Gastrodin

Catalog No.S2383 Synonyms: Gastrodine

For research use only.

Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.

Gastrodin Chemical Structure

CAS No. 62499-27-8

Selleck's Gastrodin has been cited by 1 Publication

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Biological Activity

Description Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.
In vitro

Gastrodin is the most important and effective ingredient extracted from Chinese natural herbal Gastrodia elata. Gastrodin (30, 40, and 60 mM) significantly attenuates levels of neurotoxic proinflammatory mediators and proinflammatory cytokines by inhibition of the NF-kappaB signaling pathway and phosphorylation of MAPKs in LPS-stimulated microglial cells. [1] However, It also upregulates the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling, resulting in the inhibitory effects NF-kappaB and MAPKs activation in H9c2 cardiomyocytes. [2]

In vivo Gastrodin at 5 mg/kg can improve cycloheximide- and apomorphine-induced amnesia, but not scopolamine-induced acquisition impairment in rats. Thus, GAS can facilitate memory consolidation and retrieval, but not acquisition. [3] LD50: Mice >1000mg/kg (i.v.) [4]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 286.28
Formula

C13H18O7

CAS No. 62499-27-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=CC=C1CO)OC2C(C(C(C(O2)CO)O)O)O

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00297245 Unknown status Drug: cognitive function Cognitive Decline Huazhong University of Science and Technology February 2006 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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