N-Acetyl-D-mannosamine

Catalog No.S3371 Synonyms: ManNAc, N-acetyl-beta-mannosamine

For research use only.

N-Acetyl-D-mannosamine (ManNAc, N-acetyl-beta-mannosamine), a precursor of a sialic acid, improves the age-dependent attenuation of synaptic transmission and long-term potentiation (LTP). N-Acetyl-D-mannosamine treatment is a potential therapeutic application for cognitive dysfunction.

N-Acetyl-D-mannosamine Chemical Structure

CAS No. 7772-94-3

Purity & Quality Control

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Biological Activity

Description

N-Acetyl-D-mannosamine (ManNAc, N-acetyl-beta-mannosamine), a precursor of a sialic acid, improves the age-dependent attenuation of synaptic transmission and long-term potentiation (LTP). N-Acetyl-D-mannosamine treatment is a potential therapeutic application for cognitive dysfunction.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 221.21
Formula

C8H15NO6

CAS No. 7772-94-3
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03545568 Completed Other: Neu5Ac supplementation N-Acetylneuraminic Acid Storage Disease University of Lausanne|University of Modena and Reggio Emilia May 1 2018 Not Applicable
NCT02346461 Completed Drug: ManNAc GNE Myopathy National Human Genome Research Institute (NHGRI)|National Center for Advancing Translational Science (NCATS)|National Institutes of Health Clinical Center (CC) February 5 2015 Phase 2
NCT01634750 Completed Drug: ManNAc Hereditary Inclusion Body Myopathy (HIBM)|GNE Myopathy National Human Genome Research Institute (NHGRI)|National Center for Advancing Translational Science (NCATS)|Therapeutics for Rare and Neglected Diseases (TRND)|National Institutes of Health Clinical Center (CC) September 11 2012 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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