Quinic acid

Catalog No.S3886 Synonyms: Chinic acid, Kinic acid

For research use only.

Quinic acid (Chinic acid, Kinic acid) is a crystalline acid obtained from cinchona bark, coffee beans, and other plant products and made synthetically by hydrolysis of chlorogenic acid.

Quinic acid Chemical Structure

CAS No. 77-95-2

Purity & Quality Control

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Biological Activity

Description Quinic acid (Chinic acid, Kinic acid) is a crystalline acid obtained from cinchona bark, coffee beans, and other plant products and made synthetically by hydrolysis of chlorogenic acid.
In vitro

Quinic acid inhibits NF-nB activity in cells grown in tissue culture in vitro[1]. Pre-incubation of MOVAS cells, the mouse vascular smooth muscle cell line for 2 h with Quinic acid (0.1, 1 and 10 μg/mL) dose-dependently inhibits TNF-α-induced mRNA and protein expression of VCAM-1 and monocyte adhesion. Quinic acid inhibits TNF-α-stimulated phosphorylation of MAP kinase and NK-κB activation. It inhibits the TNF-α-stimulated induction of VCAM-1 in VSMC by inhibiting the MAP kinase and NF-κB signaling pathways and the adhesion capacity of VSMC, which may explain the ability of Quinic acid to inhibit vascular inflammation such as atherosclerosis[2]. Quinic acids are capable of promoting neurite outgrowth. Treatment of PC12 cells with quinic acids instead of NGF induces neuronal differentiation[3].

In vivo Quinic acid increases splenic leukocyte numbers in vivo[1].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: Raji cell
  • Concentrations: 0-2.5mg/ml
  • Incubation Time: 48 h
  • Method: Raji cells (2×105) are cultured in the presence of indicated concentrations of C-Med 100, QAA or QA. Growth rate is assayed after 48 h by counting triplicate samples of duplicate cultures in a Coulter cell counter.
  • (Only for Reference)
Animal Research:[2]
  • Animal Models: C57BL/6 mice
  • Dosages: 1, 2 and 4 mg/ml
  • Administration: oral
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 38 mg/mL
(197.74 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 192.17
Formula

C7H12O6

CAS No. 77-95-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C(C(C(CC1(C(=O)O)O)O)O)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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