Indirubin-3'-monoxime

Catalog No.S2009 Synonyms: Indirubin-3'-oxime

For research use only.

Indirubin-3'-monoxime (Indirubin-3'-oxime) is a selective CDK inhibitor with IC50 of 0.18 μM, 0.44 μM, 0.25 μM, 3.33 μM, 0.065 μM for CDK1-cyclinB, CDK2-cyclinA, CDK2-cyclinE, CDK4-cyclinD1, CDK5-p35,respectively. Indirubin-3'-monoxime is a direct and selective 5-lipoxygenase inhibitor with IC50 of 7.8-10 µM.

Indirubin-3'-monoxime Chemical Structure

CAS No. 160807-49-8

Purity & Quality Control

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Biological Activity

Description Indirubin-3'-monoxime (Indirubin-3'-oxime) is a selective CDK inhibitor with IC50 of 0.18 μM, 0.44 μM, 0.25 μM, 3.33 μM, 0.065 μM for CDK1-cyclinB, CDK2-cyclinA, CDK2-cyclinE, CDK4-cyclinD1, CDK5-p35,respectively. Indirubin-3'-monoxime is a direct and selective 5-lipoxygenase inhibitor with IC50 of 7.8-10 µM.
Targets
CDK5-P35 [1]
(Cell-free assay)
CDK1-cyclinB [1]
(Cell-free assay)
CDK2-cyclinE [1]
(Cell-free assay)
CDK2-cyclinA [1]
(Cell-free assay)
CDK4-cyclinD1 [1]
(Cell-free assay)
0.065 μM 0.18 μM 0.25 μM 0.44 μM 3.33 μM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 55 mg/mL
(198.35 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 277.28
Formula

C16H11N3O2

 

CAS No. 160807-49-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C2C(=C1)C(=C(N2)O)C3=C(C4=CC=CC=C4N3)N=O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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