Cyclocytidine HCl

For research use only.

Catalog No.S1973 Synonyms: NSC 145668 HCl

3 publications

Cyclocytidine HCl Chemical Structure

CAS No. 10212-25-6

Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.

Selleck's Cyclocytidine HCl has been cited by 3 publications

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Biological Activity

Description Cyclocytidine (NSC 145668) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia.
In vitro

Cyclocytidine HCl (Ancitabine) is the prodrug of cytarabine, which is structurally similar to human deoxycytidine to be incorporated into human DNA and then kills the cell. Cyclocytidine most affects rapidly dividing cells, which require DNA replication for mitosis. Cyclocytidine also inhibits both DNA and RNA polymerases and nucleotide reductase enzymes needed for DNA synthesis. [1]

In vivo Cyclocytidine is a potent immunosuppresant, antiviral and antitumor agent in animals and man, maximum inhibitor effects require the use of complex injection schedules. [2]Cyclocytidine provides treatment for leukemia. [3]

Protocol

Animal Research:[2]
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  • Animal Models: BDF1 mice inoculated L1210 cells
  • Dosages: 20 or 100 mg/kg/day
  • Administration: i.p. or s.c.
    (Only for Reference)

Solubility (25°C)

In vitro Water 44 mg/mL warmed (168.15 mM)
DMSO 10 mg/mL warmed (38.21 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 261.66
Formula

C9H12ClN3O4

CAS No. 10212-25-6
Storage powder
in solvent
Synonyms NSC 145668 HCl
Smiles C1=CN2C3C(C(C(O3)CO)O)OC2=NC1=N.Cl

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID