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Tyrosol NF-κB inhibitor

Cat.No.S3773

Tyrosol (4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol) is an antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives. This compound is a derivative of phenethyl alcohol. It attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects.
Tyrosol NF-κB inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 138.16

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Quality Control

Chemical Information, Storage & Stability

Molecular Weight 138.16 Formula

C8H10O2

 Storage (From the date of receipt)
CAS No. 501-94-0 Download SDF Storage of Stock Solutions

Synonyms 4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol Smiles C1=CC(=CC=C1CCO)O

Solubility

In vitro
Batch:

DMSO : 27 mg/mL (195.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
NF-κB [2]
In vitro

Tyrosol (Tyr) suppresses TNF-α-induced intracellular production of ROS, depletion of GSH, and down-regulation of genes encoding antioxidant enzymes in hECs. This compound inhibits palmitic acid-induced oxidative stress in human liver HepG2 cells[1].
In vivo

After ingestion, Tyrosol (Tyr) undergoes extensive first pass intestinal/hepatic metabolism[1].
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06285682 Active not recruiting
Healthy
Anglia Ruskin University|Fattoria La Vialla|Instituto Kurz
 February 3 2024 Not Applicable
NCT02783989 Completed
Cardiovascular Disease
Parc de Salut Mar
 January 20 2016 Not Applicable

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