Astilbin

Catalog No.S3932 Synonyms: Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside, Taxifolin 3-rhamnoside

For research use only.

Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.

Astilbin Chemical Structure

CAS No. 29838-67-3

Purity & Quality Control

Choose Selective Immunology & Inflammation related Inhibitors

Biological Activity

Description Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.
In vitro

In vitro, astilbin inhibits Th17 cell differentiation and IL-17 secretion of isolated T cells, and inhibits Jak/Stat3 signaling in Th17 cells, while up-regulating Stat3 inhibitor SCOSE3 expression in psoriatic lesions. Astilbin has been reported to possess multiple clinically relevant bioactivities, including antioxidant, anti-inflammatory, anti-arthritic, and anti-diabetic nephropathy properties. Nevertheless, the molecular mechanisms by which astilbin interacts with inflammatory processes are poorly understood. Astilbin not only inhibits T lymphocyte function in acute heart allograft rejection, but also inhibits migration and antigen presenting of dendritic cells (DCs)[1].

In vivo Astilbin is reported to reduce activation of both T and B cells in lupus-prone mice. It significantly inhibits inflammatory responses and keratinocyte over-proliferation in a mouse model of imiquimod (IMQ)-induced psoriasis[1]. Astilbin undergoes extensive biotransformation specifically due to enzyme catechol-O-methyl transferase. It gives rise to 3′-O-methylastilbin, a major metabolite of astilbin, which plays important role against the inhibition activated T lymphocytes. The pharmacokinetic parameters of astilbin followed by intragastric administration astilbin (40 mg/kg): Cmax=37.7±14.7 ng/mL, Tmax=25.8±34.3 min, t1/2=161.6±44.1 min[2].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: CD4+ T cells
  • Concentrations: 0-100 μg/ml
  • Incubation Time: 3 days
  • Method: Cell viability is assessed using the Cell Counting Kit-8 (CCK8) assay at 3 days after induction of Th17 differentiation. The mean optical density (OD) of the three wells in each group is used to calculate the percentage of cell proliferation.
  • (Only for Reference)
Animal Research:[1]
  • Animal Models: BALB/c mice (male, 18 to 20 g, 8 week-old)
  • Dosages: 25 to 50 mg/kg
  • Administration: orally administered
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(222.02 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 450.39
Formula

C21H22O11

CAS No. 29838-67-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1C(C(C(C(O1)OC2C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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