Cyclocytidine HCl

For research use only. Not for use in humans.

Catalog No.S1973 Synonyms: NSC 145668 HCl

Cyclocytidine HCl Chemical Structure

Molecular Weight(MW): 261.66

Cyclocytidine is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.

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Biological Activity

Description Cyclocytidine is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.
In vitro

Cyclocytidine HCl (Ancitabine) is the prodrug of cytarabine, which is structurally similar to human deoxycytidine to be incorporated into human DNA and then kills the cell. Cyclocytidine most affects rapidly dividing cells, which require DNA replication for mitosis. Cyclocytidine also inhibits both DNA and RNA polymerases and nucleotide reductase enzymes needed for DNA synthesis. [1]

In vivo Cyclocytidine is a potent immunosuppresant, antiviral and antitumor agent in animals and man, maximum inhibitor effects require the use of complex injection schedules. [2]Cyclocytidine provides treatment for leukemia. [3]

Protocol

Animal Research:[2]
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  • Animal Models: BDF1 mice inoculated L1210 cells
  • Formulation: Vehicle 122
  • Dosages: 20 or 100 mg/kg/day
  • Administration: i.p. or s.c.
    (Only for Reference)

Solubility (25°C)

In vitro Water 44 mg/mL warmed (168.15 mM)
DMSO 10 mg/mL warmed (38.21 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 261.66
Formula

C9H12ClN3O4

CAS No. 10212-25-6
Storage powder
in solvent
Synonyms NSC 145668 HCl
Smiles Cl.OCC1OC2C(OC3=NC(=N)C=CN23)C1O

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID