Secoisolariciresinol diglucoside

Catalog No.S3780

For research use only.

Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.

Secoisolariciresinol diglucoside Chemical Structure

CAS No. 148244-82-0

Purity & Quality Control

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Biological Activity

Description Secoisolariciresinol diglucoside (SDG), a plant lignan isolated from flaxseed, has strong antioxidant activity, cardioprotective effects, reduces the blood levels of low-density lipoprotein cholesterol, and reduces the risk of hormone related cancer.
In vitro

Secoisolariciresinol diglucoside (SDG) inhibits colon cancer cell growth by inducing S-phase cell cycle arrest[1]. SDG is effective in mitigating iron-induced cellular damage and death. SDG is capable of preventing the increase in inflammation in iron treated cells[2].

In vivo Secoisolariciresinol diglucoside (SDG) has been shown to decrease the production of inflammatory mediators and reduce oxidative stress. Its treatment is also found to reduce the development of hypercholesterolemic atherosclerosis in rabbits fed a high cholesterol diet, and reduce the development of diabetes in rats. SDG prevents the development of hypercholesterolemic atherosclerosis, induces angiogenesis-mediated cardioprotection, and prevents the development of type 1 and type 2 diabetes. SDG may have a cardioprotective role in cardiac iron overload[2].

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(145.62 mM)
Water 100 mg/mL
(145.62 mM)
Ethanol 100 mg/mL
(145.62 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 686.7
Formula

C32H46O16

CAS No. 148244-82-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=C(O)C=CC(=C1)CC(COC2OC(CO)C(O)C(O)C2O)C(COC3OC(CO)C(O)C(O)C3O)CC4=CC(=C(O)C=C4)OC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04816890 Recruiting Drug: M1 Pram P037|Drug: Insulin lispro Type 1 Diabetes Mellitus Adocia March 23 2021 Phase 2
NCT01276704 Completed Drug: Placebo|Drug: secoisolariciresinol Breast Cancer Carol Fabian MD|Lignan Research Inc.|University of Kansas Medical Center January 2011 Phase 2
NCT01234506 Completed Dietary Supplement: secoisolariciresinol diglucoside Oxidative Stress|Inflammation|Aging|Dementia|Pain University of Saskatchewan|Saskatchewan Health Research Foundation October 2010 Phase 2

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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