Patchouli alcohol

Catalog No.S3778 Synonyms: (-)-Patchouli Alcohol, Patchoulol, Patchouli camphor

Patchouli alcohol Chemical Structure

Molecular Weight(MW): 222.37

Patchouli alcohol, an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.

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Biological Activity

Description Patchouli alcohol, an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.
In vitro

Patchouli alcohol inhibits the overexpression of iNOS and IL-6 in protein and mRNA levels in LPS-stimulated RAW264.7 and TNF-a stimulated HT-29 cells. Patchouli alcohol inhibits IkB-α degradation and p65 nuclear translocation, and subsequently suppresses transcriptional activity of NF-kB in LPS-stimulated RAW264.7 and TNF-α-stimulated HT-29 cells. In addition, Patchouli alcohol inhibits LPS- or TNF-α-stimulated ERK1/2 activation by decreasing phosphorylation of ERK1/2[1].

Protocol

Cell Research:[1]
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  • Cell lines: RAW264.7 and HT-29 cells
  • Concentrations: 50 and 75 μM
  • Incubation Time: 21 h
  • Method: RAW264.7 and HT-29 cells (2×105 cells/well) are seeded in 12-well plates and incubated overnight. Then, plasmid mixtures containing 0.5 μg of pNF-kB-Luc plasmid and 0.1 μg of pRL-null vector are transfected for 24 h (for RAW264.7) and 48 h (for HT-29). The empty pGL3-basic vector is used as a negative control. After transfection, cells are pre-treated with Patchouli alcohol, tolfenamic acid (TA), or sulindac sulfide (SS) for 6 h and then co-treated with LPS (for RAW264.7) or TNF-α (for HT-29) for an additional 15 h. The cells are harvested in 1×luciferase lysis buffer, and luciferase activity is measured and normalized to the pRL-null luciferase activity using a dual-luciferase assay kit.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 44 mg/mL (197.86 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 222.37
Formula

C15H26O

CAS No. 5986-55-0
Storage powder
in solvent
Synonyms (-)-Patchouli Alcohol, Patchoulol, Patchouli camphor

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID