Lysionotin

Catalog No.S3877

For research use only.

Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities.

Lysionotin Chemical Structure

CAS No. 152743-19-6

Selleck's Lysionotin has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities.
In vitro

Lysionotin is an efficient inhibitor of α-toxin expression and shows significant protection against S. aureus in vitro and in vivo[1].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: A549 human lung epithelial cells
  • Concentrations: 0-16 μg/ml
  • Incubation Time: 5 h
  • Method: A549 human lung epithelial cells (ATCC CCL 185) are maintained in DMEM supplemented with 10% fetal serum at 37 ℃ and seeded in 96-well plates at a density of approximately 2 × 104 cells per well. Then, the cells are cultured with 200 μl of bacteria with various concentrations of lysionotin and incubated for 5 h at 37 ℃. For LDH assays, the supernatants from wells are assessed for LDH release with the Cytotoxicity Detection Kit.
Animal Research:[1]
  • Animal Models: 6- to 8-week-old female C57BL/6J mice
  • Dosages: 100 mg/kg
  • Administration: by hypodermic injection in the back skin

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 344.32
Formula

C18H16O7

CAS No. 152743-19-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C(=C3O2)OC)O)OC)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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