For research use only.

Catalog No.S3968

1 publication

Histamine Chemical Structure

Molecular Weight(MW): 111.15

Histamine, an organic nitrogenous compound, is involved in local immune responses regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. It is a potent H1 and H2 receptor agonist.

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Biological Activity

Description Histamine, an organic nitrogenous compound, is involved in local immune responses regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. It is a potent H1 and H2 receptor agonist.
In vitro

Histamine stimulates the proliferation of human articular chondrocytes in culture. Histamine is reported to modify the behaviour of many cell types in vitro, including chondrocytes, fibroblasts, macrophages, epithelial cells, endothelial cells, and T cells. Histamine also modulates the production of many cytokines and the expression of their receptors. Histamine regulates cellular processes through the expression of histamine receptors. Histamine stimulates the production of matrix metalloproteinases (MMPs)-13 and -3 (collagenase 3 and stromelysin-1, respectively) by histidine decarboxylase (HAC) in vitro[1].

In vivo Histamine has a recognised role in allergic and inflammatory reactions and is an important modulator of numerous physiological processes, including cell proliferation, angiogenesis, and vasopermeability[1]. Histamine dilates vasculature, increases blood flow, while it induces hyperpermeability in venula. It disrupts endothelial barrier formation of venula indicated by changes in vascular endothelial cadherin (VE-cadherin) localization at endothelial cell junction[3].


Cell Research:[1]
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  • Cell lines: human articular chondrocytes
  • Concentrations: 1-100 μmol/l
  • Incubation Time: 6 days
  • Method: Cells are grown to confluence in 80 cm2 culture flasks in Dulbecco's modified Eagle's medium (DMEM) + 10% fetal calf serum (FCS). At first or second passage, cells are seeded into 96 well culture plates, at densities of approximately 2×103 cells/well. After 24 hours the cells are treated with either DMEM +2% FCS alone (control), or DMEM + 2% FCS plus histamine range 1-100 μmol/l (minimum of eight wells for each treatment). The medium with or without histamine is replenished every 48 hours, and after six days cell growth is estimated.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: New Zealand adult healthy albino rabbits
  • Dosages: 50, 100, 200 μg/kg
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 22 mg/mL (197.93 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 111.15


CAS No. 51-45-6
Storage powder
in solvent
Synonyms N/A
Smiles NCCC1=C[NH]C=N1

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04286542 Recruiting Diagnostic Test: Cold dry air Hyperactivity|Allergic Rhinitis Due to House Dust Mite|Chronic Rhinosinusitis With Nasal Polyps Universitaire Ziekenhuizen Leuven January 20 2020 Not Applicable
NCT03930537 Completed Device: Hip replacement Arthroplasty Complications University Clinical Centre of Kosova March 17 2019 Not Applicable
NCT03826004 Completed Drug: Clemastine|Drug: Saline Solution Efficacy and Safety Chinese Academy of Medical Sciences Fuwai Hospital February 20 2019 Not Applicable

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Histamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID