Panaxatriol

Catalog No.S3847

For research use only.

Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities.

Panaxatriol Chemical Structure

CAS No. 32791-84-7

Purity & Quality Control

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Biological Activity

Description Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities.
In vitro

Panaxatriol exerts dose-dependent cytotoxic effects on prostate DU-15 cancer cells. The IC50 of panaxatriol is 30 μM. Panaxatriol is found to exert its anticancer activity through induction of apoptosis. The apoptosis of DU-15 cancer cells is prompted by ROS-mediated alterations in mitochondrial membrane potential. Additionally, panaxatriol induces sub-G1 cell cycle arrest and suppresses the DU-15 cell migration ability in a concentration-dependent manner[1].

In vivo Panaxatriol can relieve myelosuppression induced by radiation injury[2].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: DU-15 cancer cells
  • Concentrations: 0-120 μM
  • Incubation Time: 48-72 h
  • Method:

    The cytotoxic effect of panaxatriol against prostate cancer cells is determined by MTT assay. DU-15 cells are cultured at the density of 1×106 cells per well in 96 well plates for 12 hrs and then treated with varying concentrations of panaxatriol (0-120 μM) for 48-72 hrs. MTT solution (20 μl) is added to each well. After-wards, 500 μl of DMSO is added to solubilize MTT formazan crystals, and ELISA plate reader is used for the determination of optical density.

  • (Only for Reference)
Animal Research:

[2]

  • Animal Models: albino mice
  • Dosages: 200 mg/kg
  • Administration: oral administration
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 95 mg/mL
(199.27 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 476.73
Formula

C30H52O4

CAS No. 32791-84-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1(CCCC(O1)(C)C2CCC3(C2C(CC4C3(CC(C5C4(CCC(C5(C)C)O)C)O)C)O)C)C

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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