Home PI3K/Akt/mTOR AMPK activator Trans-ferulic acid

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Trans-ferulic acid AMPK activator

Cat.No.E0653

Trans-ferulic acid is a potent activator of AMPK under high glucose condition.
Trans-ferulic acid AMPK activator Chemical Structure

Chemical Structure

Molecular Weight: 194.18

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Quality Control

Chemical Information, Storage & Stability

Molecular Weight 194.18 Formula

C10H10O4

 Storage (From the date of receipt) 2 years -20°C liquid
CAS No. 537-98-4 -- Storage of Stock Solutions

Solubility

In vitro
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In vivo
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Mechanism of Action

Targets/IC50/Ki
AMPK [1]
In vitro

Trans-ferulic acid can promote the activation of AMPK and the phosphorylation of acetyl-CoA carboxylase in hyperglycemia-induced human liver cells (HepG2) and rat skeletal muscle cells (L6). This compound reduces the level of intracellular reactive oxygen species (ROS) and nitric oxide (NO) induced by hyperglycemia and subsequently increases the level of glutathione.[2]
In vivo

TFA exhibits a potential protective effect againstf cisplatin induced testicular injury by inhibiting oxidative stress as well as TLR4/IRF3/INF-γ, P38-MAPK/NF-κB-p65/TNF-α, and JAK1/STAT-3/ERK1/2 inflammatory signaling pathways.[2]
References

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