Kaempferol (NSC 407289)

Catalog No.S2314 Synonyms: Robigenin

For research use only.

Kaempferol (NSC 407289, Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.

Kaempferol (NSC 407289) Chemical Structure

CAS No. 520-18-3

Selleck's Kaempferol (NSC 407289) has been cited by 12 Publications

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Biological Activity

Description Kaempferol (NSC 407289, Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.
Targets
ERRα [1] ERRγ [1] Topo I [2] fatty acid synthase [3]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 FS cells MWLGeY5kfGmxbjDhd5NigQ>? MV\Jcohq[mm2aX;uJI9nKE6RWESg[ZhxemW|c3XkJIlvKEiHS{K5N{BHWyClZXzsd{Bie3Onc4Pl[EBieyCKMl:yJJBzd2S3Y4Tpc44h[nliSELPNk9VgXJxTGDPJIF{e2G7LDDJR|UxRTFwMjFOwG0> M{nHOFIxPzNzM{W3
human HeLa cells NX\XSI5yTnWwY4Tpc44h[XO|YYm= MYnJcohq[mm2aX;uJI9nKE2UUEGgeJJidnOoZXP0[YQhcW5iaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFt|SG3MWGM1KHS{YX7zdI9zfCCkeTDyZZBq\CCoaXz0doF1cW:wIHHzd4F6NCCNaU2yMlQh|ryP NVnUSW13OTl5MkW1O|g>
human MV4-11 cells NWi0[HM5S3m2b4TvfIlkcXS7IHHzd4F6 MmqyO|IhcA>? NYjPTo1[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVVZ2LUGxJINmdGy|IHjhdoJwemmwZzDGUHQ{KG23dHH0bY9vKGGodHXyJFczKGi{czDifUB1\XS{YYrvcIl2dSCkYYPl[EBGgiCFeWTvfEBk\WyuII\pZYJqdGm2eTDhd5NigSxiR1m1NF0{NjN2IN88US=> MnTxNlM1OTFyN{O=
MDCK cells NHHOUoJHfW6ldHnvckBie3OjeR?= M4fTNWlvcGmkaYTpc44hd2ZiQlPSVEBmgHC{ZYPz[YQhcW5iTVTDT{Bk\WyuczD1d4lv\yCKb3XjbJN1KDN|M{SyJJN1[WmwaX7nMEBKSzVyPUSuO{DPxE1? NXnTbHpLOjF|NUS4NFA>
human MDA-kb2 cells MVjGeY5kfGmxbjDhd5NigQ>? NFv4TVBCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHHu[JJw\2WwIILlZ4VxfG:{IHnuJIh2dWGwIF3ERU1s[jJiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBFUFRvaX7keYNm\CCudXPp[oVz[XOnIHHjeIl3cXS7IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiSVO1NF06NjdizszN M2P2blE6PTl{MkS1
B16-4A5 cells NGfobIxHfW6ldHnvckBie3OjeR?= M1vkPWlvcGmkaYTpc44hd2ZibXXsZY5w\2WwZYPpd{BqdiC2aHXvdIh6dGyrbnWtd5RqdXWuYYTl[EBud3W|ZTDCNVYuPEF3IHPlcIx{KGGodHXyJFczKGi{czygTWM2OD1{MDFOwG0> MXKxPVYyPTlzMB?=
human HL60 cells NGm0cIhEgXSxdH;4bYNqfHliYYPzZZk> MnzhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGw3OCClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJN2en[rdnHsJIF1KDVyIIXNJIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG|c3H5 MYCyOVA4PDhzNR?=
mouse 3T3L1 cells M1;1b2Z2dmO2aX;uJIF{e2G7 M3[0N2lvcGmkaYTpc44hd2ZiQV3QT{1u\WSrYYTl[EBi\Gmyb3P5eIUh\GmoZnXy[Y51cWG2aX;uJIlvKG2xdYPlJFNVO0xzIHPlcIx{ MoTNNlA5OjJ7MEK=
mouse RAW264.7 cells M1[4N2Z2dmO2aX;uJIF{e2G7 NIHKfIpCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKEySUz3zeIlufWyjdHXkJI1wfXOnIGLBW|I3PC55IHPlcIx{KGG|c3Xzd4VlKGG|IH7peJJqfGVibHX2[Ywh[XRiMTD0c{AyODBidV2gZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyCvZYToc4Q> NVjZT2g1OjF|NUO1OFM>
mouse L929 cells MmnXSpVv[3Srb36gZZN{[Xl? NHL6OJdKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIGTOSk1idHCqYT3pcoR2[2WmIHP5eI91d3irY3n0fUBw\iCvb4Xz[UBNQTJ7IHPlcIx{KGG|c3Xzd4VlKGG|IIP1dpZqfmGuaYT5JJRz\WG2ZXSge4l1cCCmcoXnJIFnfGW{IEKgbJJ{KG:oIGTOSoFteGijIITy[YF1dWWwdB?= NIj4SZc6Ojh5NEG1
human U87 cells NEe1O|ZEgXSxdH;4bYNqfHliYYPzZZk> NFHONXQ2NTRyIN88US=> M1zJN|czKGh? MmPtR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVg4KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjdDC1JJRwKDRyIIXNJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYm= NIfDPJIzOjh5MUKxOy=>
human A549 cells M{nE[2N6fG:2b4jpZ4l1gSCjc4PhfS=> NUK3SndvPS12MDFOwG0> NHPa[4k4OiCq NEnqXYtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDheEA2KHSxIESwJJVOKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZk> NIn1OowzOjh5MUKxOy=>
human MCF7 cells M3jRNWN6fG:2b4jpZ4l1gSCjc4PhfS=> M2W2e|UuPDBizszN NGDwOoQ4OiCq M1rwWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHH0JFUhfG9iNECgeW0h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfS=> MXqyNlg4OTJzNx?=
MDA-MB-231 cells MX\DfZRwfG:6aXPpeJkh[XO|YYm= M3XkT|UuPDBizszN NVL0TVVKPzJiaB?= MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBifCB3IITvJFQxKHWPIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[Xl? NITxOHczOjh5MUKxOy=>
MDCK cells NIi1eZhHfW6ldHnvckBie3OjeR?= M2TlN|UxKM7:TR?= NYDoVXhlSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhcW6obIXlcppiKEFidnnyeZMhUDGQMTDBM3BTNzhxM{SgbY5n\WO2ZXSgbY4hVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h\my3b4Lld4NmdmOnIIDvd4l1cX[nIHPlcIx{KGG2IEWwJJVOKGmvbYXuc4ZtfW:{ZYPj[Y5k\SCjc4PhfS=> MX:xPVczQTNzNh?=
human NCI-H2126 cells Mo[wR5l1d3SxeHnjbZR6KGG|c3H5 NIDnWW02NTRyIN88US=> MoO0O|IhcA>? NFzhTFFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEKxNlYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGG2IEWgeI8hPDBidV2gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeR?= NVP3c5ZoOjJ6N{GyNVc>
human SMMC7721 cells MlXWR5l1d3SxeHnjbZR6KGG|c3H5 MkSwOU01OCEQvF2= NWexT3pWPzJiaB?= MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTUW1EPzd{MTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhPSC2bzC0NEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6 NYC3UnN4OjJ6N{GyNVc>
human PANC1 cells Mn7KR5l1d3SxeHnjbZR6KGG|c3H5 MWC1MVQxKM7:TR?= M4D0dlczKGh? Mne1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGFPSzFiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHH0JFUhfG9iNECgeW0h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfS=> MmCwNlI5PzF{MUe=
human BxPC3 cells NWTtOI9wS3m2b4TvfIlkcXS7IHHzd4F6 NWS0ZZFWPS12MDFOwG0> Mn61O|IhcA>? NXS0bZNuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSniSQ{OgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIF1KDVidH:gOFAhfU1iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigQ>? MnXrNlI5PzF{MUe=

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 57 mg/mL warmed
(199.14 mM)
Ethanol 3 mg/mL
(10.48 mM)
Water Insoluble

Chemical Information

Molecular Weight 286.23
Formula

C15H10O6

CAS No. 520-18-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05073523 Recruiting Other: Diet Healthy Chalmers University of Technology September 27 2021 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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