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Quinic acid NF-κB chemical

Cat.No.S3886

Quinic acid (Chinic acid, Kinic acid) is a crystalline acid obtained from cinchona bark, coffee beans, and other plant products and made synthetically by hydrolysis of chlorogenic acid.
Quinic acid NF-κB chemical Chemical Structure

Chemical Structure

Molecular Weight: 192.17

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Quality Control

Batch: S388601 DMSO]38 mg/mL]false]]]false]]]false Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 192.17 Formula

C7H12O6

 Storage (From the date of receipt)
CAS No. 77-95-2 Download SDF Storage of Stock Solutions

Synonyms Chinic acid, Kinic acid Smiles C1C(C(C(CC1(C(=O)O)O)O)O)O

Solubility

In vitro
Batch:

DMSO : 38 mg/mL ( (197.74 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

In vitro
Quinic acid inhibits NF-nB activity in cells grown in tissue culture in vitro[1]. Pre-incubation of MOVAS cells, the mouse vascular smooth muscle cell line for 2 h with this compound (0.1, 1 and 10 μg/mL) dose-dependently inhibits TNF-α-induced mRNA and protein expression of VCAM-1 and monocyte adhesion. It inhibits TNF-α-stimulated phosphorylation of MAP kinase and NK-κB activation. This chemical inhibits the TNF-α-stimulated induction of VCAM-1 in VSMC by inhibiting the MAP kinase and NF-κB signaling pathways and the adhesion capacity of VSMC, which may explain the ability of this compound to inhibit vascular inflammation such as atherosclerosis[2]. Quinic acids are capable of promoting neurite outgrowth. Treatment of PC12 cells with these compounds instead of NGF induces neuronal differentiation[3].
In vivo
Quinic acid increases splenic leukocyte numbers in vivo[1].
References

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