Tryptamine

Tryptamine is a monoamine alkaloid and may play a role as a neuromodulator or neurotransmitter. It is an agonist of hTAAR1. It acts as a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent (SNDRA).

Tryptamine Chemical Structure

Tryptamine Chemical Structure

CAS: 61-54-1

Purity & Quality Control

Batch: S362701 DMSO] 32 mg/mL] false] Ethanol] 32 mg/mL] false] Water] Insoluble] false Purity: 99.55%
99.55

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Biological Activity

Description Tryptamine is a monoamine alkaloid and may play a role as a neuromodulator or neurotransmitter. It is an agonist of hTAAR1. It acts as a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent (SNDRA).
Targets
hTAAR1 [2]
(COS-7 cells)
1.08 μM(Ki)
In vitro
In vitro High concentrations of tryptamine (0.1-1 mM) induce autophagy in HT22 and SK-N-SH nerve cell lines and in primary cultures of astrocytes, glial cells being less sensitive than neurons[2].
Cell Research Cell lines HT22 cells
Concentrations 100 nM-1 mM
Incubation Time 24 h
Method HT22 cells are incubated for 24 hr with concentrations of tryptamine or 5-methoxytryptamine between 100 nM and 1 mM.
In Vivo
In vivo Tryptamine at a dose of 50 mg/kg i.p. induces an inhibition of locomotor activity and, at doses ranging from 150 to 300 mg/kg, induces peculiar behaviors such as head twitch, head weaving, forepaw treading, hindlimb abduction and Straub tail. Tryptamine induces both the depression and excitation in the behavior of mice depending on the dosage and Tryptamine-induced excitatory behaviors may be attributed to both its direct stimulation of 5-HT receptors and facilitation of 5-HT release[3].

Chemical Information & Solubility

Molecular Weight 160.22 Formula

C10H12N2

CAS No. 61-54-1 SDF Download Tryptamine SDF
Smiles C1=CC=C2C(=C1)C(=CN2)CCN
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 32 mg/mL ( (199.72 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 32 mg/mL

Water : Insoluble


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In vivo
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