N-Acetylneuraminic acid

Catalog No.S4792 Synonyms: Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid

For research use only.

N-Acetylneuraminic acid (Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid, NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes.

N-Acetylneuraminic acid Chemical Structure

CAS No. 131-48-6

Selleck's N-Acetylneuraminic acid has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description N-Acetylneuraminic acid (Neu5Ac, NeuAc, Acido aceneuramico, Acide aceneuramique, Acidium aceneuramicum, Sialic acid, NANA) is the predominant sialic acid found in mammalian cells. Sialic acids are negatively charged monosaccharides attached to the end of sugar chains, giving rise to a wide variety of glycoproteins and glycolipids in biological fluids and cell membranes.
In vivo N-Acetylneuraminic acid (Neu5Ac) could improve lipid metabolism and hyperlipidemia-associated coagulation. It prevents HFD-induced hypercholesterolemia and hypercoagulation through regulation of serum lipid levels, metabolic indices, and coagulation-related indices[2].

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Sprague-Dawley rats
  • Dosages: 20 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 309.27
Formula

C11H19NO9

CAS No. 131-48-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03545568 Completed Other: Neu5Ac supplementation N-Acetylneuraminic Acid Storage Disease University of Lausanne|University of Modena and Reggio Emilia May 1 2018 Not Applicable
NCT02346461 Completed Drug: ManNAc GNE Myopathy National Human Genome Research Institute (NHGRI)|National Center for Advancing Translational Science (NCATS)|National Institutes of Health Clinical Center (CC) February 5 2015 Phase 2
NCT01236898 Completed Drug: NPC-09 Nonaka Myopathy|Hereditary Inclusion Body Myopathy Tohoku University November 2010 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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