Tyrosol

Catalog No.S3773 Synonyms: 4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol

For research use only.

Tyrosol (4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol) is an antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives. Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects.

Tyrosol Chemical Structure

CAS No. 501-94-0

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Biological Activity

Description Tyrosol (4-Hydroxyphenylethanol, 4-Hydroxyphenethyl alcohol, 2-(4-Hydroxyphenyl)ethanol) is an antioxidant that is naturally present in several foods such as wines and green tea and is present most abundantly in olives. Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects.
Targets
NF-κB [2]
()
In vitro

Tyrosol (Tyr) suppresses TNF-α-induced intracellular production of ROS, depletion of GSH, and down-regulation of genes encoding antioxidant enzymes in hECs. Tyr inhibits palmitic acid-induced oxidative stress in human liver HepG2 cells[1].

In vivo

After ingestion, Tyrosol (Tyr) undergoes extensive first pass intestinal/hepatic metabolism[1].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: hECs (human endothelial cells)
  • Concentrations: 0-200 μM
  • Incubation Time: 48 h
  • Method:

    hECs are cultured in 96-well plates in eight replicate sets at a density of 104 cells per well in the presence of Tyr or its metabolites at the indicated concentrations for 48 h. Cell viability is assayed based on the ability of live cells to reduce methylthiazolyldiphenyl-tretrazolium bromide (MTT).

  • (Only for Reference)
Animal Research:

[1]

  • Animal Models: Swiss albino mice
  • Dosages: 0.5 mg/kg
  • Administration: i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 27 mg/mL
(195.42 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 138.16
Formula

C8H10O2

CAS No. 501-94-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=CC=C1CCO)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02783989 Completed Other: white wine|Dietary Supplement: tyrosol Cardiovascular Disease Parc de Salut Mar January 20 2016 Not Applicable

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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