Phytohemagglutinin

Catalog No.S6990 Synonyms: PHA, Phaseolus vulgaris agglutinin

For research use only.

Phytohemagglutinin (PHA, Phaseolus vulgaris agglutinin) is expressed in Pichia pastoris using native signal peptides, or the Saccharomyces alpha-factor preprosequence, to direct proteins into the secretory pathway. Phytohemagglutinin induces apoptosis in human HEp-2 carcinoma cells via increasing proapoptotic protein Bax and activating caspases-3.

CAS No. 9008-97-3

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Biological Activity

Description

Phytohemagglutinin (PHA, Phaseolus vulgaris agglutinin) is expressed in Pichia pastoris using native signal peptides, or the Saccharomyces alpha-factor preprosequence, to direct proteins into the secretory pathway. Phytohemagglutinin induces apoptosis in human HEp-2 carcinoma cells via increasing proapoptotic protein Bax and activating caspases-3.

Targets
Bax [2] caspases-3 [2]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight N/A
Formula

N/A

CAS No. 9008-97-3
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04650607 Recruiting Other: Adverse event after injection of phages Prosthetic Joint Infection|Severe Infection Hospices Civils de Lyon May 9 2022 --
NCT05380089 Recruiting Other: Increasing water intake Dehydration|Hyperhydration Faculdade de Motricidade Humana November 1 2021 Not Applicable
NCT02860559 Not yet recruiting Biological: TBX-1400 Severe Combined Immunodeficiency Taiga Biotechnologies Inc. August 2021 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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