Licochalcone D

For research use only.

Catalog No.S6899 Synonyms: Lico D, LCD, LD

Licochalcone D Chemical Structure

CAS No. 144506-15-0

Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. Licochalcone D inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone D inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage.

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Biological Activity

Description Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. Licochalcone D inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone D inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage.
Targets
NF-κB [1]
()
JAK2 [2]
()
EGFR [3]
()
Met [3]
()
Caspase [3]
()

Protocol

References

Solubility (25°C)

In vitro DMSO 100 mg/mL (282.16 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 354.40
Formula

C21H22O5

CAS No. 144506-15-0
Storage powder
in solvent
Synonyms Lico D, LCD, LD

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04697810 Not yet recruiting Drug: Namodenoson|Drug: Placebo NASH - Nonalcoholic Steatohepatitis Can-Fite BioPharma August 15 2021 Phase 2
NCT04161118 Recruiting Drug: CTL019 Non Hodgkin Lymphoma University of Cologne|Novartis May 12 2021 Phase 2
NCT04786418 Not yet recruiting Other: Standard of care|Dietary Supplement: Low-calorie diet Obesity|NAFLD|Fatty Liver|Pre Diabetes|Metabolic Syndrome University of Liverpool|University of Surrey|Perspectum April 2021 Not Applicable

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NF-κB Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID