5-hydroxytryptophan (5-HTP)

Catalog No.S2374 Synonyms: NSC-92523

For research use only.

5-Hydroxytryptophan (5-HTP, NSC-92523), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor for the treatment of depression.

5-hydroxytryptophan (5-HTP) Chemical Structure

CAS No. 56-69-9

Selleck's 5-hydroxytryptophan (5-HTP) has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description 5-Hydroxytryptophan (5-HTP, NSC-92523), also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor for the treatment of depression.
In vitro

5-Hydroxytryptophan (5-HTP) is the intermediate metabolite of the essential amino acid L-tryptophan (LT) in the biosynthesis of serotonin. It easily crosses the blood-brain barrier and effectively increases central nervous system (CNS) synthesis of serotonin. Therapeutic administration of 5-HTP has been shown to be effective in treating a wide variety of conditions, including depression, fibromyalgia, binge eating associated with obesity, chronic headaches, and insomnia. [1] Clinical available evidence suggests 5-Hydroxytryptophan is better than placebo at alleviating depression. [2]

In vivo LD50: Mice 1800mg/kg (i.g.); Rats 300mg/kg (i.g.) [3]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 44 mg/mL
(199.8 mM)
Water 4 mg/mL
(18.16 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 220.22
Formula

C11H12N2O3

CAS No. 56-69-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03574948 Completed Drug: 5-HTP|Drug: Placebo oral capsule Crohn Disease|Ulcerative Colitis|Fatigue|Remission University Hospital Ghent December 6 2018 Phase 2
NCT03112655 Completed Diagnostic Test: RNA and neopterin detection African Trypanosomiasis|African; Trypanosomiasis West|Sleeping Sickness; West African|Trypanosoma Brucei Gambiense; Infection Institut de Recherche pour le Developpement|Institute of Tropical Medicine Belgium|Institut National de Recherche Biomédicale. Kinshasa République Démocratique du Congo|Ministry of Public Health Democratic Republic of the Congo February 24 2017 Not Applicable
NCT02815969 Completed Other: vena punction Neuroendocrine Tumors University Medical Center Groningen September 2016 --

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

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