Home JAK/STAT JAK inhibitor Curcumol

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Curcumol JAK inhibitor

Cat.No.S2407

Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.
Curcumol JAK inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 236.35

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  • Purity >95%
  • Cited in Nature Medicine for its top-tier quality
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Chemical Information, Storage & Stability

Molecular Weight 236.35 Formula

C15H24O2

 Storage (From the date of receipt)
CAS No. 4871-97-0 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC1CCC2C13CC(C(O3)(CC2=C)O)C(C)C

Mechanism of Action

Targets/IC50/Ki
JAK
In vitro
Curcumol induced cell death in human lung adenocarcinoma (ASTC-a-1) cells by inducing G(2)/M phase arrest, nuclear fragmentation, phosphatidylserine externalization and a rapid translocation of Bax from cytosol into mitochondria. While, caspases are not involved in this compound-induced apoptosis. It also benefits rheumatoid arthritis treatment through suppressing the fibroblast-like synoviocytes (FLS) proliferation and DNA synthesis. This chemical attenuates PDGF-BB-induced Jak2 phosphorylation and downregulates STAT1 and STAT3 DNA-binding activities.
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