Home Cytoskeletal Signaling PKC activator Decursinol angelate

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Decursinol angelate PKC activator

Cat.No.S3819

Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.
Decursinol angelate PKC activator Chemical Structure

Chemical Structure

Molecular Weight: 328.36

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Quality Control

Batch: S381901 DMSO]65 mg/mL]false]]]false]]]false Purity: 99.62%
99.62

Chemical Information, Storage & Stability

Molecular Weight 328.36 Formula

C19H20O5

 Storage (From the date of receipt)
CAS No. 130848-06-5 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC=C(C)C(=O)OC1CC2=C(C=C3C(=C2)C=CC(=O)O3)OC1(C)C

Solubility

In vitro
Batch:

DMSO : 65 mg/mL ( (197.95 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
PKC [2]
In vitro
Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB. This compound also inhibits PGE2-induced expression of cyclooxygenase-2 and the activation of the Ras/Raf/Erk pathway, which activates downstream targets for cell survival. It greatly reduces the PGE2-induced activation of NF-κB p50 and p65 subunits. It has been reported to suppress the growth of estrogen-stimulated and estrogen-independent growth and survival of breast cancer MCF-7 and MDA-MB-231 cells. This chemical also suppresses the growth of cancer cells through the inhibition of phosphatidylinositol 3'-kinase (PI3K)/Akt, extracellular-signal-regulated kinase (Erk) and nuclear factor-κB (NFκB). It has anti-leukemic activity through the suppression of protein kinase C activation in human leukemia cells[1].
In vivo
Decursinol angelate has anti-angiogenic activity both in vitro and in vivo[1].
References

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