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Mogroside V

Cat.No.S3815

Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit).
Mogroside V Chemical Structure

Chemical Structure

Molecular Weight: 1287.43

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S381501 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.51%
99.51

Chemical Information, Storage & Stability

Molecular Weight 1287.43 Formula

C60H102O29

 Storage (From the date of receipt)
CAS No. 88901-36-4 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC(CCC(C(C)(C)O)OC1C(C(C(C(O1)COC2C(C(C(C(O2)CO)O)O)O)O)O)OC3C(C(C(C(O3)CO)O)O)O)C4CCC5(C4(CC(C6(C5CC=C7C6CCC(C7(C)C)OC8C(C(C(C(O8)COC9C(C(C(C(O9)CO)O)O)O)O)O)O)C)O)C)C

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (77.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

In vitro
Mogroside V possesses tumor growth inhibitory activity in in vitro and in vivo models of pancreatic cancer by promoting apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells), which may in part be mediated through regulating the STAT3 signaling pathway. This compound inhibits the proliferation of pancreatic cancer cells and other tumor cell types in a dose- and time-dependent manner, and shows very little cytotoxicity against the non-tumorigenic epithelial cell line L02. It inhibits the downstream targets of the STAT3 pathway that promote cell proliferation (CCND1, CCNE1 and CDK2), while also upregulating cell cycle inhibitors (CDKN1A and CDKN1B)[1].
In vivo
Mogroside V treatment promotes apoptosis of pancreatic cancer cells in the xenograft tumors. This compound treatment significantly reduces the expression of CD31-labeled blood vessels and of the pro-angiogenic factor vascular endothelial growth factor in the xenografts, indicating that it might limit the growth of pancreatic tumors by inhibiting angiogenesis and reducing vascular density. This chemical treatment inhibits tumor cell growth, induces apoptosis and causes tumor regression[1].
References

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