3280
|
Linderene
|
Linderene (Lindenenol) is a furanosesquiterpenoid isolated from Lindera pulcherrima with antibacterial and antioxidant activities.
|
S3281
|
Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobioside
|
Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobioside (Quercetin 3-O-β-D-glucose-7-O-β-D-gentiobiosiden, Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside) is an active constituent of Descurainiae Semen.
|
S3298
|
Caulophylline (N-Methylcytisine)
|
Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation.
|
S3302
|
β,β-dimethyl-acryl-alkannin
|
β,β-dimethyl-acryl-alkannin (AN-I, β,β-Dimethylacrylalkannin) is a napthoquinone isolated from roots of Arnebia nobilis Reichb.f. that has the potential to be used as an anti-aging ingredient.
|
S3304
|
Stylopine
|
Stylopine ((R,S)-Stylopine, Tetrahydrocoptisine) reduces nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation. Stylopine is a major component of the leaf of Chelidonium majus L.
|
S3306
|
1,1,1,1-Kestohexaose
|
1,1,1,1-Kestohexaose is a major DP 6 fructan in crested wheatgrass leaves.
|
S3205
|
Perillaldehyde
|
Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway.
|
S3227
|
5,7-Dimethoxyflavone
|
5,7-Dimethoxyflavone (5,7-DMF) is an inhibitor of cytochrome P450 (CYP) 3As that markedly decreases the expression of CYP3A11 and CYP3A25 in the liver. 5,7-Dimethoxyflavone (5,7-DMF) is also a potent Breast Cancer Resistance Protein (BCRP, ABCG2) inhibitor. 5,7-Dimethoxyflavone (5,7-DMF) is one of the major components of Kaempferia parviflora with anti-obesity, anti-inflammatory, and antineoplastic effects.
|
S3237
|
Deoxyaconitine
|
3-Deoxyaconitine is a diterpenoid alkaloid isolated from the root of Aconitum Carmichaeli Debx.
|
S3241
|
Loureirin A
|
Loureirin A is a flavonoid extracted from the red resin of the herbs of Dracaena cochinchinensis, which is known as Dragon's Blood. Loureirin A inhibits platelet activation by an impairment of PI3K/Akt signaling. Loureirin A inhibits Akt phosphorylation.
|
S3247
|
Icariside I
|
Icariside I (Icarisid I) is one of the main components in Epimedii Folium that significantly stimulates cell proliferation and osteoblasts differentiation.
|
S3249
|
Corypalmine
|
Corypalmine ((R)-(+)-Corypalmine), an alkaloid isolated from Stephania cepharantha, is an inhibitor of prolyl endopeptidase/oligopeptidase (PREP/POP) with IC50 of 128.0 μM.
|
S3255
|
Pectolinarigenin
|
Pectolinarigenin, an active anti-inflammatory ingredient in Cirsium chanroenicum, is a dual inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX).
|
S3256
|
Tectochrysin
|
Tectochrysin (Techtochrysin, NSC 80687) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin significantly increases the expression of DR3, DR4 and Fas and inhibits activity of NF-κB. Tectochrysin induces apoptotic cell death.
|
S3257
|
Rebaudioside B
|
Rebaudioside B (Reb B) is one of the minor steviol glycosides (SGs) isolated from Stevia rebaudiana and has a better taste quality than many of the major SGs.
|
S3259
|
Rebaudioside D
|
Rebaudioside D (Reb D) is one of the several glycosides (SGs) found in the leaves of Stevia rebaudiana (Bertoni) which has been identified as a potential sweetener.
|
S3272
|
Steviol (Hydroxydehydrostevic acid)
|
Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation.
|
S3274
|
Glucosyl-vitexin
|
Glucosyl-vitexin (Glucosylvitexin), the major C-glycosylflavone present in millet, inhibits thyroid peroxidase (TPO) activity.
|
S3282
|
Rebaudioside M
|
Rebaudioside M, isolated from Stevia rebaudiana Bertoni, is a natural non-caloric potential sweetener in food and beverage products.
|
S3283
|
Marmesin
|
Marmesin (S-(+)-Marmesin, (+)-Marmesin, (S)-Marmesin) is a natural coumarin with COX-2 and 5-LOX dual inhibitory activity.
|
S3284
|
Tracheloside
|
Tracheloside is a lignan glycoside isolated from seeds of Carthamus tinctorius with anti-estrogenic effects. Tracheloside significantly decreases the activity of alkaline phosphatase (AP) (an estrogen-inducible marker enzyme) with IC50 of 0.31 μg/ml. Tracheloside promotes keratinocyte proliferation through ERK1/2 stimulation.
|
S3285
|
Dihydrolycorine
|
Dihydrolycorine is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb. Dihydrolycorine blocks protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. Dihydrolycorine exhibits antihypertensive and neuroprotective activities.
|
S3299
|
Demethyleneberberine
|
Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways.
|
S0553
|
Butyl isobutyl phthalate
|
Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.
|
S3206
|
5a-Pregnane-3,20-dione
|
5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. 5a-Pregnane-3,20-dione depolymerizes actin and decreases expression of actin and vinculin. 5a-Pregnane-3,20-dione is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.
|
S2440
|
Vindesine sulfate
|
Vindesine sulfate (Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS), a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.
|
S0949
|
Cucurbitacin IIb
|
Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB, blocks nuclear translocation of NF-κB and decreases mRNA levels of IκBα and TNF-α. Cucurbitacin IIb exhibits anti-inflammatory activity and induces apoptosis. Cucurbitacin IIb is isolated from Hemsleya amabilis.
|
S6852
|
Gossypol
|
Gossypol (BL 193) is an orally-active polyphenol isolated from cotton seeds and roots. Gossypol is a potent inhibitor of 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase with IC50 of 3.33 μM and 0.52 μM in cell-free assay, respectively. Gossypol also inhibits the binding of BH3 peptide to Bcl protein with IC50 of 0.4 μM and 10 μM for Bcl-XL and Bcl-2, respectively. Gossypol induces apoptosis and cell growth inhibition in various cancer cells.
|
S3210
|
3'-Hydroxy-4'-methoxyacetophenone
|
3'-Hydroxy-4'-methoxyacetophenone (Acetoisovanillone, Isoacetovanillone, Diosmin EP Impurity A) is an active P. spinosa extract with anti-inflammatory potential.
|
S3213
|
Veratryl alcohol
|
Veratryl alcohol (VA, Veratrole alcohol, 3,4-Dimethoxybenzyl alcohol), a secondary metabolite of some lignin degrading fungi, is the natural substrate of Lignin peroxidase (LiP).
|
S3214
|
Veratraldehyde (3,4-Dimethoxybenzaldehyde)
|
Veratraldehyde (3,4-dimethoxybenzaldehyde, VD, VAD, VAld, Verapamil Related Compound E, Methylvanillin), a derivative of vanillin, is the chemical that is found and isolated from peppermint, ginger, bourbon vanilla, and fruits such as raspberry. Veratraldehyde is widely used as a flavorant and odorant because of its pleasant woody fragrance. Veratraldehyde also acts as a redox cycle agent.
|
S3215
|
2-O-α-D-Glucopyranosyl-L-ascorbic acid
|
2-O-α-D-Glucopyranosyl-l-ascorbic acid (AA-2G), which is a glucoside derivative of ascorbic acid (AA), shows vitamin C activity after enzymatic hydrolysis to ascorbic acid. The antitumor activity of AA-2G is caused by ROS generated by AA released by rapid hydrolysis of AA-2G.
|
S3203
|
D-Alanine
|
D-alanine (Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286) is an endogenous co-agonist at the glycine site of the N-methyl-d-aspartate (NMDA) receptor.
|
S3293
|
Gardenoside
|
Gardenoside is a natural compound extracted from Gardenia fruits, with hepatoprotective properties. Gardenoside inhibits TNF-α, IL-1β, IL-6 and NFκB activation. Gardenoside also has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside suppresses the pain in rats model of chronic constriction injury by regulating the P2X3 and P2X7 receptors.
|
S3292
|
Falcarindiol
|
Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.
|
S3263
|
Agarotetrol
|
Agarotetrol is a chromone derivative found in high concentrations in the water-extract fraction of agarwood. Agarotetrol contributes to the fragrance of agarwood through the generation of LACs upon heating.
|
S3216
|
Uridine 5'-diphosphoglucose disodium salt
|
Uridine-5'-diphosphoglucose (UDPG, UDP-Glc, UDP-D-Glucose, UDP-α-D-Glucose) activates the P2Y(14) receptor, a neuroimmune system GPCR. Uridine-5'-diphosphoglucose is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms.
|
S3250
|
Veratrine
|
Veratridine (Cevadine, Cevadin, Cevadene), a steroidal alkaloid found in plants of the lily family, is a voltage-gated sodium channel activator. Veratridine induces anxiogenic-like behaviors in rats.
|
S7904
|
2',3'-cGAMP Sodium Salt
|
2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). 2',3'-cGAMP binds to STING with Kd of 3.79 nM.
|
S6630
|
Dimethylcurcumin (ASC-J9)
|
Dimethylcurcumin (ASC-J9, Dimethyl curcumin, GO-Y025) is an androgen receptor (AR) degradation enhancer that suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.
|
S2766
|
Glycerol
|
Glycerol (Glycerin) is a clear, colourless and viscous liquid that can be used as emollient, solvent or sweetening agent. Glycerol changes the separation characteristics of polyacrylamide nucleoprotein gels.
|
S8587
|
Withaferin A
|
Withaferin A (WA, WFA) potently inhibits NF-κB activation by preventing the tumor necrosis factor-induced activation of IκB kinase β via a thioalkylation-sensitive redox mechanism. Withaferin A binds to the intermediate filament (IF) protein, vimentin with antitumor and antiangiogenesis activity. Withaferin A is a steroidal lactone isolated from Withania somnifera.
|
S2653
|
9-amino-CPT (9-Aminocamptothecin)
|
9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.
|
S8620
|
6-Diazo-5-oxo-L-norleucine
|
6-Diazo-5-oxo-L-norleucine (Diazooxonorleucine, L-6-Diazo-5-oxonorleucine, DON), an antibiotic isolated from Streptomyces, is a glutaminase antagonist with IC50 of ~1 mM for cKGA (kidney-type glutaminase). 6-Diazo-5-oxo-L-norleucine exhibits analgesic, antibacterial, antiviral and anticancer properties.
|
S2654
|
Neoruscogenin
|
Neoruscogenin, a natural sapogenin isolated from R. rhizoma, is a potent and high-affinity agonist of RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1).
|
S8970
|
HQNO
|
HQNO (2-heptyl-4-hydroxyquinoline-N-oxide) is a natural quinolone secreted by P. aeruginosa. HQNO is a potent inhibitor of the electron transport chain with Kd of 64 nM for the ubiquinol-ferricytochrome c oxidoreductase segment (Complex III) of the respiratory chain. HQNO is also an inhibitor of bacterial and mitochondrialType II NADH : quinone oxidoreductase (NDH-2) with IC50 of 7.3 μM in the presence of 50μM menadione.
|
S7895
|
Thapsigargin
|
Thapsigargin is a potent, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50 of 0.353 nM or 0.448 nM for the carbachol-evoked [Ca2+]i-transients with or without a KCl-prestimulation. Thapsigargin induces cell apoptosis. Thapsigargin is extracted from a plant, Thapsia garganica.
|
S7905
|
3',3'-cGAMP
|
3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.
|
S7821
|
Bufalin
|
Bufalin (BF) is a potent inhibitor of steroid receptor coactivator SRC-3, SRC-1 and Na+/K+-ATPase. Bufalin binds to the subunit α1, α2 and α3 of Na+/K+-ATPase with Kd of 42.5 nM, 45 nM and 40 nM, respectively. Bufalin is a major digoxin-like immunoreactive component isolated from the Chinese medicine Chan Su with anti-cancer activity.
|
S7862
|
Rottlerin
|
Rottlerin (Mallotoxin, NSC 56346, NSC 94525), a natural compound purified from Mallotus Philippinensis, is a specific Protein kinase inhibitor with IC50 of 3 μM, 6 μM and 5.3 μM for PKCδ(from baculovirus-infected Sf9 insect cells), PKCδ(from porcine spleen) and CaM kinase III, respectively. Rottlerin also inhibits PKCα, PKCγ, PKCβ, PKCη, CKII and PKA with IC50 of 30 μM, 40 μM, 42 μM, 82 μM, 30 μM and 78 μM, respectively.
|
S2447
|
Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)
|
Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.
|
S6790
|
Ellipticine hydrochloride
|
Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity.
|
S8964
|
Actinomycin D (Dactinomycin)
|
Actinomycin D (Dactinomycin, Act D, RASP-101) is a significant polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. Actinomycin D (Dactinomycin) inhibits DNA repair and rests the cell cycle at G1 phase with IC50 of 0.42 μM and 0.4 nM, respectively. Actinomycin D is an autophagy activator, induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.
|
S2288
|
Rubitecan
|
Rubitecan (9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000) is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity.
|
S2009
|
Indirubin-3'-monoxime
|
Indirubin-3'-monoxime (Indirubin-3'-oxime) is a selective CDK inhibitor with IC50 of 0.18 μM, 0.44 μM, 0.25 μM, 3.33 μM, 0.065 μM for CDK1-cyclinB, CDK2-cyclinA, CDK2-cyclinE, CDK4-cyclinD1, CDK5-p35,respectively. Indirubin-3'-monoxime is a direct and selective 5-lipoxygenase inhibitor with IC50 of 7.8-10 µM.
|
S1031
|
3-Hydroxybutyric acid
|
3-Hydroxybutyric acid (3-hydroxybutanoic acid, β-Hydroxybutyric acid, BHB) is a small molecule metabolite that is elevated in type I diabetes.
|
S2342
|
Phloretin (RJC 02792)
|
Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
|
S9440
|
Naringenin chalcone
|
Naringenin chalcone (Chalconaringenin, Isosalipurpol, trans-2'4'6'4-tetrahydroxychalcone) is the main active component of tomato skin extract, has been proposed as an antioxidant, an anti-inflammatory, and a regulator of fat and sex hormone metabolism.
|
S2325
|
Morin Hydrate
|
Morin hydrate (Aurantica) is a flavonoid isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and from leaves of Psidium guajava (common guava).
|
S6670
|
GPNA (L-γ-Glutamyl-p-nitroanilide)
|
GPNA (L-γ-Glutamyl-p-nitroanilide) is a potent and selective inhibitor of the glutamine (Gln) transporter ASCT2(SLC1A5) with Ki of 55 µM.
|
S2210
|
Sphingosine
|
Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine) is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.
|
S6674
|
Cytosporone B
|
Cytosporone B is a naturally occurring agonist for nuclear orphan receptor Nur77(NR4A1) with an EC50 of 0.278nM.
|
S6474
|
3,5-diiodo-L-thyronine (3,5-T2)
|
3,5-diiodo-L-thyronine (3,5-T2, NSC 90469) is an endogenous metabolite of thyroid hormones. 3,5-Diiodo-l-thyronine has been proposed as a potential hypolipidemic agent for treatment of obesity and hepatic steatosis.
|
S9218
|
Phytolaccagenin
|
Phytolaccagenin, a triterpenoid saponin, is the active component of Radix Phtolaccae.
|
S6653
|
Nigericin (NSC 292567) sodium salt
|
Nigericin (NSC 292567) sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.
|
S3911
|
Veratramine
|
Veratramine (NSC 17821, NSC 23880), a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.
|
S9403
|
Ecliptasaponin A
|
Ecliptasaponin A, a natural triterpenoid glucoside, has protective effects against the pulmonary fibrosis induced by bleomycin via reducing the oxidative stress, lung tissue inflammation, and the subsequent epithelial-mesenchymal transition.
|
S3928
|
Baccatin Ⅲ
|
Baccatin Ⅲ is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It exhibits immunomodulatory and anticancer chemotherapeutic activities.
|
S4938
|
Cedrol
|
Cedrol, a natural occuring sesquiterpene alcohol, is a potent competitive inhibitor of CYP2B6-mediated bupropion hydroxylase with inhibition constant (Ki) value of 0.9 μM. It also inhibits CYP3A4-mediated midazolam hydroxylation with a Ki value of 3.4 μM while only weakly inhibits CYP2C8, CYP2C9, and CYP2C19 activities.
|
S3942
|
Cardamonin
|
Cardamonin (Alpinetin chalcone), isolated from the fruits of Alpinia species, is a chalconoid with anti-inflammatory and anti-tumor activity. It has been shown to be a novel antagonist of hTRPA1 cation channel with IC50 of 454 nM while does not interact with TRPV1 nor TRPV4 channel.
|
S3756
|
Methyl salicylate
|
Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.
|
S3763
|
Cinnamaldehyde
|
Cinnamaldehyde is a flavonoid that is naturally synthesized by the shikimate pathway. Its supplementation can improve glucose and lipid homeostasis in diabetic animals; a TRPA1 agonist.
|
S3605
|
Borneol
|
Borneol is a bicyclic monoterpenoid compound extracted from medicinal plants such as Blumea balsamifera, and Dryobalanops aromatica. It is a TRPM8 agonist that increases ocular surface wetness.
|
S4787
|
Methyl syringate
|
Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.
|
S3867
|
(E)-Cardamonin
|
(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.
|
S4714
|
(-)-Menthol
|
(-)-Menthol is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8.
|
S2332
|
Neohesperidin
|
Neohesperidin (NSC 31048), a flavanone glycoside found in citrus fruits, is an antioxidant agent.
|
S5755
|
Methyl Eugenol
|
Methyl eugenol (4-allylveratrole, eugenyl methyl ether, O-methyleugenol), as a constituent in leaves, fruits, stems, and/or roots, is used as a flavoring agent, as a fragrance and as an anesthetic in rodents.
|
S2935
|
Nicotinamide Riboside Chloride
|
Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.
|
S3607
|
Sarsasapogenin
|
Sarsasapogenin (SAR, Parigenin) is a steroidal sapogenin. It can provoke the generation of reactive oxygen species and activate unfolded protein response (UPR) signaling pathways. SAR potently inhibits NF-κB and MAPK activation, as well as IRAK1, TAK1, and IκBα phosphorylation in LPS-stimulated macrophages.
|
S2425
|
Apocynin (NSC 2146)
|
Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
|
S9332
|
(+)-Dipentene
|
(+)-Dipentene, occurring commonly in nature as the fragrance of oranges, is a flavoring agent in food manufacturing.
|
S5578
|
Cadaverine
|
Cadaverine is a foul-smelling diamine formed by bacterial decarboxylation of lysine that occurs during protein hydrolysis during putrefaction of animal tissue.
|
S5140
|
Cinene
|
Cinene (Limonene, Dipentene) is a clear, colorless liquid hydrocarbon classified as a cyclic monoterpene, and is the major component in oil of citrus fruit peels. It is usually used to make fragrances and flavors.
|
S5408
|
Isoprene
|
Isoprene, also called 2-methyl-1,3-butadiene, is usually used as a chemical raw materia.
|
S6206
|
1-Butanol
|
1-Butanol occurs naturally as a minor product of the fermentation of sugars and other carbohydrates, and is present in many foods and beverages.
|
S6019
|
2-Phenylphenol
|
2-Phenylphenol, found in lemon, is an antifungal agent and preservative used in food seasonings.
|
S5429
|
Diallyl sulfide
|
Diallyl sulfide, a thioether found naturally in garlic, is a selective inhibitor and also a substrate of CYP2E1 with an IC50 of 17.3 μM. It has protective effects against alcohol- and acetaminophen-induced hepatotoxicity in many studies.
|
S6751
|
Brevianamide F
|
Brevianamide F, belonging to a class of naturally occurring 2,5-diketopiperazines, is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by the fungi A.fumigates and Aspergillus sp..
|
S6359
|
Purine
|
Purine is a heterocyclic aromatic organic compound which plays crucial roles in DNA and RNA. It is also significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A.
|
S2353
|
Sapogenins Glycosides
|
Sapogenins glycosides (Saponins) are a mixture of triterpene and steroid saponins isolated from medicinal plants such as Aesculus hippocastanum L., Hedera helix L. and Ruscus aculeatus L., which are claimed to be effective for the treatment/prevention of venous insufficiency.
|
S3627
|
Tryptamine
|
Tryptamine is a monoamine alkaloid and may play a role as a neuromodulator or neurotransmitter. It is an agonist of hTAAR1. It acts as a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent (SNDRA).
|
S5153
|
Tetrahydroberberine
|
Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.
|
S3823
|
Schizandrol A
|
Schizandrol A is one of the effective components in the dried fruit of Schizandra chinensis Bail and works by increasing dopamine, a neurotransmitter, in the brain.
|
S5642
|
Homovanillic acid
|
Homovanillic acid (Vanillacetic acid) is a major catecholamine metabolite that is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain.
|
S9087
|
Tenuifolin
|
Tenuifolin, a secondary saponin isolated from hydrolysates of polygalasaponins, inhibits beta-amyloid synthesis in vitro and has nootropic activity in vivo via acetylcholine esterase inhibition and increases norepinephrine and dopamine production.
|
S2367
|
Tetrahydropapaverine HCl
|
Tetrahydropapaverine (Norlaudanosine), one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons.
|
S3937
|
Pterostilbene
|
Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries. It has been implicated in anticarcinogenesis, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes.
|
S6428
|
Wilforlide A
|
Wilforlide A is an active compound in Tripterygium wilfordii Hook F (TW) which is a traditional Chinese medicine for treatment of autoimmune diseases.
|
S5850
|
Vasicine
|
Vasicine, an alkaloid isolated from A. vasica, is a potential natural cholinesterase inhibitor, exhibits promising anticholinesterase activity in preclinical models and has been in development for treatment of Alzheimer’s disease.
|
S7956
|
Brusatol
|
Brusatol (NSC 172924), isolated from the fruit of B. javanica, is a NRF2 inhibitor.
|
S3781
|
Ginkgolide C
|
Ginkgolide C (BN-52022), isolated from Ginkgo biloba leaves, is a flavone reported to have multiple biological functions, from decreased platelet aggregation to ameliorating Alzheimer disease. It is an activator of MMP-9.
|
S9513
|
Senkyunolide A
|
Senkyunolide A is one of the major bioactive ingredients in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments.
|
S6049
|
(+)-(S)-Carvone
|
(+)-(S)-Carvone, a monoterpene found mainly in caraway and dill seed oils, is used in cosmetic, food and pharmaceutical preparations.
|
S6700
|
Castor oil
|
Castor oil is a popular natural treatment for various common conditions and often used in natural beauty products.
|
S3830
|
Protodioscin
|
Protodioscin (Furostanol I), a steroidal saponin compound found in a number of plant species, is able to stimulate testosterone production and it also has an androgen-mimetic action, binding and activating the testosterone receptors.
|
S8870
|
Epibrassinolide
|
Epibrassinolide is a brassinosteroid isolated from various plants and has been shown to decrease toxicity and stimulate healthy plant growth in plants under stress.
|
S6701
|
Corn Oil
|
Corn oil is a refined vegetable oil, and is used as delivery vehicle for fat-soluble compounds.
|
S9326
|
Scopolamine
|
Scopolamine (Skopolamin) is a tropane alkaloid derived from plants of the nightshade family, specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties.
|
S3860
|
Allicin
|
Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.
|
S6493
|
n-Butylidenephthalide
|
n-Butylidenephthalide ((Z)-Butylidenephthalide, 3-Butylidenephthalide, Butylidenephthalide), isolated from the chloroform extract of Angelica sinensis (AS-C), contributes to a range of biological activities, including diminution of angina, platelet aggregation, proliferation, non-specific spasmosis.
|
S6601
|
(±)-Equol
|
(±)-Equol, an isoflavandiol estrogen, is a metabolite of the soy isoflavones, daidzin and daidzein.
|
S3687
|
Urea
|
Urea (Carbonyldiamide, Ureophil) is a highly soluble organic compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
|
S3839
|
1-Deoxynojirimycin
|
1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.
|
S3190
|
N6-methyladenosine (m6A)
|
N6-methyladenosine (m6A, NSC-29409, 6-Methyladenosine, N-Methyladenosine) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs.
|
S2370
|
Ursolic Acid
|
Ursolic acid (NSC 167406, NSC-4060, Prunol, Urson, Malol) is a pentacyclic triterpene acid, used in cosmetics.
|
S6426
|
Hesperidin methylchalcone
|
Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity.
|
S3821
|
Nuciferine
|
Nuciferine (Sanjoinine E, (-)-Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
|
S9227
|
Sinensetin
|
Sinensetin (Pedalitin Permethyl ether), a natural polymethoxylated flavone, has potent antiangiogenesis activity.
|
S3973
|
L-SelenoMethionine
|
L-SelenoMethionine (SeMet), a naturally occurring amino acid, is a major food-form of selenium. It has been used as a supplement, and exhibits some important functions like cancer prevention and antioxidative defense.
|
S2324
|
Sodium Monensin (NSC 343257)
|
Sodium Monensin (NSC 343257), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics.
|
S2348
|
Rotenone (Barbasco)
|
Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
|
S2265
|
Artesunate (WR-256283)
|
Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.
|
S6176
|
Scyllo-Inositol
|
Scyllo-Inositol (Scyllitol, Cocositol, Quercinitol, AZD 103, Scyllo-Cyclohexanehexol) is a naturally occurring plant sugar alcohol found most abundantly in the coconut palm.
|
S6292
|
(S)-2-Hydroxysuccinic acid
|
(S)-2-Hydroxysuccinic acid (L-Malic acid), is a naturally occurring isomer of malic acid, found mainly in sour and unripe fruits.
|
S6346
|
L-(+)-Arabinose
|
L-(+)-Arabinose (DL-Arabinose, Pectinose) is used as a substrate to identify, differentiate and characterize pentose sugar isomerase(s).
|
S6061
|
DL-m-Tyrosine
|
DL-m-Tyrosine is a potent, structurally unusual broad-spectrum phytotoxin exuded by the roots of some fine leaf fescue grasses.
|
S6163
|
Traumatic acid
|
Traumatic acid (Trans-2-dodecenedioic acid) is a plant hormone that was first isolated from damaged green beans. It is a potent wound healing agent and an intermediate in prostaglandin synthesis.
|
S6264
|
Rutin hydrate
|
Rutin (Quercetin-3-O-rutinoside, Rutoside, Sophorin) is a glycoside found in a wide variety of plants including citrus fruit.
|
S6112
|
Oxalacetic acid
|
Oxalacetic acid (Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid) is an intermediate of the citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalysed by citrate synthase. It is also involved in gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. Oxaloacetate is also a potent inhibitor of Complex II.
|
S6221
|
Methyl cinnamate
|
Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.
|
S6008
|
p-Hydroxybenzaldehyde
|
p-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol), which can be found in the orchids Gastrodia elata, Galeola faberi and vanilla, is a hydroxybenzaldehyde that reacts with NAD+ and H2O to produce 4-hydroxybenzoate, NADH, and 2 protons. p-Hydroxybenzaldehyde at 101.7 μM can significantly reduce the GABA-induced chloride current of GABAA receptors(α1β2γ2S subtype) expressed.
|
S6011
|
Acetamide
|
Acetamide (ethanamide, Acetic acid amide) is an organic compound that can be used as a plasticizer and an industrial solvent.
|
S6018
|
2,3,4-Trihydroxybenzoic acid
|
2,3,4-Trihydroxybenzoic acid is a phenol constituent of Pachysandra terminalis with antioxidant activity.
|
S6043
|
3-Indoleacetonitrile
|
3-Indoleacetonitrile, a plant growth hormone, is a light-induced auxin-inhibitory substance that is isolated from light-grown cabbage (Brassica olearea L.) shoots.
|
S6045
|
L-Arabinitol
|
L-Arabinitol (L-lyxitol) is a member of the class of compounds known as sugar alcohols that exists in all living species, ranging from bacteria to humans. It can be found in a number of food items such as sweet potato, deerberry, moth bean, and European chestnut, which makes L-arabitol a potential biomarker for the consumption of these food products.
|
S6047
|
Lactose
|
Lactose is a disaccharide naturally found in milk and dairy.
|
S6071
|
3,5-Dimethoxyphenol
|
3,5-Dimethoxyphenol (Phloroglucinol dimethyl ether) is a toxin metabolite that can be found in human consuming yew (Taxus baccata) leaves.
|
S6076
|
Phenylacetylglutamine
|
Phenylacetylglutamine is a product formed by the conjugation of phenylacetate and glutamine. It is a normal constituent of human urine, but other mammals such as the dog, cat, rat, monkey, sheep, and horse do not excrete this compound.
|
S9564
|
p-Hydroxy-cinnamic Acid
|
p-Hydroxy-cinnamic Acid has in vitro antimalarial activity and in vivo anti-osteoporotic properties.
|
S2254
|
4-Demethylepipodophyllotoxin(NSC-122819,VM-26)
|
4-Demethylepipodophyllotoxin (NSC-122819, VM-26, DMEP) is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly.
|
S2442
|
Inosine
|
Inosine (NSC 20262, INO 495) is a nucleoside that is formed when hypoxanthine is attached to a ribose ring via a β-N9-glycosidic bond.
|
S2280
|
Chlorogenic Acid
|
Chlorogenic acid (NSC 407296, Heriguard) is a hydroxycinnamic acid and a member of a family of naturally occurring organic compounds.
|
S6250
|
L-Lactic acid
|
L-Lactic acid is a natural product that is used as a food additive.
|
S6275
|
(−)-β-Pinene
|
(−)-β-Pinene (Nopinene) is a natural organic compound in various plants. It is lethal to S. littoralis third instar larvae (LD50 = 65 μg/larva), inhibits infectious bronchitis virus (IBV) replication (IC50 = 1.32 mM) and exhibits a cytotoxic concentration (CC50) value of greater than 10 mM in Vero cells.
|
S6287
|
3-Methylbutanoic acid
|
3-Methylbutanoic acid (Isovaleric acid, Delphinic acid, 3-Methylbutyric acid, Isopentanoic acid, β-methylbutyric acid) is a natural fatty acid found in a wide variety of plants and essential oils. It has a strong pungent cheesy or sweaty smell, but its volatile esters have pleasing scents and are used widely in perfumery.
|
S6296
|
Octanoic acid
|
Octanoic acid (caprylic acid) is found naturally in the milk of various mammals, and as a minor constituent of coconut oil and palm kernel oil. It is used in the production of esters used in perfumery and also in the manufacture of dyes.
|
S6303
|
trans-2-Hexenal
|
Trans-2-hexenal (Leaf aldehyde) is an α,β-unsaturated carbonyl compound protecting plants against harmful substances.
|
S5887
|
Khellin
|
Khellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Kalangin), a compound isolated from the seeds of Ammi Visnaga Lam (Umbelliferae), is used to treat a variety of maladies.
|
S2331
|
Neohesperidin Dihydrochalcone (Nhdc)
|
Neohesperidin dihydrochalcone(Nhdc, NCI-c60764), sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus.
|
S9432
|
Ginkgolic Acid
|
Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).
|
S9445
|
Ginkgolic Acid (C13:0)
|
Ginkgolic Acid (C13:0) is a natural anticariogenic agent in Ginkgo biloba L. that exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity. Ginkgolic acid is a potent sumoylation inhibitor and reported to inhibit histone acetylation transferase (HAT).
|
S2360
|
Solanesol (Nonaisoprenol)
|
Solanesol (Nonaisoprenol, Betulanonaprenol) is a long-chain polyisoprenoid alcohol compound with inhibitory activities toward FAK. It mainly accumulates in solanaceous crops, including tobacco, tomato, potato, eggplant, and pepper plants.
|
S2369
|
Troxerutin
|
Troxerutin, a natural bioflavonoid isolated from Sophora japonica, has been reported to have many benefits and medicinal properties. Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.
|
S5934
|
(-)-Fenchone
|
Fenchone is a constituent of absinthe and the essential oil of fennel. It is used as a flavor in foods and in perfumery.
|
S6055
|
(S)-(−)-Limonene
|
(S)-(−)-Limonene, a fragrance monoterpene mainly found in citrus peel oil, is also naturally occurs in the essential oils of herbs, tea tree oil, and turpentine oil.
|
S6058
|
β-Caryophyllene
|
β-Caryophyllene is a natural bicyclic sesquiterpene that is a constituent of many essential oils. It acts as a non-steroidal anti-inflammatory drug, a fragrance and a metabolite.
|
S6059
|
cis-3-Hexen-1-ol
|
cis-3-Hexen-1-ol (Leaf alcohol) is a very important aroma compound that is used in fruit and vegetable flavors and in perfumes and acts as an attractant to many predatory insects.
|
S6118
|
Terpinen-4-ol
|
Terpinen-4-ol, a naturally occurring monoterpene, is the main bioactive component of tea-tree oil and has been shown to have many biological activities such as antifungal properties.
|
S6150
|
Farnesyl Acetate (mixture of isomers)
|
Farnesyl Acetate is a flavouring compound identified in foods such as blueberries.
|
S6162
|
2-Octenoic acid
|
2-Octenoic acid (2-Octenoate) is a normal organic acid produced by hepatic microsomal oxidation of aliphatic aldehydes and is a metabolite naturally found in the urine and plasma.
|
S6164
|
(-)-Citronellal
|
(-)-Citronellal, a constituent of citronella oil, is used in the synthesis of bioactive compounds.
|
S6185
|
Arachidonic acid
|
Arachidonic acid (Arachidonate) is an unsaturated, essential fatty acid found in animal and human fat as well as in the liver, brain, and glandular organs. It is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
|
S6208
|
Diethyl malonate
|
Diethyl malonate, naturally occuring in grapes and strawberries, is used in the synthesis of chemicals.
|
S9476
|
Dendrobine
|
Dendrobine, a plant alkaloid isolated from Dendrobium nobile, has been used for the quality control and discrimination of Dendrobium.
|
S9551
|
Uvaol
|
Uvaol is a pentacyclic triterpene, found in the non-glyceride fraction of olive pomace oil, exhibiting both pro- and anti-inflammatory properties.
|
S4792
|
N-Acetylneuraminic acid
|
N-Acetylneuraminic acid (Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid, NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes.
|
S5526
|
β-Alanine
|
β-Alanine (beta-Alanine, 3-Aminopropanoic acid) is a naturally occurring beta amino acid formed in vivo by the degradation of dihydrouracil and carnosine. It acts as a neurotransmitter by activating glycine and GABA receptors.
|
S4676
|
Gluconolactone
|
Gluconolactone is a naturally occurring polyhydroxy acid with metal chelating, moisturizing and antioxidant activity.
|
S5851
|
4'-Methoxychalcone
|
4'-Methoxychalcone, found in citrus, is chalcone derivative that has shown diverse pharmacological properties, including anti-tumor and anti-inflammatory activities. 4'-Methoxychalcone significantly enhanced adipocyte differentiation, in part, by its potent effects on PPARγ activation and by its reverse effect on TNF-α.
|
S9481
|
Blinin
|
Blinin, isolated from the whole plant of Conyza blinii, is used in folk medicine in the south-west of China.
|
S9557
|
Isobergapten
|
Isobergapten is a furanocoumarin with plant growth regulating activity.
|
S9560
|
Anisodamine Hydrobromide
|
Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).
|
S5865
|
Hyaluronic acid
|
Hyaluronic acid (HA, Hyaluronan, Hyaluronate) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is widely used in skin care.
|
S9193
|
Aristolochic acid A
|
Aristolochic acid A (Aristolochic Acid I, Aristolochin, Aristolochine, TR 1736) is a carcinogenic, mutagenic, and nephrotoxic agent extracted from the flowering plant family Aristolochiaceae.Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and nuclear factor-κB (NF-κB) activities.
|
S9563
|
Evodine
|
Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia. Evodine is a potent P-gp inhibitor.
|
S9554
|
Bakkenolide A
|
Bakkenolide A (Fukinanolid), extracted from Petasites tricholobus, has been suggested to against cancer and display protective effects on inflammatory cytokines formation.
|
S9552
|
Farrerol
|
Farrerol, an important bioactive constituent of rhododendron, exhibits broad activities such as anti-oxidative and anti-inflammatory effects.
|
S9487
|
Praeruptorin C
|
Praeruptorin C is a natural compound derived from the dried roots of Peucedanum praeruptorum and has beneficial effects in suppressing osteoclast formation and resorption function. It is frequently utilized in traditional Chinese medicine for treating upper respiratory infections and as an antipyretic, antitussive, and mucolytic agent.
|
S9484
|
Darutoside
|
Darutoside, derived from botanical extracts, has a powerful regenerating action via decreasing inflammation and restoring collagen.
|
S9480
|
Raspberry Ketone
|
Raspberry ketone (p-Hydroxybenzyl acetone, Frambinone, Oxyphenylon, Rheosmin, Rasketone) is a natural phenolic compound that is the primary aroma compound of red raspberries. Raspberry ketone shows cardioprotective action against isoproterenol-induced myocardial infarction in rats, and the effects may be due to its PPAR-α agonistic activity.
|
S9473
|
Nuzhenide
|
Nuzhenide (Specnuezhenide), a major component of olive seeds, is a member of the class of compounds known as saccharolipids. It has strong antioxidant activity.
|
S9474
|
Acetylharpagide
|
Acetylharpagide is a monomeric compound extracted from Ajuga decumbens, widely used for remedying infectious and inflammatory diseases.
|
S5846
|
Apocarotenal
|
Apocarotenal is a carotenoid found in spinach and citrus fruits and plays a role as a precursor of vitamin A.
|
S9475
|
Hupehenine
|
Hupehenine is a steriodal alkaloid extracted from the bulbs of Fritillaria Hupehensis, with the potential for inhibiting acetylcholine, antagonism for muscarinic receptors and cholinesterase inhibition.
|
S9479
|
Complanatoside A
|
Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus and is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia.
|
S9488
|
Praeruptorin D
|
Praeruptorin D, a major pyranocoumarin isolated from Radix Peucedani, exhibits antitumor and anti-inflammatory activities.
|
S9491
|
(+)-Guaiacin
|
(+)-Guaiacin, found in herbs and spices, belongs to the class of organic compounds known as aryltetralin lignans.
|
S9555
|
Vincristine
|
Vincristine (Leurocristine, NSC-67574, 22-Oxovincaleukoblastine) is a natural alkaloid isolated from the plant Vinca rosea Linn. with anti-tumor activity. Vincristine inhibits microtubule formation in mitotic spindle and binds to microtubule with Ki of 85 nM.
|
S9562
|
Pomolic acid
|
Pomolic acid is a pentacyclic triterpene isolated from Euscaphis japonica, and is highly effective in inhibiting cell growth and induces apoptosis.
|
S9192
|
Vitexin
|
Vitexin (Apigenin-8-C-glucoside), an naturally occuring apigenin flavone glycoside, acts as a platelet aggregation and alpha-glucosidase inhibitor and shows antineoplastic activity.
|
S3964
|
Mucic Acid
|
Mucic Acid (Schleimsaure, Saccharolactic acid, Tetrahydroxyadipic acid, D-Glucaric acid, Galactaric acid) is the dicarboxylic sugar acid resulting from oxidation glactose with dilute nitric acid. It is a substrate of galactarate O-hydroxycinnamoyltransferase.
|
S5928
|
Zerumbone
|
Zerumbone, derived from several plant species of the Zingiberaceae family, is a naturally occurring dietary compound and may have multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities.
|
S5794
|
Glycochenodeoxycholic acid
|
Glycochenodeoxycholic acid (Glycochenodeoxycholate, Chenodeoxycholylglycine, Glycine chenodeoxycholate) is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption. Glycochenodeoxycholic acid
|
S5820
|
L-Hydroxyproline
|
L-Hydroxyproline (trans-4-Hydroxy-L-proline) is a collagen-specific amino acid. It is used as a diagnostic marker of bone turnover and liver fibrosis.
|
S5824
|
Cinnamyl alcohol
|
Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. Cinnamyl alcohol can be significantly attenuated the enhanced expression of obesity-related proteins PPARγ in MDI medium-cultivated 3T3-L1 cells.
|
S5821
|
Linoleic acid
|
Linoleic acid (9,12-octadecadienoic acid) is an essential fatty acid used in the biosynthesis of arachidonic acid and found in the lipids of cell membranes.
|
S5823
|
L-Pyroglutamic acid
|
L-pyroglutamic acid (L-pyroglutamate, 5-Oxoproline, pidolic acid) is a natural nutrient and amino acid derived from glutamic acid. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase.
|
S5828
|
L-Abrine
|
L-Abrine (N-Methyl-L-tryptophan), an extremely toxic toxalbumin found in the seeds of the rosary pea, is a ribosome inhibiting protein.
|
S9367
|
Adenosine disodium triphosphate
|
Adenosine disodium triphosphate (ATP disodium) is the sodium salt form of adenosine triphosphate (ATP), a complex organic chemical that provides energy to drive many processes in living cells.
|
S5805
|
Allopregnanolone
|
Allopregnanolone, a neurosteroid synthesized from progesterone in brain, acts as a highly potent positive allosteric modulator of the GABAA receptor.
|
S5771
|
Sulforaphane
|
Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.
|
S9334
|
2-Pentylfuran
|
2-Pentylfuran (2-Amylfuran) is a naturally occuring flavouring ingredient.
|
S9383
|
Methyl palmitate
|
Methyl palmitate (Methyl hexadecanoate, Palmitic acid methyl ester), a kind of fatty acid methyl ester, could be found in many plants and possesses acaricidal activity.
|
S9453
|
2-Undecanol
|
2-Undecanol (Methyl nonyl carbinol, 2-Hydroxyundecane, 2-Hendecanol) is a fatty alcohol lipid molecule.
|
S9454
|
Undecanoic acid
|
Undecanoic acid (Undecylic acid) is a medium chain length monocarboxylic acid that appears to be involved in the control of triacylglycerol synthesis.
|
S9385
|
Ligustilide
|
Ligustilide is the most abundant bioactive ingredient in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments. Solutions are best fresh-prepared.
|
S9033
|
Incensole acetate
|
Incensole acetate, isolated from Boswellia Resin, is a novel anti-inflammatory compound that inhibits NF-κB activation.
|
S9043
|
6-Shogaol
|
6-Shogaol, a naturally occuring product found in ginger, has anti-inflammatory and anticancer properties.
|
S9071
|
Nootkatone
|
Nootkatone, a natural ingredient that occurs in grapefruit and certain other plants, has antioxidant and anti-inflammatory effects.
|
S9094
|
Pogostone
|
Pogostone is one of the secondary metabolites from Pogostemon cablin (Blanco) Benth. (Lamiaceae), serving as the effective component of the antimicrobial activity.
|
S9118
|
Beta-Asarone
|
Beta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects.
|
S9140
|
Pulegone
|
Pulegone, a naturally occurring organic compound, is a fragrance and flavour ingredient.pulegone stimulates both TRPM8 and TRPA1 channel in chicken sensory neurons and suppresses the former but not the latter at high concentrations.
|
S9142
|
Sparteine
|
Sparteine, which could be extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent.
|
S9236
|
α-Cyperone
|
α-Cyperone (alpha-cyperone), a major active compound of Cyperus rotundus, exhibits biological activities, such as antivirulence, antigenotoxic, and antibacterial activities. α-Cyperone (alpha-cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1.
|
S9263
|
3-n-Butylphathlide
|
3-n-Butylphathlide, initially isolated from the seeds of Apium graveolens Linn., has shown significant neuroprotective effects.
|
S5370
|
10-Hydroxydecanoic acid
|
10-Hydroxydecanoic acid, a minor constituent of royal jelly, is a saturated fatty acid that has cytotoxic effects.
|
S9450
|
1-Undecanol
|
1-Undecanol (Undecyl alcohol, 1-Hendecanol), found naturally in many foods such as fruits (including apples and bananas), butter, eggs and cooked pork, is used as a flavoring ingredient.
|
S5761
|
Citric acid
|
Citric acid is a weak organic acid that occurs naturally in citrus fruits. It is an intermediate in the citric acid cycle.
|
S5763
|
D-Mannose
|
D-mannose is a naturally occurring simple sugar that may help your body cleanse the urinary tract and maintain a healthy bladder lining.
|
S5391
|
α-Boswellic acid
|
α-Boswellic acid is a naturally occuring triterpenoic acid.
|
S5757
|
Isoeugenol
|
Isoeugenol (4-Propenylguaiacol), an essential oil constituent of nutmeg, clove, and cinnamon, shows antimicrobial activity.
|
S5759
|
Methyl linoleate
|
Methyl linoleate (Linoleic acid methyl ester), found in cloves, is a fatty acid methyl ester of linoleic acid which is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes.
|
S5756
|
Methyl Stearate
|
Methyl Stearate (Methyl Octadecanoate, Stearic Acid methyl ester), found in cloves, is an antifoaming agent and fermentation nutrient.
|
S5577
|
6-Biopterin
|
6-Biopterin ( L-Biopterin, L-Erythro-Biopterin) is a natural product that has been considered as a growth factor for some insects.
|
S5743
|
γ-Linolenic acid
|
γ-Linolenic Acid (18:3, n-6), the Δ6-desaturase product of linolenic acid, is an unsaturated fatty acid found primarily in vegetable oils.
|
S5600
|
Flavokawain A
|
Flavokawain A, extracted from kava, is an apoptotic inducers and anticarcinogenic agent. Flavokawain A can down-regulation of antiapoptotic proteins, such as XIAP, survivin, and Bcl-xL, thereby changing the balance between apoptotic and antiapoptotic molecules and then induce cell death in tumor cells.
|
S5732
|
Sebacic acid
|
Sebacic acid (1,8-Octanedicarboxylic acid) is a saturated, straight-chain naturally occurring dicarboxylic acid
|
S5733
|
Stearic acid
|
Stearic acid (Octadecanoic acid, Isostearic acid, Cetylacetic acid) is a natural saturated fatty acid found in animal and vegetable fats. It could be used as a food additive and used in soaps, cosmetics and detergents.
|
S9375
|
2'-Hydroxyacetophenone
|
2'-Hydroxyacetophenone is a flavouring ingredient.
|
S9379
|
Dihydrocoumarin
|
Dihydrocoumarin, a compound found in Melilotus officinalis (sweet clover) and Dipteryx odorata Willd (tonka beans), is added as a flavoring agent to a wide variety of foods, including soft drinks, yogurt, and muffins, and is used as a common fragrance in cosmetics, lotions, and soaps.
|
S9382
|
Thymine
|
Thymine (5-methyluracil) is one of the four nucleobases in the nucleic acid of DNA.
|
S9333
|
Gibberellins A4/A7
|
Gibberellins A4/A7 (Gibberellin A4 and A7) is the Gibberellin A4 Mixture With Gibberellin A7. Gibberellins A4/A7 promotes internode elongation & breaks certain dormancies in seeds. Gibberellins A4/A7 is an endogenous plant growth regulator, promotes the growth and elongation of cells.
|
S5691
|
Terpinyl Acetate
|
Terpinyl Acetate (alpha-Terpinyl), a naturally occuring compound found in several essential oils, is a flavouring agent.
|
S5616
|
4-Methylcatechol
|
4-Methylcatechol (P-Methylcatechol, 3,4-Dihydroxytoluene, Homocatechol) is an inducer of nerve growth factor. It is used to synthesize antimicrobial and antioxidant.
|
S9352
|
Homogentisic Acid
|
Homogentisic Acid (Melanic acid, 2,5-dihydroxyphenylacetic acid) is found in Arbutus unedo (strawberry-tree) honey or present in the bacterial plant pathogen Xanthomonas campestris pv. phaseoli as well as in the yeast Yarrowia lipolytica.
|
S5684
|
Lapachol
|
Lapachol (Tecomin, CI75490, Bethabarra wood, Greenhartin), a natural compound isolated from the bark of the lapacho tree, shows both antimicrobial and antiviral activity.
|
S5640
|
Ethyl caffeate
|
Ethyl caffeate, a naturally occurring compound found in Bidens pilosa, suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro.
|
S5680
|
(-)-Verbenone
|
(-)-Verbenone (2-Pinen-4-one), an important component of the essential oil from rosemary, is an insect pheromone with a spicy odor and camphoraceous fragrance.
|
S5617
|
Myristic Acid
|
Myristic acid (Tetradecanoic acid) is a fatty acid that occurs naturally in some foods. Myristic acid inhibits the phosphorylation of poly E4Y by Src with an Ki of 35 μM.
|
S9046
|
Berberine
|
Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.
|
S9047
|
Leonurine Hydrochloride
|
Leonurine (SCM-198), a natural alkaloid extracted from Herba leonuri, is a promising anti-glycation agent with vasodilator, antioxidative, cardioprotective and neuroprotective effects.
|
S9037
|
Tenacissoside H
|
Tenacissoside H, a natural compound found in M. tenacissima, exerts anti-inflammatory and anti-tumor effects.
|
S9027
|
Corynoxine
|
Corynoxine, a natural oxindole alkaloid, is a new autophagy enhancer.
|
S9041
|
Corosolic acid
|
Corosolic acid (Glucosol, Colosic acid, 2α-Hydroxyursolic acid) is one of the pentacyclic triterpenoids isolated from Lagerstroemia speciose and has been reported to exhibit anti-cancer and anti-proliferative activities in various cancer cells.
|
S9035
|
Isovitexin
|
Isovitexin (saponaretin, Apigenin-6-C-glucoside), an active component of many traditional Chinese medicines, has various activities, such as anti-oxidant, anti-inflammatory, anti-alzheimer disease (AD) effects and so on.
|
S9032
|
Sanguinarine
|
Sanguinarine (Pseudochelerythrine, Sanguinarin, Sanguinarium), a benzophenanthridine alkaloid known as an anti-inflammatory agent, is a potent inhibitor of NF-κB activation.
|
S9036
|
(20R)Ginsenoside Rh2
|
(20R)Ginsenoside Rh2, a natural compound found in Panax ginseng, shows antiviral and anticancer activities. It is a matrix metalloproteinase (MMP) inhibitor.
|
S9024
|
3-O-Acetyl-11-keto-β-boswellic acid (AKBA)
|
3-O-Acetyl-11-keto-β-boswellic acid (AKBA), the major active ingredient of the gum resin from Boswellia serrata and Boswellia carteri Birdw., exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase.
|
S9044
|
Ginsenoside F2
|
Ginsenoside F2, a ginsenoside found in Panax species, is an autophagic initiater with anti-cancer, and anti-obesity activities.
|
S9042
|
Wedelolactone
|
Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11.
|
S9030
|
Tenacissoside I
|
Tenacissoside I is a natural compound found in M. tenacissima at relatively high level.
|
S5677
|
Xanthopterin Hydrate
|
Xanthopterin, isolated from butterfly wings and found in many other sources, replace folic acid in the nutrition of many animal species.
|
S9353
|
L-serine
|
L-serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
S9349
|
D-(+)-Raffinose pentahydrate
|
Raffinose is a trisaccharide composed of galactose, glucose, and fructose.
|
S9341
|
3,4-Dimethoxycinnamic acid
|
3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.
|
S9344
|
DL-Methionine
|
DL-Methionine is an amino acid that has a role in the defence of oxidative stress.
|
S9004
|
Chondroitin 4-sulfate
|
Chondroitin 4-sulfate is an important structural component of cartilage and has been used as a dietary supplement to treat symptoms of joint discomfort.
|
S9373
|
Neryl acetate
|
Neryl acetate (Nerol, Acetic acid neryl ester, cis-Geranyl), a chemical compound found in citrus oils, is a flavouring agent.
|
S9339
|
S-(-)-Cotinine
|
S-(-)-Cotinine, a constituent of tobacco products and the major metabolite of nicotine, stimulates nicotinic receptors to evoke the release of DA in a calcium-dependent manner from superfused rat striatal slices.
|
S9372
|
Ethyl palmitate
|
Ethyl palmitate (Ethyl hexadecanoate, Palmitic acid ethyl ester) is a long-chain fatty acid ethyl ester that is used as a hair- and skin-conditioning agent.
|
S4937
|
4'-Hydroxychalcone
|
4'-Hydroxychalcone (P-Cinnamoylphenol), found in herbs and spices and tea, is a member of the class of compounds known as retrochalcones. It has diverse biological activities, inhibiting TNFα-induced NF-κB pathway activation in a dose-dependent manner and activating BMP signaling.
|
S3622
|
Diammonium Glycyrrhizinate
|
Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). It is known for its anti-inflammatory effects, resistance to biologic oxidation and membranous protection. DG is able to reduce inflammatory injury via suppression of NF‑κB, TNF‑α and intercellular adhesion molecule 1.
|
S3769
|
Palmatine
|
Palmatine (Berbericinine, Burasaine), an isoquinoline alkaloid, has sedative, antidepressant, antioxidative, anti-ulcerative, antacid, anticancer, and anti-metastatic activities.
|
S3788
|
Carvacrol
|
Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.
|
S5176
|
Fructose
|
Fructose (D-(-)-Fructose, Fruit sugar, levulose, fructosteril, D-fructofuranose, D-arabino-hexulose) is a simple ketonic monosaccharide found in many plants.
|
S5178
|
4-Hydroxy-2,5-dimethyl-3(2H)furanone
|
4-Hydroxy-2,5-dimethyl-3(2H)furanone (furaneol, HDMF) is a naturally occurring substance found in a variety of fruits and has been shown to have antimicrobial activity.
|
S5592
|
Vitamin A
|
Vitamin A (Retinol) is a naturally occuring fat-soluble vitamin that is important for normal vision, the immune system, and reproduction. It also plays roles in normal functioning of heart, lungs, kidneys, and other organs.
|
S5591
|
Ectoine
|
Ectoine ( THP(B)) is a natural amino acid derivate with membrane stabilizing and inflammation reducing capacities. It is produced by bacteria living under extreme harsh environmental conditions where it serves as osmoregulatory compatible solute.
|
S4888
|
Guanine
|
Guanine is one of the four main nucleobases found in the nucleic acids DNA and RNA.
|
S5505
|
2’-deoxyuridine
|
2'-deoxyuridine (dU, 2'-dU) is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms.
|
S5503
|
O-Acetyl-L-carnitine hydrochloride
|
O-Acetyl-L-carnitine (Acetyl-L-carnitine, O-acetyl-L-carnitine, O-Acetylcarnitine) can be synthesis or is naturally found in healthy humans. It could help transport fatty acids into the mitochondrial matrix where fatty acid metabolism occurs.
|
S9368
|
ADP
|
ADP (Adenosine diphosphate, adenosine pyrophosphate, Adenosine 5'-diphosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells.
|
S5550
|
Ethyl gallate
|
Ethyl gallat (Phyllemblin, gallic acid ethyl ester), which could be found naturally in a variety of plant sources, is a food additive with antimicrobial activity. Ethyl gallat activates the death receptor-dependent pathway of apoptosis by enhancing the expression of caspases-8, -9, and -3 and the Bcl-2 interacting domain (Bid).
|
S9390
|
Astragaloside II
|
Astragaloside II, extracted from Astragalus membranaceus, has been reported to promote tissue wound repair and could be a potential adjunctive agent in cancer chemotherapy, enhancement of osteogenesis, and modulation of T cell activation.
|
S9166
|
Griffonilide
|
Griffonilide is a natural product that has been reported to induce bone remodeling activity resulting in structural changes.
|
S9169
|
Polygalasaponin F
|
Polygalasaponin F, a triterpenoid saponin isolated from Polygala japonica, possesses anxiolytic and sedative-hypnotic activities, and has cognition improving and cerebral protective effects.
|
S9198
|
Obtusifolin
|
Obtusifolin is anthraquinone found in the seeds of Cassia obtusifolia, has inhibitory effects on platelet aggregation and aldose reductase.
|
S9220
|
Stylopine hydrochloride
|
Stylopine (Tetrahydrocoptisine, Coptisine), a major component of the leaf of Chelidonium majus L., is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.
|
S9241
|
Polygalaxanthone III
|
Polygalaxanthone III is a natural product with the efficacy of tranquilization, glaangal, eliminating sputum and detumescence. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1 with an IC50 of 50.56 μM.
|
S9259
|
Lithospermic acid
|
Lithospermic acid, an active component isolated from Salvia miltiorrhiza radix, is known to have multiple pharmacological actions such as antihypertensive and antioxidant effects.
|
S9262
|
Raddeanin A
|
Raddeanin A (Raddeanin R3, NSC382873), a triterpenoid saponin from Anemone raddeana Regel, displays moderate inhibitory activity against histone deacetylases (HDACs) and has high antiangiogenic potency, antitumor activity.
|
S9264
|
Decursin
|
Decursin (D), purified from Angelica gigas Nakai, shows potential anti-inflammatory activity and neuroprotective property.
|
S9306
|
Corynoxeine
|
Corynoxeine, which could be isolated from Uncaria rhynchophylla, is a useful and prospective compound in the prevention and treatment for vascular diseases. It is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation.
|
S9310
|
Isorhychophylline
|
Isorhynchophylline (IsoRhy, 7-Isorhyncophylline) is a major tetracyclic oxindole alkaloid isolated from the Chinese herbal medicine Uncaria rhynchophylla (Miq.)Jacks (Gouteng in Chinese). It acts as a neuronal autophagy inducer with therapeutic potential for cardiovascular and central nervous system diseases.
|
S9414
|
Cyasterone
|
Cyasterone is the main phytoecdysteroid component found in Cyathula capitata. It is a natural EGFR inhibitor and maybe a promising anti-cancer agent.
|
S9448
|
D-(+)-Turanose
|
D(+)-Turanose is a naturally occuring compound. It is a reducing disaccharide.
|
S5745
|
Glyceryl 1,3-dipalmitate
|
Glyceryl 1,3-dipalmitate acts as a metabolite of saccharomyces cerevisiae, plant and human.
|
S9507
|
(−)-Norepinephrine
|
(−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
|
S9505
|
Oleanonic Acid
|
Oleanonic Acid (3-Ketooleanolic Acid, 3-Oxooleanolic acid), extracted from Pistacia terebinthus galls, is a cell cycle inhibitor and used as antitumor agents.
|
S5686
|
Tryptanthrin
|
Tryptanthrin is a natural alkaloidal compound having basic indoloquinazoline moiety. It has broad spectrum of biological activities including anticancer activity, anti-inflammatory, antiprotozoal, antiallergic, antioxidant, and antimicrobial.
|
S5690
|
Triacanthine
|
Triacanthine, which could be isolated from the leaves of G. triacanthos, shows hypertensive activity, also cardiotonic, antispasmodic and a respiratory analeptic.
|
S5554
|
Lanatoside C
|
Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
|
S5312
|
Urolithin A
|
Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.
|
S3817
|
Harmine hydrochloride
|
Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs) and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.
|
S5318
|
Acacetin
|
Acacetin (Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin) is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.
|
S9345
|
Disodium 5'-Inosinate
|
Disodium 5'-Inosinate, widely distributed in all animal and plant tissues, is used as a flavor enhancer.
|
S9059
|
4'-O-Glucosylvitexin
|
4'-O-Glucosylvitexin is a kind of flavonoid fraction from the leaves of Crataegus pinnatifida.
|
S9364
|
6-Hydroxycoumarin
|
6-Hydroxycoumarin demonstrates cytotoxic effect against the cancer cell lines.
|
S9365
|
Disodium uridine-5'-monophosphate
|
Disodium uridine-5'-monophosphate is a nucleotide that is a major component of ribonucleic acid.
|
S9366
|
5'-Adenylic acid
|
AMP, also known as 5'-Adenylic acid and Adenosine monophosphate, is a nucleotide that is found in RNA. It is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet.
|
S9369
|
Xanthosine
|
Xanthosine (Xanthine riboside) is an intermediate in purine metabolism, formed from IMP, and forming GMP.
|
S9370
|
Adenosine Cyclophosphate
|
Adenosine Cyclophosphate (Cyclic adenosine monophosphate, cAMP, cyclic AMP, 3',5'-cyclic adenosine monophosphate) is useful for improving myocardial hypoxia, dilating coronary artery and strengthening myocardiac contraction.
|
S9384
|
Sophocarpine Monohydrate
|
Sophocarpine, a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, and antivirus activities.
|
S9386
|
Polygalacic acid
|
Polygalacic acid is the triterpenoid tetrahydroxyacid isolated from Polygala paenea L.. Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13 and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner.
|
S9387
|
Maackiain
|
Maackiain (Demethylpterocarpin) is a pterocarpan that is widely distributed in leguminous plants. It has anticancer and antimicrobial effects.
|
S9388
|
(+)-Praeruptorin A
|
Praeruptorin A is a coumarin compound naturally occurring in the roots of Peucedanum praeruptorum Dunn., a commonly used traditional Chinese medicine for the treatment of certain respiratory diseases and hypertension. Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of NF-κB activation. (+)-Praeruptorin A is one of enantiomers.
|
S9389
|
Phorbol
|
Phorbol is a natural, plant-derived organic compound that exerts a broad range of biological activities.
|
S9401
|
3,6'-Disinapoyl sucrose
|
3,6'-Disinapoyl sucrose (Disinapoyl sucrose), an oligosaccharide ester natural product originating from the root of wild Polygala tenuifolia, has neuroprotective effects and antidepressive activity in rats.
|
S9400
|
Rhynchophylline
|
Rhynchophylline (Mitrinermine), an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension.
|
S9398
|
Crassicauline A
|
Crassicauline A, a diterpenoid alkaloid in Aconitum herbs, is an analgesic drug clinically used in China.
|
S9397
|
Alliin
|
Alliin (S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine) is a sulfoxide that is a natural constituent of fresh garlic.
|
S9396
|
Geraniin
|
Geraniin, a hydrolysable polyphenol derived from Nephelium lappaceum L. fruit rind, has been shown to possess significant antioxidant activity in vitro.The IC50 values of TNF-α release inhibition were 43 μM for geraniin.
|
S9392
|
Praeruptorin B
|
Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities.praeruptorin B exerts lipid-lowering effects through inhibits SREBPs and could serve as a possible therapeutic option to improve hyperlipidemia and hyperlipidemia-induced comorbidities.
|
S9402
|
(20R)-Protopanaxadiol
|
(20R)-Protopanaxadiol, isolated from the roots of Panax ginseng, has protective effect on myocardial ischemia.
|
S9404
|
Pristimerin
|
Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon. Pristimerin can inhibits monoacylglycerol lipase(MGL) with an IC50 of 93 nM through a reversible mechanism.
|
S9405
|
Sesamoside
|
Sesamoside, a main chemical ingredient iridoid glycoside from Lamiophlomic rotata, has analgesic and anti-inflammatory effects in animal studies.
|
S9406
|
Sauchinone
|
Sauchinone, one of the active lignan isolated from the roots of Saururus chinensis, possesses diverse pharmacological properties, such as hepatoprotective, anti-inflammatory and anti-tumor effects.
|
S9407
|
Angoroside C
|
Angoroside C, an important phenylpropanoid glycoside of the traditional Chinese medicine Scrophulariae Radix, possesses the effects of preventing ventricular remodeling, reducing pulmonary oedema, and reducing blood pressure, as well as having the properties of anti-platelet aggregation, hepatoprotection and anti-nephritis, etc.
|
S9408
|
Beta-Elemonic acid
|
Beta-Elemonic acid (3-Oxotirucallenoic Acid), a known triterpene isolated from Boswellia (Burseraceae), exhibits anti‑inflammatory effects.
|
S9409
|
Kavain
|
Kavain ((+)-Kavain), the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor.
|
S9410
|
Euphorbia factor L1
|
Euphorbia factor L1, a diterpenoid isolated from Euphorbia lathyris, inhibits osteoclastogenesis and induces osteoclast apoptosis.
|
S9411
|
Liensinine
|
Liensinine, an important functional compound in lotus seeds, has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.
|
S9412
|
Flavokawain B
|
Flavokawain B is a natural chalcone first isolated from extracts of kava roots that induces apoptosis in cancer cells.
|
S9413
|
Yangonin
|
Yangonin (Y100550) is a dienolide kavalactone originally found in Piper methysticum (kava plant) and exhibits neuroprotective, neuromodulatory, and antifungal activities. It activates cannabinoid (CB1) receptors and potentiates the effects of GABA-A receptors.
|
S9416
|
Triptonide
|
Triptonide, isolated from the roots of Tripterygium wilfordii, can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin. It is also an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent.
|
S9417
|
Homoplantaginin
|
Homoplantaginin (Hispidulin-7-glucoside), a main flavonoid from a traditional Chinese medicine Salvia plebeia, has anti-inflammatory and anti-oxidant properties. Homoplantaginin inhibits TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.
|
S9420
|
Sinoacutine
|
Sinoacutine (Salutaridine), isolated from the Chinese drug Ching-fengteng, elicits mild antitussive properties.
|
S9421
|
Demethylnobiletin
|
Demethylnobiletin (5-Demethylnobiletin) is a unique flavonoid found in citrus fruits with potential chemopreventive effects against human cancers.5-Demethylnobiletin is a direct inhibitor of 5-LOX with IC50 of 0.1 μM, without affecting the expression of COX-2. 5-Demethylnobiletin has anti-inflammatory activity, inhibits leukotriene B 4(LTB4) formation in rat neutrophils and elastase release in human neutrophils with IC50 of 0.35 μM.
|
S9422
|
Diosbulbin B
|
Diosbulbin B is the main hepatotoxic compound in Airpotato yam, which is traditionally used for treating thyroid disease and cancer.
|
S9423
|
Narcissoside
|
Narcissoside has antioxidant and antiproliferative activity in cancer.
|
S9425
|
Trifolirhizin
|
Trifolirhizin, a natural pterocarcan flavonoid extracted from Sophora flavescens, has many pharmacological activities, such as hepatoprotective, anti-inflammatory, anti-proliferation, and skin-whitening.
|
S9427
|
Tabersonine
|
Tabersonine is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus and shows hypotensive activity, anti-tumor activity, hypoglycemic, diuretic activity.
|
S9428
|
Brazilin
|
Brazilin (Natural Red 24) is a red pigment obtained from the wood of the brazilwood family. It is used to dye fabric and has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.
|
S9429
|
6α-Hydroxygeniposide
|
6α-Hydroxygeniposide, an iridoid glycoside, is a chemical constituents of Pittosporum glabratum Lindl.
|
S9430
|
Tomatidine Hydrochloride
|
Tomatidine Hydrochloride, a natural steroidal alkaloid, possesses potent antibacterial activity and has anti-inflammatory effects in macrophages.
|
S9431
|
Dehydrocorydalin
|
Dehydrocorydalin is an alkaloidal component isolated from Rhizoma corydalis. It has anti-inflammatory and anti-tumor effects and can protect the cardiovascular system.
|
S9433
|
Tubeimoside II
|
Tubeimoside II (Tubeimoside B), a natural triterpenoid saponin isolated from herb, show anti-inflammatory, antitumor, and antitumor-promoting effects.
|
S9434
|
8-Gingerol
|
8-Gingerol is a bioactive ingredient of ginger root (Zingiber officinale), a medicinal plant having anti-nausea, anti-inflammatory, and anti-carcinogenic properties and a carminative effect.
|
S9435
|
Secoxyloganin
|
Secoxyloganin is a secoiridoids that is extensively used in synthetic and biosynthetic studies of monoterpene indole alkaloids and related natural products.
|
S9436
|
Pinoresinol dimethyl ether
|
Pinoresinol dimethyl ether, which could be isolated from the wood of the basal tree Humbertieae, show a variety of activities as the inhibitor of cyclic AMP phosphodiesterase.
|
S9437
|
Echinatin
|
Echinatin is a licorice extract that displays antioxidant properties and anti-inflammatory activities.
|
S9438
|
Isosakuranetin
|
Isosakuranetin (4'-Methylnaringenin), an O-methylated flavonoid, is the 4'-methoxy derivative of naringenin, a flavanone found in Citrus species.
|
S9120
|
Scutellarein
|
Scutellarein (6-Hydroxyapigenin), extracted from the perennial herb Scutellaria lateriflora, has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities
|
S9439
|
Kaurenoic acid
|
Kaurenoic acid (kaurenoate, kaur-16-en-18-oic acid) is a natural diterpenoid found in the herbs of Croton antisyphiliticus. Kaurenoic acid has anti-inflammatory activity, the mechanisms may through inhibition of iNOS and COX-2 expression.
|
S9441
|
Sibiricose A5
|
Sibiricose A5, which could be isolated from traditional Chinese medicine Polygalae Radix, shows potent antioxidant activity.
|
S9442
|
Bergaptol
|
Bergaptol (5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin) is a natural furanocoumarin found in the essential oils of citrus including lemon and bergamot.Bergaptol is a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM.
|
S9443
|
Schisantherin B
|
Schisantherin B (Gomisin-B, Wuweizi ester-B) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine.
|
S9444
|
Tomatine
|
Tomatine (Lycopersicin) is a natural glycoalkaloid with fungicidal, antimicrobial, and insecticidal properties.
|
S9446
|
Dihydrokavain
|
Dihydrokavain (Marindinin) is a kavalactone source from kava beverages used in herbal medicine to treat sleep disturbances, as well as stress and anxiety.
|
S9447
|
1F-Fructofuranosylnystose
|
1F-Fructofuranosylnystose is a kind of Fructooligosaccharides which are naturally occurring sugars with potentially beneficial nutritional effects.
|
S9503
|
Fraxetin
|
Fraxetin (7,8-dihydroxy-6-methoxy coumarin), found in Fraxinus rhynchophylla, shows potent antioxidant activity.fraxetin alleviates lipid peroxidation, enhances hepatic antioxidant capabilities, inhibits CYP2E1 activity, and reduced the inflammatory mediators, including TNF-α and IL-1β via up-regulation of hemeoxygenase-1 (HO-1) protein.
|
S9502
|
Madecassic acid
|
Madecassic acid (Brahmic acid), a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blocking NF-κB activation in macrophages and causing by iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 inhibition.
|
S9001
|
Malic acid
|
Malic acid (Hydroxybutanedioic acid, 2-Hydroxysuccinic acid) is a common, naturally occurring ingredient in many foods. It is the main acid found in apples and other fruits.
|
S9002
|
L-Fucose
|
Fucose (6-Deoxy-L-Galactose, L-fucopyranose) is found on N-linked glycans on the mammalian, insect and plant cell surface. L-Fucose is claimed to have application in cosmetics, pharmaceuticals, and dietary supplements.
|
S9006
|
Perillartine
|
Perillartine (Perilla sugar, Peryllartine) is a sweetener. Perillartine can activation of the Tas1r2 monomeric receptors of human, rhesus monkey and squirrel monkey but not mouse in a species-dependent manner.
|
S9014
|
AstragalosideⅠ
|
AstragalosideⅠ, is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.
|
S5083
|
Lentinan
|
Lentinan (A823605, Bromoduline), isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects.
|
S9272
|
Koumine
|
Koumine, a Gelsemium alkaloid, possesses analgesic, anti-inflammatory and neurosteroid modulating activities.
|
S9273
|
Timosaponin BII
|
Timosaponin BII (BII, Prototimosaponin AIII) is a steroidal saponin showing potential anti-dementia and antioxidant activity.
|
S9274
|
Isochlorogenic acid B
|
Isochlorogenic acid B, naturally isolated from Laggera alata, has antioxidative and hepatoprotective properties.
|
S9275
|
Isoguanosine
|
Isoguanosine (Crotonoside) inhibits FLT3 and HDAC3/6 for the treatment of AML.Isoguanosine is a naturally occurring active isomer of guanosine that is found in the seeds of Croton tiglium.
|
S9276
|
Alisol B
|
Alisol B, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.
|
S9277
|
Alisol A
|
Alisol A is one of the major active triterpenes isolated from Rhizoma Alismatis (RA), a famous Traditional Chinese Medicine widely used for diuretic, hypolipidemic, anti-nephrolithic, anti-atherosclerotic, anti-inflammatory and anti-diabetic purposes.
|
S9278
|
Saikosaponin C
|
Saikosaponin C is a triterpene saponin found in Bupleurum that exhibits antiviral and pro-angiogenic activities.
|
S9279
|
Euphorbia factor L3
|
Euphorbia factor L3 (5,15-Diacetyl-3-benzoyllathyrol), belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed, shows potent cytotoxicity and induces apoptosis via the mitochondrial pathway in A549 cells.
|
S9280
|
Demethoxycurcumin
|
Demethoxycurcumin, a natural demethoxy derivative of curcumin, has anti-oxidant, anti-inflammatory, anti-cancer, and anti-angiogenesis properties.
|
S9281
|
Peimine
|
Peimine (Verticine, Wanpeinine A) is a major biologically active component of Fritillaria ussuriensis, exhibits anti-inflammatory and pain suppression properties at the cellular level.
|
S9267
|
Epimedin A
|
Epimedin A is a major component of Herba Epimedii with bioactivities.
|
S9268
|
Epmedin B
|
Epmedin B (Epimedin B) is a component extracted from Epimedii Folium and may have antiosteoporotic activity.
|
S9269
|
Epmedin C
|
Epimedin C (Baohuoside VI), a flavonoid isolated from the herbs of Epimedium brevicornum Maxim, exhibits immunostimulatory and anticancer activities.
|
S9270
|
Dracohodin perochlorate
|
Dracohodin perochlorate, extracted from Dragon's blood, is widely used in traditional Chinese medicine, especially in wound healing.
|
S9271
|
Pulchinenoside A
|
Pulchinenoside A (Anemoside A3), a natural triterpenoid saponin, is a AMPARs and NMDAR modulator.
|
S9282
|
Isochlorogenic acid A
|
Isochlorogenic acid A (3,5-dicaffeoylquinic acid), isolated from Brazilian propolis and Suaeda glauca, exhibits hepatoprotective and cytotoxic activities.
|
S9283
|
Aristolone
|
Aristolone, which could be extracted from essential oil of Elyonurus hensii, is likely to induce an antalgic activity.
|
S9284
|
Aloesin
|
Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.
|
S9285
|
Fargesin
|
Fargesin is a neolignan isolated from Magnolia plants. It is a potential β1AR antagonist through cAMP/PKA pathway.
|
S9286
|
Neobavaisoflavone
|
Neobavaisoflavone, isolated from seeds of Psoralea corylifolia, exhibits inhibitory activity against DNA polymerase and platelet aggregation.
|
S9287
|
Genkwanin
|
Genkwanin (Apigenin 7-methyl ether) is one of the major non-glycosylated flavonoids in herbs. It has a variety of pharmacological effects including anti-inflammatory, anti-bacterial, antiplasmodial, radical scavenging, chemopreventive and inhibiting 17β-Hydroxysteroid dehydrogenase type 1 activities.
|
S9288
|
Casticin
|
Casticin (Vitexicarpin), as the major active substance in Lithospermum erythrorhyzon, had been reported to mediate multiple pharmacological activities such as antioxidation, antiviral, cardiovascular protection, antineoplastic and anti-inflammation.
|
S9289
|
Astragalin
|
Astragalin (kaempferol-3-glucoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside), a flavonoid from leaves of persimmon and green tea seeds, has anti-tumor, anti-inflammatory and anti-oxidant activities.
|
S9290
|
Linarin
|
Linarin (Acaciin, Buddleoside, Acacetin-7-O-rutinoside), a natural flavonoid cpompound, has pharmacological effects, including anti-inflammatory, neuro-protective, cardioprotective and antioxidative effects.
|
S9291
|
Isopimpinellin
|
Isopimpinellin (5,8-Dimethoxypsoralen) is a natural product synthesized by numerous plant species. It may acts as an anticarcinogen.
|
S9292
|
Dictamnine
|
Dictamnine, a natural plant product, has been reported to have antimicrobial activity against bacteria and fungi.
|
S9293
|
Isoliquiritin
|
Isoliquiritin (Neoisoliquritin) is a flavonoid glycoside compound from licorice possessing a broad spectrum of pharmacological activities including antioxidant, anti-inflammatory, and anti-depression activities.
|
S9294
|
Gelsemine
|
Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., is a highly toxic compound and may be a glycine receptor agonist with significantly higher binding affinity for some of these receptors than its native agonist, glycine.
|
S9295
|
Dauricine
|
Dauricine, a plant metabolite isolated from the Asian vine Menispermum dauricum, plays a variety of biological roles in the human body, from inhibiting cancer cell growth to blocking cardiac transmembrane Na+, K+, and Ca2+ ion currents.Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF‐κB signaling pathway in colon cancer cells.
|
S9296
|
Fraxin
|
Fraxin (Fraxetin-8-O-glucoside), a main active component isolated from Cortex Fraxini, possesses a variety of bioactivities such as anti-inflammatory, antioxidant, analgesic, antimicrobial, antiviral, immunomodulatory, anti-hyperuricemia and diuresis.
|
S9297
|
Kirenol
|
Kirenol is a biologically active substance isolated from Herba Siegesbeckiae. It has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, anti-adipogenic, and anti-arthritic activities.
|
S9298
|
Corylin
|
Corylin, a main compound isolated from Psoralea corylifolia L. (Fabaceae), has a variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties.
|
S9300
|
Methylprotodioscin
|
Methyl protodioscin, a bioactive natural compound isolated from Dioscorea collettii Makino (Dioscoreaceae), has numerous pharmacological activities, including anti-inflammation, lipid-lowering, and
anticancer activities.
|
S9301
|
Verbenalin
|
Verbenalin (Verbenalol β-D-glucopyranoside, Verbenalol glucoside, Cornin), an iridoid glycoside found in Verbena officinalis, has been reported to exhibit uterine stimulant activity and demonstrated cardioprotection against experimental myocardial ischemic injury.
|
S9302
|
Polyphyllin VI
|
Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.
|
S9303
|
Saikosaponin B2
|
Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.
|
S9304
|
Platycodin D
|
Platycodin D, the main saponin isolated from Chinese herb Platycodonis Radix, exhibits anti-inflammatory, anti-allergic, cholesterol-lowering and neuroprotective properties.
|
S9305
|
Toosendanin
|
Toosendanin, a triterpenoid extracted from Melia toosendan Sieb et Zucc, possesses broad biological actions from blocking neurotransmission and antibotulism to inducing cell differentiation and apoptosis.
|
S9307
|
Shanzhiside methyl ester
|
Shanzhiside methylester is a principle effective iridoid glycoside of L. rotata and serves as a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist.
|
S9308
|
Pulsatilla saponin D
|
Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla koreana, targets c-Met and exerts antiangiogenic and antitumor activities.
|
S9309
|
Micheliolide
|
Micheliolide, a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, inhibits various inflammatory response and may serve as a neuroprotective agent in neuroinflammation-related neurodegenerative disorders.
|
S9311
|
Germacrone
|
Germacrone, a major activity component found in Curcuma zedoaria oil product, shows anti-inflammatory, antiandrogenic, and antimicrobial activities.
|
S9312
|
Cyanidin-3-O-glucoside chloride
|
Cyanidin-3-O-glucoside chloride (Kuromanin, Chrysontemin, Glucocyanidin) is a natural product with anti-oxidant and neuroprotective effects.
|
S9313
|
Atractylenolide III
|
Atractylenolide III, a major component of Atractylodes rhizome, has anti-inflammatory and anti-angiogenesis activities.
|
S9314
|
Atractylenolide II
|
Atractylenolide II (AT-II, Asterolide, 2-Atractylenolide), a major sesquiterpenoids isolated from the dried Rhizome of Atractylodes macrocephala, shows a wide range of biological and pharmacological activities, for example, against insomnia and anxiety, neuroprotective, platelet activation and anti-cancer effect.
|
S9315
|
Praeruptorin A
|
Praeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. Praeruptorin A inhibits p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. Praeruptorin A can significantly upregulates multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.
|
S9316
|
Polyphyllin II
|
Polyphyllin II, a natural compound extracted from Rhizoma of Paris polyphyllin, shows hemolytic activity.
|
S9317
|
Forsythoside A
|
Forsythoside A, one of the main active ingredients in Forsythiae fructus, has been shown to possess anti-bacterial and immunomodulatory properties.
|
S9318
|
(20R)-Ginsenoside Rh1
|
(20R)-Ginsenoside Rh1, isolated from the root of Panax Ginseng, exhibits various pharmacological activities including vasorelaxation, antioxidation, anti-inflammation, and anticancer.
|
S9319
|
Cryptochlorogenic acid
|
Cryptochlorogenic acid (4-Caffeoylquinic acid, 4-O-Caffeoylquinic acid), a phenolic acid found in various plant species, including Artemisia, honeysuckle, and H. sabdariffa, possesses antioxidant properties.
|
S9322
|
Neodiosmin
|
Neodiosmin (Diosmetin-7-neohesperidoside, Diosmetin-7-O-neohesperidoside), a flavone glycoside isolated from C. aurantium, is a strong antioxidant with potential applications in foods, beverages, and pharmaceutical preparations.
|
S9324
|
Alnustone
|
Alnustone, a naturally occuring compound found in the rhizomes of Curcuma xanthorrhiza, exhibits anti-inflammatory, antihepatotoxic and antiemetic activities.
|
S9329
|
Orcinol
|
Orcinol (5-Methylresorcinol; 3,5-ToluenediolOrcin; 5-Methyl-1,3-benzenediol; 3,5-Dihydroxytoluene), occurs in many species of lichens including Roccella tinctoria and Lecanora, exhibits antimutagenic, antioxidant, antibacterial, radical-scavenging effects.
|
S9343
|
Sequoyitol
|
Sequoia alcohol (Sequoyitol) is isolated from Taxus natural organic compounds, it can be used to treat diabetes and other indications.
|
S9347
|
Allitol
|
Allitol (Allodulcitol) is a rare polyol found in nature that is useful not only as a sweetener, but also as the raw material for production of chemical compounds.
|
S9348
|
D-(+)-Trehalose Anhydrous
|
Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.
|
S9350
|
Ethyl 4-Methoxycinnamate
|
Ethyl 4-Methoxycinnamate (Ethyl p-methoxycinnamate, 4-Methoxycinnamic Acid Ethyl Ester), a natural product found in K. galanga and C. zedoaria extracts, has anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities.
|
S9354
|
Oxalic acid
|
Oxalic acid (Ethanedioic acid, Wood bleach) is a strong dicarboxylic acid occurring in many plants and vegetables.
|
S5636
|
Methyl furan-2-carboxylate
|
Methyl furan-2-carboxylate (Methyl pyromucate, Methyl 2-furoate) is found in cocoa and cocoa products. It is used in food flavouring and preparation of sesquiterpene lactone.
|
S3814
|
Tubeimoside I
|
Tubeimoside I (Lobatoside H, TBMS1), a triterpenoid saponin, isolated from the tubers of Bolbostemma paniculatum, shows potent antitumor and antitumor-promoting effects.
|
S8068
|
Chaetocin
|
Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).
|
S3790
|
Methyl gallate
|
Methyl Gallate (Methylgallate, Gallic acid methyl ester, Gallicin) is a plant polyphenol with antioxidant, anticancer, and anti-inflammatory activities.
|
S9188
|
Magnoflorine chloride
|
Magnoflorine (Escholine, Thalictrine, Corytuberine methochloride), isolated from the rhizome of Sinomenium acutum and from Pachygone ovata, is usually used as an anxiolytic chemical with anti-oxidant, α-tyrosinase inhibitory and anti-inflammationary activities.
|
S9189
|
Oroxin A
|
Oroxin A (Baicalein 7-O-glucoside), an active component isolated from the herb Oroxylum indicum (L.) Kurz, activates PPARγ and inhibits α-glucosidase, exerting antioxidant activity.
|
S9190
|
Oroxin B
|
Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.
|
S9191
|
Loganic acid
|
Loganic acid (Loganate) is a naturally occurring iridoid monoterpeneglusoside involved in the biosynthesis of indole alkaloids in Vinca rosea.
|
S9194
|
Toddalolactone
|
Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM.
|
S9195
|
Maltotetraose
|
Maltotetraose, found in many foods, belongs to the class of organic compounds known as oligosaccharides.
|
S9196
|
Calceolarioside B
|
Calceolarioside B (Nuomioside A), found in the herbs of Ajuga becumbens Thunb., has anti-proliferation property.Calceolarioside B exhibits significant inhibitory activity against rat lens aldose reductase (RLAR) with an IC50 of 23.99 μM. Calceolarioside B displays inhibitory effect on DPPH radical scavenging activity with an IC50 of 94.60 μM.
|
S9199
|
Pseudoginsenoside F11
|
Pseudoginsenoside F11, a natural product found in American ginseng but not in Asian ginseng, is a novel partial PPARγ agonist.
|
S9200
|
Pneumocandin B0
|
Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent.
|
S9203
|
Notopterol
|
Notopterol is a kind of furanocoumarin that possesses anti-inflammatory, analgesic, and anticancer activities.
|
S9204
|
Oroxylin A
|
Oroxylin A (6-Methoxybaicalein) is a flavonoid isolated from Scutellaria root that exhibits multiple pharmacological activities, including anti-oxidative, anti-inflammatory, anti-viral and anti-tumor properties.
|
S9205
|
Hydroxygenkwanin
|
Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, has anti-oxidant ability and can act as tissue factor (TF) inhibitor to prevent thrombosis.
|
S9206
|
Hydroprotopine
|
Hydroprotopine (W1171) is a kind of natural herbal extract.
|
S9514
|
Rotundic acid
|
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.
|
S9207
|
Gypenoside XVII
|
Gypenoside XVII (GP-17, Gynosaponin S), a ginsenoside found in Panax species, has neuroprotective effects and is widely used to prevent cardiovascular disease.GP-17 treatment predominantly up-regulating the expression of ERα but not ERβ.
|
S9208
|
Ginsenoside Rb3
|
Ginsenoside Rb3, extracted from the plant Panax ginseng, plays important roles in cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL).
|
S9209
|
Tritetradecanoin
|
Tritetradecanoin, found in Myristica fragrans Houtt., is used as an antiadhesion agent and lubricating agent.
|
S9210
|
Ginsenoside Rk1
|
Ginsenoside Rk1, one of the main elements of Sung Ginseng, has been confirmed as a new endothelial barrier enhancer recently and has anti-cancer activity.
|
S9211
|
Eriocitrin
|
Eriocitrin (eriodictyol 7-rutinoside, Eriodictyol glycoside, Eriodictioside) is a flavone glycoside mainly found in lemon with antioxidant activity.
|
S9213
|
Jujuboside A
|
Jujuboside A, isolated from Semen Ziziphi Spinosae, exerts anti-oxidant, anti-inflammatory activities, and reduces the cell apoptosis.
|
S9214
|
Jujuboside B
|
Jujuboside B, one of the saponins isolated from the seeds of Zizyphus jujuba var. spinosa, is used in traditional chinese medicine for treating cardiovascular diseases and neurodegenerative diseases.
|
S9215
|
Pinoresinol diglucoside
|
Pinoresinol diglucoside, one of the major lignans isolated from Eucommia ulmoides Oliver bark, has various pharmacological functions, including antihypertension and prevention of osteoporosis.
|
S9216
|
Esculentoside A
|
Esculentoside A, isolated from the Chinese herb phytolacca esculenta, possesses a broad inhibitory effect on a panel of pro-inflammation molecules with less toxicity.
|
S9217
|
Complanatuside
|
Complanatuside, a flavonoid compound isolated from Astragalus complanatus and Lysimachia christinae, has anti-inflammation, lipid-lowering and hepatoprotective effects.
|
S9219
|
Huperzine B
|
Huperzine B, a natural alkaloid existed in Lycopodium plants, is a novel acetylcholinesterase inhibitor and has neuroprotective effects.
|
S9221
|
Ferulaldehyde
|
Ferulaldehyde (Coniferaldehyde, Ferulyl aldehyde) is a natural intermediate of polyphenol metabolism of intestinal microflora.
|
S9222
|
Dipotassium glycyrrhizinate
|
Glycyrrhizinate dipotassium (Neubormitin) is a widely used anti-inflammatory agent isolated from the licorice root.
|
S9223
|
Talatisamine
|
Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities.
|
S9224
|
Dehydroandrographolide Succinate
|
Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects.
|
S9226
|
Steviolbioside
|
Steviolbioside (CCRIS-6025), a natural sweetener, exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro.
|
S9228
|
Schisandrin C
|
Schisandrin C, a dibenzocyclooctadiene lignan isolated from the fruits of Schisandra chinensis (Turcz.) Baill, has many characteristics including anti-inflammation, anti-tumor, and anti-oxidation.
|
S9229
|
Linderane
|
Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache.
|
S9230
|
Vaccarin
|
Vaccarin, a major flavonoid glycoside found in Semen vaccariae, exhibits extensive biological activities including vascular endothelial cell protective effects.
|
S9231
|
Schisanhenol
|
Schisanhenol (Gomisin K3) is a compound derived from the fruit of a traditional Chinese herb Schisandra rubriflora, exhibiting strong inhibition toward UGT2B7.
|
S9232
|
Crocin II
|
Crocin II (Crocin B, Crocetin gentiobiosylglucosyl ester, Tricrocin), a carotenoid chemical compound that is found in the flowers crocus and gardenia, is an antioxidant and neural protective agent.
|
S9233
|
Imperialine
|
Imperialine (Sipeimine, Kashmirine) is an alkaloid found in the bulbs of species of the genus Fritillaria.
|
S9234
|
Schaftoside
|
Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
|
S9235
|
Didymin
|
Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.
|
S9237
|
Berberrubine
|
Berberrubine (Beroline, 9-Berberoline), an isoquinoline alkaloid isolated from many medicinal plants, possesses diverse pharmacological activities, including glucose-lowering, lipid-lowering, anti-inflammatory, and anti-tumor effects.
|
S9238
|
Polygalic acid
|
Polygalic acid (Senegenic acid), a triterpenoid saponin, shows expectorant, emetic and stimulant effects.
|
S9239
|
Isocorynoxeine
|
Isocorynoxeine (7-Isocorynoxeine), a major alkaloid found in Uncaria rhynchophylla, exhibits wide beneficial effects on the cardiovascular and cardiocerebral vascular systems. Isocorynoxeine suppress 5-HT2A receptor-mediated current response with IC50 of 72.4 μM.
|
S9240
|
Isofraxidin
|
Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
|
S9242
|
Narirutin
|
Narirutin (Naringenin-7-O-rutinoside, Isonaringin), a flavanone abundant in citrus fruits, possesses anti-inflammatory and anti-oxidative effects.
|
S9243
|
Protosappanin B
|
Protosappanin B (FT-0689654, Q-100961), extracted from Lignum Sappan, possesses anti-inflammation and anti-oxidation properties.
|
S9244
|
8-O-acetyl shanzhiside methyl ester
|
8-O-acetyl shanzhiside methyl ester (Barlerin, ND01), isolated from the leaves of Lamiophlomis rotata Kudo, promotes angiogenesis, which leads to the improvement of functional outcome after stroke.8-O-Acetyl shanzhiside methyl ester can inhibts NF-κB.
|
S9245
|
Phellodendrine chloride
|
Phellodendrine chloride, isolated from the Phellodrndron amurensis, exhibits immunosuppressive and anti-inflammatory activities.
|
S9246
|
Tiliroside
|
Tiliroside, a glycosidic flavonoid, possesses anti-inflammatory, antioxidant, anticarcinogenic and hepatoprotective activities.
|
S9247
|
Isoliensinine
|
Isoliensinine is an alkaloid produced by the edible plant Nelumbo nucifera. It possesses anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.
|
S9248
|
Homoorientin
|
Homoorientin (Isoorientin, Luteolin-6-C-glucoside) is a flavone that acts as a radical scavenger and an antineoplastic agent.
|
S9249
|
Securinine
|
Securinine, a major natural alkaloid product from the root of the plant Securinega suffruticosa, acts as a γ-amino butyric acid (GABA) receptor antagonist.
|
S9250
|
Isosilybin
|
Isosilybin (Silymarin, Silybin B, Isosilybinin, Q-100795) is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. Isosilybin inhibits CYP3A4 induction with an IC50 of 74 μM.
|
S9251
|
Oxypeucedanin
|
Oxypeucedanin is a major coumarin aglycone that can be extracted from Ostericum koreanum. It is a kind of open-channel blocker of the hKv1.5 channel.
|
S9252
|
Corydaline
|
Corydaline is a bioactive alkaloid with various anti-acetylcholinesterase, anti-allergic, and anti-nociceptive activities found in the medicinal herb Corydalis Tubers.
|
S9253
|
Coixol
|
Coixol (6-methoxybenzoxazolone, MBOA) acts as a central muscle relaxant with an anti-convulsant effect.
|
S9254
|
Skimmin
|
Skimmin is one of the major pharmacologically active molecules present in Hydrangea paniculata, a medical herb used in the traditional Chinese medicine as an anti-inflammatory agent.
|
S9255
|
Isoscopoletin
|
Isoscopoletin (7-Methoxyesculetin) is a member of the class of compounds known as hydroxycoumarins. Isoscopoletin can be found in coriander and eggplant, which makes isoscopoletin a potential biomarker for the consumption of these food products.
|
S9256
|
Isobavachin
|
Isobavachin is a flavonoid compound obtained from Psoralea Corylifolia Linn.
|
S9257
|
Acetylshikonin
|
Acetylshikonin is a biologically active compound with anti-cancer and anti-inflammatory activity, which is isolated from the roots of Lithospermum erythrorhizoma. It is a novel general P450 inhibitor with IC50 values of 1.4-4.0 μM for all tested P450s.
|
S9258
|
(+)-Isocorynoline
|
Isocorynoxeine, a major bioactive tetracyclic oxindole alkaloids found in Uncaria rhynchophylla, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM and shows various beneficial effects, including lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage.
|
S9260
|
Nodakenin
|
Nodakenin ((+)-Marmesinin), a coumarin compound, acts as an AChE inhibitor that inhibits AChE activity in a dosedependent manner with an IC50 value of 84.7 μM.
|
S9265
|
7-Epitaxol
|
7-Epitaxol (7-Epipaclitaxel) is the major derivative of taxol found in cells. Taxol (paclitaxel) is a well-known natural-source cancer drug.
|
S9266
|
Ginsenoside Rc
|
Ginsenoside Rc, isolated from Panax ginseng, may exert various activities including anti-cancer, anti-inflammatory, antiobesity, and anti-diabetic effects.
|
S9186
|
Liensinine perchlorate
|
Liensinine is the active constituent of plumula nelambinis with anti-hypertension.
|
S9187
|
Phillygenin
|
Phillygenin (Sylvatesmin), a bioactive intergradient in Osmanthus fragrans, has anti-inflammatory, anti-obesity and antipyretic activities. It could reduce blood lipid levels and low density lipoprotein.
|
S9517
|
Liriope muscari baily saponins C
|
Liriope muscari baily saponins C, extracted from the roots of Liriope muscari (Decne.) Baily, induces autophagy and has an anti-thrombotic activity.
|
S9201
|
Levistilide A
|
Levistilide A (Diligustilide), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is a potential P-gp modulator and used for treating cancer.
|
S9512
|
1,3-Dicaffeoylquinic acid
|
1,3-Dicaffeoylquinic acid (Cynarin; Cinarine; 1,5-Dicaffeoylquinic acid) is a phenolic compound found in artichoke. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
|
S9114
|
Polyphyllin I
|
Polyphyllin I, a small molecular monomer extracted from Rhizoma of Paris polyphyllin, is used in the treatment of infectious disease and cancer. Polyphyllin I inhibits proliferation and induces apoptotic cell death in U251 cells. Polyphyllin I is an activator of the JNK signaling pathway with a potential anti-glioma effect.
|
S9115
|
Wogonoside
|
Wogonoside (Oroxindin, Wogonin 7-O-glucuronide, Glychionide B), the main flavonoid component derived from the root of Scutellaria baicalensis Georgi, displays anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities.
|
S9116
|
Chikusetsusaponin IVa
|
Chikusetsusaponin IVa (Calenduloside F), a major active ingredient of triterpenoid saponins, has numerous pharmacological activities, including cytotoxic activity against various cancer cells, anti-inflammatory activity, prevention of dental caries and induction of genta-micin nephrotoxicity. Chikusetsusaponin IVa is a novel AMPK activator.
|
S9117
|
(20S)Ginsenoside Rg2
|
(20S)Ginsenoside Rg2, a constituent existing in red ginseng, has been reported to exert strong inhibitory action on various cancer cells.
|
S9119
|
Leonuride
|
Leonuride (Ajugol), an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri, is a terpene glycoside that can be used for some gynecological disease.
|
S9121
|
Irigenin
|
Irigenin, an O-methylated isoflavone, can be isolated from the rhizomes of the leopard lily (Belamcanda chinensis), and Iris kemaonensis.
|
S9122
|
Tectorigenin
|
Tectorigenin (TEC) is an isoflavone isolated from various medicinal plants, such as Pueraria thunbergiana Benth, Belamcanda chinensis, and Iris unguicularis. It has been reported to exert pharmacological actions, including antitumor and antibacterial effects, free radical neutralization, and selective estrogen receptor modulation.
|
S9123
|
Eriodictyol
|
Eriodictyol, a flavonoid extracted from yerba santa, has anti-inflammatory and antioxidant activities and taste-modifying properties.
|
S9125
|
Apigetrin
|
Apigetrin (Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside), a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties.
|
S9126
|
Schizandrol B
|
Schizandrol B (Gomisin A, Besigomsin, Wuweizi alcohol B, Gamma-Schisandrin), extracted from the fruit of Schisandra chinensis Baill., exhibits potent antitumor activities.
|
S9127
|
Carnosol
|
Carnosol is a naturally occurring phenolic diterpene found in rosemary. It has anti-oxidant, anti-inflammatory and anti-cancer activities.
|
S9128
|
Isoacteoside
|
Isoacteoside, a phenylethanoid isolated from Monochasma savatieri Franch. ex Maxim., is an anti‐inflammatory herb widely used in traditional Chinese medicine.
|
S9129
|
20(S)-Ginsenoside Rh1
|
20(S)-Ginsenoside Rh1 (Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1) is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. It exhibits potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. Ginsenoside Rh1 inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.
|
S9130
|
Rubusoside
|
Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties.
|
S9131
|
Punicalagin
|
Punicalagin, a major ellagitannin found in pomegranate extracts, has been shown to have antioxidant, anti-inflammatory, and anticancer effects.
|
S9132
|
Harpagide
|
Harpagide, isolated from the secondary roots of Harpagophytum procumbens (Hp), has valuable medicinal properties, such as anti-inflammatory, analgesic and potential antirheumatic effects.
|
S9133
|
Chicoric acid
|
Chicoric acid (Dicaffeoyltartaric acid), identified in many plants, exerts various properties include anti-cancer, anti-obesity, antiviral, and anti-diabetic effects.
|
S9134
|
Spinosin
|
Spinosin (Flavoayamenin), a flavone-C-glycoside, is a bioactive ingredient isolated from a traditional Chinese herb Zizyphi Spinosi Semen. It acts as a plant metabolite and an anxiolytic drug.
|
S9135
|
Artemisic acid
|
Artemisic acid (Artemisinic acid), an amorphane sesquiterpene isolated from Artemisia annua L., has a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect.
|
S9136
|
Neochlorogenic acid
|
Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
|
S9137
|
Erianin
|
Erianin, a natural product derived from Dendrobium chrysotoxum, has been used as an analgesic in traditional Chinese medicine and is a potential anti-tumor agent. Erianin can inhibit IDO-induced tumor angiogenesis.
|
S9138
|
Picfeltarraenin IA
|
Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system.
|
S9141
|
Berbamine
|
Berbamine (BA), a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA) induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).
|
S9143
|
Ammonium Glycyrrhizate
|
Ammonium glycyrrhizate (Glycamil, Glycyrram) is an ammonium salt extract isolated from licorice root and is commonly used as a flavoring agent and is also used in fragrances, and skin and hair care products.
|
S9144
|
Solasonine
|
Solasonine, a natural glycoalkaloid compound, has anti-inflammation and anti-tumor properties.
|
S9145
|
Solamargine
|
Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum, induces potent, non-selective cytotoxicity and P-gp inhibition.
|
S9146
|
Anwuligan
|
Anwuligan (Macelignan), a natural compound isolated from Myristica fragrans Houtt, has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities.
|
S9148
|
Peiminine
|
Peiminine (Verticinone, Zhebeinone, Raddeanine), a biologically active component extracted from Fritillaria walujewii Regel, has been reported to have potent anti-inflammatory, antitussive, and expectorant effects. It induces autophagic cell death thus represses colorectal carcinoma tumor growth.
|
S9149
|
Benzoylpaeoniflorin
|
Benzoylpaeoniflorin, a natural product isolated from Chinese paeony root, could inhibit COX-1 and COX-2 in vitro.
|
S9150
|
Daurisoline
|
Daurisoline, a bis-benzylisoquinoline alkaloid isolated from the rhizomes of Menispermum dauricum, is a potent autophagy blockers with antiarrhythmic effects.
|
S9151
|
Praeruptorin E
|
Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect.
|
S9152
|
Epiberberine
|
Epiberberine, a natural protoberberine alkaloid, is a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean).
|
S9153
|
Betulinicaldehyde
|
Betulinicaldehyde (Betulinal, Betunal), isolated from the bark of tectona grandis., is an anti-tumor agent.
|
S9154
|
Chelidonine
|
Chelidonine (Stylophorin, Helidonine), a major bioactive, isoquinoline alkaloid ingredient in Chelidonium majus, exhibits anti-inflammatory properties and acetylcholinesterase and butyrylcholinesterase inhibitory activity.
|
S9155
|
Aurantio-obtusin
|
Aurantio-obtusin is a natural effective compound isolated from Semen Cassiae, which possesses hypotensive and hypolipidemic effects.
|
S9156
|
Chonglou Saponin VII
|
Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
|
S9157
|
Neoandrographolide
|
Neoandrographolide, a principle diterpenoids isolated from A. paniculata, exerts a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, anti-viral, anti-bacterial, anti-diabetic, anti-oxidative stress, antipyretic, anti-edematogenic, and anti-nociceptive activities.
|
S9159
|
momordin-Ic
|
Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo.
|
S5742
|
Deferoxamine mesylate (Ba 33112)
|
Deferoxamine mesylate (Ba 33112, Desferrioxamine B, DFOM, NSC 644468) is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.
|
S9160
|
Ziyu-glycoside I
|
Ziyuglycoside I is one of the major active ingredients in Sanguisorba officinalis and could be used as an active ingredient for cosmetics.
|
S9161
|
Ziyuglycoside II
|
Ziyuglycoside II is an active compound of Sanguisorba officinalis L. that has anti-inflammation, antioxidation, antibiosis, and homeostasis properties.
|
S9162
|
Rubimaillin
|
Rubimaillin (Mollugin), found in the Chinese medical plant Rubia cordifola, is a dual inhibitor of acetyl-CoA cholesterol acyltransferase 1 (ACAT1) and acetyl-CoA cholesterol acyltransferase 2 (ACAT2), but is more selective for the ACAT2 isozyme.
|
S9163
|
Rhapontigenin
|
Rhapontigenin (Protigenin), produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation, is a selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM).
|
S9164
|
Curdione
|
Curdione, one of the major components of Curcuma zedoaria, shows an excellent antithrombotic activity in vivo.
|
S9165
|
Poncirin
|
Poncirin (Isosakuranetin-7-neohesperidoside), extracted from trifoliate orange, has anti-bacterial and anti-inflammatory activities.
|
S9167
|
Columbin
|
Columbin, a diterpenoid furanolactone, is a potential anti-inflammatory drug.
|
S9168
|
Periplogenin
|
Periplogenin (Desoxostrophanthidin, 5-beta-Hydroxydigitoxigenin), isolated from Lagenaria siceraria, has potent anti-psoriatic effects in vitro and in vivo.
|
S9171
|
Harpagoside
|
Harpagoside, a natural product found in the plant Harpagophytum procumbens, has potent anti-rheumatic, anti-inflammatory and analgesic effects.
|
S9172
|
Phellodendrine
|
Phellodendrine, a quaternary ammonium alkaloid extracted from the dried bark of Phellodendrom chinensis Schneid and Phellodendrom amurense Rupr, has the effect of suppressing cellular immune response, reducing blood pressure and antinephritis.
|
S9173
|
Sec-O-Glucosylhamaudol
|
Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) is one of the major bioactive compounds of the Saposhnikoviae Radix.
|
S9174
|
Xanthotoxol
|
Xanthotoxol (8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen), a biologically active linear furocoumarin found in a large number of plants, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.
|
S9175
|
Macranthoidin A
|
Macranthoidin A, found in the herbs of Lonicera japonica Thunb., has anti-inflammation activity.
|
S9176
|
Pimpinellin
|
Pimpinellin is a furocoumarin that acts as antagonist of proteins with GABA receptor activity.
|
S9177
|
Gypenoside XLIX
|
Gypenoside XLIX, a naturally occurring gynosaponin, is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator.
|
S9178
|
Sinapine thiocyanate
|
Sinapine thiocyanate is the thiocyanate salt form of Sinapine, which shows favorable biological activities such as antioxidant and radio-protective activities.
|
S9179
|
Catharanthine hemitartrate
|
Catharanthine hemitartrate is the starting material for the synthesis of the antitumor drugs vinblastine and vincristine.
|
S9180
|
Tussilagone
|
Tussilagone, isolated from the flower of buds of Tussilago farfara (Compositae), is a sesquiterpenoid that is used as a traditional oriental medicine for asthma and bronchitis. It shows anti-inflammatory activity in in vitro studies.
|
S9181
|
Periplocin
|
Periplocin (Periplocoside), extracted from the traditional herbal medicine cortex periplocae, has cardiac and anticancer activity. Periplocin could significantly boost proliferation, migration and stimulate collagen production in fibroblast L929 cells, which is dependent on activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase, and thus promoting wound healing.
|
S9182
|
Crebanine
|
Crebanine, an aporphine alkaloid isolated from the crude hexane extract of the dried tuber of Stephania venosa, exhibits anti-cancer effects.
|
S9183
|
Ruscogenin
|
Ruscogenin, a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been reported to exert significant anti-inflammatory and anti-thrombotic activities.
|
S9184
|
Forsythoside B
|
Forsythoside B is a phenylethanoid glycoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant. Forsythoside B has potent neuroprotective effects and has anti-inflammation, antioxidant, and antisepsis properties. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.
|
S9185
|
Nitidine Chloride
|
Nitidine Chloride, a benzophenanthridine alkaloid found in species of the genus Zanthoxylum, has an anti-malarial activity.
|
S9455
|
Isorhamnetin 3-O-neohesperoside
|
Isorhamnetin 3-O-neohesperoside is the major active substance of Puhuang, a traditional herb medicine widely used in clinical practice to tackle many chronic diseases. It has significant biological and pharmacological activities, including antioxidant, antiatherogenic and antimicrobial effects.
|
S9511
|
Crocin I
|
Crocin-I, a major member of the crocin family, has antidepressant activity and ameliorates the disruption of lipid metabolism and dysbiosis of the gut microbiota induced by chronic corticosterone in mice.
|
S9515
|
Polyphyllin VII
|
Polyphyllin VII (Y-0166), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocellular carcinoma and osteosarcoma.
|
S5129
|
D-Aspartic acid
|
D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).
|
S9055
|
Salvianolic acid A
|
Salvianolic acid A (Dan Phenolic Acid A), a water-soluble compound extracted from Radix Salvia miltiorrhiza (Danshen), is an antioxidant and free radical scavenging compound that also acts as an inhibitor of the protein-protein interaction mediated by SH2 domains of Src-family kinases Src and Lck.
|
S9052
|
Auraptene
|
Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8 and chemokine (C-C motif) ligand-5(CCL5).
|
S9045
|
Triptophenolide
|
Triptophenolide (Hypolide), derived from Tripterygium wilfordii, is a pan-antagonist for wild-type and mutant androgen receptors with the IC50 values of 260 nM for AR-WT, 480 nM for AR-F876L, 388 nM for AR-T877A, and 437 nM for W741C+T877A.
|
S9061
|
Hydroxy safflor yellow A
|
Hydroxy safflor yellow A, a monomer extracted from Carthamus tinctorius L., possesses various kinds of bio-activities, including anti-oxidation, anti-inflammatory actions, anti-platelet aggregation, anti-tumor and anti-myocardial injury effects.
|
S9062
|
4-Hydroxyisoleucine
|
4-Hydroxyisoleucine, an atypical branched-chain amino acid derived from fenugreek, has effects on the glucose and lipid metabolism, stimulates glucose-dependent insulin secretion and reduces insulin resistance in muscle and/or liver.
|
S9063
|
Harringtonine
|
Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities.
|
S9064
|
Trilobatin
|
Trilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect.
|
S9065
|
Songorine
|
Songorine, a ubiquitous alkaloid in the genus Aconitum, is a novel antagonist of the GABAA receptor in rat brain and has antiarrhythmic, antinociceptive, anti-inflammatory, regenerative and CNS-modulating properties.
|
S9066
|
Specnuezhenide
|
Specnuezhenide (Nuezhenide), one of the main ingredients of Chinese medicine, has anti-angiogenic and vision improvement effects.
|
S9067
|
Pseudoprotodioscin
|
Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
|
S9068
|
Trillin
|
Trillin (Disogluside, Diosgenin glucoside) is an active ingredient isolated from Trillium tschonoshii Maxim and acts as a potential anti-inflammatory drug for chronic hepatic inflammation.
|
S9069
|
Jatrorrhizine chloride
|
Jatrorrhizine chloride (Neprotine, Yatrorhizine) is the hydrochloride salt form of jatrorrhizine, which is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
|
S9070
|
Isoxanthohumol
|
Isoxanthohumol is one of the most important prenylflavonoids found in hops. It exhibits an antiproliferative activity against human breast cancer cell lines, ovarian cancer, prostate cancer, and colon cancer cells. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV).
|
S9072
|
Sweroside
|
Sweroside, a bioactive herbal ingredient isolated from Fructus Corni, exhibits diverse biological activities, such as anti-fungal, anti-diabetic, anti-inflammatory, and anti-tumor effects.
|
S9073
|
Lithospermoside
|
Lithospermoside (Griffonin), extracted from the roots of Lithospermum purpurocaeruleum and L.officinale (Borginaceae), and Thalictrum rugosum and T. dasycarpum (Ranunculaceae), has anti-oxidant, anti-tumor promoting activities.
|
S9074
|
Buddlejasaponin IVb
|
Buddlejasaponin IVb (Saikosaponin 1b), a major component of Pleurospermum kamtschaticum, exerts anti-inflammatory and cytotoxic effects against cancer cells.
|
S9075
|
Mulberroside A
|
Mulberroside A, isolated from the ethanol extract of Morus alba roots, is widely employed as an active ingredient in cosmetic products due to its anti-tyrosinase and anti-oxidant activities. Mulberroside A decreases the expressions of TNF-α, IL-1β and IL-6 and inhibits the activation of NALP3, caspase-1 and NF-κB and the phosphorylation of ERK, JNK and p38.
|
S9076
|
Typhaneoside
|
Typhaneoside is a flavonoid glycoside plant extract that has an inhibitory effect on the proliferation of human umbilical arterial smooth muscle cell(HUASMC).
|
S9077
|
Plantamajoside
|
Plantamajoside (Y0160, C10485), a hydroxycinnamic acid, is used as a biomarker in chemotaxonomical studies, and is a compound with numerous biological applications and considerable pharmacological potential.
|
S9078
|
Epigoitrin
|
Epigoitrin (Goitrin, BA-51-090278), the main bioactive constituent of Radix isatidis, exerts antiviral, anticancer, and antithyroid activities.
|
S9079
|
Ginsenoside Rb2
|
Ginsenoside Rb2 (Ginsenoside C) is a ginsenoside found in Panax ginseng that has a role as a plant metabolite, an antiviral agent and a hypoglycemic agent.
|
S9080
|
Anhydroicaritin
|
Anhydroicaritin (Cycloicaritin), a prenylated flavonoid natural product, is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. It is a potent inhibitor of transcription factor SREBPs.
|
S9081
|
Anemoside B4
|
Anemoside B4 (Pulchinenoside B4, Chinensioside A, Pulchinenoside C, Pulsatilla saponin B4), extracted from the herb of Pulsatilla chinensis (Bge.) Regel, is a potential antiviral constituent and inhibits the secretion of IL-10.
|
S9082
|
Manninotriose
|
Manninotriose, found in many foods, is a novel and important player in the RFO metabolism of red dead deadnettle.
|
S9083
|
Rhapontin
|
Rhapontin (Ponticin, Rhaponticin, Rhapontigenin glucoside), a stibene-type glycoside distributed widely in medicinal plants of Rheum genus (Polygonaceae), has anti-inflammatory effect and anti-proliferative activity.
|
S9084
|
Rhoifolin
|
Rhoifolin (Rhoifoloside, Apigenin 7-O-neohesperidoside, Apigenin-7-O-rhamnoglucoside), a natural glycoside of apigenin, has been obtained from the green leaves of Rhus succedanea and possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects.
|
S9085
|
Corynoline
|
Corynoline is one of the major active components of many ethnopharmacological plants and exhibits anti-tumor, anti-inflammatory and hepatoprotective activities, etc.
|
S9111
|
Isorhamnetin
|
Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.
|
S9112
|
Kaempferitrin
|
Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.
|
S9113
|
Ononin
|
Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects.
|
S9101
|
Ingenol
|
Ingenol, a plant-derived diterpenoid, is a weak PKC activator and possesses important anticancer activity.
|
S9019
|
Quillaic acid
|
Quillaic acid is the major aglycone of the widely studied saponins of the Chilean indigenous tree Quillaja saponaria Mol and shows strong anti-inflammatory activity.
|
S9020
|
Dihydrotanshinone I
|
Dihydrotanshinone I (15,16-dihydrotanshinone I) is a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, also known as Chinese sage, red sage root, and the Chinese herbal Dan Shen. It is a potent inhibitor of the HuR:RNA interaction, active in the low nanomolar range, mainly by limiting the association rate of HuR with RNA.
|
S9021
|
(20R)Ginsenoside Rg3
|
(20R)Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It has a role as an antioxidant and a plant metabolite.
|
S9022
|
20S-Ginsenoside Rg3
|
20S-Ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. It exihits neuromodulatory, cognition enhancing, anti-inflammatory, antioxidative, anti-angiogenic, and anticancer activities.
|
S9023
|
20S-Ginsenoside Rh2
|
20S-Ginsenoside Rh2 is a ginsenoside found in Panax species and inhibits cancer development, progression, and metastasis.
|
S9026
|
Hastatoside
|
Hastatoside is a characteristic constituent of V. officinalis and exhibit various biological activities including sleep-promoting, antioxidant and hepatoprotective activity.
|
S9029
|
Prim-o-glucosylcimifugin
|
Prim-O-glucosylcimifugin (Cimifugin beta-D-glucopyranoside, Cimifugin 7-glucoside) is a major constituent in Radix Saposhnikovia that has been long used for the treatment of pyrexia, rheumatism, and cancer in traditional Chinese medicine. It shows potential anticancer activity. Prim-O-glucosylcimifugin downregulates the mRNA and protein expression inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) in LPS-activated RAW 264.7 macrophages in a concentration-dependent manner.
|
S9031
|
Gambogenic acid
|
Gambogenic Acid, identified from Gamboge, is an inhibitor of the FGFR signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC) and exhibits anti-tumor effects. Gambogenic acid acts is also an effective inhibitor of EZH2 that specifically and covalently binds to Cys668 within the EZH2-SET domain, and triggers EZH2 ubiquitination.
|
S9034
|
Isochlorogenic acid C
|
Isochlorogenic acid C (3,4-Dicaffeoylquinic acid; 4,5-Dicaffeoylquinic acid), which is a di-O-caffeoyl derivative of chlorogenic acid, is a well-known antioxidant from herbal plants and shows anti-viral effects against EV71.
|
S9039
|
Albiflorin
|
Albiflorin, a natural product isolated from Paeoniae Radix, is a novel 5-HT and NE reuptake inhibitor with high selectivity.
|
S9040
|
Maslinic acid
|
Maslinic Acid (Crategolic Acid, 2α-Hydroxyoleanoic Acid), a Natural Triterpene, exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. MA significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells.
|
S9054
|
Pectolinarin
|
Pectolinarin is a major compound in Cirsium setidens with anti-inflammatory activity. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin induces apoptosis via inactivation of the PI3K/Akt pathway.
|
S9050
|
Boldine
|
Boldine, isolated from Peumus boldus, has alpha-adrenergic antagonist activities in vascular tissue with anti-oxidant, hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.
|
S9049
|
Parishin A
|
Parishin A, isolated from the rhizomes of Gastrodia elata, has good neuroprotective effects against brain disorders.
|
S9060
|
Nystose
|
Nystose (1,1-Kestotetraose, Fungitetraose), a constituent of seeds of onions and roots of Asparagus, is a low-calorie sweetening agent for food and chewing gum.
|
S9092
|
Norisoboldine
|
Norisoboldine (Laurelliptine), a natural aryl hydrocarbon receptor (AhR) agonist, attenuates ulcerative colitis (UC) and induces the generation of Treg cells.
|
S9093
|
Nardosinone
|
Nardosinone, isolated from Nardostachys root, an important Chinese herbal medicine, is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects, including sedative, adaptogen-like, anti-depressive, anti-leukemic, anti-tumorous, and anti-trypanosomal activities.
|
S9097
|
Alisol B Acetate
|
Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.
|
S9098
|
Dehydrodiisoeugenol
|
Dehydrodiisoeugenol, a naturally occurring lignan from Aristolochia taliscana (Aristolochiaceae), acts as a potent anti-inflammatory agent and shows various pharmacological activities, including anti-lipid peroxidation, anti-bacteial function, and hepatic drug metabolism enzyme inhibition.
|
S9099
|
Orientin
|
Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.
|
S9100
|
Fraxinellone
|
Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities.
|
S9102
|
Magnolin
|
Magnolin is a natural compound abundantly found in Magnolia flos targeting ERK1 (IC50=87 nM) and ERK2 (IC50=16.5 nM) and inhibits cell transformation induced by tumor promoters such as epidermal growth factor (EGF).
|
S9103
|
Ginsenoside Ro
|
Ginsenoside Ro (Chikusetsusaponin V), one of the high-abundance saponins in ginseng, is widely used as a dietary supplement and has many health-promoting effects.
|
S9104
|
Maltopentaose
|
Maltopentaose is a substrate for energy metabolism and carbon for E. coli.
|
S9105
|
Ginsenoside CK
|
Ginsenoside CK is a ginsenoside found in Panax species and has a role as a plant metabolite, an antineoplastic agent, a hepatoprotective agent, an anti-allergic agent and an anti-inflammatory agent.
|
S9108
|
Timosaponin A3
|
Timosaponin A3 (Filiferin B, AneMarsaponin A3), one of the major steroidal saponin components isolated from Anemarrhena asphodeloides, displays promising pharmacological activity in improving learning, memory, and antineoplastic activity.
|
S9056
|
Tuberostemonine
|
Tuberostemonine, a natural product found in Stemona phyllantha and Stemona tuberosa, is an alkaloid and a metabolite.
|
S9053
|
Irisflorentin
|
Irisflorentin derived from the roots of Belamcanda chinensis (L.) DC. is an herb which has been used for the treatment of inflammatory disorders in traditional Chinese medicine.
|
S9051
|
Asperuloside
|
Asperuloside, an iridoid glycoside found in Herba Paederiae, is a component from traditional Chinese herbal medicine and exerts anti-inflammatory effect.
|
S9048
|
(+)-Gallocatechin
|
(+)-Gallocatechin, found notably in green tea, has moderate affinity to the human cannabinoid receptor and acts as an antioxidant.
|
S9057
|
Sinigrin
|
Sinigrin (Allylglucosinolate, 2-Propenylglucosinolate) is a glucosinolate found in some plants of the Brassicaceae family and exerts various activities including anticancer, anti-inflammatory, antibacterial, antifungal, antioxidant, and wound healing effects.
|
S9058
|
Gallocatechin gallate
|
Gallocatechin galleate (GCG) is a polyphenol originally derived from a variety of sources, including green tea, coffee, safflower, and almonds.
|
S9086
|
Dihydrocapsaicin
|
Dihydrocapsaicin (6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide, CCRIS1589), found in pepper (C. annuum), is a potential nutriceutical.DHC is a selective TRPV1 agonist.
|
S9088
|
Calycosin-7-O-beta-D-glucoside
|
Calycosin-7-O-beta-D-glucoside, an isoflavone glycoside isolated from A. mongholicus and A. membranaceus, has antioxidant, anti-inflammatory, and neuroprotective biological activities.
|
S9089
|
Magnoflorine
|
Magnoflorine (Escholin, Thalictrin), an important compound in Aristolochia, was usually used as an anxiolytic chemical. It shows significant antioxidant activity as a DPPH free radical scavenger and inhibits α-tyrosinase.
|
S9090
|
Corilagin
|
Corilagin, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others. It is an inhibitor of TNF-α.
|
S9091
|
10-Gingerol
|
10-Gingerol is a bioactive compound found in ginger with anti-inflammatory and antioxidant activity.
|
S9095
|
Senegenin
|
Senegenin (Tenuigenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and antiinflammatory activity.
|
S9096
|
ligustroflavone
|
Ligustroflavone (Nuezhenoside), isolated from the leaves of Turpinia montana, shows high antioxidant capacity and is reported to be an AMPK activator.
|
S9106
|
Eleutheroside E
|
Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction.
|
S9107
|
Glycitein
|
Glycitein is an aglycone isoflavone found in soy and red clover and exhibits a wide variety of beneficial properties, including neuroprotective, antioxidative, anticancer, anti-osteoporotic, and anti-atherosclerotic activities.
|
S9109
|
1-Kestose
|
1-Kestose (1F-beta-D-Fructosylsucrose), a fructooligosaccharide, could efficiently stimulates Faecalibacterium prausnitzii as well as Bifidobacteria in humans.
|
S9110
|
Morin
|
Morin (Al-Morin, Aurantica, Calico Yellow, Toxylon pomiferum), a constituent of various woods, has a role as an antioxidant, a metabolite, an antihypertensive agent, a hepatoprotective agent, a neuroprotective agent, an anti-inflammatory agent, an antineoplastic agent, an antibacterial agent, a DNA topoisomerase inhibitor and an angiogenesis modulating agent.
|