For research use only.
Catalog No.S9827 Synonyms: IA, IAM, 2-Iodoacetamide
CAS No. 144-48-9
Iodoacetamide (IA, IAM, 2-Iodoacetamide) is an alkylating agent that is commonly used for alkylation of cysteine during sample preparation for proteomics.
Purity & Quality Control
|Description||Iodoacetamide (IA, IAM, 2-Iodoacetamide) is an alkylating agent that is commonly used for alkylation of cysteine during sample preparation for proteomics.|
A multiple cleavage cascade mechanism is partially utilized to produce virus structural proteins. In infected cells, the largest viral induced protein obtained has a molecular weight of 144,000. Pretreatment of the infected cells with iodoacetamide before pulsing with 35S-methionine results in the appearance of two polypeptides of molecular weights 205,000 and 190,000. Other changes occur in viral protein precursors in the presence of iodoacetamide.
Iodoacetamide induces a concentration-dependent weight loss and reduces water intake in both species (Wistar rats and CD1, C57Bl/6J mice). Iodoacetamide induces gastritis in rats.
|In vitro||DMSO||40 mg/mL (216.26 mM)|
|Water||40 mg/mL (216.26 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||IA, IAM, 2-Iodoacetamide|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03948984||Not yet recruiting||Behavioral: Therapeutic Music Session||Anxiety|Pain|Critical Illness|Relaxation||Vanderbilt University Medical Center||July 2022||Not Applicable|
|NCT05016960||Not yet recruiting||Behavioral: Sleep-SMART||Insomnia|Mild Cognitive Impairment||VA Office of Research and Development||January 4 2022||Not Applicable|
|NCT04999436||Not yet recruiting||Behavioral: APOL1 Counseling Training Program||Chronic Kidney Diseases|Genetic Predisposition||Northwestern University|Georgetown University||December 2021||Not Applicable|
|NCT04890548||Not yet recruiting||Drug: AZD3427||Heart Failure||AstraZeneca|Parexel||October 4 2021||Phase 1|
|NCT04965363||Not yet recruiting||--||Internet Addiction|Internet Gaming Disorder||Assiut University||October 1 2021||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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