Home Apoptosis Other chemical S-allyl-L-cysteine For research use only.

S-allyl-L-cysteine

Synonyms: S-Allylcysteine

S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest.

S-allyl-L-cysteine Chemical Structure

S-allyl-L-cysteine Chemical Structure

CAS: 21593-77-1

Purity & Quality Control

Batch: Purity: 98.74%
98.74

S-allyl-L-cysteine Related Products

Biological Activity

Description S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest.
In vitro
In vitro S-Allyl cysteine (SAC) could suppress NF-κB activation and lower nitric oxide (NO) production in interferon-γ-stimulated RAW264.7 cells[2]. SAC is known for its anti-apoptotic and antioxidant effects in a range of types of somatic cells. SAC manifests antioxidant properties for example in the nervous and cardiovascular systems[3].
Cell Research Cell lines Oocytes
Concentrations 0.1, 0.5, 1.0 and 5.0 mM
Incubation Time 24 and 48 h
Method --
In Vivo
In vivo SAC significantly prevents NSAID-induced gastric ulceration by blocking inflammation[1]. The dietary intake of SAC suppresses protein expression of NF-κB, MAPK, and PKC in kidney of diabetic mice, which in turn declines renal activity and mRNA expression of NOS and COX-2, finally lowers the formation of ROS, nitric oxide, IL-6, TNF-α, and PGE2, as well as improves renal functions. Therefore, SAC is potent anti-inflammatory agents against diabetic nephropathy[2].
Animal Research Animal Models male C57BL/6 mice
Dosages 3, 10, 30 mg/kg
Administration by gavage

Chemical Information & Solubility

Molecular Weight 161.22 Formula

C6H11NO2S
CAS No. 21593-77-1 SDF Download S-allyl-L-cysteine SDF
Smiles C=CCSCC(C(=O)O)N
Storage (From the date of receipt)

In vitro
Batch:

Water : 32 mg/mL

DMSO : 4 mg/mL ( (24.81 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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