Hypericin

Catalog No.S3273 Synonyms: Hyp, HY

For research use only.

Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).

Hypericin Chemical Structure

CAS No. 548-04-9

Selleck's Hypericin has been cited by 1 Publication

Purity & Quality Control

Choose Selective MAO Inhibitors

Other MAO Products

Biological Activity

Description Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).
Targets
MAO [1] PKC [1] dopamine-beta-hydroxylase [1] Reverse transcriptase [1] Telomerase [1] Click to View More Targets

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 504.44
Formula

C30H16O8

CAS No. 548-04-9
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05013567 Not yet recruiting Drug: Ibuprofen gel|Other: Placebo Musculoskeletal Pain|Acute Pain|Stretch|Sprains Brainfarma Industria Química e Farmacêutica S/A August 2022 Phase 3
NCT05113537 Recruiting Drug: Abemaciclib|Drug: Lutetium Lu 177-PSMA-617 Castration-Resistant Prostate Carcinoma|Metastatic Prostate Adenocarcinoma|Stage IV Prostate Cancer AJCC v8|Stage IVA Prostate Cancer AJCC v8|Stage IVB Prostate Cancer AJCC v8|Metastatic Castration-resistant Prostate Carcinoma|Metastatic Castration-resistant Prostate Cancer Vadim S Koshkin|Prostate Cancer Foundation|Eli Lilly and Company|University of California San Francisco July 8 2022 Phase 1|Phase 2
NCT05362708 Not yet recruiting Device: Clinical - Hypnosis with VR (VRH) Cancer University of Liege|Oncomfort|Biowin May 1 2022 Not Applicable
NCT05312086 Not yet recruiting Other: MRI Muscle Weakness|XLH Assistance Publique - Hôpitaux de Paris April 15 2022 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Hypericin | Hypericin supplier | purchase Hypericin | Hypericin cost | Hypericin manufacturer | order Hypericin | Hypericin distributor