Silibinin (NSC 651520)

Synonyms: Silybin, Silibinin A, Silymarin I, Flavobin

Silibinin (NSC 651520, Silybin, Silibinin A, Silymarin I, Flavobin), the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.

Silibinin (NSC 651520) Chemical Structure

Silibinin (NSC 651520) Chemical Structure

CAS: 22888-70-6

Selleck's Silibinin (NSC 651520) has been cited by 4 Publications

1 Customer Review

Purity & Quality Control

Batch: Purity: 99.93%
99.93

Silibinin (NSC 651520) Related Products

Biological Activity

Description Silibinin (NSC 651520, Silybin, Silibinin A, Silymarin I, Flavobin), the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.
In vitro
In vitro Silibinin itself is mixture of two diastereomers silibinin A and silybinin B in approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. [1] Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells. [2] [3] [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03440164 Completed
Liver Diseases|Chronic Liver Disease
Medica Sur Clinic & Foundation
November 11 2016 --
NCT01129570 Completed
Advanced Hepatocellular Carcinoma
Abby Siegel|Lotte & John Hecht Memorial Foundation|Columbia University
February 2010 Phase 1
NCT00487721 Completed
Prostate Cancer
University of Colorado Denver|Sir Mortimer B. Davis - Jewish General Hospital
August 2006 Phase 2
NCT00181662 Completed
Healthy
Massachusetts General Hospital
August 2005 Not Applicable

Chemical Information & Solubility

Molecular Weight 482.44 Formula

C25H22O10

CAS No. 22888-70-6 SDF Download Silibinin (NSC 651520) SDF
Smiles COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 96 mg/mL ( (198.98 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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