Home PI3K/Akt/mTOR AMPK activator Euphorbiasteroid

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Euphorbiasteroid AMPK activator

Cat.No.S3832

Euphorbiasteroid (Euphorbia factor L1), a component of Euphorbia lathyris L., inhibits adipogenesis of 3T3-L1 cells through activation of the AMPK pathway and induces HL-60 cells to apoptosis via promoting Bcl-2/Bax apoptotic signaling pathway in a dose-dependent manner. This compound is a tricyclic diperpene of Euphorbia lathyris L., inhibits tyrosinase, and increases the phosphorylation of AMPK, with anti-cancer, anti-virus, anti-obesity and multidrug resistance-modulating effect.
Euphorbiasteroid AMPK activator Chemical Structure

Chemical Structure

Molecular Weight: 552.66

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Quality Control

Batch: S383201 DMSO]21 mg/mL]false]]]false]]]false Purity: 99.86%
99.86

Chemical Information, Storage & Stability

Molecular Weight 552.66 Formula

C32H40O8

 Storage (From the date of receipt)
CAS No. 28649-59-4 -- Storage of Stock Solutions

Synonyms Euphorbia factor L1 Smiles CC1CC2(C(C1OC(=O)CC3=CC=CC=C3)C(C4(CCC5C(C5(C)C)C=C(C2=O)C)CO4)OC(=O)C)OC(=O)C

Solubility

In vitro
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DMSO : 21 mg/mL ( (37.99 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
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Mechanism of Action

In vitro
Euphorbiasteroid suppresses adipogenic differentiation of 3T3‐L1 cells, mainly at the early stage, and stimulates the AMPK signalling pathway. The anti-adipogenic effects of this compound could possibly be attributed to activation of the AMPK pathway, by decreasing the level of FAS and its up-regulators, including C/EBPs, PPAR-γ and SREBP-1c, without involving insulin signalling pathway[1]. This chemical could be a transport substrate for P-gp that can effectively inhibit P-gp-mediated drug transport and reverse resistance to anticancer drugs in MES-SA/Dx5 cells[2].
References

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