Lysionotin

Catalog No.S3877

Lysionotin Chemical Structure

Molecular Weight(MW): 344.32

Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities.

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Biological Activity

Description Lysionotin is a natural flavonoid predominantly found in fewflower lysionotus herbs and possesses many pharmacological properties, such as antibacterial, anti-inflammatory, antihypertensive, and free radical scavenging activities.
In vitro

Lysionotin is an efficient inhibitor of α-toxin expression and shows significant protection against S. aureus in vitro and in vivo[1].

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: A549 human lung epithelial cells
  • Concentrations: 0-16 μg/ml
  • Incubation Time: 5 h
  • Method: A549 human lung epithelial cells (ATCC CCL 185) are maintained in DMEM supplemented with 10% fetal serum at 37 ℃ and seeded in 96-well plates at a density of approximately 2 × 104 cells per well. Then, the cells are cultured with 200 μl of bacteria with various concentrations of lysionotin and incubated for 5 h at 37 ℃. For LDH assays, the supernatants from wells are assessed for LDH release with the Cytotoxicity Detection Kit.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: 6- to 8-week-old female C57BL/6J mice
  • Formulation: DMSO
  • Dosages: 100 mg/kg
  • Administration: by hypodermic injection in the back skin
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 68 mg/mL (197.49 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 344.32
Formula

C18H16O7

CAS No. 152743-19-6
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID