Tabersonine hydrochloride

For research use only.

Catalog No.S5101

Tabersonine hydrochloride Chemical Structure

Molecular Weight(MW): 372.89

Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.

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Biological Activity

Description Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.
Aβ(1−42) aggregation [1]
In vitro

Tabersonine disrupts Aβ(1−42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. It binds to Aβ(1−42) oligomers more strongly than to Aβ(1−42) monomers with Kd values of 69 μM and 535 μM, respectively[1].

In vivo The biocompatibility and small size essential for permeating the blood−brain barrier make tabersonine a potential therapeutic drug candidate for treating Alzheimer's disease (AD)[1].


Cell Research:


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  • Cell lines: SH-SY5Y cell
  • Concentrations: 10 μM
  • Incubation Time: 24 h
  • Method:

    The cultured cells were transferred to a sterile 96-well plate with approximately 1×104 cells/well. Cells acclimatized overnight in the media in a humidified incubator under 5% CO2 at 37℃. Aβ(1−42)solutions and Aβ(1−42)−tabersonine mixtures were preincubated at 37℃ for different times, and the resultant solutions were mixed with the SH-SY5Y cells for 24 h. The viability of the SH-SY5Y cells exposed to each solution was determined with MTT assay. Cell viability was estimated by dividing the absorbance of wells containing samples by that of wells containing only cell culture media.

    (Only for Reference)

Solubility (25°C)

In vitro DMSO 40 mg/mL (107.27 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 372.89


CAS No. 29479-00-3
Storage powder
in solvent
Synonyms N/A
Smiles Cl.CCC12CC(=C3NC4=C(C=CC=C4)C35CCN(CC=C1)C25)C(=O)OC

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID