Silibinin

Catalog No.S2357 Synonyms: Silybin

Silibinin Chemical Structure

Molecular Weight(MW): 482.44

Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.

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Cited by 2 Publications

1 Customer Review

  • Growth-inhibiting effects of gefitinib and/or silibinin in hepatocellular carcinoma cells (HCCs). A: Huh7, Huh-BAT, HepG2, SNU475, and SNU761 HCC cell lines were cultured in medium containing 5% fetal bovine serum (FBS) and treated with gefitinib (A, left), silibinin (A, right) for 72 hr. The resulting cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.

    Clin Mol Hepatol, 2015, 21(1):49-59. . Silibinin purchased from Selleck.

Purity & Quality Control

Biological Activity

Description Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.
In vitro

Silibinin itself is mixture of two diastereomers silibinin A and silybinin B in approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. [1] Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells. [2] [3] [4]

Protocol

Solubility (25°C)

In vitro DMSO 96 mg/mL (198.98 mM)
Water Insoluble
Ethanol Insoluble warmed

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 482.44
Formula

C25H22O10

CAS No. 22888-70-6
Storage powder
in solvent
Synonyms Silybin

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03687073 Recruiting Smoking Masonic Cancer Center University of Minnesota November 29 2018 Phase 1
NCT03687073 Recruiting Smoking Masonic Cancer Center University of Minnesota November 29 2018 Phase 1
NCT02146118 Unknown status Carcinoma Non-Small-Cell Lung MedicalLogic|Kosin University Gospel Hospital April 2014 Phase 2
NCT02146118 Unknown status Carcinoma Non-Small-Cell Lung MedicalLogic|Kosin University Gospel Hospital April 2014 Phase 2
NCT03538327 Completed Hypertension University Magna Graecia October 2013 Phase 4
NCT02633696 Completed Healthy Volunteers Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal|Fundación Mutua Madrileña October 2013 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID