Curcumol

Catalog No.S2407

For research use only.

Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.

Curcumol Chemical Structure

CAS No. 4871-97-0

Selleck's Curcumol has been cited by 5 Publications

Purity & Quality Control

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Biological Activity

Description Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.
Targets
JAK [2]
In vitro

Curcumol induced cell death in human lung adenocarcinoma (ASTC-a-1) cells by inducing G(2)/M phase arrest, nuclear fragmentation, phosphatidylserine externalization and a rapid translocation of Bax from cytosol into mitochondria. While, caspases are not involved in Curcumol-induced apoptosis. [1] Curcumol also benefits rheumatoid arthritis treatment through suppressing the fibroblast-like synoviocytes (FLS) proliferation and DNA synthesis. It attenuates PDGF-BB-induced Jak2 phosphorylation and downregulates STAT1 and STAT3 DNA-binding activities. [2]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 47 mg/mL
(198.85 mM)
Ethanol 47 mg/mL
(198.85 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 236.35
Formula

C15H24O2

CAS No. 4871-97-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1CCC2C13CC(C(O3)(CC2=C)O)C(C)C

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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