Picroside II

Catalog No.S3765 Synonyms: 6-Vanilloylcatalpol, Vanilloyl catalpol

Picroside II Chemical Structure

Molecular Weight(MW): 512.46

Picroside II is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.

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Biological Activity

Description Picroside II is the main active ingredient in iridoid glycosides, which is the principal component of Picrorrhiza kurroa Royle. It has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.
In vitro

Picroside II can reduce H2O2-induced PC12 cell damage and improve cell survival[3]. Picroside II effectively attenuates fatty acid accumulation by decreasing FFAs uptake and lipogenesis. Picroside II also decreases the expression of gluconeogenic genes[4]. Picroside II significantly decreases the concentrations of TNF-α, IL-1β, and IL-6 in cells. It suppresses the activation of p65 NF-κB signaling pathway compared with LPS stimulation[5].

In vivo Picroside II could protect the nervous system possibly through reducing the content of ROS by down-regulating the expression of Rac-1 and Nox2 and could protect the BBB through reducing the expression of ROCK, MLCK, and MMP-2, while enhancing the expression of claudin-5[1]. In the HDM-induced asthmatic model, picroside II significantly reduces inflammatory cell counts in the bronchoalveolar lavage fluid (BALF), the levels of total immunoglobulin (Ig) E and HDM-specific IgE and IgG1 in serum, airway inflammation, and mucus hypersecretion in the lung tissues[2].

Protocol

Cell Research:[4]
+ Expand
  • Cell lines: HepG2 cells
  • Concentrations: 0-300 μM
  • Incubation Time: 24 h
  • Method: HepG2 cells are loaded with different concentrations of FFAs, picroside I, picroside II, and silibinin for 24 hours. Cytotoxicity is measured via MTT assay.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: adult male Wistar rats
  • Formulation: normal saline
  • Dosages: 20 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (195.13 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 512.46
Formula

C23H28O13

CAS No. 39012-20-9
Storage powder
in solvent
Synonyms 6-Vanilloylcatalpol, Vanilloyl catalpol

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID