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Garlic oil

Garlic oil blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis by inducing phase II drug-metabolizing enzymes.

Garlic oil Chemical Structure

Garlic oil Chemical Structure

CAS: 8000-78-0

Purity & Quality Control

Batch: E065101 Purity: 99%
99

Garlic oil Related Products

Biological Activity

Description Garlic oil blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis by inducing phase II drug-metabolizing enzymes.
In vitro
In vitro

Garlic oil exhibits favorable anti‑cancer potential towards gliomas of various degrees of differentiation. Garlic oil induces apoptotic death in Human astrocytoma cell lines at a low concentration(0.75 µg/ml-1.5 µg/ml). [2]
Cell Research Cell lines Human astrocytoma cell lines
Concentrations 0.015 µg/ml-150 µg/ml
Incubation Time 24 h
Method

Human astrocytoma cell lines are incubated with 15 or 150 µg/ml garlic oil for 24 h, and then used for the MTT assay to determine viability of cells. Annexin V conjugated to fluorescein isothiocyanate (FITC) fluorochrome is used for flow cytometry analysis of cells which are undergoing apoptosis.
In Vivo
In vivo

Garlic oil supplementation during pregnancy and lactation protects against hypertension induced by high-fat (HF) diet in adult male offspring. The beneficial effects of garlic oil are associated with increased renal mRNA expression and activity of Hydrogen sulfide (H2 S)-generating enzymes, increased NO bioavailability, increased plasma short chain fatty acid levels, and alterations of gut microbiota composition. Garlic oil supplementation increases abundance of genus Lactobacillus, but decreases genera Turicibacter and Staphylococcus.[3]
Animal Research Animal Models Pregnant rats
Dosages 100 mg/kg
Administration o.g.

Chemical Information & Solubility

Molecular Weight Formula

N/A
CAS No. 8000-78-0 SDF --
Storage (From the date of receipt) 2 years -20°C liquid

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