Mogroside V

Catalog No.S3815

For research use only.

Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit).

Mogroside V Chemical Structure

CAS No. 88901-36-4

Purity & Quality Control

Related Other Products

Biological Activity

Description Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit).
In vitro

Mogroside V possesses tumor growth inhibitory activity in in vitro and in vivo models of pancreatic cancer by promoting apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells), which may in part be mediated through regulating the STAT3 signaling pathway. Mogroside V inhibits the proliferation of pancreatic cancer cells and other tumor cell types in a dose- and time-dependent manner, and shows very little cytotoxicity against the non-tumorigenic epithelial cell line L02. Mogroside V inhibits the downstream targets of the STAT3 pathway that promote cell proliferation (CCND1, CCNE1 and CDK2), while also upregulating cell cycle inhibitors (CDKN1A and CDKN1B)[1].

In vivo Mogroside V treatment promotes apoptosis of pancreatic cancer cells in the xenograft tumors. Mogroside V treatment significantly reduces the expression of CD31-labeled blood vessels and of the pro-angiogenic factor vascular endothelial growth factor in the xenografts, indicating that mogroside V might limit the growth of pancreatic tumors by inhibiting angiogenesis and reducing vascular density. Mogroside V treatment inhibits tumor cell growth, induces apoptosis and causes tumor regression[1].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: PANC-1 cells
  • Concentrations: 0 to 250 μmol/l
  • Incubation Time: 24 or 72 h
  • Method: Cells are added to 96-well cell culture plates at an initial concentration of 1 × 104 cells/ml and are incubated with the indicated concentrations of mogroside V. After 24 or 72 h of incubation, MTT solution (5 mg/ml) is added to the wells and the cells are incubated for another 4 h. The growth medium is removed and formazan crystals formed by oxidation of the MTT dye are analyzed by measuring the absorbance at 490 nm using an ELISA reader.
  • (Only for Reference)
Animal Research:[2]
  • Animal Models: BALB/c nude mice xenografted with PANC-1 cells
  • Dosages: 2 mg/kg, 10 mg/kg, 30 mg/kg
  • Administration: i.v.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(77.67 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1287.43
Formula

C60H102O29

CAS No. 88901-36-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(CCC(C(C)(C)O)OC1C(C(C(C(O1)COC2C(C(C(C(O2)CO)O)O)O)O)O)OC3C(C(C(C(O3)CO)O)O)O)C4CCC5(C4(CC(C6(C5CC=C7C6CCC(C7(C)C)OC8C(C(C(C(O8)COC9C(C(C(C(O9)CO)O)O)O)O)O)O)C)O)C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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