Home Proteases MMP inhibitor - NF-κB inhibitor Isoliquiritin apioside For research use only.

Isoliquiritin apioside

Synonyms: ISLA, ILA

Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.

Isoliquiritin apioside Chemical Structure

Isoliquiritin apioside Chemical Structure

CAS: 120926-46-7

Purity & Quality Control

Batch: S092301 DMSO] 100 mg/mL] false] Ethanol] 70 mg/mL] false] Water] 5 mg/mL] false Purity: 99.89%
99.89

Isoliquiritin apioside Related Products

Signaling Pathway

MMP Signaling Pathways

MMP Signaling Pathway

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Biological Activity

Description Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
Targets
MMP [1] MAPK [1] NF-κB [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05195762 Not yet recruiting
Epidermal Nevi|Nevus Sebaceus
Albert Chiou|NFlection Therapeutics Inc.|Stanford University
 June 2023 Phase 2
NCT05546606 Recruiting
COPD Acute Exacerbation
Assistance Publique - Hôpitaux de Paris|Ministry of Health France|Xenios AG
 April 18 2023 Not Applicable
NCT06072261 Completed
Rehabilitation
Suleyman Demirel University
 April 15 2023 Not Applicable
NCT05514522 Recruiting
Interstitial Lung Disease|SARS-CoV-2 Infection
Imperial College London|Medical Research Council|University of Nottingham|University of Southampton|University of Leicester|University of Manchester|University of Liverpool|University of Sheffield|University of Oxford|University College London|University of Newcastle Upon-Tyne|University of Edinburgh
 August 18 2021 --

Chemical Information & Solubility

Molecular Weight 550.51 Formula

C26H30O13
CAS No. 120926-46-7 SDF --
Smiles C1C(C(C(O1)OC2C(C(C(OC2OC3=CC=C(C=C3)C=CC(=O)C4=C(C=C(C=C4)O)O)CO)O)O)O)(CO)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (181.64 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 70 mg/mL

Water : 5 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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