Curcumenol

Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.

Curcumenol Chemical Structure

Curcumenol Chemical Structure

CAS: 19431-84-6

Selleck's Curcumenol has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.89%
99.89

Curcumenol Related Products

Signaling Pathway

Choose Selective NF-κB Inhibitors

Biological Activity

Description Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.
Targets
NF-κB [1] CYP3A4 [2]
12.6 μM
In vitro
In vitro Curcumenol markedly decreases LPS-induced production of nitric oxide (NO), pro-inflammatory cytokines [(IL-6) and (TNF-α)] and pro-inflammatory proteins expression, iNOS and COX-2. Curcumenol has also been shown to exhibit hepatoprotective properties. Curcumenol can suppress the LPS-induced NF-κB activity by inhibiting the phosphorylation of Akt. Its treatment significantly inhibits LPS-induced phosphorylation of p38 MAPK but not JNK and ERK[1]. The activity of CYP3A4 is strongly inhibited by curcumenol with an IC50 value of 12.6 ± 1.3 μM. Kinetic analysis shows curcumenol competitively inhibits testosterone 6β-hydroxylation activity (CYP3A4) with Ki of 10.8 μM[2].
Cell Research Cell lines BV-2 cell line
Concentrations 2.5–20 μM
Incubation Time 2 h
Method BV-2 cells are seeded into a sterile flat bottom 96-well plate. The cells are then allowed to adhere overnight. The cells are pretreated with various concentrations of curcumenol for 2 h followed by LPS exposure (0.4 μg/mL) for 12 h to 24 h.

Chemical Information & Solubility

Molecular Weight 234.33 Formula

C15H22O2

CAS No. 19431-84-6 SDF Download Curcumenol SDF
Smiles CC1CCC2C13CC(=C(C)C)C(O3)(C=C2C)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 46 mg/mL ( (196.3 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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