GPCR Compound Library

Cat.No.L2200

A unique collection of 1417 small molecules targeting G protein coupled receptors for high throughput screening (HTS) and high content screening (HCS).

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Specific Compounds
Quantities
96 or 384 well Plate Map
Dry/solid or DMSO solution

Cited by 332 Publications

Featured Inhibitors	Y-27632 Dihydrochloride SB431542 CHIR-99021 (Laduviglusib) RMC-7977 RMC-6236 (Daraxonrasib) MRTX1133 MG132 Z-VAD-FMK VT3989 IAG933

GPCR Compound Library Contents

Description & Advantages

•A unique collection of 1417 small molecules targeting G protein coupled receptors for high throughput screening (HTS) and high content screening (HCS)
• All of the small molecules in the GPCR library are well characterized with biological and pharmaceutical activity
• A powerful tool for discovering GPCR-based drugs that are the richest signal receptor targets for drug discovery
• It is estimated about 200 so-called orphan GPCRs are functionally unknown, as a result, use of our GPCR Small Molecule Compound Library for screening the functionally unknown GPCRs may yield potentially new GPCR-based drug candidates
• The GPCR compound library contains small molecules associated with receptors including 5-HT Receptor, Dopamine Receptor, Opioid Receptor, Adrenergic Receptors, Cannabinoid Receptor, mGluR, and ETA-receptor etc.
• Structurally diverse, medicinally active, and cell permeable
• Rich documentation with structure and customer reviews
• NMR and HPLC validated to ensure the highest purity

Product Details

Formulation	1299 compounds pre-dissolved in 10mM DMSO, 76 compounds pre-dissolved in 10mM water, 37 compounds pre-dissolved in 2mM DMSO and 5 compounds pre-dissolved in 2mM water
Container	96 Deep Well Plate Sealed With Aluminum Foil
Stability	12 months	-20°C	in DMSO
Stability	24 months	-80°C	in DMSO
Shipping	Blue ice or dry ice

Case Studies using Selleck Compound Libraries

Application of GPCR Compound Library in liver cancer (This article was published in Nature (IF=43) and took about 15 months):

Nature.2019;574(7777):268-272
Application of Kinase Inhibitor Library in colorectal cancer (This article was published in Nature Communications (IF=11) and took about 8 months):

Nat Commun. 2019 16;10(1):2197
Application of FDA-approved Drug Library in antivirus (This article was published in Cell Research (IF=17) and took about 13 months):

Cell Res. 2019;29(9):739-753
Application of FDA-approved Drug Library in metabolism (This article was published in Movement Disorders (IF=8) and took about 10 months):

Mov Disord. 2019;34(3):323-334
Application of Epigenetics Compound Library in acute lymphoblastic leukemia (This article was published in Blood (IF=16) and took about 16 months):

Blood. 2019 17;134(16):1323-1336
Application of Inhibitor Library in tumor immunology (This article was published in Cancer Immunol Res (IF=8.6) and took about 12 months):

Cancer Immunol Res.2017;5(9):790-803