Decursinol angelate

Catalog No.S3819

For research use only.

Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.

Decursinol angelate Chemical Structure

CAS No. 130848-06-5

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Biological Activity

Description Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.
Targets
PKC [2]
()
In vitro

Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB. Decursinol angelate also inhibits PGE2-induced expression of cyclooxygenase-2 and the activation of the Ras/Raf/Erk pathway, which activates downstream targets for cell survival. Decursinol angelate greatly reduces the PGE2-induced activation of NF-κB p50 and p65 subunits. It has been reported to suppress the growth of estrogen-stimulated and estrogen-independent growth and survival of breast cancer MCF-7 and MDA-MB-231 cells. Decursinol angelate also suppresses the growth of cancer cells through the inhibition of phosphatidylinositol 3'-kinase (PI3K)/Akt, extracellular-signal-regulated kinase (Erk) and nuclear factor-κB (NFκB). Decursinol angelate has anti-leukemic activity through the suppression of protein kinase C activation in human leukemia cells[1].

In vivo Decursinol angelate has anti-angiogenic activity both in vitro and in vivo[1].

Protocol (from reference)

Cell Research:

[4]

  • Cell lines: MCF-7 cells
  • Concentrations: 10 μM, 20 μM, 50 μM
  • Incubation Time: 24 hours
  • Method:

    Cells are treated with decursinol angelate at different exposure concentrations (10 μM, 20 μM, 50 μM) for 24 hours in complete medium.

  • (Only for Reference)
Animal Research:

[3]

  • Animal Models: Jugular vein cannulated CD male rats
  • Dosages: 50 mg/kg
  • Administration: oral
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 65 mg/mL
(197.95 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 328.36
Formula

C19H20O5

CAS No. 130848-06-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC=C(C)C(=O)OC1CC2=C(C=C3C(=C2)C=CC(=O)O3)OC1(C)C

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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