Astaxanthin

Catalog No.S3834 Synonyms: β-Carotene-4,4'-dione, Trans-Astaxanthin

For research use only.

Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.

Astaxanthin Chemical Structure

CAS No. 472-61-7

Selleck's Astaxanthin has been cited by 2 Publications

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Biological Activity

Description Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.
In vitro

Astaxanthin is a carotenoid nutrient with molecular properties that precisely position it within cell membranes and circulating lipoproteins, thereby imbuing them with potent antioxidant and anti-inflammatory actions. Astaxanthin also effectively protects the double membrane system of mitochondria, to the point of boosting their energy production efficiency. In cultured cells, astaxanthin protects the mitochondria against endogenous oxygen radicals, conserves their redox (antioxidant) capacity, and enhances their energy production efficiency. Astaxanthin has also protected human LDL against oxidative attack. Astaxanthin specifically protects the mitochondria of cultured nerve cells against toxic attack and stimulates the proliferation of cultured nerve stem cells. It effectively protects cultured nerve cells against hydrogen peroxide toxicity, and down-regulates genes linked to cell death and up-regulates genes linked to cell survival[1].

In vivo In pharmacokinetic studies, after ingestion of esterified natural astaxanthin, only unesterified astaxanthin appears in the blood. Astaxanthin's bioavailability is substantially affected by meal timing and by smoking. Supplementation with astaxanthin may lower lipid peroxidation in vivo. Astaxanthin significantly improves the memory performance of mice in the Morris water maze. It has demonstrated safety in numerous human clinical trials. The doses of astaxanthin used in clinical trials have ranged from 1 mg/day to 40 mg/day (with the majority in the 6-12 mg range); single-dose pharmacokinetic studies use up to 100 mg per dose[1].

Protocol (from reference)

Cell Research:[2]
  • Cell lines: Vero cells
  • Concentrations: 1, 5, 10, 20, or 30 μg/100 μL
  • Incubation Time: 24 h
  • Method: Vero cells (5 × 103/well) are seeded and cultured for 24 h and then infected with trypomastigotes (10 parasites/cell). Once intracellular parasites are observed (about 96 h after infection), the old medium is replaced with fresh supplemented DMEM with different ASTX (Astaxanthin) doses (1, 5, 10, 20, or 30 μg/100 μL). As a control, co-cultures are kept with NFMX (400 μg/100 μL) or with no ASTX or NFMX supplementation. After 24 h of incubation, microscopic morphological changes in the co-culture, such as loss of normal shape of T. cruzi infected Vero cell, changes of normal parasite shape or motility, and variations in the presence of intra- or extra-cellular parasites are evaluated by a trained technician. Additionally, parasite viability is evaluated by Trypan blue stain assay.
  • (Only for Reference)
Animal Research:[2]
  • Animal Models: BALB/c mice (4-6 weeks old) infected with Trypanosoma cruzi
  • Dosages: 10 mg/kg/day
  • Administration: oral administration
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(167.54 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 596.84
Formula

C40H52O4

CAS No. 472-61-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C(CC(C1=O)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(C(=O)C(CC2(C)C)O)C)C)C

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05138549 Not yet recruiting Drug: Astaxanthin|Other: Placebo Osteoarthritis Knee|Osteoarthritis Knees Both|Joint Inflammation Prisma Health-Midlands January 2022 Phase 2|Phase 3
NCT02343497 Completed Dietary Supplement: Astaxanthin|Dietary Supplement: Placebo Dyslipidemias Ajinomoto Foods Europe SAS|Institut Polytechnique LaSalle Beauvais|Naturalpha August 2014 Not Applicable
NCT03945526 Completed Drug: Astaxanthine|Drug: Placebo Oral Tablet Cerebral Stroke|Malondialdehyde|Oxidative Stress Indonesia University March 23 2010 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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