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Goitrin Antiviral modulator

Name: Goitrin
Brand: Selleck Chemicals
SKU: S3251
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3251

Goitrin (DL-Goitrin, (R, S)-Goitrin, R,S-goitrin) is one of the main constituent of Radix isatidis (Banlangen) which is widely used as a traditional Chinese medicine for treating fever and removing toxic heat. This compound exhibits antiviral and antiendotoxin activity.

Chemical Structure

Molecular Weight: 129.18

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Quality Control

Batch: S325101 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.94%

Cited in Nature Medicine for its top-tier quality
COA
SDS/MSDS
Datasheet

99.94

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection Antioxidant COX
Other Antiviral Inhibitors	Moroxydine HCl Aloperine GS-441524 NGI-1 Harringtonine Oleanolic Acid LL-37 acetate U-18666A Aloin B Lanatoside C

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (774.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.300mg/ml (10.06mM)	Taking the 1 mL working solution as an example, add 50 μL of 26 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.650mg/ml (5.03mM)	Taking the 1 mL working solution as an example, add 50 μL of 13 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	129.18	Formula	C₅H₇NOS	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	13190-34-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	DL-Goitrin, (R, S)-Goitrin, R,S-goitrin			SMILES	C=CC1CNC(=S)O1

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/28894621/ [2] https://pubmed.ncbi.nlm.nih.gov/31132308/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05367401	Withdrawn	Myelodysplastic Syndromes\|Acute Myeloid Leukemia	Novartis Pharmaceuticals\|Novartis	2024-12-20	Phase 1\|Phase 2
NCT06273527	Not yet recruiting	Anxiety Disorders\|Depression\|Post Traumatic Stress Disorder	University of California San Diego	2024-11	Not Applicable
NCT06091176	Not yet recruiting	Essential Hypertension\|Primary Hypertension	Newel Health SRL	2024-11-01	Not Applicable
NCT06005649	Not yet recruiting	Non-hodgkin Lymphoma	Juventas Cell Therapy Ltd.	2024-08-31	Phase 1\|Phase 2

Tech Support

Handling Instructions

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