Home Neuronal Signaling NMDAR agonist D-Alanine

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D-Alanine NMDAR agonist

Cat.No.S3203

D-alanine (Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286) is an endogenous co-agonist at the glycine site of the N-methyl-d-aspartate (NMDA) receptor.
D-Alanine NMDAR agonist Chemical Structure

Chemical Structure

Molecular Weight: 89.09

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Quality Control

Batch: S320301 Water]18 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.87%
99.87

Solubility

In vitro
Batch:

Water : 18 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 89.09 Formula

C3H7NO2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 338-69-2 -- Storage of Stock Solutions

Synonyms Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286 Smiles CC(C(=O)O)N

Mechanism of Action

Targets/IC50/Ki
NMDA receptor
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05105958 Not yet recruiting
Amyotrophic Lateral Sclerosis
University Hospital Geneva|University of Lausanne Hospitals|University of Zurich|University of Bern|Cantonal Hospital of St. Gallen
 December 1 2025 Phase 2
NCT05847179 Not yet recruiting
Werner Syndrome
PRG Science & Technology Co. Ltd.
 January 1 2025 Phase 2
NCT06404333 Not yet recruiting
Scabies
University of Oxford|Fundação de Medicina Tropical Dr. Heitor Vieira Dourado|Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta (FUAM)|University of Basel|ClinSearch
 October 1 2024 Phase 2
NCT06405555 Not yet recruiting
Heart Failure With Reduced Ejection Fraction|Hypotension|LV Dysfunction
Ottawa Heart Institute Research Corporation
 August 1 2024 Phase 2|Phase 3

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