Glycyrrhizin (NSC 167409)

Catalog No.S2302

For research use only.

Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).

Glycyrrhizin (NSC 167409) Chemical Structure

CAS No. 1405-86-3

Selleck's Glycyrrhizin (NSC 167409) has been cited by 23 publications

Purity & Quality Control

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Biological Activity

Description Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).
Targets
11 beta-hydroxysteroid dehydrogenase [1] HMGB1 [2]
()
MAO [4]
(Cell-free)
0.16 μM
In vitro

Glycyrrhizin inhibits monoamine oxidase (MAO) with the IC50 value of 0.16 μM[4].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 M4DzOmZ2dmO2aX;uJIF{e2G7 NF3VWFJKdmirYnn0bY9vKG:oIHj1cYFvKG2rY4Lvd49u[WxiMUHi[ZRiNUiVREKg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{Bkd264ZYLzbY9vKG:oIGuzTH1kd3K2aYPvcoUhfG9iW{PIYYNwenSrc3;sJIJ6KHOlaX70bYxt[XSrb36gdJJwgGmvaYT5JIF{e2G7LDDJR|UxRTBwMECx{txONg>? NFnPTGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW2OFExQCd-MUm1OlQyODh:L3G+
HEK293 NHfhN4pHfW6ldHnvckBie3OjeR?= NFzGR2pKdmirYnn0bY9vKG:oIH3veZNmKG2rY4Lvd49u[WxiMUHi[ZRiNUiVREGg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{Bkd264ZYLzbY9vKG:oIGuzTH1kd3K2aYPvcoUhfG9iW{PIYYNwenSrc3;sJIJ6KHOlaX70bYxt[XSrb36gdJJwgGmvaYT5JIF{e2G7LDDJR|UxRTBwMEC4{txONg>? NI\mUlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW2OFExQCd-MUm1OlQyODh:L3G+
HEK293 NILoPVRHfW6ldHnvckBie3OjeR?= NHvxb5VKdmirYnn0bY9vKG:oIHj1cYFvKG2rY4Lvd49u[WxiMUHi[ZRiNUiVREGg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDhd5Nme3OnZDDhd{Bkd264ZYLzbY9vKG:oIGuzTH1kd3K2aYPvcoUhfG9iW{PIYYNwenSrc3;sJIJ6KHOlaX70bYxt[XSrb36gdJJwgGmvaYT5JIF{e2G7LDDJR|UxRTBwMEJOwG0v NIDnSXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW2OFExQCd-MUm1OlQyODh:L3G+
HEK293 M{TXe2Z2dmO2aX;uJIF{e2G7 M{jwRWlvcGmkaYTpc44hd2ZibX;1d4UhdGm4ZYKgcYlkem:|b33lJFEy[mW2YVjTSFEh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bie3Onc4Pl[EBieyClb372[ZJ{cW:wIH;mJHs{UF2lb4L0bZNwdmViaX70c{BcO0ifY3;yeIl{d2xiYomgd4NqdnSrbHzheIlwdiCycn;4bY1qfHliYYPzZZktKEmFNUC9NE4xOTYQvF2u NVfK[mhMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1O|QxPTZpPkG5OVc1ODV4PD;hQi=>
HEK293 NYDvfXFuTnWwY4Tpc44h[XO|YYm= MX3Jcohq[mm2aX;uJI9nKGi3bXHuJFEy[mW2YT3IV2QzKGW6cILld5Nm\CCrbjDoeY1idiCKRVuyPVMh[2WubIOgZZN{\XO|ZXSgZZMh[2:wdnXyd4lwdiCxZjDbN2he[2:{dHnzc45mKHSxIGuzTH1kd3K2aYPvcEBjgSC|Y3nueIltdGG2aX;uJJBzd3irbXn0fUBie3OjeTygTWM2OD1yLkCwNFfPxE1w MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF2OEK0NUc,OjJzNEiyOFE9N2F-
HEK293 MYTGeY5kfGmxbjDhd5NigQ>? NFXJbYpKdmirYnn0bY9vKG:oIHj1cYFvKDFzYnX0ZU1JW0RzIHX4dJJme3OnZDDpckBpfW2jbjDISWszQTNiY3XscJMh[XO|ZYPz[YQh[XNiY3;ueoVze2mxbjDv[kBcO0ifY3;yeIl{d26nIITvJHs{UF2lb4L0bZNwdCCkeTDzZ4lvfGmubHH0bY9vKHC{b4jpcYl1gSCjc4PhfUwhUUN3ME2wMlAyQDcQvF2u MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF2OEK0NUc,OjJzNEiyOFE9N2F-
HEK293 M4q1WWZ2dmO2aX;uJIF{e2G7 MWDJcohq[mm2aX;uJI9nKG2xdYPlJFEy[mW2YT3IV2QyKGW6cILld5Nm\CCrbjDoeY1idiCKRVuyPVMh[2WubIOgZZN{\XO|ZXSgZZMh[2:wdnXyd4lwdiCxZjDbN2he[2:{dHnzc45mKHSxIGuzTH1kd3K2aYPvcEBjgSC|Y3nueIltdGG2aX;uJJBzd3irbXn0fUBie3OjeTygTWM2OD1yLkCyPVXPxE1w NGXqVVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG0PFI1OSd-MkKxOFgzPDF:L3G+
HEK293 NF3MWXJHfW6ldHnvckBie3OjeR?= NYTIWVBLUW6qaXLpeIlwdiCxZjDoeY1idiBzMXLleIEuUFOGMjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJINwdn[ncoPpc44hd2ZiW{PIYYNwenSrc3;u[UBqdnSxIGuzTH1kd3K2aYPvcEBjgSC|Y3nueIltdGG2aX;uJJBzd3irbXn0fUBie3OjeTygTWM2OD1yLkCwNFTPxE1w M{XWd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{[wOlM6Lz5{MkO2NFY{QTxxYU6=
HEK293 MorsSpVv[3Srb36gZZN{[Xl? MnzzTY5pcWKrdHnvckBw\iCvb4Xz[UAyOWKndHGtTHNFOSCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHPvcpZmenOrb36gc4YhYzOKXXPvdpRqe2:wZTDpcpRwKFt|SG3jc5J1cXOxbDDifUB{[2mwdHnscIF1cW:wIIDyc5hqdWm2eTDhd5NigSxiSVO1NF0xNjByM988UU4> NWTMUHBRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzOlA3OzlpPkKyN|YxPjN7PD;hQi=>
HEK293 M3nzUmZ2dmO2aX;uJIF{e2G7 M3zQSGlvcGmkaYTpc44hd2ZiaIXtZY4hOTGkZYThMWhUTDFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDjc453\XK|aX;uJI9nKFt|SG3jc5J1cXOxbnWgbY51dyCdM1jdZ49zfGm|b3ygZpkhe2OrboTpcIxifGmxbjDwdo95cW2rdImgZZN{[XluIFnDOVA:OC5yMEdOwG0v MmXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|NkC2N|koRjJ{M{[wOlM6RC:jPh?=
HEK293 NVHiRYdjTnWwY4Tpc44h[XO|YYm= Ml7EOlAhdWmwcx?= NGXxOFJKdmirYnn0bY9vKG:oIHj1cYFvKDFzYnX0ZU1JW0R{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgX|NJZWOxcoTpd49tKHC{b3T1Z5Rqd25iYX\0[ZIhPjBibXnud{BjgSCVUFGsJGVEPTB;MD6wNFHPxE1w M3rOT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NESwOlI2Lz5{MkS0NFYzPTxxYU6=
HEK293 NGqxe2FHfW6ldHnvckBie3OjeR?= MlrsOlAhdWmwcx?= M4XMPWlvcGmkaYTpc44hd2ZibX;1d4UhOTGkZYThMWhUTDFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDbN2he[2:{dHnzc4wheHKxZIXjeIlwdiCjZoTldkA3OCCvaX7zJIJ6KFOSQTygSWM2OD1yLkCwPO69VS5? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR2ME[yOUc,OjJ2NEC2NlU9N2F-
HEK293 M3rLfWZ2dmO2aX;uJIF{e2G7 MYG2NEBucW6| M3Kx[GlvcGmkaYTpc44hd2ZiaIXtZY4hOTGkZYThMWhUTDFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDbN2he[2:{dHnzc4wheHKxZIXjeIlwdiCjZoTldkA3OCCvaX7zJIJ6KFOSQTygSWM2OD1yLkCx{txONg>? NEDXUWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS0NFYzPSd-MkK0OFA3OjV:L3G+
MDCK NF;o[GREgXSxdH;4bYNqfHliYYPzZZk> MXG0PEBpenN? NFnG[m5EgXSxdH;4bYNqfHliYXfhbY5{fCCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUG1MlLPxE1w MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPThyMUmzN{c,OjV6MEG5N|M9N2F-
MDCK M1XwO2FvfGm4aYLhcEBie3OjeR?= NGi0R5VCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBqdm[udXXufoEhSSC4aYL1d{ApSS:FYXzp[o9zdmmjL{C3M|A6MEhzTkGpLUBx\G1yOTDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJJZqenW|IITpeIVzKGK7IHjlcYFo\2y3dHnuZZRqd25iYYPzZZkhcW5icILld4Vv[2Vib3[gNUUhe3W|cHXud4lwdiCxZjDjbIlkc2WwIHXyfZRpem:leYTld{whS0R3ME20O{42|ryPLh?= Ml3LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MEG5N|MoRjJ3OECxPVM{RC:jPh?=
MDCK NYnYWndlSW62aY\pdoFtKGG|c3H5 MVSxOUBucW6| NEG1VGZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBKdm[udXXufoEhSSC4aYL1d{BCN1eVTj:zN{hJOU5zKTDpcoZm[3SnZDDpckBld2diTVTDT{Bk\WyuczDwdoVqdmO3YnH0[YQhf2m2aDD2bZJ2eyCob4KgNVUhdWmwczDmc4xtd3enZDDifUBk\WyuczDh[IRqfGmxbjDt[YF{fXKnZDDheEA{PiCqcoOgdI9{fCCrbn\lZ5Rqd25uIFnDOVA:OzlwNt88UU4> MmS2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6NEGxOlgoRjJ4OESxNVY5RC:jPh?=
Raji NH7IdXVCdnSrdnnyZYwh[XO|YYm= MYHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDFRnYhcW6oZXP0[YQhcW5iaIXtZY4hWmGsaTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hfmm{YXyg[4Vvd22nIHPvdJkhdnWvYnXyd{BjgSCzUmStVGNTKGGwYXz5d4l{NCCHQ{WwQVMx|ryPLh?= NIX2Nmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEezNVQxOSd-M{C3N|E1ODF:L3G+
Vero E6 NX;aN4VvSW62aY\pdoFtKGG|c3H5 NIq5dIk6PiCqcoO= NGjmNFNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBFTU6YMjCxOlY5OSCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIFW2JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTvdpkhemG2ZTDv[kBPWzSEIIDvd4l1cX[nIHPlcIx{KG2nYYP1doVlKGGodHXyJFk3KGi{czDpcoN2[mG2aX;uJIJ6KESDUFmgd5RicW6rbnegZoF{\WRiaX3teY5w\my3b4Lld4NmdmOnIH3leIhw\CxiSVO1NF05NjIQvF2u NEXBZmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUWxPVM4PSd-M{G1NVk{PzV:L3G+
Vero E6 NGTuS4lCdnSrdnnyZYwh[XO|YYm= MYOxNEB2VQ>? NYnrd2kzQTZiaILz NFf2UGVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBFTU6YMjCxOlY5OSCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIFW2JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{BqdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIF1KDFyIIXNJI1m[XO3cnXkJIFnfGW{IEm2JIhzeyCkeTDy[ZZmenOnIIDoZZNmKGOxboTyZZN1KG2rY4Lvd4NweHl? NUjicY9qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1NVk{PzVpPkOxOVE6Ozd3PD;hQi=>
RAW264.7 MXrBcpRqNWmwZnzhcY1ifG:{eTDhd5NigQ>? MoLWOFAhfU1? NIrz[mUzKGi{cx?= MYPBcpRqNWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIF7PJJBzd2S3Y4Tpc44h[XRiNECgeW0heHKnaX7jeYJifGWmIH\vdkAzKGi{czDmc4xtd3enZDDifUBNWFNiYXTkbZRqd25ibXXhd5Vz\WRiYX\0[ZIhOjBiaILzJIJ6KEe{aXXzd{Bie3OjeTDy[YxifGm4ZTD0c{Bkd262cn;s M4Cx[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OTZ6Nz:nQmNpTU2ETEyvZV4>
RAW264.7 MYLBcpRqNWmwZnzhcY1ifG:{eTDhd5NigQ>? NVzU[XhEOTBidH:gOFAhfU1? NYPtSnVYOiCqcoO= MnfiRY51cS2rbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hdW:3c3WgVmFYOjZ2LkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDJUE03KHC{b3T1Z5Rqd25iYYSgNVAhfG9iNECgeW0heHKnaX7jeYJifGWmIH\vdkAzKGi{czDmc4xtd3enZDDifUBNWFNiYXTkbZRqd25ibXXhd5Vz\WRiYX\0[ZIhOjBiaILzJIJ6KEWOSWPB M{LYclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQ1OTZ6Nz:nQmNpTU2ETEyvZV4>
In vivo Glycyrrhizin increases the levels of monoamines like epinephrine and dopamine in brains of mice[3].

Protocol (from reference)

Animal Research:

[3]

  • Animal Models: Swiss albino mice
  • Dosages: 1.5, 3.0 and 6.0 mg/kg
  • Administration: i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(121.51 mM)
Ethanol 100 mg/mL
(121.51 mM)
Water Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 822.93
Formula

C42H62O16

CAS No. 1405-86-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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