Home Metabolism P450 (e.g. CYP17) chemical - Topoisomerase inhibitor - Other chemical Ellipticine hydrochloride For research use only.

Ellipticine hydrochloride

Synonyms: NSC 71795 hydrochloride, PZE

Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity.

Ellipticine hydrochloride Chemical Structure

Ellipticine hydrochloride Chemical Structure

CAS: 5081-48-1

Selleck's Ellipticine hydrochloride has been cited by 1 publication

Purity & Quality Control

Batch: S679001 DMSO] 3 mg/mL] false] Water] ˂1 mg/mL] false] Ethanol] ˂1 mg/mL] false Purity: 99.6%
99.6

Ellipticine hydrochloride Related Products

Signaling Pathway

P450 (e.g. CYP17) Signaling Pathways

P450 (e.g. CYP17) Signaling Pathway

Choose Selective P450 (e.g. CYP17) Inhibitors

Biological Activity

Description Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity.
Targets
P450 [1] peroxidase [1] Topo II [1]

Chemical Information & Solubility

Molecular Weight 282.77 Formula

C17H15ClN2
CAS No. 5081-48-1 SDF --
Smiles CC1=C2C=CN=CC2=C(C3=C1NC4=CC=CC=C43)C.Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 3 mg/mL ( (10.6 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : ˂1 mg/mL

Ethanol : ˂1 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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