Glycyrrhizin (NSC 167409)

For research use only.

Catalog No.S2302

19 publications

Glycyrrhizin (NSC 167409) Chemical Structure

CAS No. 1405-86-3

Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).

Selleck's Glycyrrhizin (NSC 167409) has been cited by 19 publications

Purity & Quality Control

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Biological Activity

Description Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).
Targets
11 beta-hydroxysteroid dehydrogenase [1] HMGB1 [2]
()
MAO [4]
(Cell-free)
0.16 μM
In vitro

Glycyrrhizin inhibits monoamine oxidase (MAO) with the IC50 value of 0.16 μM[4].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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HEK293 M4jZUGZ2dmO2aX;uJIF{e2G7 MVHJcohq[mm2aX;uJI9nKG2xdYPlJI1q[3Kxc3;tZYwhOTGkZYThMWhUTDFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDjc453\XK|aX;uJI9nKFt|SG3jc5J1cXOxbnWgeI8hYzOKXXPvdpRqe2:uIHL5JJNkcW62aXzsZZRqd25icILvfIlucXS7IHHzd4F6NCCLQ{WwQVAvODB6zszNMi=> MlHwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3NkSxNFgoRjF7NU[0NVA5RC:jPh?=
HEK293 NI\0W29HfW6ldHnvckBie3OjeR?= NUPoc|lmUW6qaXLpeIlwdiCxZjDoeY1idiCvaXPyc5NwdWGuIEGxZoV1[S2KU1SxJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZZN{\XO|ZXSgZZMh[2:wdnXyd4lwdiCxZjDbN2he[2:{dHnzc45mKHSxIGuzTH1kd3K2aYPvcEBjgSC|Y3nueIltdGG2aX;uJJBzd3irbXn0fUBie3OjeTygTWM2OD1yLkCx{txONg>? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV4NEGwPEc,OTl3NkSxNFg9N2F-
HEK293 Mm\SSpVv[3Srb36gZZN{[Xl? NXvnVWZFUW6qaXLpeIlwdiCxZjDtc5V{\SCuaY\ldkBucWO{b4PvcYUhOTGkZYThTHNFOSCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHPvcpZmenOrb36gc4YhYzOKXXPvdpRqe2:wZTDpcpRwKFt|SG3jc5J1cXOxbDDifUB{[2mwdHnscIF1cW:wIIDyc5hqdWm2eTDhd5NigSxiSVO1NF0xNjBzNd88UU4> NFPiNJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW3OFA2Pid-MUm1O|QxPTZ:L3G+
HEK293 MVfGeY5kfGmxbjDhd5NigQ>? NU\BUXRiUW6qaXLpeIlwdiCxZjDoeY1idiBzMXLleIEuUFOGMjDlfJBz\XO|ZXSgbY4hcHWvYX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHPvcpZmenOrb36gc4YhYzOKXXPvdpRqe2:wZTD0c{BcO0ifY3;yeIl{d2xiYomgd4NqdnSrbHzheIlwdiCycn;4bY1qfHliYYPzZZktKEmFNUC9NE4xODB5zszNMi=> NFfjNYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG0PFI1OSd-MkKxOFgzPDF:L3G+
HEK293 MYnGeY5kfGmxbjDhd5NigQ>? M4\SUWlvcGmkaYTpc44hd2ZiaIXtZY4hOTGkZYThMWhUTDFiZYjwdoV{e2WmIHnuJIh2dWGwIFjFT|I6OyClZXzsd{Bie3Onc4Pl[EBieyClb372[ZJ{cW:wIH;mJHs{UF2lb4L0bZNwdmVidH:gX|NJZWOxcoTpd49tKGK7IIPjbY51cWyuYYTpc44heHKxeHntbZR6KGG|c3H5MEBKSzVyPUCuNFE5Ps7:TT6= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF2OEK0NUc,OjJzNEiyOFE9N2F-
HEK293 Mk\2SpVv[3Srb36gZZN{[Xl? NEDUSGZKdmirYnn0bY9vKG:oIH3veZNmKDFzYnX0ZU1JW0RzIHX4dJJme3OnZDDpckBpfW2jbjDISWszQTNiY3XscJMh[XO|ZYPz[YQh[XNiY3;ueoVze2mxbjDv[kBcO0ifY3;yeIl{d26nIITvJHs{UF2lb4L0bZNwdCCkeTDzZ4lvfGmubHH0bY9vKHC{b4jpcYl1gSCjc4PhfUwhUUN3ME2wMlAzQTYQvF2u NXj6S4JwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOFgzPDFpPkKyNVQ5OjRzPD;hQi=>
HEK293 NEnheWFHfW6ldHnvckBie3OjeR?= NH\CSmVKdmirYnn0bY9vKG:oIHj1cYFvKDFzYnX0ZU1JW0R{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ49vfmW{c3nvckBw\iCdM1jdZ49zfGm|b37lJIlvfG9iW{PIYYNwenSrc3;sJIJ6KHOlaX70bYxt[XSrb36gdJJwgGmvaYT5JIF{e2G7LDDJR|UxRTBwMECwOO69VS5? M1HKbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{[wOlM6Lz5{MkO2NFY{QTxxYU6=
HEK293 M{Wwc2Z2dmO2aX;uJIF{e2G7 NEDMd4xKdmirYnn0bY9vKG:oIH3veZNmKDFzYnX0ZU1JW0RzIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ49vfmW{c3nvckBw\iCdM1jdZ49zfGm|b37lJIlvfG9iW{PIYYNwenSrc3;sJIJ6KHOlaX70bYxt[XSrb36gdJJwgGmvaYT5JIF{e2G7LDDJR|UxRTBwMECz{txONg>? NHnuOpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkO2NFY{QSd-MkKzOlA3Ozl:L3G+
HEK293 NYjQZmM2TnWwY4Tpc44h[XO|YYm= M17WOWlvcGmkaYTpc44hd2ZiaIXtZY4hOTGkZYThMWhUTDFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDjc453\XK|aX;uJI9nKFt|SG3jc5J1cXOxbnWgbY51dyCdM1jdZ49zfGm|b3ygZpkhe2OrboTpcIxifGmxbjDwdo95cW2rdImgZZN{[XluIFnDOVA:OC5yMEdOwG0v M1LmUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{[wOlM6Lz5{MkO2NFY{QTxxYU6=
HEK293 NVzRZoJzTnWwY4Tpc44h[XO|YYm= MlXxOlAhdWmwcx?= NY[zSZlZUW6qaXLpeIlwdiCxZjDoeY1idiBzMXLleIEuUFOGMjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJHs{UF2lb4L0bZNwdCCycn;keYN1cW:wIHHmeIVzKDZyIH3pcpMh[nliU2DBMEBGSzVyPUCuNFAy|ryPLh?= MmrEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NEC2NlUoRjJ{NESwOlI2RC:jPh?=
HEK293 NX\2d5BtTnWwY4Tpc44h[XO|YYm= MUO2NEBucW6| M4O1NGlvcGmkaYTpc44hd2ZibX;1d4UhOTGkZYThMWhUTDFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDbN2he[2:{dHnzc4wheHKxZIXjeIlwdiCjZoTldkA3OCCvaX7zJIJ6KFOSQTygSWM2OD1yLkCwPO69VS5? M2nVSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NESwOlI2Lz5{MkS0NFYzPTxxYU6=
HEK293 MlPtSpVv[3Srb36gZZN{[Xl? Mlj3OlAhdWmwcx?= NFPTXHNKdmirYnn0bY9vKG:oIHj1cYFvKDFzYnX0ZU1JW0RzIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgX|NJZWOxcoTpd49tKHC{b3T1Z5Rqd25iYX\0[ZIhPjBibXnud{BjgSCVUFGsJGVEPTB;MD6wNe69VS5? M4fu[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NESwOlI2Lz5{MkS0NFYzPTxxYU6=
MDCK MYDDfZRwfG:6aXPpeJkh[XO|YYm= MVm0PEBpenN? M3vETmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQ1ugZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGVEPTB;MUWuNu69VS5? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPThyMUmzN{c,OjV6MEG5N|M9N2F-
MDCK NWj3S5BbSW62aY\pdoFtKGG|c3H5 NUS3eI9iSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcW6obIXlcppiKEFidnnyeZMhMEFxQ3HsbYZwem6rYT:wO{8xQSiKMV6xLUkheGSvMEmgbY5n\WO2ZXSgbY4hVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckB3cXK3czD0bZRmeiCkeTDo[Y1i\2eudYTpcoF1cW:wIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFEmKHO3c4DlcpNqd25ib3[gZ4hq[2unbjDldpl1cHKxY4n0[ZMtKEOGNUC9OFcvPc7:TT6= M33jZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OECxPVM{Lz5{NUiwNVk{OzxxYU6=
MDCK MWHBcpRqfmm{YXygZZN{[Xl? MlLsNVUhdWmwcx?= M1X0UmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGlv\my3ZX76ZUBCKH[rcoXzJGEwX1OQL{OzLGgyVjFrIHnu[oVkfGWmIHnuJIRw\yCPRFPLJINmdGy|IIDy[Ylv[3WkYYTl[EB4cXSqII\pdpV{KG[xcjCxOUBucW6|IH\vcIxwf2WmIHL5JINmdGy|IHHk[Il1cW:wIH3lZZN2emWmIHH0JFM3KGi{czDwc5N1KGmwZnXjeIlwdixiSVO1NF0{QS54zszNMi=> NGj2d2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki0NVE3QCd-Mk[4OFEyPjh:L3G+
Raji MmnDRY51cX[rcnHsJIF{e2G7 M3P1dmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGVDXiCrbn\lZ5Rm\CCrbjDoeY1idiCUYXrpJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYLhcEBo\W6xbXWgZ49xgSCwdX3i[ZJ{KGK7IIHSWE1RS1JiYX7hcJl{cXNuIFXDOVA:OzEQvF2u Mn:wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB5M{G0NFEoRjNyN{OxOFAyRC:jPh?=
Vero E6 M1X1SWFvfGm4aYLhcEBie3OjeR?= MUK5OkBpenN? MlK4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgSGVPXjJiMU[2PFEhcW6oZXP0[YQhcW5iQX\ybYNidiCpcnXlckBud26tZYmgWoVzdyCHNjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2b4L5JJJifGVib3[gUnM1SiCyb4PpeIl3\SClZXzsd{Bu\WG|dYLl[EBi\nSncjC5OkBpenNiaX7jeYJifGmxbjDifUBFSVCLIIP0ZYlvcW6pIHLhd4VlKGmvbYXuc4ZtfW:{ZYPj[Y5k\SCvZYToc4QtKEmFNUC9PE4y|ryPLh?= MmjOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3MUmzO|UoRjNzNUG5N|c2RC:jPh?=
Vero E6 NXfGeINHSW62aY\pdoFtKGG|c3H5 NHTYcpEyOCC3TR?= M{nndlk3KGi{cx?= NHHPdY5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBFTU6YMjCxOlY5OSCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIFW2JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYL1d{BqdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JIF1KDFyIIXNJI1m[XO3cnXkJIFnfGW{IEm2JIhzeyCkeTDy[ZZmenOnIIDoZZNmKGOxboTyZZN1KG2rY4Lvd4NweHl? M{G4OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUG5N|c2Lz5|MUWxPVM4PTxxYU6=
RAW264.7 NXe4bYpvSW62aT3pcoZt[W2vYYTvdpkh[XO|YYm= MYC0NEB2VQ>? M1nX[VIhcHK| MXPBcpRqNWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIF7PJJBzd2S3Y4Tpc44h[XRiNECgeW0heHKnaX7jeYJifGWmIH\vdkAzKGi{czDmc4xtd3enZDDifUBNWFNiYXTkbZRqd25ibXXhd5Vz\WRiYX\0[ZIhOjBiaILzJIJ6KEe{aXXzd{Bie3OjeTDy[YxifGm4ZTD0c{Bkd262cn;s MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0OFE3QDdxJ{7DbGVOSkx:L3G+
RAW264.7 M1Xo[mFvfGlvaX7mcIFudWG2b4L5JIF{e2G7 Ml65NVAhfG9iNECgeW0> MXyyJIhzew>? MoXIRY51cS2rbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hdW:3c3WgVmFYOjZ2LkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDJUE03KHC{b3T1Z5Rqd25iYYSgNVAhfG9iNECgeW0heHKnaX7jeYJifGWmIH\vdkAzKGi{czDmc4xtd3enZDDifUBNWFNiYXTkbZRqd25ibXXhd5Vz\WRiYX\0[ZIhOjBiaILzJIJ6KEWOSWPB NFvpb2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1PDF4OEevK|5EcEWPQly8M4E,

... Click to View More Cell Line Experimental Data

In vivo Glycyrrhizin increases the levels of monoamines like epinephrine and dopamine in brains of mice[3].

Protocol

Animal Research:

[3]

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  • Animal Models: Swiss albino mice
  • Dosages: 1.5, 3.0 and 6.0 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (121.51 mM)
Ethanol 100 mg/mL (121.51 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 822.93
Formula

C42H62O16

CAS No. 1405-86-3
Storage powder
in solvent
Synonyms N/A
Smiles CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID