S-allyl-L-cysteine

Catalog No.S4791 Synonyms: S-Allylcysteine

For research use only.

S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest.

S-allyl-L-cysteine Chemical Structure

CAS No. 21593-77-1

Purity & Quality Control

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Biological Activity

Description S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of apoptosis and a cell cycle arrest.
In vitro

S-Allyl cysteine (SAC) could suppress NF-κB activation and lower nitric oxide (NO) production in interferon-γ-stimulated RAW264.7 cells[2]. SAC is known for its anti-apoptotic and antioxidant effects in a range of types of somatic cells. SAC manifests antioxidant properties for example in the nervous and cardiovascular systems[3].

In vivo SAC significantly prevents NSAID-induced gastric ulceration by blocking inflammation[1]. The dietary intake of SAC suppresses protein expression of NF-κB, MAPK, and PKC in kidney of diabetic mice, which in turn declines renal activity and mRNA expression of NOS and COX-2, finally lowers the formation of ROS, nitric oxide, IL-6, TNF-α, and PGE2, as well as improves renal functions. Therefore, SAC is potent anti-inflammatory agents against diabetic nephropathy[2].

Protocol (from reference)

Cell Research:[3]
  • Cell lines: Oocytes
  • Concentrations: 0.1, 0.5, 1.0 and 5.0 mM
  • Incubation Time: 24 and 48 h
  • Method: --
  • (Only for Reference)
Animal Research:[1]
  • Animal Models: male C57BL/6 mice
  • Dosages: 3, 10, 30 mg/kg
  • Administration: by gavage
  • (Only for Reference)

Solubility (25°C)

In vitro

Water 32 mg/mL
(198.48 mM)
DMSO Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 161.22
Formula

C6H11NO2S

CAS No. 21593-77-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C=CCSCC(C(=O)O)N

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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