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Picroside II

Name: Picroside II
Brand: Selleck Chemicals
SKU: S3765
Rating: 5 (1 reviews)

Synonyms: 6-Vanilloylcatalpol, Vanilloyl catalpol

Catalog No.S3765 Purity: 99.71%

Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.

Picroside II Chemical Structure

CAS: 39012-20-9

Purity & Quality Control

Batch: S376501 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 99.71%

99.71

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Biological Activity

Description	Picroside II (6-Vanilloylcatalpol, Vanilloyl catalpol) is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.

In vitro
In vitro	Picroside II can reduce H2O2-induced PC12 cell damage and improve cell survival^[3]. Picroside II effectively attenuates fatty acid accumulation by decreasing FFAs uptake and lipogenesis. Picroside II also decreases the expression of gluconeogenic genes^[4]. Picroside II significantly decreases the concentrations of TNF-α, IL-1β, and IL-6 in cells. It suppresses the activation of p65 NF-κB signaling pathway compared with LPS stimulation^[5].
Cell Research	Cell lines	HepG2 cells
	Concentrations	0-300 μM
	Incubation Time	24 h
	Method	HepG2 cells are loaded with different concentrations of FFAs, picroside I, picroside II, and silibinin for 24 hours. Cytotoxicity is measured via MTT assay.

In Vivo
In vivo	Picroside II could protect the nervous system possibly through reducing the content of ROS by down-regulating the expression of Rac-1 and Nox2 and could protect the BBB through reducing the expression of ROCK, MLCK, and MMP-2, while enhancing the expression of claudin-5^[1]. In the HDM-induced asthmatic model, picroside II significantly reduces inflammatory cell counts in the bronchoalveolar lavage fluid (BALF), the levels of total immunoglobulin (Ig) E and HDM-specific IgE and IgG1 in serum, airway inflammation, and mucus hypersecretion in the lung tissues^[2].
Animal Research	Animal Models	adult male Wistar rats
	Dosages	20 mg/kg
	Administration	i.p.

References

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Chemical Information & Solubility

Molecular Weight	512.46	Formula	C₂₃H₂₈O₁₃
CAS No.	39012-20-9	SDF	Download Picroside II SDF
Smiles	COC1=C(C=CC(=C1)C(=O)OC2C3C=COC(C3C4(C2O4)CO)OC5C(C(C(C(O5)CO)O)O)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (195.13 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

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% DMSO + % + % Tween 80 + % ddH₂O

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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