Curcumenol

Catalog No.S3874

Curcumenol Chemical Structure

Molecular Weight(MW): 234.33

Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.

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Biological Activity

Description Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.
Targets
CYP3A4 [2]
()
12.6 μM
In vitro

Curcumenol markedly decreases LPS-induced production of nitric oxide (NO), pro-inflammatory cytokines [(IL-6) and (TNF-α)] and pro-inflammatory proteins expression, iNOS and COX-2. Curcumenol has also been shown to exhibit hepatoprotective properties. Curcumenol can suppress the LPS-induced NF-κB activity by inhibiting the phosphorylation of Akt. Its treatment significantly inhibits LPS-induced phosphorylation of p38 MAPK but not JNK and ERK[1]. The activity of CYP3A4 is strongly inhibited by curcumenol with an IC50 value of 12.6 ± 1.3 μM. Kinetic analysis shows curcumenol competitively inhibits testosterone 6β-hydroxylation activity (CYP3A4) with Ki of 10.8 μM[2].

Protocol

Cell Research:[1]
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  • Cell lines: BV-2 cell line
  • Concentrations: 2.5–20 μM
  • Incubation Time: 2 h
  • Method: BV-2 cells are seeded into a sterile flat bottom 96-well plate. The cells are then allowed to adhere overnight. The cells are pretreated with various concentrations of curcumenol for 2 h followed by LPS exposure (0.4 μg/mL) for 12 h to 24 h.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 46 mg/mL (196.3 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 234.33
Formula

C15H22O2

CAS No. 19431-84-6
Storage powder
in solvent
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID