Home Metabolism DHFR inhibitor Calcium folinate (Leucovorin calcium) For research use only.

Calcium folinate (Leucovorin calcium)

Synonyms: Folinic acid calcium salt

Calcium folinate (Leucovorin calcium) is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives.Solutions are unstable and should be fresh-prepared.

Calcium folinate (Leucovorin calcium) Chemical Structure

Calcium folinate (Leucovorin calcium) Chemical Structure

CAS: 1492-18-8

Purity & Quality Control

Batch: Purity: 99.72%
99.72

Calcium folinate (Leucovorin calcium) Related Products

Signaling Pathway

DHFR Signaling Pathways

DHFR Signaling Pathway

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Biological Activity

Description Calcium folinate (Leucovorin calcium) is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives.Solutions are unstable and should be fresh-prepared.
In Vivo
In vivo Calcium folinate (also known as Leucovorin) treatment has no effect on tumor growth. The combination of bortezomib and leucovorin is able to induce apoptosis and attenuate tumor growth in vivo[2].
Animal Research Animal Models Human colorectal HCT116 xenograft tumors (female NSG mice)
Dosages 80 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04060030 Recruiting
Autism Spectrum Disorder|Language Disorders
Southwest Autism Research & Resource Center|Autism Speaks|State University of New York - Downstate Medical Center
 October 8 2020 Phase 2
NCT04060017 Recruiting
Autism Spectrum Disorder|Language Disorders
Southwest Autism Research & Resource Center|State University of New York - Downstate Medical Center|United States Department of Defense
 September 22 2020 Phase 2

Chemical Information & Solubility

Molecular Weight 511.5 Formula

C20H21N7O7.Ca
CAS No. 1492-18-8 SDF Download Calcium folinate (Leucovorin calcium) SDF
Storage (From the date of receipt) Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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