2',3'-cGAMP Sodium Salt

For research use only.

Catalog No.S7904 Synonyms: 2'-3'-cyclic GMP-AMP Sodium, 2',3'-cGAMP Sodium

2',3'-cGAMP Sodium Salt Chemical Structure

CAS No. 1441190-66-4 (free acid)

2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). 2',3'-cGAMP binds to STING with Kd of 3.79 nM.

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Biological Activity

Description 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). 2',3'-cGAMP binds to STING with Kd of 3.79 nM.
Targets
STING [1]
(Cell-free assay)
3.79 nM(Kd)
In vitro

2',3'-cGAMP is an endogenous second messenger produced by mammalian cells. 2',3'-cGAMP is a high affinity ligand for STING. 2',3'-cGAMP is a potent inducer of type-I interferons. 2',3'-cGAMP binding induces conformational changes of STING.[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
293T M3fFRWZ2dmO2aX;uJIF{e2G7 M4m5Z|MxKG2rboO= NEDBN5JC[3SrdnH0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIGPUTW5IKGijcHzveJlx\SCUN{HIM2czOzCDL2KyPVNSKG23dHHueEBmgHC{ZYPz[YQhcW5iMkmzWEBk\WyuczDt[YF{fXKnZDDh[pRmeiB|MDDtbY5{KGmwIIDy[ZNmdmOnIH;mJIRq\2m2b37pckBCKGK7IHLybYdpfCCJbH:tcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwJF0hOC5yMjFOwG0v MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTdzNUC5PUc,OzF5MUWwPVk9N2F-
293T M{m1dWZ2dmO2aX;uJIF{e2G7 NYrBfm83OzBibXnudy=> MYjBZ5RqfmG2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKHerbHSteJlx\SCVVFnOS{BmgHC{ZYPz[YQhcW5iMkmzWEBk\WyuczDt[YF{fXKnZDDh[pRmeiB|MDDtbY5{KGmwIIDy[ZNmdmOnIH;mJIRq\2m2b37pckBCKGK7IHLybYdpfCCJbH:tcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwJF0hOC5yMjFOwG0v MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTdzNUC5PUc,OzF5MUWwPVk9N2F-
293T MUfGeY5kfGmxbjDhd5NigQ>? NHrv[JY{OCCvaX7z NFu3RXBC[3SrdnH0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIGPUTW5IKGijcHzveJlx\SCJMkOwRU9TOjl|UTDteZRidnRiZYjwdoV{e2WmIHnuJFI6O1RiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgN|AhdWmwczDpckBxemW|ZX7j[UBw\iCmaXfpeI9vcW5iQTDifUBjemmpaISgS4xwNWy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OCB;IECuNFQh|ryPLh?= M1Lzc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzN{G1NFk6Lz5|MUexOVA6QTxxYU6=
293T M2nIbWZ2dmO2aX;uJIF{e2G7 NXGyR5JWOzBibXnudy=> NVS0R5JlSWO2aY\heIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDTWGlPTyCqYYDsc5R6eGViUkK5N3EhdXW2YX70JIV5eHKnc4Pl[EBqdiB{OUPUJINmdGy|IH3lZZN2emWmIHHmeIVzKDNyIH3pcpMhcW5icILld4Vv[2Vib3[g[IlocXSxbnnuJGEh[nliYoLp[4h1KEeubz3seYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUCgQUAxNjB3IN88UU4> NXHLUYM6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G3NVUxQTlpPkOxO|E2ODl7PD;hQi=>
293T MYTGeY5kfGmxbjDhd5NigQ>? NF7H[Yk{OCCvaX7z MonDRYN1cX[jdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCVVFnOS{Bp[XCub4T5dIUhWjJ|MligcZV1[W62IHX4dJJme3OnZDDpckAzQTOWIHPlcIx{KG2nYYP1doVlKGGodHXyJFMxKG2rboOgbY4heHKnc3XuZ4Uhd2ZiZHnnbZRwdmmwIFGgZpkh[nKrZ3j0JGdtdy2udXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTBiPTCwMlA4KM7:TT6= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTdzNUC5PUc,OzF5MUWwPVk9N2F-
293T M3v4bGZ2dmO2aX;uJIF{e2G7 NXfl[ohtPyCqcoO= NF36XYxC[3SrdnH0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIIfpcIQufHmyZTDTWGlPTyCneIDy[ZN{\WRiaX6gNlk{XCClZXzsd{BqdmO3YnH0[YQh\m:{IEegbJJ{KGmwIHHid4Vv[2Vib3[g[IlocXSxbnnuJGEh[nliYoLp[4h1KEeubz3seYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUCgQUAyOy55IN88UU4> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTdzNUC5PUc,OzF5MUWwPVk9N2F-
THP1 NUO0eJY1TnWwY4Tpc44h[XO|YYm= MYmyNEBpenN? MWPB[49vcXO2IHHjeIl3cXS7IHH0JHNVUU6JIHnuJIh2dWGwIGTIVFEh[2WubIOgZZN{\XO|ZXSgZZMhe3SrbYXsZZRqd25ib3[gTXJHOyCyYYToe4F6KG2nYYP1doVlKGGodHXyJFIxKGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVAhRSB|OD62JO69VS5? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTh{MEm4OUc,OzF6MkC5PFU9N2F-
PBMC MXrGeY5kfGmxbjDhd5NigQ>? NVz5UFVTPjlwNjD1US=> M{nUU|QhcHK| NUW2R2k4SWexbnnzeEBi[3Srdnn0fUBifCCVVFnOS{BqdiCqdX3hckBRSk2FIHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJGNZS0xzMDDtVm5CKGyndnXsJIF1KDZ7Lk[geW0hdWWjc4Xy[YQh[W[2ZYKgOEBpenNiYomgdXJVNVCFUjDhcoFtgXOrcx?= NHznRpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUiyNFk5PSd-M{G4NlA6QDV:L3G+
PBMC NVrXPGo6TnWwY4Tpc44h[XO|YYm= MVexMlM6KHSxIEGzPUB2VQ>? Mo\aOEBpenN? NVzOUZVpSWexbnnzeEBi[3Srdnn0fUBifCCVVFnOS{BqdiCqdX3hckBRSk2FIHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJGlHVmKndHGgdoVt\WG|ZTDheEAyNjN7IITvJFE{QSC3TTDt[YF{fXKnZDDh[pRmeiB2IHjyd{BjgSCHTFnTRS=> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTh{MEm4OUc,OzF6MkC5PFU9N2F-
PBMC NXuw[Y9UTnWwY4Tpc44h[XO|YYm= MoDsOlkvPiC3TR?= Mom3OEBpenN? NVz5d5JmSWexbnnzeEBi[3Srdnn0fUBifCCVVFnOS{BqdiCqdX3hckBRSk2FIHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJGlHVmKndHGgcXJPSSCuZY\lcEBifCB4OT62JJVOKG2nYYP1doVlKGGodHXyJFQhcHK|IHL5JJFTXC2SQ2KgZY5idHm|aYO= NVrRdZhmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G4NlA6QDVpPkOxPFIxQTh3PD;hQi=>
PBMC NEXqc5hHfW6ldHnvckBie3OjeR?= MoHQOlkvPiC3TR?= M3jEd|QhcHK| NUj1O4xtSWexbnnzeEBi[3Srdnn0fUBifCCVVFnOS{BqdiCqdX3hckBRSk2FIHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJGlNPiCvUl7BJIxmfmWuIHH0JFY6NjZidV2gcYVie3W{ZXSgZYZ1\XJiNDDodpMh[nlicWLUMXBEWiCjbnHsfZNqew>? M4\rWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzOEKwPVg2Lz5|MUiyNFk5PTxxYU6=
PBMC NVzRZnB4TnWwY4Tpc44h[XO|YYm= NXmyc4NxOTN7IIXN NInZNmE1KGi{cx?= M1XTemFod26rc4SgZYN1cX[rdImgZZQhW1SLTlegbY4hcHWvYX6gVGJOSyClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDJUFYheHKxZIXjeIlwdiCjdDCxN|khfU1ibXXhd5Vz\WRiYX\0[ZIhPCCqcoOgZpkhTUyLU1G= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTh{MEm4OUc,OzF6MkC5PFU9N2F-
B16-OVA MYXBcpRqfHWvb4KgZZN{[Xl? MUXBcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEMU[tU3ZCKGOnbHzzJIlueGyjboTl[EBqdiCvb4Xz[UBie3Onc4Pl[EBieyC2dX3veZIhemWpcnXzd4lwdiCrbjDpcopm[3SnZDDmcIFvcyCjdDCxNEB2\yCjZH3pcol{fGW{ZXSgbY51emG2dX3vdoFtdHlib36g[IF6KDZuIEmgZY5lKDF{IIDvd5QhcW2ybHHueIF1cW:w MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTVyMEm5Okc,OzF3MEC5PVY9N2F-
B16-OVA M2qwbWFvfGm2dX3vdkBie3OjeR?= NVO5SGx4SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhdW:3c3WgRlE3NU:YQTDj[YxteyCrbYDsZY51\WRiaX6gcY92e2ViYYPz[ZN{\WRiYYOgeJVud3W{IILl[5Jme3Orb36gbY4h[2:wdILhcIF1\XKjbDDmcIFvcyCjdDCxNEB2\yCjZH3pcol{fGW{ZXSgbY51emG2dX3vdoFtdHlib36g[IF6KDZuIEmgZY5lKDF{IIDvd5QhcW2ybHHueIF1cW:w Mn3JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3MEC5PVYoRjNzNUCwPVk3RC:jPh?=
B16-OVA M3P5PWFvfGm2dX3vdkBie3OjeR?= NVz1e494SW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhdW:3c3WgRlE3NU:YQTDj[YxteyCrbYDsZY51\WRiaX6gcY92e2ViYYPz[ZN{\WRiYYOgbIlocGW{IH71cYJmeiCxZjDtc5V{\SCldYLl[EBw\iC2dX3vdpMh[XRiMUCgeYch[WSvaX7pd5RmemWmIHnueJJifHWvb4LhcIx6KG:wIHThfUA3NCB7IHHu[EAyOiCyb4P0JIlueGyjboTheIlwdg>? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTVyMEm5Okc,OzF3MEC5PVY9N2F-

... Click to View More Cell Line Experimental Data

Protocol

Cell Research:

[2]

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  • Cell lines: A549, BSC-40, BSR-T7, Vero cells
  • Concentrations: 25 μM, 20 μM, 2.5 μM
  • Incubation Time: 30 min
  • Method:

    A549 cells are infected at an MOI of 5 with WT VACV or VACV-ΔPoxin and lysed 5 hpi. As a positive control, cells are permeabilized for 30 min with digitonin buffer (10 μg ml−1 digitonin, 50 mM HEPES-KOH pH 7.5, 100 mM KCl, 3 mM MgCl2, 0.1 mM DTT, 85 mM sucrose, 0.2% BSA, 1 mM ATP, and 0.1 mM GTP) and stimulated with or without 25 μM 2',3'-cGAMP. After stimulation, the cells are washed once with DMEM supplemented with 10% FBS, media is replaced, and cells are incubated 5 h before lysis.


    (Only for Reference)

Solubility (25°C)

In vitro Water 50 mg/mL (69.6 mM)
DMSO 12.5 mg/mL (17.4 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 718.37
Formula

C20H22N10Na2O13P2

CAS No. 1441190-66-4 (free acid)
Storage powder
in solvent
Synonyms 2'-3'-cyclic GMP-AMP Sodium, 2',3'-cGAMP Sodium
Smiles C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C(N=CN=C76)N)O)OP(=O)(O1)O)O)O

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID