Licochalcone D

Catalog No.S6899 Synonyms: Lico D, LCD, LD

For research use only.

Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. Licochalcone D inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone D inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage.

Licochalcone D Chemical Structure

CAS No. 144506-15-0

Purity & Quality Control

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Biological Activity

Description Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. Licochalcone D inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone D inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage.
Targets
NF-κB [1] JAK2 [2] EGFR [3] Met [3] Caspase [3] Click to View More Targets

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 354.40
Formula

C21H22O5

CAS No. 144506-15-0
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05458479 Not yet recruiting Drug: Fluoxetine Down Syndrome|Depression Massachusetts General Hospital August 2022 Phase 4
NCT05464368 Recruiting Drug: [18F]RO-948|Drug: 18F-MK6240|Drug: 18F-GTP1 Alzheimer Disease Washington University School of Medicine|Roche Pharma AG August 2022 Phase 1
NCT05235451 Recruiting Other: Human-Animal Interactions Animal-Human Bonding|Learning Problem|Child Development Vanderbilt University June 20 2022 Not Applicable
NCT05346315 Not yet recruiting Other: RDN Medical Nutrition Therapy Nutrition Disorders Academy of Nutrition and Dietetics May 2022 --
NCT05186688 Recruiting Behavioral: Braining Mental Disorder Region Stockholm|Karolinska Institutet March 2 2022 Not Applicable
NCT05094050 Recruiting Drug: ABBV-951 Parkinson''s Disease AbbVie January 18 2022 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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