Catalog No.S3765 Synonyms: 6-Vanilloylcatalpol, Vanilloyl catalpol
Molecular Weight(MW): 512.46
Picroside II is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
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|Description||Picroside II is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.|
Picroside II can reduce H2O2-induced PC12 cell damage and improve cell survival. Picroside II effectively attenuates fatty acid accumulation by decreasing FFAs uptake and lipogenesis. Picroside II also decreases the expression of gluconeogenic genes. Picroside II significantly decreases the concentrations of TNF-α, IL-1β, and IL-6 in cells. It suppresses the activation of p65 NF-κB signaling pathway compared with LPS stimulation.
|In vivo||Picroside II could protect the nervous system possibly through reducing the content of ROS by down-regulating the expression of Rac-1 and Nox2 and could protect the BBB through reducing the expression of ROCK, MLCK, and MMP-2, while enhancing the expression of claudin-5. In the HDM-induced asthmatic model, picroside II significantly reduces inflammatory cell counts in the bronchoalveolar lavage fluid (BALF), the levels of total immunoglobulin (Ig) E and HDM-specific IgE and IgG1 in serum, airway inflammation, and mucus hypersecretion in the lung tissues.|
|In vitro||DMSO||100 mg/mL (195.13 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||6-Vanilloylcatalpol, Vanilloyl catalpol|
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