Indole-3-acetic acid

Catalog No.S4799 Synonyms: indolylacetic acid, 1H-Indole-3-acetic acid, indoleacetic acid, heteroauxin, IAA

For research use only.

Indole-3-acetic acid (indolylacetic acid, 1H-Indole-3-acetic acid, indoleacetic acid, heteroauxin, IAA) is the most common plant hormone of the auxin class and it regulates various aspects of plant growth and development.

Indole-3-acetic acid Chemical Structure

CAS No. 87-51-4

Purity & Quality Control

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Biological Activity

Description Indole-3-acetic acid (indolylacetic acid, 1H-Indole-3-acetic acid, indoleacetic acid, heteroauxin, IAA) is the most common plant hormone of the auxin class and it regulates various aspects of plant growth and development.
In vitro

Indole-3-acetic acid (IAA) induces cytotoxicity in fibroblasts, neutrophils, and several cancer lineages in vitro[1].

In vivo IAA administration in pregnant rats during days 12-14 might selectively affect the S phase neurons and lead to their apoptosis in the neuroepithelium. It induces microencephaly in rats[1].

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Pathogen-free Wistar Hannover GALAS rats
  • Dosages: 500 mg/kg and 1000 mg/kg
  • Administration: orally

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 175.18
Formula

C10H9NO2

CAS No. 87-51-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C2C(=C1)C(=CN2)CC(=O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05351333 Not yet recruiting Other: placebo Spinal Cord Injuries|Polytrauma|Burns Spaulding Rehabilitation Hospital|National Institute on Drug Abuse (NIDA) July 1 2022 Not Applicable
NCT05194358 Recruiting Drug: Stabilized Isoamyl Nitrite (SIAN) Cyanide Poisoning Emergent BioSolutions|Department of Health and Human Services December 21 2021 Phase 1
NCT04509791 Recruiting Drug: Anti-Human Thymocyte Immunoglobulin Rabbit Diabetes Mellitus Type 1 Universitaire Ziekenhuizen Leuven November 24 2020 Phase 2
NCT04309019 Completed -- Constipation|Inflammation Tungs'' Taichung Metroharbour Hospital March 10 2020 --
NCT04117191 Completed Dietary Supplement: Doctor''s Best L-Tryptophan Healthy|Chronic Kidney Diseases Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation October 1 2019 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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