GPCR Compound Library

Catalog No.L2200

A unique collection of 1325 small molecules targeting G protein coupled receptors for high throughput screening (HTS) and high content screening (HCS).

96 well box

Customize Your Library:

Cited by 260 Publications

Description & Advantages

•A unique collection of 1325 small molecules targeting G protein coupled receptors for high throughput screening (HTS) and high content screening (HCS)
• All of the small molecules in the GPCR library are well characterized with biological and pharmaceutical activity
• A powerful tool for discovering GPCR-based drugs that are the richest signal receptor targets for drug discovery
• It is estimated about 200 so-called orphan GPCRs are functionally unknown, as a result, use of our GPCR Small Molecule Compound Library for screening the functionally unknown GPCRs may yield potentially new GPCR-based drug candidates
• The GPCR compound library contains small molecules associated with receptors including 5-HT Receptor, Dopamine Receptor, Opioid Receptor, Adrenergic Receptors, Cannabinoid Receptor, mGluR, and ETA-receptor etc.
• Structurally diverse, medicinally active, and cell permeable
• Rich documentation with structure and customer reviews
• NMR and HPLC validated to ensure the highest purity

Product Details
Formulation 1204 compounds pre-dissolved in 10mM DMSO, 80 compounds pre-dissolved in 10mM water, 36 compounds pre-dissolved in 2mM DMSO and 5 compounds pre-dissolved in 2mM water
Container 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Stability 12 months -20°C in DMSO
24 months -80°C in DMSO
Shipping Blue ice or dry ice
Case Studies using Selleck Compound Libraries
  • Application of GPCR Compound Library in liver cancer (This article was published in Nature (IF=43) and took about 15 months):

    Nature.2019;574(7777):268-272

  • Application of Kinase Inhibitor Library in colorectal cancer (This article was published in Nature Communications (IF=11) and took about 8 months):

    Nat Commun. 2019 16;10(1):2197

  • Application of FDA-approved Drug Library in antivirus (This article was published in Cell Research (IF=17) and took about 13 months):

    Cell Res. 2019;29(9):739-753

  • Application of FDA-approved Drug Library in metabolism (This article was published in Movement Disorders (IF=8) and took about 10 months):

    Mov Disord. 2019;34(3):323-334

  • Application of Epigenetics Compound Library in acute lymphoblastic leukemia (This article was published in Blood (IF=16) and took about 16 months):

    Blood. 2019 17;134(16):1323-1336

  • Application of Inhibitor Library in tumor immunology (This article was published in Cancer Immunol Res (IF=8.6) and took about 12 months):

    Cancer Immunol Res.2017;5(9):790-803

GPCR Compound Library Composition
HTS Facility Partners