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Vincamine

Name: Vincamine
Brand: Selleck Chemicals
SKU: S3891
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3891

Vincamine (Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan), an indole alkaloid found in the leaves of V. minor and C. roseus, is a peripheral vasodilator that increases blood flow to the brain.

Chemical Structure

Molecular Weight: 354.44

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Quality Control

Batch: Purity: 99.87%

99.87

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Solubility

In vitro
Batch:

DMSO : 3 mg/mL (8.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.550mg/ml (1.55mM)	Taking the 1 mL working solution as an example, add 50 μL of 11 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.550mg/ml (1.55mM)	Taking the 1 mL working solution as an example, add 50 μL of 11 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	354.44	Formula	C₂₁H₂₆N₂O₃	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	1617-90-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Angiopac, Devincan, Equipur, Minorin, Novicet, Oxybral, Perval, Sostenil, Tripervan			Smiles	CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(C2)(C(=O)OC)O

Mechanism of Action

In vitro	Vincamine decreases amyloid-β 25-35 induced oxidative stress and reduces reactive oxygen species levels. It significantly reduces the rate of apoptosis in a dose-dependent manner. This compound could provide neuroprotection from Aβ25-35 induced PC12 apoptosis through the phosphatidylinositol-3 kinase/Akt signaling pathway.
In vivo	Vincamine could cross the blood-brain barrier, and its antioxidant scavenging capacity to inactivate hydroxyl free radicals is actually ranked in part with Vitamin E. This compound decreases the mean arterial blood pressure (by 5-35%), the cardial output and the heart rate. After oral application of 20 mg/kg vincamine in rats, this chemical is rapidly absorbed and eliminated. The apparent elimination half life is 1.71 h. The bioavailability of this compound after oral administration is 58% suggesting a significant firstpass metabolism. It is taken up in a high concentration by the different organs, the maximal organ-plasma concentration ratio is 21 for lungs, 14.6 for brain, 14.3 for the kidneys, 8.9 for the liver and 7.6 for the heart. There is no steady-state between plasma and heart, lungs and brain, the elimination from these organs is significantly more rapid than from plasma. This chemical is mainly metabolized in the liver and excreted by the kidneys and it may also go through cerebral metabolism. In the pharmacokinetic profile of vincamine, the compound is about 64% bound to plasma proteins, and 6% bound to erythrocytes.
References	[1] https://pubmed.ncbi.nlm.nih.gov/28216895/ [2] https://pubmed.ncbi.nlm.nih.gov/3899662/ [3] https://pubmed.ncbi.nlm.nih.gov/16130744/

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