Home Proteases MMP inhibitor - NF-κB inhibitor Isoliquiritin apioside

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Isoliquiritin apioside MMP inhibitor

Cat.No.S0923

Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. This compound possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
Isoliquiritin apioside MMP inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 550.51

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S092301 DMSO]100 mg/mL]false]Ethanol]70 mg/mL]false]Water]5 mg/mL]false Purity: 99.89%
99.89

Chemical Information, Storage & Stability

Molecular Weight 550.51 Formula

C26H30O13

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 120926-46-7 -- Storage of Stock Solutions

Synonyms ISLA, ILA Smiles C1C(C(C(O1)OC2C(C(C(OC2OC3=CC=C(C=C3)C=CC(=O)C4=C(C=C(C=C4)O)O)CO)O)O)O)(CO)O

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (181.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 70 mg/mL

Water : 5 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC50/Ki
MMP [1]
MAPK [1]
NF-κB [1]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05195762 Not yet recruiting
Epidermal Nevi|Nevus Sebaceus
Albert Chiou|NFlection Therapeutics Inc.|Stanford University
 June 2023 Phase 2
NCT05546606 Recruiting
COPD Acute Exacerbation
Assistance Publique - Hôpitaux de Paris|Ministry of Health France|Xenios AG
 April 18 2023 Not Applicable
NCT06072261 Completed
Rehabilitation
Suleyman Demirel University
 April 15 2023 Not Applicable
NCT05514522 Recruiting
Interstitial Lung Disease|SARS-CoV-2 Infection
Imperial College London|Medical Research Council|University of Nottingham|University of Southampton|University of Leicester|University of Manchester|University of Liverpool|University of Sheffield|University of Oxford|University College London|University of Newcastle Upon-Tyne|University of Edinburgh
 August 18 2021 --

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