Phytohemagglutinin

For research use only.

Catalog No.S6990 Synonyms: PHA, Phaseolus vulgaris agglutinin

CAS No. 9008-97-3

Phytohemagglutinin (PHA, Phaseolus vulgaris agglutinin) is expressed in Pichia pastoris using native signal peptides, or the Saccharomyces alpha-factor preprosequence, to direct proteins into the secretory pathway. Phytohemagglutinin induces apoptosis in human HEp-2 carcinoma cells via increasing proapoptotic protein Bax and activating caspases-3.

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Biological Activity

Description

Phytohemagglutinin (PHA, Phaseolus vulgaris agglutinin) is expressed in Pichia pastoris using native signal peptides, or the Saccharomyces alpha-factor preprosequence, to direct proteins into the secretory pathway. Phytohemagglutinin induces apoptosis in human HEp-2 carcinoma cells via increasing proapoptotic protein Bax and activating caspases-3.

Targets
Bax [2]
()
caspases-3 [2]
()

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL
DMSO Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight N/A
Formula

N/A

CAS No. 9008-97-3
Storage powder
in solvent
Synonyms PHA, Phaseolus vulgaris agglutinin

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02860559 Not yet recruiting Biological: TBX-1400 Severe Combined Immunodeficiency Taiga Biotechnologies Inc. August 2021 Phase 1
NCT04483271 Enrolling by invitation Dietary Supplement: 300 mg of omega3-FA Cytokine Storm|Cytokines Applied Science Private University October 2 2020 Not Applicable
NCT04337515 Recruiting Device: CliniMacs® Graft Vs Host Disease|Graft-versus-host-disease Christopher Dvorak|University of California San Francisco December 19 2019 Not Applicable
NCT03931668 Unknown status Drug: TPN-672 PHA1A Shanghai Mental Health Center|Jiangsu Kanion Pharmaceutical Co. April 17 2019 Early Phase 1
NCT04119778 Recruiting Behavioral: Aerobic Exercise Tai chi Sleep The University of Hong Kong April 1 2019 Not Applicable
NCT04142346 Completed Behavioral: Sitting + moderate intensity breaks Old Age University of Lisbon|Associação Protectora dos Diabéticos de Portugal April 1 2019 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID