Sophocarpine

Potassium Channel inhibitor

Home Transmembrane Transporters Potassium Channel inhibitor Sophocarpine

research use only

Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.

Sophocarpine Chemical Structure

Chemical Structure

Molecular Weight: 246.35

Purity & Quality Control

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Signaling Pathway

Potassium Channel Signaling Pathways

Potassium Channel Signaling Pathway

Mechanism of Action

In vitro
In vitro Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. [1] Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. [2] In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. [3]

In Vivo
In vivo Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. [1] LD50: Mice 63.94mg/kg (i.v.) [4]

References
  • https://pubmed.ncbi.nlm.nih.gov/18775799/
  • https://pubmed.ncbi.nlm.nih.gov/11933118/
  • https://pubmed.ncbi.nlm.nih.gov/18379053/

Chemical Information

Molecular Weight 246.35 Formula

C15H22N2O
CAS No. 6483-15-4 SDF Download SDF
Synonyms N/A
Smiles C1CC2CN3C(CC=CC3=O)C4C2N(C1)CCC4

Storage and Stability

Storage (From the date of receipt)

In vitro
Batch:

DMSO : 49 mg/mL ( (198.9 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 49 mg/mL

Water : 6 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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