Kaempferol (NSC 407289)

For research use only.

Catalog No.S2314 Synonyms: Robigenin

12 publications

Kaempferol (NSC 407289) Chemical Structure

CAS No. 520-18-3

Kaempferol (NSC 407289, Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.

Selleck's Kaempferol (NSC 407289) has been cited by 12 publications

1 Customer Review

  • Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).

    Food Funct, 2015, 6(8):2824-33. Kaempferol (NSC 407289) purchased from Selleck.

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Biological Activity

Description Kaempferol (NSC 407289, Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.
Targets
ERRα [1] ERRγ [1] Topo I [2] fatty acid synthase [3]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 FS cells MnXoSpVv[3Srb36gZZN{[Xl? MUHJcohq[mm2aX;uJI9nKE6RWESg[ZhxemW|c3XkJIlvKEiHS{K5N{BHWyClZXzsd{Bie3Onc4Pl[EBieyCKMl:yJJBzd2S3Y4Tpc44h[nliSELPNk9VgXJxTGDPJIF{e2G7LDDJR|UxRTFwMjFOwG0> NV;LcHFwOjB5M{GzOVc>
human HeLa cells M1v2eGZ2dmO2aX;uJIF{e2G7 M3nwbmlvcGmkaYTpc44hd2ZiTWLQNUB1emGwc3\lZ5Rm\CCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiW{PIYWxVSzRidILhcpNxd3K2IHL5JJJieGmmIH\pcJRz[XSrb36gZZN{[XluIFvpQVIvPCEQvF2= M3SxSVE6PzJ3NUe4
human MV4-11 cells MXvDfZRwfG:6aXPpeJkh[XO|YYm= NY\nZnZxPzJiaB?= NIPUZlJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOXjRvMUGgZ4VtdHNiaHHyZo9zcW6pIF\MWFMhdXW2YYTpc44h[W[2ZYKgO|IhcHK|IHL5JJRmfHKjen;sbZVuKGKjc3XkJGV7KEO7VH;4JINmdGxidnnhZoltcXS7IHHzd4F6NCCJSUWwQVMvOzRizszN MVyyN|QyOTB5Mx?=
MDCK cells NFX3VYdHfW6ldHnvckBie3OjeR?= MWLJcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW|c3XkJIlvKE2GQ1ugZ4VtdHNidYPpcochUG:nY3jzeEA{OzN2MjDzeIFqdmmwZzygTWM2OD12Lkeg{txO MUmyNVM2PDhyMB?=
human MDA-kb2 cells M1zGSGZ2dmO2aX;uJIF{e2G7 NIXRSnBCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHHu[JJw\2WwIILlZ4VxfG:{IHnuJIh2dWGwIF3ERU1s[jJiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBFUFRvaX7keYNm\CCudXPp[oVz[XOnIHHjeIl3cXS7IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiSVO1NF06NjdizszN NIrEcoMyQTV7MkK0OS=>
B16-4A5 cells MVzGeY5kfGmxbjDhd5NigQ>? MX3Jcohq[mm2aX;uJI9nKG2nbHHuc4dmdmW|aYOgbY4hfGinb4DofYxtcW6nLYP0bY12dGG2ZXSgcY92e2ViQkG2MVRCPSClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:OjBizszN NY\BNmprOTl4MUW5NVA>
human HL60 cells M1jaSGN6fG:2b4jpZ4l1gSCjc4PhfS=> MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygd5Vzfmm4YXygZZQhPTBidV2gZYZ1\XJiN{KgbJJ{KGK7IFPDT|gh[XO|YYm= M4f1S|I2ODd2OEG1
mouse 3T3L1 cells MmDpSpVv[3Srb36gZZN{[Xl? NVHWTHpoUW6qaXLpeIlwdiCxZjDBUXBMNW2nZHnheIVlKGGmaYDvZ5l1\SCmaX\m[ZJmdnSrYYTpc44hcW5ibX;1d4UhO1R|TEGgZ4VtdHN? MlrLNlA5OjJ7MEK=
mouse RAW264.7 cells M1;WeWZ2dmO2aX;uJIF{e2G7 NI\3XoxCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKEySUz3zeIlufWyjdHXkJI1wfXOnIGLBW|I3PC55IHPlcIx{KGG|c3Xzd4VlKGG|IH7peJJqfGVibHX2[Ywh[XRiMTD0c{AyODBidV2gZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyCvZYToc4Q> NFjndFMzOTN3M{W0Ny=>
mouse L929 cells MmP2SpVv[3Srb36gZZN{[Xl? MlrjTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCWTl[tZYxxcGFvaX7keYNm\CCleYTveI95cWOrdImgc4YhdW:3c3WgUFkzQSClZXzsd{Bie3Onc4Pl[EBieyC|dYL2bZZidGm2eTD0doVifGWmIIfpeIgh\HK3ZzDh[pRmeiB{IHjyd{Bw\iCWTl\hcJBp[SC2cnXheI1mdnR? MnWyPVI5PzRzNR?=
human U87 cells NX\2Zm0yS3m2b4TvfIlkcXS7IHHzd4F6 NUHsdJF5PS12MDFOwG0> NVXzNphGPzJiaB?= M1XiXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU5PyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYYSgOUB1dyB2MDD1UUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5 NYjiNll[OjJ6N{GyNVc>
human A549 cells NUexW4xCS3m2b4TvfIlkcXS7IHHzd4F6 NXXicFljPS12MDFOwG0> M1e5fVczKGh? NWLlTphQS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZZQhPSC2bzC0NEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6 MmPFNlI5PzF{MUe=
human MCF7 cells MX3DfZRwfG:6aXPpeJkh[XO|YYm= MWC1MVQxKM7:TR?= NVXhUXU6PzJiaB?= MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjdDC1JJRwKDRyIIXNJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYm= MWKyNlg4OTJzNx?=
MDA-MB-231 cells NHnLdINEgXSxdH;4bYNqfHliYYPzZZk> MYS1MVQxKM7:TR?= MWm3NkBp NF3ibYxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjdDC1JJRwKDRyIIXNJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYm= NWTLfIJZOjJ6N{GyNVc>
MDCK cells Mk\ISpVv[3Srb36gZZN{[Xl? MYK1NEDPxE1? MXzBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDpcoZtfWWwenGgRUB3cXK3czDINW4yKEFxUGKvPE8{PCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDmcJVwemW|Y3XuZ4UheG:|aYTpeoUh[2WubIOgZZQhPTBidV2gbY1ufW6xZnz1c5Jme2OnbnPlJIF{e2G7 NXPCe4E2OTl5MkmzNVY>
human NCI-H2126 cells MVzDfZRwfG:6aXPpeJkh[XO|YYm= NHnPZXc2NTRyIN88US=> MVq3NkBp NFPld5BEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEKxNlYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGG2IEWgeI8hPDBidV2gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeR?= MWCyNlg4OTJzNx?=
human SMMC7721 cells MkDGR5l1d3SxeHnjbZR6KGG|c3H5 NVXERmx{PS12MDFOwG0> MYW3NkBp NH\5OXNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUVU2FN{eyNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[XRiNTD0c{A1OCC3TTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7 NUHNWXZ3OjJ6N{GyNVc>
human PANC1 cells M{mzemN6fG:2b4jpZ4l1gSCjc4PhfS=> MW[1MVQxKM7:TR?= MV63NkBp MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQRW5EOSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYYSgOUB1dyB2MDD1UUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5 M1fS[|IzQDdzMkG3
human BxPC3 cells NHK0Z21EgXSxdH;4bYNqfHliYYPzZZk> M{nDWlUuPDBizszN NGj0S|A4OiCq MkSzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRphRSzNiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHH0JFUhfG9iNECgeW0h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfS=> NGDYXIUzOjh5MUKxOy=>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL warmed (199.14 mM)
Ethanol 3 mg/mL (10.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 286.23
Formula

C15H10O6

CAS No. 520-18-3
Storage powder
in solvent
Synonyms Robigenin
Smiles C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID