Home Protein Tyrosine Kinase NF-κB inhibitor Licochalcone D

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Licochalcone D NF-κB inhibitor

Cat.No.S6899

Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. This compound inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. It inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. This chemical also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage.
Licochalcone D NF-κB inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 354.40

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Quality Control

Batch: S689901 DMSO]100 mg/mL]false]Ethanol]20 mg/mL]false]Water]Insoluble]false Purity: 99.95%
99.95

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (282.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 354.40 Formula

C21H22O5

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 144506-15-0 -- Storage of Stock Solutions

Mechanism of Action

Targets/IC50/Ki
NF-κB
JAK2
EGFR
Met
Caspase
PARP
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06045416 Not yet recruiting
Lyme Disease|Borrelia Infections
University Children''s Hospital Zurich|Institute of Medical Microbiology University of Zurich Zurich Switzerland
 April 1 2024 --
NCT06003179 Not yet recruiting
Lymphoma Large B-Cell Diffuse
University Health Network Toronto
 April 2024 Phase 1
NCT06014762 Recruiting
Diffuse Large B Cell Lymphoma|Follicular Lymphoma|Mantle Cell Lymphoma|Marginal Zone Lymphoma|Primary Mediastinal Large B-cell Lymphoma (PMBCL)|Chronic Lymphocytic Leukemia
Poseida Therapeutics Inc.|Roche-Genentech
 April 2024 Phase 1
NCT06358859 Not yet recruiting
Cardiometabolic Risk Factors|Diabetes|High Blood Pressure|Obesity|Nutrition Security
Tufts University|National Institute on Minority Health and Health Disparities (NIMHD)|Tougaloo College Mississippi|Delta Health Center Mississippi|Reuben V. Anderson Center for Justice at Tougaloo
 April 2024 Not Applicable
NCT05559801 Not yet recruiting
Osteogenesis Imperfecta|Osteogenesis Imperfecta Type III
Emory University
 April 2024 Phase 1|Phase 2

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