D-Alanine

Catalog No.S3203 Synonyms: Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286

For research use only.

D-alanine (Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286) is an endogenous co-agonist at the glycine site of the N-methyl-d-aspartate (NMDA) receptor.

D-Alanine Chemical Structure

CAS No. 338-69-2

Purity & Quality Control

Choose Selective NMDAR Inhibitors

Biological Activity

Description D-alanine (Ala, (R)-Alanine, Ba 2776, D-α-Alanine, NSC 158286) is an endogenous co-agonist at the glycine site of the N-methyl-d-aspartate (NMDA) receptor.
Targets
NMDA receptor [1]
()

Protocol (from reference)

Solubility (25°C)

In vitro

Water 18 mg/mL
(202.04 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 89.09
Formula

C3H7NO2

CAS No. 338-69-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C(=O)O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04094948 Not yet recruiting Drug: Clenbuterol|Drug: Placebos Pompe Disease (Late-onset) Duke University January 1 2023 Phase 2
NCT05154747 Not yet recruiting Drug: Cabotegravir Rilpivirine Drug Combination|Drug: TLD Hiv|HIV Infections|HIV-1-infection|Paediatric Human Immunodeficiency Virus Infection University College London|European and Developing Countries Clinical Trials Partnership (EDCTP)|Janssen-Cilag Ltd.|ViiV Healthcare|Department of Clinical Pharmacy University Medical Centre St Radboud The Netherlands.|London School of Hygiene and Tropical Medicine|MRC/UVRI and LSHTM Uganda Research Unit|Africa Health Research Institute|PENTA Foundation|University of York August 2022 Phase 3
NCT05181267 Not yet recruiting Dietary Supplement: Intermittent fasting Obesity|Insulin Resistance University of Aarhus April 2022 Not Applicable
NCT05025865 Not yet recruiting Drug: Sodium Hyaluronate|Drug: Placebo Healthy Controls The Cleveland Clinic March 1 2022 Early Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy D-Alanine | D-Alanine supplier | purchase D-Alanine | D-Alanine cost | D-Alanine manufacturer | order D-Alanine | D-Alanine distributor