Home Immunology & Inflammation Immunology & Inflammation related chemical Gastrodin

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Gastrodin Immunology & Inflammation related chemical

Cat.No.S2383

Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.
Gastrodin Immunology & Inflammation related chemical Chemical Structure

Chemical Structure

Molecular Weight: 286.28

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Quality Control

Batch: S238301 DMSO]50 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.70%
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99.70

Solubility

In vitro
Batch:

DMSO : 50 mg/mL (174.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 286.28 Formula

C13H18O7

 Storage (From the date of receipt)
CAS No. 62499-27-8 Download SDF Storage of Stock Solutions

Synonyms Gastrodine Smiles C1=CC(=CC=C1CO)OC2C(C(C(C(O2)CO)O)O)O

Mechanism of Action

In vitro
Gastrodin is the most important and effective ingredient extracted from Chinese natural herbal Gastrodia elata. This compound (30, 40, and 60 mM) significantly attenuates levels of neurotoxic proinflammatory mediators and proinflammatory cytokines by inhibition of the NF-kappaB signaling pathway and phosphorylation of MAPKs in LPS-stimulated microglial cells. However, It also upregulates the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling, resulting in the inhibitory effects NF-kappaB and MAPKs activation in H9c2 cardiomyocytes.
In vivo
Gastrodin at 5 mg/kg can improve cycloheximide- and apomorphine-induced amnesia, but not scopolamine-induced acquisition impairment in rats. Thus, this compound can facilitate memory consolidation and retrieval, but not acquisition. LD50: Mice >1000mg/kg (i.v.)
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00297245 Unknown status
Cognitive Decline
Huazhong University of Science and Technology
 February 2006 Phase 4

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