Sophocarpine

Catalog No.S2405

For research use only.

Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.

Sophocarpine Chemical Structure

CAS No. 6483-15-4

Selleck's Sophocarpine has been cited by 4 Publications

Purity & Quality Control

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Biological Activity

Description Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
In vitro

Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. [1] Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. [2] In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. [3]

In vivo Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. [1] LD50: Mice 63.94mg/kg (i.v.) [4]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 49 mg/mL
(198.9 mM)
Ethanol 49 mg/mL
(198.9 mM)
Water 6 mg/mL
(24.35 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 246.35
Formula

C15H22N2O

CAS No. 6483-15-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC2CN3C(CC=CC3=O)C4C2N(C1)CCC4

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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