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Secoisolariciresinol diglucoside Immunology & Inflammation related chemical

Name: Secoisolariciresinol diglucoside
Brand: Selleck Chemicals
SKU: S3780
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3780

Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.

Chemical Structure

Molecular Weight: 686.7

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S378001 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]100 mg/mL]false Purity: 99.43%

99.43

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Chemical Information, Storage & Stability

Molecular Weight	686.7	Formula	C₃₂H₄₆O₁₆	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	148244-82-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	COC1=C(O)C=CC(=C1)CC(COC2OC(CO)C(O)C(O)C2O)C(COC3OC(CO)C(O)C(O)C3O)CC4=CC(=C(O)C=C4)OC

Solubility

In vitro
Batch:

DMSO : 100 mg/mL ( (145.62 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	Secoisolariciresinol diglucoside (SDG) inhibits colon cancer cell growth by inducing S-phase cell cycle arrest^[1]. SDG is effective in mitigating iron-induced cellular damage and death. SDG is capable of preventing the increase in inflammation in iron treated cells^[2].
In vivo	Secoisolariciresinol diglucoside (SDG) has been shown to decrease the production of inflammatory mediators and reduce oxidative stress. Its treatment is also found to reduce the development of hypercholesterolemic atherosclerosis in rabbits fed a high cholesterol diet, and reduce the development of diabetes in rats. SDG prevents the development of hypercholesterolemic atherosclerosis, induces angiogenesis-mediated cardioprotection, and prevents the development of type 1 and type 2 diabetes. SDG may have a cardioprotective role in cardiac iron overload^[2].
References	https://pubmed.ncbi.nlm.nih.gov/21130295/ https://pubmed.ncbi.nlm.nih.gov/25822525/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04816890	Completed	Type 1 Diabetes Mellitus	Adocia	March 23 2021	Phase 2
NCT01234506	Completed	Oxidative Stress\|Inflammation\|Aging\|Dementia\|Pain	University of Saskatchewan\|Saskatchewan Health Research Foundation	October 2010	Phase 2

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