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Arbutin Tyrosinase inhibitor

Name: Arbutin
Brand: Selleck Chemicals
SKU: S2263
Availability: InStock
Rating: 5 (4 reviews)

Cat.No.S2263

Arbutin (Uva, p-Arbutin, β-Arbutin) is a tyrosinase inhibitor with IC50 of 0.9 mM and 0.7 mM for Monophenolase and Diphenolase, respectively.

Arbutin Tyrosinase inhibitor Chemical Structure

Quality Control

Batch: Purity: 99.89%

99.89

Related Targets	HDAC Caspase Proteasome Secretase MMP HCV Protease Cysteine Protease HIV Protease DPP Serine Protease
Other Tyrosinase Inhibitors	Aloin (Barbaloin) Echinacoside 2-Ketoglutaric acid (alpha-ketoglutarate) Oxyresveratrol Isorhamnetin Kojic acid Hexylresorcinol Glycolic acid Deoxyarbutin Kojic acid dipalmitate

Solubility

In vitro
Batch:

DMSO : 54 mg/mL (198.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 54 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	272.25	Formula	C₁₂H₁₆O₇	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	497-76-7	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Uva,p-Arbutin, β-Arbutin			SMILES	C1=CC(=CC=C1O)OC2C(C(C(C(O2)CO)O)O)O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	Diphenolase (Cell-free assay) 0.7 mM Monophenolase (Cell-free assay) 0.9 mM
References	[1] https://pubmed.ncbi.nlm.nih.gov/28493937/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-03-06)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05986123	COMPLETED	Healthy	USMARI Research & Innovation Centre	2023-11-01
NCT05693948	COMPLETED	Healthy	USMARI Research & Innovation Centre	2022-09-01
NCT03868748	COMPLETED	Healthy Volunteers	SP Nutraceuticals Inc.	2019-10-23	PHASE1
NCT02130713	COMPLETED	Chronic Bacterial Prostatitis	University of Roma La Sapienza	2012-01	PHASE4
NCT00717652	SUSPENDED	Melasma	Azidus Brasil	2008-07	PHASE2; PHASE3
NCT00717652	Suspended	Melasma	Azidus Brasil	2008-07	Phase 2\|Phase 3

Tech Support

Handling Instructions

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