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Quinic acid NF-κB chemical

Quinic acid (Chinic acid, Kinic acid) is a crystalline acid obtained from cinchona bark, coffee beans, and other plant products and made synthetically by hydrolysis of chlorogenic acid.

Quinic acid NF-κB chemical Chemical Structure

Chemical Structure

Molecular Weight: 192.17

Purity & Quality Control

Batch: S388601 DMSO]38 mg/mL]false]]]false]]]false Purity: 98%
98

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Mechanism of Action

In vitro
In vitro Quinic acid inhibits NF-nB activity in cells grown in tissue culture in vitro[1]. Pre-incubation of MOVAS cells, the mouse vascular smooth muscle cell line for 2 h with this compound (0.1, 1 and 10 μg/mL) dose-dependently inhibits TNF-α-induced mRNA and protein expression of VCAM-1 and monocyte adhesion. It inhibits TNF-α-stimulated phosphorylation of MAP kinase and NK-κB activation. This chemical inhibits the TNF-α-stimulated induction of VCAM-1 in VSMC by inhibiting the MAP kinase and NF-κB signaling pathways and the adhesion capacity of VSMC, which may explain the ability of this compound to inhibit vascular inflammation such as atherosclerosis[2]. Quinic acids are capable of promoting neurite outgrowth. Treatment of PC12 cells with these compounds instead of NGF induces neuronal differentiation[3].
Cell Research Cell lines Raji cell
Concentrations 0-2.5mg/ml
Incubation Time 48 h
Method Raji cells (2×105) are cultured in the presence of indicated concentrations of C-Med 100, QAA or this compound. Growth rate is assayed after 48 h by counting triplicate samples of duplicate cultures in a Coulter cell counter.

In Vivo
In vivo Quinic acid increases splenic leukocyte numbers in vivo[1].
Animal Research Animal Models C57BL/6 mice
Dosages 1, 2 and 4 mg/ml
Administration oral

References
  • https://pubmed.ncbi.nlm.nih.gov/15589483/
  • https://pubmed.ncbi.nlm.nih.gov/29032340/
  • https://pubmed.ncbi.nlm.nih.gov/11510486/

Chemical Information

Molecular Weight 192.17 Formula

C7H12O6
CAS No. 77-95-2 SDF Download SDF
Synonyms Chinic acid, Kinic acid
Smiles C1C(C(C(CC1(C(=O)O)O)O)O)O

Storage and Stability

Storage (From the date of receipt)

In vitro
Batch:

DMSO : 38 mg/mL ( (197.74 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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