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Astilbin Immunology & Inflammation related chemical

Name: Astilbin
Brand: Selleck Chemicals
SKU: S3932
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3932

Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.

Chemical Structure

Molecular Weight: 450.39

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: Purity: 99.84%

99.84

Related Targets	CD markers Interleukins Anti-infection Antioxidant COX Histamine Receptor TNF-alpha ROS Parasite PD-1/PD-L1 TLR Prostaglandin Receptor IFN CXCR Nrf2 NOS CCR NLRP3 eIF STING AhR IL Receptor NADPH-oxidase Complement System IRAK β-lactamase IDO/TDO PGES FKBP LTR
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Chemical Information, Storage & Stability

Molecular Weight	450.39	Formula	C₂₁H₂₂O₁₁	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	29838-67-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside, Taxifolin 3-rhamnoside			Smiles	CC1C(C(C(C(O1)OC2C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O

Solubility

In vitro
Batch:

DMSO : 90 mg/mL (199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (11.10mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	In vitro, astilbin inhibits Th17 cell differentiation and IL-17 secretion of isolated T cells, and inhibits Jak/Stat3 signaling in Th17 cells, while up-regulating Stat3 inhibitor SCOSE3 expression in psoriatic lesions. This compound has been reported to possess multiple clinically relevant bioactivities, including antioxidant, anti-inflammatory, anti-arthritic, and anti-diabetic nephropathy properties. Nevertheless, the molecular mechanisms by which this chemical interacts with inflammatory processes are poorly understood. It not only inhibits T lymphocyte function in acute heart allograft rejection, but also inhibits migration and antigen presenting of dendritic cells (DCs)^[1].
In vivo	Astilbin is reported to reduce activation of both T and B cells in lupus-prone mice. It significantly inhibits inflammatory responses and keratinocyte over-proliferation in a mouse model of imiquimod (IMQ)-induced psoriasis^[1]. This compound undergoes extensive biotransformation specifically due to enzyme catechol-O-methyl transferase. It gives rise to 3′-O-methylastilbin, a major metabolite of this chemical, which plays important role against the inhibition activated T lymphocytes. The pharmacokinetic parameters of this compound followed by intragastric administration astilbin (40 mg/kg): C_max=37.7±14.7 ng/mL, T_max=25.8±34.3 min, t_1/2=161.6±44.1 min^[2].
References	[1] https://pubmed.ncbi.nlm.nih.gov/26784569/ [2] https://www.hindawi.com/journals/njos/2016/7830367/

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