2',3'-cGAMP

For research use only.

Catalog No.S7904 Synonyms: 2',3'-cyclic GMP-AMP

2',3'-cGAMP Chemical Structure

Molecular Weight(MW): 672.4

2',3'-cGAMP is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). The binding affinity of 2 ’, 3’-cGAMP to STING is 3.79 nM (Kd value).

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USD 337

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Biological Activity

Description 2',3'-cGAMP is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). The binding affinity of 2 ’, 3’-cGAMP to STING is 3.79 nM (Kd value).

Protocol

References

Solubility (25°C)

Chemical Information

Molecular Weight 672.4
Formula

C20H24N10O13P2·xNa+

CAS No. 1441190-66-4(freeacid)
Storage powder
in solvent
Synonyms 2',3'-cyclic GMP-AMP

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01199250 Not yet recruiting Other: Laboratory Biomarker Analysis Lynch Syndrome|Recurrent Uterine Corpus Carcinoma|Stage I Uterine Corpus Cancer|Stage II Uterine Corpus Cancer|Stage III Uterine Corpus Cancer|Stage IV Uterine Corpus Cancer Gynecologic Oncology Group|National Cancer Institute (NCI) January 2100 --
NCT02442752 Withdrawn Drug: Dexlansoprazole Pediatric Gastroesophageal Reflux Disease Takeda June 15 2025 Phase 1
NCT04134910 Not yet recruiting Procedure: Physical Therapy Back Pain|Intervertebral Disc Degeneration VA Office of Research and Development February 1 2022 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID