Decursinol angelate

For research use only.

Catalog No.S3819

Decursinol angelate Chemical Structure

CAS No. 130848-06-5

Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.

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Biological Activity

Description Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.
PKC [2]
In vitro

Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB. Decursinol angelate also inhibits PGE2-induced expression of cyclooxygenase-2 and the activation of the Ras/Raf/Erk pathway, which activates downstream targets for cell survival. Decursinol angelate greatly reduces the PGE2-induced activation of NF-κB p50 and p65 subunits. It has been reported to suppress the growth of estrogen-stimulated and estrogen-independent growth and survival of breast cancer MCF-7 and MDA-MB-231 cells. Decursinol angelate also suppresses the growth of cancer cells through the inhibition of phosphatidylinositol 3'-kinase (PI3K)/Akt, extracellular-signal-regulated kinase (Erk) and nuclear factor-κB (NFκB). Decursinol angelate has anti-leukemic activity through the suppression of protein kinase C activation in human leukemia cells[1].

In vivo Decursinol angelate has anti-angiogenic activity both in vitro and in vivo[1].


Cell Research:


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  • Cell lines: MCF-7 cells
  • Concentrations: 10 μM, 20 μM, 50 μM
  • Incubation Time: 24 hours
  • Method:

    Cells are treated with decursinol angelate at different exposure concentrations (10 μM, 20 μM, 50 μM) for 24 hours in complete medium.

    (Only for Reference)
Animal Research:


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  • Animal Models: Jugular vein cannulated CD male rats
  • Dosages: 50 mg/kg
  • Administration: oral
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 65 mg/mL (197.95 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 328.36


CAS No. 130848-06-5
Storage powder
in solvent
Synonyms N/A
Smiles CC=C(C)C(=O)OC1CC2=C(C=C3C(=C2)C=CC(=O)O3)OC1(C)C

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID