Home Others Other chemical 5-hydroxytryptophan (5-HTP) For research use only.

5-hydroxytryptophan (5-HTP)

Synonyms: NSC-92523

5-Hydroxytryptophan (5-HTP, NSC-92523), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor for the treatment of depression.

5-hydroxytryptophan (5-HTP) Chemical Structure

5-hydroxytryptophan (5-HTP) Chemical Structure

CAS: 56-69-9

Selleck's 5-hydroxytryptophan (5-HTP) has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.73%
99.73

5-hydroxytryptophan (5-HTP) Related Products

Biological Activity

Description 5-Hydroxytryptophan (5-HTP, NSC-92523), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor for the treatment of depression.
In vitro
In vitro 5-Hydroxytryptophan (5-HTP) is the intermediate metabolite of the essential amino acid L-tryptophan (LT) in the biosynthesis of serotonin. It easily crosses the blood-brain barrier and effectively increases central nervous system (CNS) synthesis of serotonin. Therapeutic administration of 5-HTP has been shown to be effective in treating a wide variety of conditions, including depression, fibromyalgia, binge eating associated with obesity, chronic headaches, and insomnia. [1] Clinical available evidence suggests 5-Hydroxytryptophan is better than placebo at alleviating depression. [2]
In Vivo
In vivo LD50: Mice 1800mg/kg (i.g.); Rats 300mg/kg (i.g.) [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03574948 Completed
Crohn Disease|Ulcerative Colitis|Fatigue|Remission
University Hospital Ghent
 December 6 2018 Phase 2
NCT03112655 Completed
African Trypanosomiasis|African; Trypanosomiasis West|Sleeping Sickness; West African|Trypanosoma Brucei Gambiense; Infection
Institut de Recherche pour le Developpement|Institute of Tropical Medicine Belgium|Institut National de Recherche Biomédicale. Kinshasa République Démocratique du Congo|Ministry of Public Health Democratic Republic of the Congo
 February 24 2017 Not Applicable
NCT02815969 Completed
Neuroendocrine Tumors
University Medical Center Groningen
 September 2016 --

Chemical Information & Solubility

Molecular Weight 220.22 Formula

C11H12N2O3
CAS No. 56-69-9 SDF Download 5-hydroxytryptophan (5-HTP) SDF
Smiles C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 44 mg/mL ( (199.8 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 7 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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