Cafestol

For research use only.

Catalog No.S0947

Cafestol Chemical Structure

CAS No. 469-83-0

Cafestol is a natural diterpenes extracted from coffee beans. Cafestol induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. Cafestol inhibits PI3K/Akt pathway. Cafestol also can reduce the production of ROS in the leukemia cell line HL60.

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Biological Activity

Description Cafestol is a natural diterpenes extracted from coffee beans. Cafestol induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. Cafestol inhibits PI3K/Akt pathway. Cafestol also can reduce the production of ROS in the leukemia cell line HL60.

Protocol

Solubility (25°C)

In vitro DMSO 63 mg/mL (199.09 mM)
Water Insoluble
Ethanol '''63 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 316.43
Formula

C20H28O3

CAS No. 469-83-0
Storage powder
in solvent
Synonyms N/A
Smiles CC12CCC3=C(C1CCC45C2CCC(C4)C(C5)(CO)O)C=CO3

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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PI3K Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID