Tabersonine hydrochloride

Catalog No.S5101

For research use only.

Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.

Tabersonine hydrochloride Chemical Structure

CAS No. 29479-00-3

Purity & Quality Control

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Biological Activity

Description Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.
Targets
Aβ(1−42) aggregation [1]
In vitro

Tabersonine disrupts Aβ(1−42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. It binds to Aβ(1−42) oligomers more strongly than to Aβ(1−42) monomers with Kd values of 69 μM and 535 μM, respectively[1].

In vivo The biocompatibility and small size essential for permeating the blood−brain barrier make tabersonine a potential therapeutic drug candidate for treating Alzheimer's disease (AD)[1].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: SH-SY5Y cell
  • Concentrations: 10 μM
  • Incubation Time: 24 h
  • Method:

    The cultured cells were transferred to a sterile 96-well plate with approximately 1×104 cells/well. Cells acclimatized overnight in the media in a humidified incubator under 5% CO2 at 37℃. Aβ(1−42)solutions and Aβ(1−42)−tabersonine mixtures were preincubated at 37℃ for different times, and the resultant solutions were mixed with the SH-SY5Y cells for 24 h. The viability of the SH-SY5Y cells exposed to each solution was determined with MTT assay. Cell viability was estimated by dividing the absorbance of wells containing samples by that of wells containing only cell culture media.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 372.89
Formula

C21H24N2O2.HCl

CAS No. 29479-00-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC12CC(=C3C4(C1N(CC4)CC=C2)C5=CC=CC=C5N3)C(=O)OC.Cl

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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