Isoquercitrin

Catalog No.S3842 Synonyms: Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside

Isoquercitrin Chemical Structure

Molecular Weight(MW): 464.38

Isoquercitrin, a flavonoid compound with anticancer activity isolated from Bidens bipinnata L, is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation.

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Biological Activity

Description Isoquercitrin, a flavonoid compound with anticancer activity isolated from Bidens bipinnata L, is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation.
Targets
Wnt/β-catenin [1]
()
In vitro

Isoquercitrin exerts inhibitory effect on Wnt/β-catenin signaling and no toxic effects on colon cancer cell lines. It supresses the proliferation of colon cancer cells but does not affect non-tumoral colon cells. Isoquercitrin inhibits cell migration in colon cancer cells, but has also no apparent effect on the non-tumor colon cells. Isoquercitrin inhibits the signaling downstream of β-catenin nuclear translocation as isoquercitrin reverses the effect of β-catenin S33A, which cannot be phosphorylated and avoids degradation[1].

In vivo Isoquercitrin treatment significantly affects Xenopus embryo development, most likely by disturbing axial patterning. Isoquercitrin affects canonical Wnt signaling downstream of β-Catenin nucleus translocation[1]. In animals receiving isoquercitrin, eosinophil counts are lower in the bronchoalveolar lavage fluid (BALF), blood and lung pa-renchyma. Neutrophil counts in blood and IL-5 levels in lung homogenate are lower in isoquercitrin-treated mice. No alterations in mononuclear cell numbers are observed. Isoquercitrin also demonstrates anti-asthmatic activity by inhibiting of carbachol- and leukotriene D4-induced contraction in guinea pig airways[2].

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: HCT-116 cells
  • Concentrations: 75 and 150 μM
  • Incubation Time: 24 h
  • Method: HCT-116 cells are treated with flavonoid isoquercitrin for 24 h at concentrations of 75 and 150 μM. DMSO (used as a vehicle to solubilize the flavonoids) is added to control cultures at 1% v/v. To stimulate the Wnt pathway, cells are treated with Wnt3a-conditioned medium (CM) for 6 h at 25% of conditioned medium. Cells are co-treated with Wnt3a-CM and isoquercitrin for 6 h at 75 or 150 μM.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: a murine model of asthma (Female BALB/c mice)
  • Formulation: propylene glycol:water, 1:1
  • Dosages: 15 mg/kg
  • Administration: by oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 92 mg/mL (198.11 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 464.38
Formula

C21H20O12

CAS No. 482-35-9
Storage powder
in solvent
Synonyms Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02818699 Recruiting Overweight|Obese Tufts University August 1 2016 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID