Kaempferol

For research use only.

Catalog No.S2314 Synonyms: Robigenin

7 publications

Kaempferol Chemical Structure

CAS No. 520-18-3

Kaempferol (Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.

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Selleck's Kaempferol has been cited by 7 publications

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  • Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).

    Food Funct, 2015, 6(8):2824-33. Kaempferol purchased from Selleck.

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Biological Activity

Description Kaempferol (Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.
Targets
ERRα [1] ERRγ [1] Topo I [2] fatty acid synthase [3]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 FS cells NHLETXVHfW6ldHnvckBie3OjeR?= NHzQRVhKdmirYnn0bY9vKG:oIF7PXFQh\XiycnXzd4VlKGmwIFjFT|I6OyCIUzDj[YxteyCjc4Pld5Nm\CCjczDINm8zKHC{b3T1Z5Rqd25iYomgTFJQOi:WeYKvUHBQKGG|c3H5MEBKSzVyPUGuNkDPxE1? M4XCbFIxPzNzM{W3
human HeLa cells MkK0SpVv[3Srb36gZZN{[Xl? NW\mc2RwUW6qaXLpeIlwdiCxZjDNVnAyKHS{YX7z[oVkfGWmIHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDbN2heVFSFNDD0doFve3CxcoSgZpkhemGyaXSg[oltfHKjdHnvckBie3OjeTygT4k:Oi52IN88US=> NVjUWGRUOTl5MkW1O|g>
human MV4-11 cells MULDfZRwfG:6aXPpeJkh[XO|YYm= MXG3NkBp MYTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNWlQuOTFiY3XscJMhcGG{Yn;ybY5oKE[OVEOgcZV1[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IITleJJigm:uaYXtJIJie2WmIFX6JGN6XG:6IHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBIUTVyPUOuN|Qh|ryP NY\vdYxuOjN2MUGwO|M>
MDCK cells M37PPGZ2dmO2aX;uJIF{e2G7 MU\Jcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW|c3XkJIlvKE2GQ1ugZ4VtdHNidYPpcochUG:nY3jzeEA{OzN2MjDzeIFqdmmwZzygTWM2OD12Lkeg{txO MnH3NlE{PTR6MEC=
human MDA-kb2 cells M3PPdmZ2dmO2aX;uJIF{e2G7 M3\B[GFvfGGpb37pd5Qh[WO2aY\peJkh[XRiYX7kdo9o\W5icnXj[ZB1d3JiaX6gbJVu[W5iTVTBMYtjOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGRJXC2rbnT1Z4VlKGy3Y3nm[ZJie2ViYXP0bZZqfHliYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCLQ{WwQVkvPyEQvF2= MXSxPVU6OjJ2NR?=
B16-4A5 cells MXnGeY5kfGmxbjDhd5NigQ>? MYXJcohq[mm2aX;uJI9nKG2nbHHuc4dmdmW|aYOgbY4hfGinb4DofYxtcW6nLYP0bY12dGG2ZXSgcY92e2ViQkG2MVRCPSClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:OjBizszN M3jBcFE6PjF3OUGw
human HL60 cells NGPtSJlEgXSxdH;4bYNqfHliYYPzZZk> NWD4U5VCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKHO3co\peoFtKGG2IEWwJJVOKGGodHXyJFczKGi{czDifUBES0t6IHHzd4F6 M4nVWVI2ODd2OEG1
mouse 3T3L1 cells Mo\WSpVv[3Srb36gZZN{[Xl? MVXJcohq[mm2aX;uJI9nKEGPUFutcYVlcWG2ZXSgZYRqeG:leYTlJIRq\m[ncnXueIlifGmxbjDpckBud3W|ZTCzWFNNOSClZXzsdy=> M2iyT|IxQDJ{OUCy
mouse RAW264.7 cells M{Tqd2Z2dmO2aX;uJIF{e2G7 MnvORY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBNWFNvc4TpcZVt[XSnZDDtc5V{\SCUQWeyOlQvPyClZXzsd{Bie3Onc4Pl[EBieyCwaYTybZRmKGyndnXsJIF1KDFidH:gNVAxKHWPIHHmeIVzKDJ2IHjyd{BjgSCJcnnld5MhdWW2aH;k NETtPZYzOTN3M{W0Ny=>
mouse L929 cells NFzJenBHfW6ldHnvckBie3OjeR?= NXrKUppLUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDUUmYu[WyyaHGtbY5lfWOnZDDjfZRwfG:6aXPpeJkhd2ZibX;1d4UhVDl{OTDj[YxteyCjc4Pld5Nm\CCjczDzeZJ3cX[jbHn0fUB1emWjdHXkJJdqfGhiZIL1[{Bi\nSncjCyJIhzeyCxZjDUUmZidHCqYTD0doVifG2nboS= MlXFPVI5PzRzNR?=
human U87 cells NXe5bFNzS3m2b4TvfIlkcXS7IHHzd4F6 NXrVOHRPPS12MDFOwG0> MYq3NkBp NVvDVVFWS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTh5IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDheEA2KHSxIESwJJVOKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZk> MkHXNlI5PzF{MUe=
human A549 cells NIH6N|VEgXSxdH;4bYNqfHliYYPzZZk> NUT4c2RKPS12MDFOwG0> MmCyO|IhcA>? NEfRO4JEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDheEA2KHSxIESwJJVOKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZk> NIW1OVYzOjh5MUKxOy=>
human MCF7 cells MXjDfZRwfG:6aXPpeJkh[XO|YYm= MVK1MVQxKM7:TR?= NYHJVlZVPzJiaB?= NFzESpVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDheEA2KHSxIESwJJVOKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZk> NEXoc4YzOjh5MUKxOy=>
MDA-MB-231 cells NIXIZppEgXSxdH;4bYNqfHliYYPzZZk> M3[zfVUuPDBizszN MmnkO|IhcA>? MkXCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[XRiNTD0c{A1OCC3TTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7 MoHZNlI5PzF{MUe=
MDCK cells NVrTWXhHTnWwY4Tpc44h[XO|YYm= MW[1NEDPxE1? MXLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDpcoZtfWWwenGgRUB3cXK3czDINW4yKEFxUGKvPE8{PCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDmcJVwemW|Y3XuZ4UheG:|aYTpeoUh[2WubIOgZZQhPTBidV2gbY1ufW6xZnz1c5Jme2OnbnPlJIF{e2G7 MmK3NVk4Ojl|MU[=
human NCI-H2126 cells MkezR5l1d3SxeHnjbZR6KGG|c3H5 NEfZWpY2NTRyIN88US=> NUnVWVJXPzJiaB?= MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDJzMk[gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIF1KDVidH:gOFAhfU1iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigQ>? NUfHdnBFOjJ6N{GyNVc>
human SMMC7721 cells NX3Fe3ZXS3m2b4TvfIlkcXS7IHHzd4F6 NFTwV5A2NTRyIN88US=> M3TCbVczKGh? MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUW1EPzd{MTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhPSC2bzC0NEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6 NHzKe3AzOjh5MUKxOy=>
human PANC1 cells MnvnR5l1d3SxeHnjbZR6KGG|c3H5 MVW1MVQxKM7:TR?= NXKyZohYPzJiaB?= NWPpTWdtS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEGQQ{GgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIF1KDVidH:gOFAhfU1iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigQ>? NEPQXVgzOjh5MUKxOy=>
human BxPC3 cells MWjDfZRwfG:6aXPpeJkh[XO|YYm= MYS1MVQxKM7:TR?= NXHjUXI4PzJiaB?= M3TYXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJ5WEN|IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDheEA2KHSxIESwJJVOKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZk> NHHjUpYzOjh5MUKxOy=>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL warmed (199.14 mM)
Ethanol 3 mg/mL (10.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 286.23
Formula

C15H10O6

CAS No. 520-18-3
Storage powder
in solvent
Synonyms Robigenin
Smiles C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID