For research use only.
Catalog No.S3747 Synonyms: L-T4 sodium, L-Thyroxine sodium, LT4 sodium
CAS No. 55-03-8
Levothyroxine (L-T4, L-Thyroxine) is the major hormone derived from the thyroid gland. It is the agonist of Thyroid hormone receptor alpha and beta.
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|Description||Levothyroxine (L-T4, L-Thyroxine) is the major hormone derived from the thyroid gland. It is the agonist of Thyroid hormone receptor alpha and beta.|
Levothyroxine can upregulate the expression of P-gp mRNA and protein in LS180 cells and can produce the same effect in Caco-2 cells, which are relatively lacking in PXR. It doea not affect the expression of CYP3A4 in either cell line.
|In vivo||Levothyroxine is a synthetic T4 hormone that is biochemically and physiologically indistinguishable from the natural one, and it is administered when the body is deficient in the natural hormone. Its nain site of absorption is small intestine, more specifically through the duodenum, jejunum and ileum. Very little is absorbed in the stomach. The bioavailability is about 70-80 % in euthyroid person and may be slightly higher in hyperthyroid patients. The absorption of levothyroxine appears to be influenced by gastric pH. Tmax=2-3 hours and the half-time T1/2 is 6.2 and 7.5 days in euthyroid and hypothyroid patients, respectively. T4 hormones is known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. T4-treatment induces a dose-dependent increase in the duration of contractions. Abnormal uterine contractile pattern are induced by T4-treatment.|
|In vitro||DMSO||100 mg/mL (125.17 mM)|
|Ethanol||3 mg/mL (3.75 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||L-T4 sodium, L-Thyroxine sodium, LT4 sodium|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04037748||Completed||Drug: Puran T4®|Drug: Eutirox®||Healthy||Merck Healthcare KGaA Darmstadt Germany an affiliate of Merck KGaA Darmstadt Germany||June 25 2019||Phase 1|
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