Home Immunology & Inflammation NF-κB chemical Quinic acid For research use only.

Quinic acid

Synonyms: Chinic acid, Kinic acid

Quinic acid (Chinic acid, Kinic acid) is a crystalline acid obtained from cinchona bark, coffee beans, and other plant products and made synthetically by hydrolysis of chlorogenic acid.

Quinic acid Chemical Structure

Quinic acid Chemical Structure

CAS: 77-95-2

Purity & Quality Control

Batch: S388601 DMSO] 38 mg/mL] false] ] ] false] ] ] false Purity: 98%
98

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Biological Activity

Description Quinic acid (Chinic acid, Kinic acid) is a crystalline acid obtained from cinchona bark, coffee beans, and other plant products and made synthetically by hydrolysis of chlorogenic acid.
In vitro
In vitro Quinic acid inhibits NF-nB activity in cells grown in tissue culture in vitro[1]. Pre-incubation of MOVAS cells, the mouse vascular smooth muscle cell line for 2 h with Quinic acid (0.1, 1 and 10 μg/mL) dose-dependently inhibits TNF-α-induced mRNA and protein expression of VCAM-1 and monocyte adhesion. Quinic acid inhibits TNF-α-stimulated phosphorylation of MAP kinase and NK-κB activation. It inhibits the TNF-α-stimulated induction of VCAM-1 in VSMC by inhibiting the MAP kinase and NF-κB signaling pathways and the adhesion capacity of VSMC, which may explain the ability of Quinic acid to inhibit vascular inflammation such as atherosclerosis[2]. Quinic acids are capable of promoting neurite outgrowth. Treatment of PC12 cells with quinic acids instead of NGF induces neuronal differentiation[3].
Cell Research Cell lines Raji cell
Concentrations 0-2.5mg/ml
Incubation Time 48 h
Method Raji cells (2×105) are cultured in the presence of indicated concentrations of C-Med 100, QAA or QA. Growth rate is assayed after 48 h by counting triplicate samples of duplicate cultures in a Coulter cell counter.
In Vivo
In vivo Quinic acid increases splenic leukocyte numbers in vivo[1].
Animal Research Animal Models C57BL/6 mice
Dosages 1, 2 and 4 mg/ml
Administration oral

Chemical Information & Solubility

Molecular Weight 192.17 Formula

C7H12O6
CAS No. 77-95-2 SDF Download Quinic acid SDF
Smiles C1C(C(C(CC1(C(=O)O)O)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 38 mg/mL ( (197.74 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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