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Tryptamine TAAR agonist

Name: Tryptamine
Brand: Selleck Chemicals
SKU: S3627
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3627

Tryptamine is a monoamine alkaloid and may play a role as a neuromodulator or neurotransmitter. It is an agonist of hTAAR1. This compound acts as a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent (SNDRA).

Chemical Structure

Molecular Weight: 160.22

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S362701 DMSO]32 mg/mL]false]Ethanol]32 mg/mL]false]Water]Insoluble]false Purity: 99.55%

99.55

Related Targets	Adrenergic Receptor AChR 5-HT Receptor Histamine Receptor Dopamine Receptor Ras GPR GluR Prostaglandin Receptor CXCR Adenosine Receptor P2 Receptor CCR Angiotensin Receptor Hedgehog/Smoothened S1P Receptor PKA Cannabinoid Receptor cAMP Glucagon Receptor SGLT Opioid Receptor Sigma Receptor PAR Endothelin Receptor LTR Neurokinin Receptor Guanylate Cyclase PKG LPA Receptor

Chemical Information, Storage & Stability

Molecular Weight	160.22	Formula	C₁₀H₁₂N₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	61-54-1	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	C1=CC=C2C(=C1)C(=CN2)CCN

Solubility

In vitro
Batch:

DMSO : 32 mg/mL ( (199.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 32 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	16.700mg/ml (104.23mM)	Taking the 1 mL working solution as an example, add 50 μL of 334 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.650mg/ml (4.06mM)	Taking the 1 mL working solution as an example, add 50 μL of 13 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	hTAAR1 ^[2] (COS-7 cells) 1.08 μM(Ki)
In vitro	High concentrations of tryptamine (0.1-1 mM) induce autophagy in HT22 and SK-N-SH nerve cell lines and in primary cultures of astrocytes, glial cells being less sensitive than neurons^[2].
In vivo	Tryptamine at a dose of 50 mg/kg i.p. induces an inhibition of locomotor activity and, at doses ranging from 150 to 300 mg/kg, induces peculiar behaviors such as head twitch, head weaving, forepaw treading, hindlimb abduction and Straub tail. This compound induces both the depression and excitation in the behavior of mice depending on the dosage and its excitatory behaviors may be attributed to both its direct stimulation of 5-HT receptors and facilitation of 5-HT release^[3].
References	https://pubmed.ncbi.nlm.nih.gov/11459929/ https://pubmed.ncbi.nlm.nih.gov/16892423/ https://pubmed.ncbi.nlm.nih.gov/2940357/

Tech Support

Handling Instructions

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