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Sodium Monensin (NSC 343257) Antineoplastic and Immunosuppressive Antibiotics chemical

Cat.No.S2324

Sodium Monensin (NSC 343257), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics.
Sodium Monensin (NSC 343257) Antineoplastic and Immunosuppressive Antibiotics chemical Chemical Structure

Chemical Structure

Molecular Weight: 692.85

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Quality Control

Batch: Purity: >97%
97

Solubility

In vitro
Batch:

Ethanol : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 692.85 Formula

C36H61NaO11

 Storage (From the date of receipt)
CAS No. 22373-78-0 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CCC1(CCC(O1)C2(CCC3(O2)CC(C(C(O3)C(C)C(C(C)C(=O)[O-])OC)C)O)C)C4C(CC(O4)C5C(CC(C(O5)(CO)O)C)C)C.[Na+]

Mechanism of Action

In vitro
Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and TI+. Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities. The antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes.
In vivo
LD50: Mice 335mg/kg (i.g.) ; Rats 36.5mg/kg (i.g.); Chickens 185mg/kg (i.g.).
References

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