Home Apoptosis Other chemical S-allyl-L-cysteine

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S-allyl-L-cysteine

Cat.No.S4791

S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest.
S-allyl-L-cysteine Chemical Structure

Chemical Structure

Molecular Weight: 161.22

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Quality Control

Batch: Purity: 98.74%
98.74

Solubility

In vitro
Batch:

Water : 32 mg/mL

DMSO : 4 mg/mL (24.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 161.22 Formula

C6H11NO2S

 Storage (From the date of receipt)
CAS No. 21593-77-1 Download SDF Storage of Stock Solutions

Synonyms S-Allylcysteine Smiles C=CCSCC(C(=O)O)N

Mechanism of Action

In vitro
S-Allyl cysteine (SAC) could suppress NF-κB activation and lower nitric oxide (NO) production in interferon-γ-stimulated RAW264.7 cells. SAC is known for its anti-apoptotic and antioxidant effects in a range of types of somatic cells. SAC manifests antioxidant properties for example in the nervous and cardiovascular systems.
In vivo
SAC significantly prevents NSAID-induced gastric ulceration by blocking inflammation. The dietary intake of SAC suppresses protein expression of NF-κB, MAPK, and PKC in kidney of diabetic mice, which in turn declines renal activity and mRNA expression of NOS and COX-2, finally lowers the formation of ROS, nitric oxide, IL-6, TNF-α, and PGE2, as well as improves renal functions. Therefore, SAC is potent anti-inflammatory agents against diabetic nephropathy.
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