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Rhynchophylline Calcium Channel inhibitor

Cat.No.S9400

Rhynchophylline (Mitrinermine), an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension.
Rhynchophylline Calcium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 384.47

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Chemical Information, Storage & Stability

Molecular Weight 384.47 Formula

C22H28N2O4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 76-66-4 -- Storage of Stock Solutions

Synonyms Mitrinermine Smiles CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O

Solubility

In vitro
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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

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