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Mogroside V

Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit).

Mogroside V Chemical Structure

Mogroside V Chemical Structure

CAS: 88901-36-4

Purity & Quality Control

Batch: S381501 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 99.51%
99.51

Mogroside V Related Products

Biological Activity

Description Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit).
In vitro
In vitro Mogroside V possesses tumor growth inhibitory activity in in vitro and in vivo models of pancreatic cancer by promoting apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells), which may in part be mediated through regulating the STAT3 signaling pathway. Mogroside V inhibits the proliferation of pancreatic cancer cells and other tumor cell types in a dose- and time-dependent manner, and shows very little cytotoxicity against the non-tumorigenic epithelial cell line L02. Mogroside V inhibits the downstream targets of the STAT3 pathway that promote cell proliferation (CCND1, CCNE1 and CDK2), while also upregulating cell cycle inhibitors (CDKN1A and CDKN1B)[1].
Cell Research Cell lines PANC-1 cells
Concentrations 0 to 250 μmol/l
Incubation Time 24 or 72 h
Method Cells are added to 96-well cell culture plates at an initial concentration of 1 × 104 cells/ml and are incubated with the indicated concentrations of mogroside V. After 24 or 72 h of incubation, MTT solution (5 mg/ml) is added to the wells and the cells are incubated for another 4 h. The growth medium is removed and formazan crystals formed by oxidation of the MTT dye are analyzed by measuring the absorbance at 490 nm using an ELISA reader.
In Vivo
In vivo Mogroside V treatment promotes apoptosis of pancreatic cancer cells in the xenograft tumors. Mogroside V treatment significantly reduces the expression of CD31-labeled blood vessels and of the pro-angiogenic factor vascular endothelial growth factor in the xenografts, indicating that mogroside V might limit the growth of pancreatic tumors by inhibiting angiogenesis and reducing vascular density. Mogroside V treatment inhibits tumor cell growth, induces apoptosis and causes tumor regression[1].
Animal Research Animal Models BALB/c nude mice xenografted with PANC-1 cells
Dosages 2 mg/kg, 10 mg/kg, 30 mg/kg
Administration i.v.

Chemical Information & Solubility

Molecular Weight 1287.43 Formula

C60H102O29
CAS No. 88901-36-4 SDF Download Mogroside V SDF
Smiles CC(CCC(C(C)(C)O)OC1C(C(C(C(O1)COC2C(C(C(C(O2)CO)O)O)O)O)O)OC3C(C(C(C(O3)CO)O)O)O)C4CCC5(C4(CC(C6(C5CC=C7C6CCC(C7(C)C)OC8C(C(C(C(O8)COC9C(C(C(C(O9)CO)O)O)O)O)O)O)C)O)C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (77.67 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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