Isoliquiritin apioside

Catalog No.S0923 Synonyms: ISLA, ILA

For research use only.

Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.

Isoliquiritin apioside Chemical Structure

CAS No. 120926-46-7

Purity & Quality Control

Choose Selective MMP Inhibitors

Other MMP Products

Biological Activity

Description Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
Targets
MMP [1]
()
MAPK [1]
()
NF-κB [1]
()

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(181.64 mM)
Water 5 mg/mL
(9.08 mM)
Ethanol '''70 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 550.51
Formula

C26H30O13

CAS No. 120926-46-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C(C(C(O1)OC2C(C(C(OC2OC3=CC=C(C=C3)C=CC(=O)C4=C(C=C(C=C4)O)O)CO)O)O)O)(CO)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04821089 Recruiting Biological: IPN10200|Biological: IPN10200 Placebo Moderate to Severe Upper Facial Lines Ipsen April 6 2021 Phase 1|Phase 2
NCT04847141 Recruiting Biological: C19-IG 20%|Drug: 0.9% Sodium chloride COVID-19|Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Grifols Therapeutics LLC April 28 2021 Phase 3
NCT04736745 Recruiting Biological: IPN59011|Biological: Azzalure|Drug: Placebo Moderate Upper Facial Lines|Severe Upper Facial Lines Ipsen February 10 2021 Phase 1|Phase 2
NCT04503044 Completed Other: Retrospective observational study Interstitial Lung Disease|IPF Lahey Clinic|Genentech Inc. January 30 2021 --
NCT04462367 Recruiting -- COVID19|Coronavirus Infection|Pregnancy Disease|Severe Acute Respiratory Syndrome Instituto Materno Infantil Prof. Fernando Figueira July 1 2020 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Isoliquiritin apioside | Isoliquiritin apioside supplier | purchase Isoliquiritin apioside | Isoliquiritin apioside cost | Isoliquiritin apioside manufacturer | order Isoliquiritin apioside | Isoliquiritin apioside distributor