Home PI3K/Akt/mTOR PI3K inhibitor - Apoptosis related inhibitor - Immunology & Inflammation related inhibitor - ROS inhibitor Cafestol

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Cafestol PI3K inhibitor

Cat.No.S0947

Cafestol is a natural diterpenes extracted from coffee beans. It induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. This compound inhibits the PI3K/Akt pathway and can also reduce the production of ROS in the leukemia cell line HL60.
Cafestol PI3K inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 316.43

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S094701 DMSO]63 mg/mL]false]Ethanol]63 mg/mL]false]Water]Insoluble]false Purity: 99.93%
99.93

Chemical Information, Storage & Stability

Molecular Weight 316.43 Formula

C20H28O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 469-83-0 -- Storage of Stock Solutions

Synonyms N/A Smiles CC12CCC3=C(C1CCC45C2CCC(C4)C(C5)(CO)O)C=CO3

Solubility

In vitro
Batch:

DMSO : 63 mg/mL (199.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 63 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04908904 Completed
Diabetes Mellitus Type 2
University of Aarhus|Aarhus University Hospital
 May 27 2021 Not Applicable

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