Tryptamine

Catalog No.S3627

For research use only.

Tryptamine is a monoamine alkaloid and may play a role as a neuromodulator or neurotransmitter. It is an agonist of hTAAR1. It acts as a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent (SNDRA).

Tryptamine Chemical Structure

CAS No. 61-54-1

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Biological Activity

Description Tryptamine is a monoamine alkaloid and may play a role as a neuromodulator or neurotransmitter. It is an agonist of hTAAR1. It acts as a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent (SNDRA).
Targets
hTAAR1 [2]
(COS-7 cells)
1.08 μM(Ki)
In vitro

High concentrations of tryptamine (0.1-1 mM) induce autophagy in HT22 and SK-N-SH nerve cell lines and in primary cultures of astrocytes, glial cells being less sensitive than neurons[2].

In vivo Tryptamine at a dose of 50 mg/kg i.p. induces an inhibition of locomotor activity and, at doses ranging from 150 to 300 mg/kg, induces peculiar behaviors such as head twitch, head weaving, forepaw treading, hindlimb abduction and Straub tail. Tryptamine induces both the depression and excitation in the behavior of mice depending on the dosage and Tryptamine-induced excitatory behaviors may be attributed to both its direct stimulation of 5-HT receptors and facilitation of 5-HT release[3].

Protocol (from reference)

Cell Research:[2]
  • Cell lines: HT22 cells
  • Concentrations: 100 nM-1 mM
  • Incubation Time: 24 h
  • Method: HT22 cells are incubated for 24 hr with concentrations of tryptamine or 5-methoxytryptamine between 100 nM and 1 mM.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 160.22
Formula

C10H12N2

CAS No. 61-54-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C2C(=C1)C(=CN2)CCN

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